551
Views
26
CrossRef citations to date
0
Altmetric
Scientific Article

A comparative study on the adverse effects of flunixin, ketoprofen and phenylbutazone in miniature donkeys: Haematological, biochemical and pathological findings

, , &
Pages 224-228 | Received 21 Oct 2009, Accepted 07 Jul 2010, Published online: 16 Feb 2011

References

  • Burrows , GE . 1981 . Therapeutic effect of phenylbutazone on experimental acute Escherichia coli endotoxemia in ponies . American Journal of Veterinary Research , 42 : 94 – 99 .
  • Carmichael , J and Shankel , SW . 1985 . Effects of nonsteroidal anti-inflammatory drugs on prostaglandins and renal function . American Journal of Medicine , 78 : 992 – 1000 .
  • Chandrasekharan , NV , Dai , H , Roos , KLT , Evanson , NK , Tomsik , J , Elton , TS and Simmons , DL . 2002 . COX-3, a cyclooxygenase-1 variant inhibited by acetaminophen and other analgesic/antipyretic drugs: cloning, structure, and expression . Proceedings of the National Academy of Sciences of the United States of America , 99 : 13926 – 13931 .
  • Clive , DM and Stoff , JS . 1984 . Renal syndromes associated with nonsteroidal antiinflammatory drugs . New England Journal of Medicine , 310 : 563 – 572 .
  • Dunkle , NJ , Bottoms , GD , Fessler , JF , Knox , K and Roesel , OF . 1985 . Effects of flunixin meglumine on blood pressure and fluid compartment volume changes in ponies given endotoxin . American Journal of Veterinary Research , 46 : 1540 – 1544 .
  • Fessler , JF , Bottoms , GD , Roesel , OF , Moore , AB , Frauenfelder , HC and Boon , GD . 1982 . Endotoxin-induced change in hemograms, plasma enzymes, and blood chemical values in anesthetized ponies: effects of flunixin meglumine . American Journal of Veterinary Research , 43 : 140 – 144 .
  • Gunson , DE . 1983 . Renal papillary necrosis in horses . Journal of the American Veterinary Medical Association , 182 : 263 – 266 .
  • Houdeshell , JW and Hennessey , PW . 1977 . A new non-steroidal, anti-inflammatory analgesic for horses . Journal of Equine Medicine and Surgery , 1 : 57 – 63 .
  • Lee , SH , Soyoola , E , Chanmugam , P , Hart , S , Sun , WQ , Zhong , H , Liou , S , Simmons , D and Hwang , D . 1992 . Selective expression of mitogen-inducible cyclooxygenase in macrophages stimulated with lipopolysaccharide . Journal of Biological Chemistry , 267 : 25934 – 25938 .
  • Lees , P and Higgins , AJ . 1987 . Physiological, biochemical and haematological effects on horses of a phenylbutazone paste . Veterinary Record , 121 : 56 – 60 .
  • Lees , P , Creed , RFS , Gerring , EEL , Gould , PW , Humphreys , DJ , Maitho , TE , Michell , AR and Taylor , JB . 1983 . Biochemical and haematological effects of phenylbutazone in horses . Equine Veterinary Journal , 15 : 158 – 167 .
  • MacAllister , CG , Morgan , SJ , Borne , AT and Pollet , RA . 1993 . Comparison of adverse effects of phenylbutazone, flunixin meglumine, and ketoprofen in horses . Journal of the American Veterinary Medical Association , 202 : 71 – 77 .
  • Manoukian , AV and Carson , JL . 1996 . Nonsteroidal anti-inflammatory drug-induced hepatic disorders: Incidence and prevention . Drug Safety , 15 : 64 – 71 .
  • Meschter , CL , Gilbert , M , Krook , L , Maylin , G and Corradino , R . 1990 . The effects of phenylbutazone on the intestinal mucosa of the horse: a morphological, ultrastructural and biochemical study . Equine Veterinary Journal , 22 : 255 – 263 .
  • Millis , DL , Weigel , JP , Moyers , T and Buonomo , FC . 2002 . Effect of deracoxib, a new COX-2 inhibitor, on the prevention of lameness induced by chemical synovitis in dogs . Veterinary Therapeutics , 3 : 453 – 464 .
  • Moore , JN , Hardee , MM and Hardee , GE . 1986 . Modulation of arachidonic acid metabolism in endotoxic horses: comparison of flunixin meglumine, phenylbutazone, and a selective thromboxane synthetase inhibitor . American Journal of Veterinary Research , 47 : 110 – 113 .
  • Morton , AJ , Campbell , NB , Gayle , FM , Redding , WR and Blikslager , AT . 2005 . Preferential and non-selective cyclooxygenase inhibitors reduce inflammation during lipopolysaccharide-induced synovitis . Research in Veterinary Science , 78 : 189 – 192 .
  • Read , WK . 1983 . Renal medullary crest necrosis associated with phenylbutazone therapy in horses . Veterinary Pathology , 20 : 662 – 669 .
  • Silverstein , FE , Faich , G , Goldstein , JL , Simon , LS , Pincus , T , Whelton , A , Makuch , R , Eisen , G , Agarwal , NM , Stenson , WF , Burr , AM , Zhao , WW , Kent , JD , Lefkowith , JB , Verburg , KM and Geis , GS . 2000 . Gastrointestinal toxicity with celecoxib vs nonsteroidal anti-inflammatory drugs for osteoarthritis and rheumatoid arthritis: the CLASS study: A randomized controlled trial. Celecoxib long-term arthritis safety study . Journal of the American Medical Association , 284 : 1247 – 1255 .
  • Snow , DH , Bogan , JA , Douglas , TA and Thompson , H . 1979 . Phenylbutazone toxicity in ponies . Veterinary Record , 105 : 26 – 30 .
  • Tobin , T , Chay , S , Kamerling , S , Woods , WE , Weckman , TJ , Blake , JW and Lees , P . 1986 . Phenylbutazone in the horse: a review . Journal of Veterinary Pharmacology and Therapeutics , 9 : 1 – 25 .
  • Traub-Dargatz , JL , Bertone , JJ , Gould , DH , Wrigley , RH , Weiser , MG and Forney , SD . 1988 . Chronic flunixin meglumine therapy in foals . American Journal of Veterinary Research , 49 : 7 – 12 .
  • Vane , JR . 1971 . Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs . Nature: New Biology , 231 : 232 – 235 .
  • Vernimb , GD and Hennessey , PW . 1977 . Clinical studies on flunixin meglumine in the treatment of equine colic . Journal of Equine Medicine and Surgery , 1 : 111 – 116 .
  • Wallace , JL . 1997 . Nonsteroidal anti-inflammatory drugs and gastroenteropathy: the second hundred years . Gastroenterology , 112 : 1000 – 1016 .

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.