Articular/epiphyseal osteochondrosis in Thoroughbred foals at 5 months of age: Influences of growth of the foal and prenatal copper supplementation of the dam

References

• Anonymous Nutrient Requirements of Horses. , 5th Edtn National Research Council. National Academy Press Washington DC, , USA 1989
   Google Scholar
• Bridges , CH and Harris , ED . 1988 . Experimentally induced cartilaginous fractures (osteochondritis dissecans) in foals fed low-copper diets . Journal of the American Veterinary Medical Association , 193 : 215 – 221 .
   PubMed Web of Science ®Google Scholar
• Brown-Douglas , CG , Parkinson , TJ , Firth , EC and Fennessy , PF . 2005 . Bodyweights and growth rates of spring- and autumn-born Thoroughbred horses raised on pasture . New Zealand Veterinary Journal , 53 : 326 – 331 .
   PubMed Web of Science ®Google Scholar
• Carlson , CS , Hilley , HD , Meuten , DJ , Hagan , JM and Moser , RL . 1988 . Effect of reduced growth rate on the prevalence and severity of osteochondrosis in gilts . American Journal of Veterinary Research , 49 : 396 – 402 .
   PubMed Web of Science ®Google Scholar
• Dik , KJ , Enzerink , E and van Weeren , PR van . 1999 . Radiographic development of osteochondral abnormalities, in the hock and stifle of Dutch Warmblood foals, from age 1 to 11 months . Equine Veterinary Journal , : 9 – 15 .
   Google Scholar
• Ekman , S and Carlson , CS . 1998 . The pathophysiology of osteochondrosis . Veterinary Clinics of North America: Small Animal Practice , 28 : 17 – 32 .
   PubMed Web of Science ®Google Scholar
• Firth , EC , van Weeren , PR van , Pfeiffer , DU , Delahunt , J and Barneveld , A . 1999 . Effect of age, exercise and growth rate on bone mineral density (BMD) in third carpal bone and distal radius of Dutch Warmblood foals with osteochondrosis . Equine Veterinary Journal , 31 ( Supplement ) : 74 – 78 .
   Google Scholar
• Fischer , AT Jr and Barclay , WP . 1984 . Osteochondrosis dissecans in the horse . Compendium on Continuing Education for the Practicing Veterinarian , 6 : S123 – S131 .
   Google Scholar
• Gabel , AA , Knight , DA , Reed , SM , Pulz , JA , Powers , JD , Bramlage , LR and Tyznik , WJ . 1987 . Comparison of incidence and severity of developmental orthopaedic disease on 17 farms before and after adjustment of ration . Proceedings of the Annual Convention of the American Association of Equine Practitioners , 33 : 163 – 169 .
   Google Scholar
• Gee , EK , Grace , ND , Firth , EC and Fennessy , PF . 2000 . Changes in liver copper concentration of Thoroughbred foals from birth to 160 days of age and the effect of prenatal copper supplementation . Australian Veterinary Journal , 78 : 347 – 353 .
   PubMed Web of Science ®Google Scholar
• Gee , EK , Fennessy , PF , Morel , PCH , Grace , ND , Firth , EC and Mogg , TD . 2003 . Chemical composition of 20 Thoroughbred foals at 160 days of age, and preliminary investigation of techniques used to predict body fatness . New Zealand Veterinary Journal , 51 : 125 – 131 .
   PubMed Web of Science ®Google Scholar
• Gee , EK , Morel , PCH , Mogg , TD , Firth , EC , Grace , ND and Fennessy , PF . 2004 . Liver copper kinetics in Thoroughbred foals at pasture from birth to 160 days of age . New Zealand Journal of Agricultural Research , 47 : 109 – 118 .
   Web of Science ®Google Scholar
• Gee , EK , Firth , EC , Morel , MCH , Fennessy , PF , Grace , ND and Mogg , TD . 2005 . Enlargements of the distal third metacarpus and metatarsus in Thoroughbred foals at pasture from birth to 160 days of age . New Zealand Veterinary Journal , 53 : 438 – 447 .
   PubMed Web of Science ®Google Scholar
• Gee , E , Davies , M , Firth , E , Jeffcott , L , Fennessy , P and Mogg , T . Osteochondrosis and copper: Histology of articular cartilage from foals out of copper-supplemented and non-supplemented dams . Veterinary Journal , (in press)
   Web of Science ®Google Scholar
• Glade , MJ and Belling , THJ . 1986 . A dietary etiology for osteochondrotic cartilage . Journal of Equine Veterinary Science , 6 : 151 – 155 .
   Google Scholar
• Grace , ND , Rogers , CW , Firth , EC , Faram , TL and Shaw , HL . 2003 . Digestible energy intake, dry matter digestibility and effect of increased calcium intake on bone parameters of grazing Thoroughbred weanlings in New Zealand . New Zealand Veterinary Journal , 51 : 165 – 173 .
   PubMed Web of Science ®Google Scholar
• Henneke , DR , Potter , GD , Kreider , JL and Yeates , BF . 1983 . Relationship between condition score, physical measurements and body fat percentage in mares. . Equine Veterinary Journal , 15 : 371 – 372 .
   PubMed Web of Science ®Google Scholar
• Henson , FMD , Davies , ME and Jeffcott , LB . 1997 . Equine dyschondroplasia (osteochondrosis) — histological findings and type VI collagen localization. . Veterinary Journal , 154 : 53 – 62 .
   PubMed Web of Science ®Google Scholar
• Hintz , HF , Hintz , RL and Vleck , LDV . 1979 . Growth rate of Thoroughbreds. Effect of age of dam, year and month of birth, and sex of foal . Journal of Animal Science , 48 : 480 – 487 .
   PubMed Web of Science ®Google Scholar
• Hurtig , MB and Pool , RR . 1996 . “ Pathogenesis of equine osteochondrosis ” . In Joint Disease in the Horse , Edited by: McIlwraith , CW and Trotter , GW . 335 – 358 . Philadelphia, , USA : WB Saunders Company .
   Google Scholar
• Hurtig , MB , Green , SL , Dobson , H , Mikuni-Takagaki , Y and Choi , J . 1993 . Correlative study of defective cartilage and bone growth in foals fed a low-copper diet. . Equine Veterinary Journal , : 66 – 73 .
   Google Scholar
• Jeffcott , LB . 1991 . Osteochondrosis in the horse — searching for the key to pathogenesis . Equine Veterinary Journal , 23 : 331 – 338 .
   PubMed Web of Science ®Google Scholar
• Jeffcott , LB . 1993 . Problems and pointers in equine osteochondrosis . Equine Veterinary Journal , : 1 – 3 .
   PubMed Web of Science ®Google Scholar
• Jeffcott , LB . 1996 . Osteochondrosis — an international problem for the horse industry . Journal of Equine Veterinary Science , 16 : 32 – 37 .
   Web of Science ®Google Scholar
• Jeffcott , LB and Davies , ME . 2000 . Osteochondrosis in the new millennium . Equine Veterinary Education , 12 : 51 – 56 .
   Google Scholar
• Jeffcott , LB and Henson , FM . 1998 . Studies on growth cartilage in the horse and their application to aetiopathogenesis of dyschondroplasia (osteochondrosis) . Veterinary Journal , 156 : 177 – 192 .
   PubMed Web of Science ®Google Scholar
• Jelan , ZA , Jeffcott , LB , Lundeheim , N and Osborne , M . 1996 . Growth rates in Thoroughbred foals . Pferdeheilkunde , 12 : 291 – 295 .
   Web of Science ®Google Scholar
• Knight , DA , Gabel , AA , Reed , SM , Embertson , RM , Tyznik , WJ and Bramlage , LR . 1985 . Correlation of dietary mineral to incidence and severity of metabolic bone disease in Ohio and Kentucky . Proceedings of the Annual Convention of the American Association of Equine Practitioners , 31 : 445 – 461 .
   Google Scholar
• Knight , DA , Weisbrode , SE , Schmall , LM , Reed , SM , Gabel , AA , Bramlage , LR and Tyznik , WI . 1990 . The effects of copper supplementation on the prevalence of cartilage lesions in foals . Equine Veterinary Journal , 22 : 426 – 432 .
   PubMed Web of Science ®Google Scholar
• McIlwraith , CW . 1993 . Inferences from referred clinical cases of osteochondritis dissecans . Equine Veterinary Journal , : 27 – 30 .
   Google Scholar
• Olsson , SE and Reiland , S . 1978 . The nature of osteochondrosis in animals. Summary and conclusions with comparative aspects on osteochondritis dissecans in man . Acta Radiologica Supplementum , 358 : 299 – 306 .
   PubMedGoogle Scholar
• Pagan , JD and Jackson , SG . 1996 . The incidence of developmental orthopaedic disease on a Kentucky Thoroughbred farm . Pferdeheilkunde , 12 : 351 – 354 .
   Web of Science ®Google Scholar
• Pagan , JD , Jackson , SG and Caddel , S . 1996 . A summary of growth rate in Thoroughbreds in Kentucky . Pferdeheilkunde , 12 : 285 – 289 .
   Web of Science ®Google Scholar
• Pearce , SG , Grace , ND , Wichtel , JJ , Firth , EC and Fennessy , PF . 1998 a . Effect of copper supplementation on copper status of pregnant mares and foals . Equine Veterinary Journal , 30 : 200 – 203 .
   PubMed Web of Science ®Google Scholar
• Pearce , SG , Firth , EC , Grace , ND and Fennessy , PF . 1998 b . Effect of copper supplementation on the evidence of developmental orthopaedic disease in pasture-fed New Zealand Thoroughbreds . Equine Veterinary Journal , 30 : 211 – 218 .
   PubMed Web of Science ®Google Scholar
• Pool , RR . 1993 . Difficulties in definition of equine osteochondrosis; differentiation of developmental and acquired lesions . Equine Veterinary Journal , : 5 – 12 .
   Google Scholar
• Ralston , SL . 1996 . Hyperglycemia/hyperinsulinemia after feeding a meal of grain to young horses with osteochondritis dissecans (OCD) lesions . Pferdeheilkunde , 12 : 320 – 322 .
   Web of Science ®Google Scholar
• Reiland , S , Ordell , N , Lundeheim , N and Olsson , SE . 1978 . Heredity of osteochondrosis, body constitution and leg weakness in the pig. A correlative investigation using progeny testing . Acta Radiologica Supplementum , 358 : 123 – 137 .
   PubMedGoogle Scholar
• Rogers , CW , Gee , EK and Faram , TL . 2004 . The effect of two different weaning procedures on the growth of pasture-reared Thoroughbred foals in New Zealand . New Zealand Veterinary Journal , 52 : 401 – 403 .
   PubMed Web of Science ®Google Scholar
• Rossdale , PD . 1999 . Editorial . Equine Veterinary Journal , : 3 – 3 .
   Web of Science ®Google Scholar
• Sandgren , B , Dalin , G and Carlsten , J . 1993 a . Osteochondrosis in the tarsocrural joint and osteochondral fragments in the fetlock joints in Standardbred trotters. I. Epidemiology . Equine Veterinary Journal , : 31 – 37 .
   Google Scholar
• Sandgren , B , Dalin , G , Carlsten , J and Lundeheim N . 1993 b . Development of osteochondrosis in the tarsocrural joint and osteochondral fragments in the fetlock joints of Standardbred trotters. II. Body measurements and clinical findings . Equine Veterinary Journal , : 48 – 53 .
   Google Scholar
• Savage , CJ , McCarthy , RN and Jeffcott , LB . 1993 a . Effects of dietary energy and protein on induction of dyschondroplasia in foals . Equine Veterinary Journal , : 74 – 79 .
   Google Scholar
• Savage , CJ , McCarthy , RN and Jeffcott , LB . 1993 b . Effects of dietary phosphorus and calcium on induction of dyschondroplasia in foals . Equine Veterinary Journal , : 80 – 83 .
   Google Scholar
• Stromberg , B . 1979 . A review of the salient features of osteochondrosis in the horse. . Equine Veterinary Journal , 11 : 211 – 214 .
   PubMed Web of Science ®Google Scholar
• Stromberg , B and Rejno , S . 1978 . Osteochondrosis in the horse. I. A clinical and radiologic investigation of osteochondritis dissecans of the knee and hock joint . Acta Radiologica Supplementum , 358 : 139 – 152 .
   PubMedGoogle Scholar
• Underwood , EJ and Suttle , NF . 1999 . “ Copper ” . In The Mineral Nutrition of Livestock , 3rd Edtn , Edited by: Underwood , EJ and Suttle , NF . 283 – 342 . Wallingford, , UK : CABI Publishing .
   Google Scholar
• van Weeren , PR van and Barneveld , A . 1999 . The effect of exercise on the distribution and manifestation of osteochondrotic lesions in the Warmblood foal . Equine Veterinary Journal , : 16 – 25 .
   Google Scholar
• van Weeren , PR van , Sloet van Oldruitenborgh-Oosterbaan , MM and Barneveld , A . 1999 . The influence of birth weight, rate of weight gain and final achieved height and sex on the development of osteochondrotic lesions in a population of genetically predisposed Warmblood foals . Equine Veterinary Journal , : 26 – 30 .
   Google Scholar
• van Weeren , PR van , Knaap , J and Firth , EC . 2003 . Influence of liver copper status of mare and newborn foal on the development of osteochondrotic lesions . Equine Veterinary Journal , 35 : 67 – 71 .
   PubMed Web of Science ®Google Scholar
• Whitton , RC . 1998 . Equine developmental osteochondral lesions: the role of biomechanics . Veterinary Journal , 156 : 167 – 168 .
   PubMed Web of Science ®Google Scholar
• PR van Weeren, Faculty of Veterinary Medicine, Utrecht University, The Netherlands
   Google Scholar