Potential molecular mechanism of ascites syndrome in broilers

References

• Arab, H. A., R. Jamshidi, A. Rassouli, G. Shams, and M. H. Hassanzadeh. 2006. “Generation of Hydroxyl Radicals during Ascites Experimentally Induced in Broilers.” British Poultry Science 47 (2): 216–222.
   PubMed Web of Science ®Google Scholar
• Baghbanzadeh, A., and E. Decuypere. 2008. “Ascites Syndrome in Broilers: Physiological and Nutritional Perspectives.” Avian Pathology 37 (2): 117–126. doi:10.1080/03079450801902062.
   PubMed Web of Science ®Google Scholar
• Berghausen, E. M., L. Feik, M. Zierden, M. Vantler, S. Rosenkranz. 2019. “Key Inflammatory Pathways Underlying Vascular Remodeling in Pulmonary Hypertension.” Herz 44 (2): 130–137. doi:10.1007/s00059-019-4795-6.
   Google Scholar
• Bonnet, S., G. Rochefort, G. Sutendra, S. L. Archer, A. Haromy, L. Webster, K. Hashimoto. 2007. “The Nuclear Factor of Activated T Cells in Pulmonary Arterial Hypertension Can Be Therapeutically Targeted.” Proceedings of the National Academy of Sciences of the United States of America 104 (27): 11418–11423. doi:10.1073/pnas.0610467104.
   PubMed Web of Science ®Google Scholar
• Bornstein, P., T. R. Kyriakides, Z. Yang, L. C. Armstrong, D. E. Birk. 2000. “Thrombospondin 2 Modulates Collagen Fibrillogenesis and Angiogenesis.” Journal of Investigative Dermatology Symposium Proceedings 5 (1): 61–66. doi:10.1046/j.1087-0024.2000.00005.x.
   Google Scholar
• Chapman, M. E., and R. J. Wideman. 2001. “Pulmonary Wedge Pressures Confirm Pulmonary Hypertension in Broilers Is Initiated by an Excessive Pulmonary Arterial (Precapillary) Resistance.” Poultry Science 80 (4): 468–473. doi:10.1093/ps/80.4.468.
   PubMed Web of Science ®Google Scholar
• Chapman, M. E., and R. J. Wideman. 2006. “Evaluation of the Serotonin Receptor Blockers Ketanserin and Methiothepin on the Pulmonary Hypertensive Responses of Broilers to Intravenously Infused Serotonin.” Poultry Science 85 (4): 777–786. doi:10.1093/ps/85.4.777.
   Google Scholar
• Chapman, M. E., R. L. Taylor, R. F. Wideman. 2008. “Analysis of Plasma Serotonin Levels and Hemodynamic Responses following Chronic Serotonin Infusion in Broilers Challenged with Bacterial Lipopolysaccharide and Microparticles.” Poultry Science 87 (1): 116–124. doi:10.3382/ps.2007-00160.
   Google Scholar
• Chen, Y., A. B. Rabson, D. H. Gorski. 2010. “MEOX2 Regulates Nuclear factor-kappaB Activity in Vascular Endothelial Cells through Interactions with P65 and IkappaBbeta.” Cardiovascular Research 87 (4): 723–731. doi:10.1093/cvr/cvq117.
   Google Scholar
• Cheng, S., X. Liu, P. Liu, G. Li, X. Guo, G. Hu, L. Li. 2021. “Dysregulated Expression of mRNA and SNP in Pulmonary Artery Remodeling in Ascites Syndrome in Broilers.” Poultry Science 100 (3): 100877. doi:10.1016/j.psj.2020.11.054.
   Google Scholar
• Chester, A. H., and M. H. Yacoub. 2014. “The Role of Endothelin-1 in Pulmonary Arterial Hypertension.” Global Cardiology Science & Practice 2014 (2): 62–78. doi:10.5339/gcsp.2014.29.
   Google Scholar
• Chmielewski, S., A. Piaszyk-Borychowska, J. Wesoly, H. A. R. Bluyssen. 2016. “STAT1 and IRF8 in Vascular Inflammation and Cardiovascular Disease: Diagnostic and Therapeutic Potential.” International Reviews of Immunology 35 (5): 434–454. doi:10.3109/08830185.2015.1087519.
   PubMed Web of Science ®Google Scholar
• Enkvetchakul, B., W. Bottje, N. Anthony, R. Moore, W. Huff. 1993. “Compromised Antioxidant Status Associated with Ascites in Broilers.” Poultry Science 72 (12): 2272–2280. doi:10.3382/ps.0722272.
   PubMed Web of Science ®Google Scholar
• Feletou, M., Y. Huang, P. M. Vanhoutte. 2011. “Endothelium-mediated Control of Vascular Tone: COX-1 and COX-2 Products.” British Journal of Pharmacology 164 (3): 894–912. doi:10.1111/j.1476-5381.2011.01276.x.
   PubMed Web of Science ®Google Scholar
• Fuhrmann, D. C., and B. Brune. 2017. “Mitochondrial Composition and Function under the Control of Hypoxia.” Redox Biology 12: 208–215. doi:10.1016/j.redox.2017.02.012.
   PubMed Web of Science ®Google Scholar
• Gao, J., L. Zhao, M. Shahzad, D. Zhang, G. Liu, B. Hou, J. Li. 2013. “Expression of Endothelin-1 and Its Receptors in the Lungs of Broiler Chickens Exposed to High-altitude Hypoxia.” Avian Pathology 42 (5): 416–419. doi:10.1080/03079457.2013.821568.
   PubMed Web of Science ®Google Scholar
• Gao, Y., T. Chen, J. U. Raj. 2016. “Endothelial and Smooth Muscle Cell Interactions in the Pathobiology of Pulmonary Hypertension.” American Journal of Respiratory Cell and Molecular Biology 54 (4): 451–460. doi:10.1165/rcmb.2015-0323TR.
   Google Scholar
• Guilluy, C., S. Eddahibi, C. Agard, C. Guignabert, M. Izikki, L. Tu, L. Savale, et al. 2009. “RhoA and Rho Kinase Activation in Human Pulmonary Hypertension: Role of 5-HT Signaling.” American Journal of Respiratory and Critical Care Medicine 179 (12): 1151–1158. doi:10.1164/rccm.200805-691OC.
   PubMed Web of Science ®Google Scholar
• Hamal, K. R., R. F. Wideman, N. B. Anthony, G. F. Erf. 2010. “Differential Expression of Vasoactive Mediators in Microparticle-challenged Lungs of Chickens that Differ in Susceptibility to Pulmonary Arterial Hypertension.” American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 298 (1): R235–42. doi:10.1152/ajpregu.00451.2009.
   Google Scholar
• Hamal, K. R., G. F. Erf, N. B. Anthony, R. F. Wideman. 2012. “Immunohistochemical Examination of Plexiform-like Complex Vascular Lesions in the Lungs of Broiler Chickens Selected for Susceptibility to Idiopathic Pulmonary Arterial Hypertension.” Avian Pathology 41 (2): 211–219. doi:10.1080/03079457.2012.663077.
   PubMed Web of Science ®Google Scholar
• Hassanpour, H., H. Momtaz, L. Shahgholian, R. Bagheri, S. Sarfaraz, B. Heydaripoor. 2011. “Gene Expression of Endothelin-1 and Its Receptors in the Heart of Broiler Chickens with T(3)-induced Pulmonary Hypertension.” Research in Veterinary Science 91 (3): 370–375. doi:10.1016/j.rvsc.2010.09.019.
   Google Scholar
• Hosoki, A., H. Oku, T. Horie, T. Kida, T. Sugiyama, K. Nakamura, T. Ikeda. 2015. “Changes in Expression of Nestin, CD44, Vascular Endothelial Growth Factor and Glutamine Synthetase by Mature Muller Cells after Dedifferentiation.” Journal of Ocular Pharmacology and Therapeutics 31 (8): 476–481. doi:10.1089/jop.2014.0117.
   Google Scholar
• Hu, G., Y. Song, S. Ke, H. Cao, C. Zhang, G. Deng, F. Yang. 2017. “Tanshinone IIA Protects against Pulmonary Arterial Hypertension in Broilers.” Poultry Science 96 (5): 1132–1138. doi:10.3382/ps/pew322.
   PubMed Web of Science ®Google Scholar
• Julian, R. J., I. McMillan, M. Quinton. 1989. “The Effect of Cold and Dietary Energy on Right Ventricular Hypertrophy, Right Ventricular Failure and Ascites in Meat-type Chickens.” Avian Pathology 18 (4): 675–684. doi:10.1080/03079458908418641.
   PubMed Web of Science ®Google Scholar
• Julian, R. J. 1993. “Ascites in Poultry.” Avian Pathology 22 (3): 419–454. doi:10.1080/03079459308418934.
   PubMed Web of Science ®Google Scholar
• Khajali, F., M. Tahmasebi, H. Hassanpour, M. R. Akbari, D. Qujeq, R. F. Wideman. 2011. “Effects of Supplementation of Canola Meal-based Diets with Arginine on Performance, Plasma Nitric Oxide and Carcass Characteristics of Broiler Chickens Grown at High Altitude.” Poultry Science 90 (10): 2287–2294. doi:10.3382/ps.2011-01618.
   Web of Science ®Google Scholar
• Kim, G. H., J. J. Ryan, G. Marsboom, S. L. Archer. 2011. “Epigenetic Mechanisms of Pulmonary Hypertension.” Pulmonary Circulation 1 (3): 347–356. doi:10.4103/2045-8932.87300.
   PubMedGoogle Scholar
• Klinger, J. R., S. H. Abman, M. T. Gladwin. 2013. “Nitric Oxide Deficiency and Endothelial Dysfunction in Pulmonary Arterial Hypertension.” American Journal of Respiratory and Critical Care Medicine 188 (6): 639–646. doi:10.1164/rccm.201304-0686PP.
   PubMed Web of Science ®Google Scholar
• Kluess, H. A., J. Stafford, K. W. Evanson, A. J. Stone, J. Worley, R. F. Wideman. 2012. “Intrapulmonary Arteries Respond to Serotonin and Adenosine Triphosphate in Broiler Chickens Susceptible to Idiopathic Pulmonary Arterial Hypertension.” Poultry Science 91 (6): 1432–1440. doi:10.3382/ps.2011-01919.
   Google Scholar
• Lai, Y. C., K. C. Potoka, H. C. Champion, A. L. Mora, M. T. Gladwin. 2014. “Pulmonary Arterial Hypertension: The Clinical Syndrome.” Circulation Research 115 (1): 115–130. doi:10.1161/CIRCRESAHA.115.301146.
   PubMed Web of Science ®Google Scholar
• Li, M., S. R. Riddle, M. G. Frid, K. C. El Kasmi, T. A. McKinsey, R. J. Sokol, D. Strassheim. 2011. “Emergence of Fibroblasts with a Proinflammatory Epigenetically Altered Phenotype in Severe Hypoxic Pulmonary Hypertension.” The Journal of Immunology 187 (5): 2711–2722. doi:10.4049/jimmunol.1100479.
   Google Scholar
• Li, H., Y. Wang, L. Chen, L. Han, L. Li, H. He, Y. Li. 2017. “The Role of MIF, cyclinD1 and ERK in the Development of Pulmonary Hypertension in Broilers.” Avian Pathology 46 (2): 202–208. doi:10.1080/03079457.2016.1245409.
   PubMed Web of Science ®Google Scholar
• Liu, P., F. Yang, Y. Zhuang, Q. Xiao, H. Cao, C. Zhang, T. Wang. 2017. “Dysregulated Expression of microRNAs and mRNAs in Pulmonary Artery Remodeling in Ascites Syndrome in Broiler Chickens.” Oncotarget 8 (2): 1993–2007. doi:10.18632/oncotarget.12888.
   PubMedGoogle Scholar
• Lorenzoni, A. G., N. B. Anthony, R. F. Wideman. 2008. “Transpulmonary Pressure Gradient Verifies Pulmonary Hypertension Is Initiated by Increased Arterial Resistance in Broilers.” Poultry Science 87 (1): 125–132. doi:10.3382/ps.2007-00178.
   Google Scholar
• Luo, Y., Z. Xu, T. Wan, Y. He, D. Jones, H. Zhang, W. Min. 2010. “Endothelial-specific Transgenesis of TNFR2 Promotes Adaptive Arteriogenesis and Angiogenesis.” Arteriosclerosis, Thrombosis, and Vascular Biology 30 (7): 1307–1314. doi:10.1161/ATVBAHA.110.204222.
   Web of Science ®Google Scholar
• MacLean, M. R., G. Sweeney, M. Baird, K. M. McCulloch, M. Houslay, I. Morecroft. 1996. “5-Hydroxytryptamine Receptors Mediating Vasoconstriction in Pulmonary Arteries from Control and Pulmonary Hypertensive Rats.” British Journal of Pharmacology 119 (5): 917–930. doi:10.1111/j.1476-5381.1996.tb15760.x.
   Google Scholar
• Marsboom, G., P. T. Toth, J. J. Ryan, Z. Hong, X. Wu, Y.-H. Fang, T. Thenappan. 2012. “Dynamin-related Protein 1-mediated Mitochondrial Mitotic Fission Permits Hyperproliferation of Vascular Smooth Muscle Cells and Offers a Novel Therapeutic Target in Pulmonary Hypertension.” Circulation Research 110 (11): 1484–1497. doi:10.1161/CIRCRESAHA.111.263848.
   PubMed Web of Science ®Google Scholar
• Masri, F. A., W. Xu, S. A. A. Comhair, K. Asosingh, M. Koo, A. Vasanji, J. Drazba. 2007. “Hyperproliferative Apoptosis-resistant Endothelial Cells in Idiopathic Pulmonary Arterial Hypertension.” American Journal of Physiology-Lung Cellular and Molecular Physiology 293 (3): L548–54. doi:10.1152/ajplung.00428.2006.
   Google Scholar
• Maxwell, M. H., S. Spence, G. W. Robertson, M. A. Mitchell. 1990. “Haematological and Morphological Responses of Broiler Chicks to Hypoxia.” Avian Pathology 19 (1): 23–40. doi:10.1080/03079459008418653.
   PubMed Web of Science ®Google Scholar
• Maxwell, M. H., G. W. Robertson, C. Farquharson. 1996. “Evidence of Ultracytochemical Mitochondria-derived Hydrogen Peroxide Activity in Myocardial Cells from Broiler Chickens with an Ascites Syndrome.” Research in Veterinary Science 61 (1): 7–12. doi:10.1016/S0034-5288(96)90102-2.
   PubMed Web of Science ®Google Scholar
• McMurtry, M. S., S. Bonnet, X. Wu, J. R. B. Dyck, A. Haromy, K. Hashimoto, E. D. Michelakis. 2004. “Dichloroacetate Prevents and Reverses Pulmonary Hypertension by Inducing Pulmonary Artery Smooth Muscle Cell Apoptosis.” Circulation Research 95 (8): 830–840. doi:10.1161/01.RES.0000145360.16770.9f.
   PubMed Web of Science ®Google Scholar
• Mutchler, S. M., and A. C. Straub. 2015. “Compartmentalized Nitric Oxide Signaling in the Resistance Vasculature.” Nitric Oxide: Biology and Chemistry / Official Journal of the Nitric Oxide Society 49: 8–15. doi:10.1016/j.niox.2015.05.003.
   Google Scholar
• Nakahata, N. 2008. “Thromboxane A2: Physiology/pathophysiology, Cellular Signal Transduction and Pharmacology.” Pharmacology & Therapeutics 118 (1): 18–35. doi:10.1016/j.pharmthera.2008.01.001.
   PubMed Web of Science ®Google Scholar
• Odom, T. W., L. A. Martinez-Lemus, R. K. Hester, E. J. Becker, J. S. Jeffrey, G. A. Meininger, G. A. Ramirez. 2004. “In Vitro Hypoxia Differentially Affects Constriction and Relaxation Responses of Isolated Pulmonary Arteries from Broiler and Leghorn Chickens.” Poultry Science 83 (5): 835–841. doi:10.1093/ps/83.5.835.
   PubMed Web of Science ®Google Scholar
• Pan, J. Q., J. C. Li, X. Tan, W.-D. Sun, J.-Y. Wang, X.-L. Wang. 2007. “The Injury Effect of Oxygen Free Radicals in Vitro on Cultured Pulmonary Artery Endothelial Cells from Broilers.” Research in Veterinary Science 82 (3): 382–387. doi:10.1016/j.rvsc.2006.08.001.
   Google Scholar
• Peacock, A. J., C. Pickett, K. Morris, and J. T. Reeves. 1989. “The Relationship between Rapid Growth and Pulmonary Hemodynamics in the Fast-growing Broiler Chicken.” The American Review of Respiratory Disease 139 (6): 1524–1530. doi:10.1164/ajrccm/139.6.1524.
   PubMed Web of Science ®Google Scholar
• Prazeres, H., J. Torres, F. Rodrigues, M. Pinto, M. C. Pastoriza, D. Gomes, J. Cameselle-Teijeiro. 2011. “Chromosomal, Epigenetic and microRNA-mediated Inactivation of LRP1B, a Modulator of the Extracellular Environment of Thyroid Cancer Cells.” Oncogene 30 (11): 1302–1317. doi:10.1038/onc.2010.512.
   Web of Science ®Google Scholar
• Ruiz-Feria, C. A., and R. J. Wideman. 2001. “Taurine, Cardiopulmonary Hemodynamics, and Pulmonary Hypertension Syndrome in Broilers.” Poultry Science 80 (11): 1607–1618. doi:10.1093/ps/80.11.1607.
   PubMed Web of Science ®Google Scholar
• Shimoda, L. A., X. Yun, G. Sikka. 2019. “Revisiting the Role of Hypoxia-inducible Factors in Pulmonary Hypertension”. Current Opinion in Physiology 7 33–40. doi:10.1016/j.cophys.2018.12.003.
   Google Scholar
• Stacher, E., B. B. Graham, J. M. Hunt, A. Gandjeva, S. D. Groshong, V. V. McLaughlin, M. Jessup. 2012. “Modern Age Pathology of Pulmonary Arterial Hypertension.” American Journal of Respiratory and Critical Care Medicine 186 (3): 261–272. doi:10.1164/rccm.201201-0164OC.
   PubMed Web of Science ®Google Scholar
• Takahashi, T., Y. Sugishita, T. Nojiri, T. Shimizu, A. Yao, K.-I. Kinugawa, K. Harada. 2001. “Cloning of Hypoxia-inducible Factor 1alpha cDNA from Chick Embryonic Ventricular Myocytes.” Biochemical and Biophysical Research Communications 281 (4): 1057–1062. doi:10.1006/bbrc.2001.4463.
   Google Scholar
• Tan, X., F. J. Shao, G.-J. Fan, Y.-T. Ying. 2018. “Expression of Angiogenic Factors and Plexiform Lesions in the Lungs of Broiler and Layer Chickens: A Comparison.” Poultry Science 97 (5): 1526–1535. doi:10.3382/ps/pey008.
   Google Scholar
• Tang, Z., M. Iqbal, D. Cawthon, W. G. Bottje. 2002. “Heart and Breast Muscle Mitochondrial Dysfunction in Pulmonary Hypertension Syndrome in Broilers (Gallus Domesticus).” Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology 132 (3): 527–540. doi:10.1016/S1095-6433(02)00005-3.
   Google Scholar
• Tarrant, K. J., S. Dey, R. Kinney, N. B. Anthony, D. D. Rhoads. 2017. “Multi-generational Genome Wide Association Studies Identify Chromosomal Regions Associated with Ascites Phenotype.” Poultry Science 96 (6): 1544–1552. doi:10.3382/ps/pew478.
   Google Scholar
• Tisljar, M., Z. Grabarevic, B. Artuković, P. Dzaja, S. Cenan, T. A. Zelenika, R. G. Cooper. 2011. “The Impact of L-NAME and L-arginine Chronic Toxicity Induced Lesions on Ascites–pulmonary Hypertension Syndrome Development in Broiler Chickens.” Collegium Antropologicum 35 (2): 547–556.
   Google Scholar
• Weir, E. K., Z. Hong, A. Varghese. 2004. “The Serotonin Transporter: A Vehicle to Elucidate Pulmonary Hypertension?” Circulation Research 94 (9): 1152–1154. doi:10.1161/01.RES.0000129568.71027.fc.
   Google Scholar
• Wideman, R. F., M. R. Fedde, C. D. Tackett, G. E. Weigle. 2000. “Cardio-pulmonary Function in Preascitic (Hypoxemic) or Normal Broilers Inhaling Ambient Air or 100% Oxygen.” Poultry Science 79 (3): 415–425. doi:10.1093/ps/79.3.415.
   PubMed Web of Science ®Google Scholar
• Wideman, R. J., G. F. Erf, M. E. Chapman. 2001. “Intravenous Endotoxin Triggers Pulmonary Vasoconstriction and Pulmonary Hypertension in Broiler Chickens.” Poultry Science 80 (5): 647–655. doi:10.1093/ps/80.5.647.
   Google Scholar
• Wideman, R. F., M. E. Chapman, G. F. Erf. 2005. “Pulmonary and Systemic Hemodynamic Responses to Intravenous Prostacyclin in Broilers.” Poultry Science 84 (3): 442–453. doi:10.1093/ps/84.3.442.
   Google Scholar
• Wideman, R. F., M. E. Chapman, K. R. Hamal, O. T. Bowen, A. G. Lorenzoni, G. F. Erf, N. B. Anthony. 2007. “An Inadequate Pulmonary Vascular Capacity and Susceptibility to Pulmonary Arterial Hypertension in Broilers.” Poultry Science 86 (5): 984–998. DOI:10.1093/ps/86.5.984.
   PubMed Web of Science ®Google Scholar
• Wideman, R. F., O. T. Bowen, G. F. Erf. 2009. “Broiler Pulmonary Hypertensive Responses during Lipopolysaccharide-induced Tolerance and Cyclooxygenase Inhibition.” Poultry Science 88 (1): 72–85. doi:10.3382/ps.2008-00314.
   Google Scholar
• Wideman, R. F., K. R. Hamal, M. T. Bayona, A. G. Lorenzoni, D. Cross, F. Khajali, D. D. Rhoads. 2011. “Plexiform Lesions in the Lungs of Domestic Fowl Selected for Susceptibility to Pulmonary Arterial Hypertension: Incidence and Histology.” The Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biology 294 (5): 739–755. doi:10.1002/ar.21369.
   Google Scholar
• Wideman, R. J., and K. R. Hamal. 2011. “Idiopathic Pulmonary Arterial Hypertension: An Avian Model for Plexogenic Arteriopathy and Serotonergic Vasoconstriction.” Journal of Pharmacological and Toxicological Methods 63 (3): 283–295. doi:10.1016/j.vascn.2011.01.002.
   Google Scholar
• Wideman, R. F., D. D. Rhoads, G. F. Erf, N. B. Anthony. 2013. “Pulmonary Arterial Hypertension (Ascites Syndrome) in Broilers: A Review.” Poultry Science 92 (1): 64–83. doi:10.3382/ps.2012-02745.
   PubMed Web of Science ®Google Scholar
• Wideman, R. J., J. G. Mason, N. B. Anthony, D. Cross. 2015. “Plexogenic Arteriopathy in Broiler Lungs: Evaluation of Line, Age and Sex Influences.” Poultry Science 94 (4): 628–638. doi:10.3382/ps/pev018.
   Google Scholar
• Wilson, J. B., R. J. Julian, I. K. Barker. 1988. “Lesions of Right Heart Failure and Ascites in Broiler Chickens.” Avian Diseases 32 (2): 246–261. doi:10.2307/1590812.
   PubMed Web of Science ®Google Scholar
• Yang, X., Y. H. Luo, Q. F. Zeng, K. Y. Zhang, X. M. Ding, S. P. Bai, J. P. Wang. 2014. “Effects of Low Ambient Temperatures and Dietary Vitamin C Supplement on Growth Performance, Blood Parameters and Antioxidant Capacity of 21-day-old Broilers.” Poultry Science 93 (4): 898–905. doi:10.3382/ps.2013-03438.
   Google Scholar
• Yang, Y. M., H. Yuan, J. G. Edwards, Y. Skayian, K. Ochani, E. J. Miller, P. B. Sehgal. 2015. “Deletion of STAT5a/b in Vascular Smooth Muscle Abrogates the Male Bias in Hypoxic Pulmonary Hypertension in Mice: Implications in the Human Disease.” Molecular Medicine 20 (1): 625–638. doi:10.2119/molmed.2014.00180.
   Google Scholar
• Yang, H., Y. Lu, H. Yang, Y. Zhu, Y. Tang, L. Li, C. Liu. 2021. “Integrated Weighted Gene Co-expression Network Analysis Uncovers STAT1(signal Transducer and Activator of Transcription 1) and IFI44L (Interferon-induced Protein 44-like) as Key Genes in Pulmonary Arterial Hypertension.” Bioengineered 12 (1): 6021–6034. doi:10.1080/21655979.2021.1972200.
   PubMed Web of Science ®Google Scholar
• Yu, L., and C. A. Hales. 2011. “Silencing of Sodium-hydrogen Exchanger 1 Attenuates the Proliferation, Hypertrophy and Migration of Pulmonary Artery Smooth Muscle Cells via E2F1.” American Journal of Respiratory Cell and Molecular Biology 45 (5): 923–930. doi:10.1165/rcmb.2011-0032OC.
   Google Scholar
• Zhang, J., X. Feng, L. Zhao, W. Wang, M. Gao, B. Wu, J. Qiao. 2013. “Expression of Hypoxia-inducible Factor 1alpha mRNA in Hearts and Lungs of Broiler Chickens with Ascites Syndrome Induced by Excess Salt in Drinking Water.” Poultry Science 92 (8): 2044–2052. doi:10.3382/ps.2013-03097.
   Google Scholar
• Zhong, G., and X. Xiong. 2015. “miR-205 Promotes Proliferation and Invasion of Laryngeal Squamous Cell Carcinoma by Suppressing CDK2AP1 Expression.” Biological Research 48 (1): 60. doi:10.1186/s40659-015-0052-5.
   Google Scholar