A review of the Neotyphodium lolii / Lolium perenne symbiosis and its associated effects on animal and plant health, with particular emphasis on ryegrass staggers

References

• Ball , OJ-P and Prestidge , R A . 1992 . “ The effect of the endophytic fungus Acremonium lolii on adult black beetle (Heteronychus arator) feeding ” . In Proceedings of the 45th New Zealand Plant Protection Conference Edited by: Prestidge , R A . 201 – 4 .
   Google Scholar
• Ball , OJ-P , Christensen , M J and Prestidge , R A . 1994 . Effect of selected isolates of Acremonium endophytes on adult black beetle (Heteronychus arator) feeding . Proceedings of the 47th New Zealand Plant Protection Conference , : 227 – 31 .
   Google Scholar
• Ball , OJ-P , Prestidge , R A and Sprosen , J M. 1995 . Interrelationships between Acremoniumlolii, peramine and lolitrem B in perennial ryegrass . Applied and Environmental Microbiology , 61 : 1527 – 33 .
   PubMed Web of Science ®Google Scholar
• Ball , OJ-P , Barker , G M , Prestidge , R A and Sprosen , J M . 1997a . Distribution and accumulation of the mycotoxin lolitrem B in Neotyphodium lolii-infected perennial ryegrass . Journal of Chemical Ecology , 23 : 1435 – 49 .
   Web of Science ®Google Scholar
• Ball , OJ-P , Barker , G M , Prestidge , R A and Lauren , D R . 1997b . Distribution andaccumulation of the alkaloid peramine in Neotyphodium lolii-infected perennial ryegrass . Journal of Chemical Ecology , 23 : 1419 – 34 .
   Web of Science ®Google Scholar
• Ball , OJ-P , Miles , C O and Prestidge , R A . 1997c . Ergopeptine alkaloids and Neotyphodium lolii-mediated resistance in perennial ryegrass against adult Heteronychus arator (Coleoptera: Scarabaeidae) . Journal of Economic Entomology , 90 : 1382 – 91 .
   Web of Science ®Google Scholar
• Barker , G M . 2008 . Mollusc herbivory influenced by endophytic clavicipitaceous fungal infections in grasses . Annals of Applied Biology , 153 : 381 – 93 .
   Web of Science ®Google Scholar
• *Barker , G M and Addison , P J . 1993 . “ Argentine stem weevil populations and damage in ryegrass swards of contrasting Acremonium infection ” . In Proceedings 6th Australasian Conference on Grassland Invertebrate Ecology , Edited by: Prestidge , R A . 161 – 8 . Hamilton, New Zealand : AgReserach .
   Google Scholar
• Barker , G M , Pottinger , R P , Addison , P J and Prestidge , R A. 1984a . Effect of Lolium endophyte fungus infections on behaviour of adult Argentine stem weevil . New Zealand Journal of Agricultural Research , 27 : 271 – 7 .
   Web of Science ®Google Scholar
• Barker , G M , Pottinger , R P and Addison , P J. 1984b . Effect of Lolium endophyte fungus infections on survival of larval Argentine stem weevil . New Zealand Journal of Agricultural Research , 27 : 279 – 81 .
   Web of Science ®Google Scholar
• Barker , G M , Pottinger , R P and Addison , P J . 1989 . Population dynamics of Argentine stem weevil (Listronotus bonariensis) in pastures of Waikato, New Zealand . Agriculture, Ecosystems and Environment , 26 : 79 – 115 .
   Web of Science ®Google Scholar
• Benkhelil , A , Grancher , D , Giraud , N , Bezille , P and Bony , S . 2004 . Intoxication par des toxines de champignons endophytes chez des taureaux reproducteurs . Revue de Medecine Veterinaire1 , 56 : 243 – 47 .
   Google Scholar
• Bluett , S J , Thom , E R , Dow , B W , Burggraaf , V T , Hume , D E , Davies , E and Tapper , B A . 2004a . Effects of natural reseeding and establishment method on contamination of a novel endophyte-infected perennial ryegrass dairy pasture with other ryegrass/endophyte associations . New Zealand Journal of Agricultural Research , 47 : 333 – 44 .
   Web of Science ®Google Scholar
• Bluett , S J , Stephens , S L , Hume , D E and Tapper , B A . 2004b . Incidence of ryegrass staggers in white rhinoceros (Ceratotherium simum) at Auckland Zoo . New Zealand Veterinary Journal , 52 : 48
   PubMed Web of Science ®Google Scholar
• Bluett , S J , Thom , E R , Clark , D A , MacDonald , K A and Minnee , E MK . 2005 . Effects of perennial ryegrass infected with either AR1 or wild endophyte on dairy production in the Waikato . New Zealand Journal of Agricultural Research , 48 : 197 – 212 .
   Web of Science ®Google Scholar
• Burggraaf , V T and Thom , E R . 2002 . Minimising endophyte contamination from ryegrass seed in cow dung . Proceedings of the New Zealand Grassland Association , 64 : 97 – 102 .
   Google Scholar
• Christensen , M J . 1996 . Antifungal activity in grasses infected with Acremonium and Epichloë endophytes . Australasian Plant Pathology , 25 : 186 – 91 .
   Web of Science ®Google Scholar
• Christensen , M J and Saulsbury , K . 2007 . “ Conspicuous epiphytic growth of a Neotyphodium endophyte on perennial ryegrass inflorescences ” . In Proceedings of the 6^thInternational Symposium on Fungal Endophytes of Grasses. Grassland Research and Practice Series 13 , Edited by: Popay , A J and Thom , E R . 155 Christchurch, New Zealand : New Zealand Grassland Association .
   Google Scholar
• Christensen , M J and Voisey , C R . 2007 . “ The biology of the endophyte/grass partnership ” . In Proceedings of the 6th International Symposium on Fungal Endophytes of Grasses. Grassland Research and Practice Series 13 , Edited by: Popay , A J and Thom , E R . 123 – 33 . Christchurch, New Zealand : New Zealand Grassland Association .
   Google Scholar
• Christensen , M J , Latch , G CM and Tapper , B A . 1991 . Variation within isolates of Acremonium endophytes in perennial ryegrasses . Mycological Research , 95 : 918 – 923 .
   Web of Science ®Google Scholar
• Christensen , M J , Leuchtmann , A , Rowan , D D and Tapper , B A. 1993 . Taxonomy of Acremonium endophytes of tall fescue (Festuca arundinacea), meadow fescue (F. pratensis) and perennial ryegrass (Lolium perenne) . Mycological Research , 97 : 1083 – 92 .
   Web of Science ®Google Scholar
• Christensen , M J , Bennett , R J and Schmid , J . 2001 . Vascular bundle colonisation by Neotyphodium endophytes in natural and novel associations with grasses . Mycological Research , 105 : 1239 – 45 .
   Web of Science ®Google Scholar
• Christensen , M J , Bennett , R J , Ansari , H A , Koga , H , Johnson , R D , Bryan , G T , Simpson , W R , Koolard , J P , Nickless , E M and Voisey , C R. 2008 . Epichloë endophytes grow by intercalary hyphal extension in elongating grass leaves . Fungal Genetics and Biology , 45 : 84 – 94 .
   PubMed Web of Science ®Google Scholar
• Clark , D A , Thom , E R and Waugh , C D . 1996 . Milk production from pastures and pasture silage with different levels of endophyte infection . Proceedings of the New Zealand Society of Animal Production , 56 : 292 – 6 .
   Google Scholar
• Crush , J R , Popay , A J and Waller , J . 2004 . Effect of different Neotyphodium endophytes on root distribution of a perennial ryegrass (Lolium perenne L.) cultivar . New Zealand Journal of AgriculturalResearch , 47 : 345 – 9 .
   Web of Science ®Google Scholar
• Cummins , L J . 2005 . “ Infertility and ryegrass staggers in sheep and beef cattle ” . In Proceedings of a Symposium on Perennial Ryegrass Toxicosis in Australia , Edited by: Reed , K FM , Oagem , S W and Lean , I J . 45 – 53 . Australia : Meat and Livestock .
   Google Scholar
• Cunningham , I J . 1958 . Non-toxicity to animals of ryegrass endophyte and other endophytic fungi of New Zealand grasses . New Zealand Journal of Agricultural Research , 1 : 489 – 97 .
   Google Scholar
• Cunningham , I J and Hartley , W J. 1959 . Ryegrass staggers . New Zealand Veterinary Journal , 7 : 1 – 7 .
   Google Scholar
• Cunningham , P J , Foot , J Z and Reed , K FM . 1993 . Perennial ryegrass (Lolium perenne) endophyte (Acremonium lolii) relationships: the Australian experience . Agriculture, Ecosystems and Environment , 44 : 157 – 68 .
   Web of Science ®Google Scholar
• Dalziel , J E , Finch , S C and Dunlop , J . 2005 . The fungal neurotoxin lolitrem B inhibits the function of human large conductance calcium-activated potassium channels . Toxicology Letters , 155 : 421 – 6 .
   PubMed Web of Science ®Google Scholar
• Dapprich , P , Paul , V H and Krohn , K. 1996 . “ Incidence of Acremonium endophyte in selected German pastures and the contents of alkaloids in Lolium perenne ” . In Proceedings of the 2nd International Conference on Harmful and Beneficial Microorganisms in Pastures , 103 – 4 . Germany : Turf and Grassland .
   Google Scholar
• *Davies , E , Lane , G A , Latch , G CM , Tapper , B A , Garthwaite , I , Towers , N R , Fletcher , L R and Pownall , D B . 1993 . “ Alkaloid concentrations in field-grown synthetic perennial ryegrass endophyte associations ” . In Proceedings of the 2nd International Symposium on Acremonium/Grass Interactions , Edited by: Hume , D E , Latch , G CM and Easton , H S . 72 – 76 . New Zealand : AgResearch, Palmerston North .
   Google Scholar
• di Menna , M E and Mantle , P G. 1978 . The role of Penicillia in ryegrass staggers . Research in Veterinary Science , 24 : 347 – 51 .
   PubMed Web of Science ®Google Scholar
• di Menna , M E and Waller , J E . 1986 . Visual assessment of seasonal changes in amount of mycelium of Acremonium loliae in leaf sheaths of perennial ryegrass . New Zealand Journal of Agricultural Research , 29 : 111 – 6 .
   Web of Science ®Google Scholar
• di Menna , M E , Mortimer , P H , Prestidge , R A , Hawkes , A D and Sprosen , J M . 1992 . Lolitrem B concentrations, counts of Acremonium lolii hyphae, and the incidence of ryegrass staggers in lambs on plots of A. lolii-infected perennial ryegrass . New Zealand Journal of Agricultural Research , 35 : 211 – 7 .
   Web of Science ®Google Scholar
• Dombrowski , J E , Baldwin , J C , Azevedo , M D and Banowetz , G M . 2006 . A sensitive PCR-based assay to detect Neotyphodium fungi in seed and plant tissue of tall fescue and ryegrass species . Crop Science , 46 : 1064 – 70 .
   Web of Science ®Google Scholar
• Dymock , J J , Prestidge , R A and Rowan , D D . 1989 . The effects oflolitrem B on Argentine stem weevil larvae . Proceedings of the 42nd New Zealand Weed and Pest Control Conference , : 73 – 75 .
   Google Scholar
• Easton , H S and Fletcher , L R . 2007 . “ The importance of endophyte in agricultural systems - changing plant and animal productivity ” . In Proceedings of the 6th International Symposium on Fungal Endophytes of Grasses. Grassland Research and Practice Series 13 , Edited by: Popay , A J and Thom , E R . 11 – 18 . Christchurch, New Zealand : New Zealand Grassland Association .
   Google Scholar
• Easton , H S , Lane , G A , Tapper , B A , Keogh , R G , Cooper , B M , Blackwell , M , Anderson , M and Fletcher , L R . 1996 . Ryegrass endophyte-related heat stress in cattle . Proceedings of the New Zealand Grassland Association , 57 : 37 – 41 .
   Google Scholar
• Easton , H S , Latch , G CM , Tapper , B A and Ball , O JP . 2002 . Ryegrass host genetic control of concentrations of endophyte-derived alkaloids . Crop Science , 42 : 51 – 57 .
   PubMed Web of Science ®Google Scholar
• Eerens , J PJ , Lucas , R J , Easton , H S and White , J GH . 1998a . Influence of the ryegrass endophyte (Neotyphodium lolii) in a cool-moist environment III. Interaction with white clover . New Zealand Journal of Agricultural Research , 41 : 201 – 7 .
   Web of Science ®Google Scholar
• Eerens , J FJ , Visker , M HPW , Lucas , R J , Easton , H S and White , J GH . 1998b . Influence of the ryegrass endophyte (Neotyphodium lolii) in a cool moist environment IV. Plant parasitic nematodes . New Zealand Journal of Agricultural Research , 41 : 209 – 17 .
   Web of Science ®Google Scholar
• Fannin , F F , Bush , L P and Siegel , M R . 1990 . Analysis of peramine in fungal endophyte-infected grasses by reversed-phase thin-layer chromatography . Journal of Chromatography , 503 : 288 – 292 .
   Web of Science ®Google Scholar
• *Fink-Gremmels , J and Blom , M . 1994 . Ryegrass staggers linked to lolitrem B: a case report . Proceedings of the 6^th Congress of European Association of Veterinary Pharmacology and Toxicology , : 129 – 30 .
   Google Scholar
• Fisher , M J , Bohnert , D W , Ackerman , C J , Schauer , C S , DelCurto , T , Craig , A M , Vanzant , E S , Harmon , D L and Schrick , F N . 2004 . Evaluation of perennial ryegrass straw as a forage source for ruminants . Journal of Animal Science , 82 : 2175 – 84 .
   PubMed Web of Science ®Google Scholar
• Fleetwood , D J , Scott , B , Lane , G A , Tanaka , A and Johnson , R D . 2007 . A complex ergovaline gene cluster in Epichloë endophytes of grasses . Applied and Environmental Microbiology , 73 : 2571 – 9 . *Non-peer-reviewed
   PubMed Web of Science ®Google Scholar
• Fletcher , L R . 1983 . Effects of presence of Lolium endophyte on growth rates of weaned lambs, growing on to hoggets, on various ryegrasses . Proceedings of the New Zealand Grassland Association , 44 : 237 – 9 .
   Google Scholar
• Fletcher , L R. 1999 . “Non-toxic” endophytes in ryegrass and their effect on livestock health and production ” . In Ryegrass Endophyte: An Essential New Zealand Symbiosis. Grassland Research and Practice Series 7 , Edited by: Woodfield , D R and Matthew , C . 133 – 9 . Palmerston North, New Zealand : New Zealand Grassland Association .
   Google Scholar
• Fletcher , L R . 2005 . “ Managing ryegrass-endophyte toxicoses ” . In Neotyphodium in Cool-Season Grasses , Edited by: Roberts , C A , West , C P and Spiers , D E . 229 – 41 . Oxford, England : Blackwell Publishing .
   Google Scholar
• Fletcher , L R and Harvey , I C . 1981 . An association of a Lolium endophyte with ryegrass staggers . New Zealand Veterinary Journal , 29 : 185 – 16 .
   PubMed Web of Science ®Google Scholar
• Fletcher , L R and Sutherland , B L . 2009 . Sheep responses to grazing ryegrass with AR37 endophyte . Proceedings of the New Zealand Grassland Association , 71 : 127 – 33 .
   Google Scholar
• Fletcher , L R , Popay , A J and Tapper , B A . 1991 . Evaluation of several lolitrem-free endophyte/perennial ryegrass combinations . Proceedings of the New Zealand Grassland Association , 53 : 215 – 9 .
   Google Scholar
• *Fletcher , L R , Garthwaite , I and Towers , N R . 1993 . “ Ryegrass staggers in the absence of lolitrem B ” . In Proceedings of the 2nd International Symposium on Acremonium/Grass Interactions , Edited by: Hume , D E , Latch , G CM and Easton , H S . 119 – 21 . New Zealand : AgResearch, Palmerston North .
   Google Scholar
• Fletcher , L R , Sutherland , B L and Fletcher , C G . 1999 . “ The impact of endophyte on the health and productivity of sheep grazing ryegrass-based pastures ” . In Ryegrass Endophyte: An Essential New Zealand Symbiosis. Grassland Research and Practice Series 7 , Edited by: Woodfield , D R and Matthew , C . 11 – 17 . New Zealand : AgResearch, Palmerston North .
   Google Scholar
• *Fletcher , L R , Lane , G A , Baird , D B and Davies , E . 2000 . “ Seasonal variation in alkaloid concentrations in two perennial ryegrass-endophyte associations ” . In Proceedings of the 4th International Symposium on Neotyphodium/Grass Interactions , Edited by: Paul , V H and Dapprich , P D . 535 – 42 . Germany : University of Paderborn .
   Google Scholar
• Galey , F D , Tracy , M L , Craigmill , A L , Barr , B C , Markegard , G , Peterson , R and O’Connor , M . 1991 . Staggers induced by consumption of perennial ryegrass in cattle and sheep from northern California . Journal of the American Veterinary Medical Association , 199 : 466 – 70 .
   PubMed Web of Science ®Google Scholar
• Gallagher , R T and Hawkes , A D . 1985 . Estimation of neurotoxin levels in perennial ryegrass by mouse bioassay . New Zealand Journal of Agricultural Research , 28 : 427 – 31 .
   Web of Science ®Google Scholar
• Gallagher , R T and Hawkes , A D . 1986 . The potent neurotoxins lolitrem B and aflatrem: a comparison of the tremor response in mice . Experientia , 42 : 823 – 5 .
   PubMedGoogle Scholar
• Gallagher , R T , Latch , G CM and Keogh , R G . 1980 . The janthitrems: fluorescent tremorgenic toxins produced by Penicillium janthinellum isolates from ryegrass pastures . Applied and Environmental Microbiology , 39 : 272 – 73 .
   PubMed Web of Science ®Google Scholar
• Gallagher , R T , White , E P and Mortimer , P H . 1981 . Ryegrass staggers: isolation of potent neurotoxins lolitrem A and lolitrem B from staggers-producing pastures . New Zealand Veterinary Journal , 29 : 189 – 90 .
   PubMed Web of Science ®Google Scholar
• Gallagher , R T , Campbell , A G , Hawkes , A D , Holland , P T , McGaveston , D A , PansierE , A and Harvey , I C . 1982a . Ryegrass staggers: the presence oflolitrem neurotoxins in perennial ryegrass seed . New Zealand Veterinary Journal , 30 : 183 – 4 .
   PubMed Web of Science ®Google Scholar
• Gallagher , R T , Smith , G S , di Menna , M E and Young , P W . 1982b . Some observations on neurotoxin production in perennial ryegrass . New Zealand Veterinary Journal , 30 : 203 – 4 .
   PubMed Web of Science ®Google Scholar
• Gallagher , R T , Hawkes , A D , Steyn , P S and Vleggaar , R . 1984 . Tremorgenic neurotoxins from perennial ryegrass causing ryegrass staggers disorder of livestock: structure elucidation of lolitrem B . Journal of the Chemical Society, Chemica, Communications , : 614 – 6 .
   Google Scholar
• Garner , G B , Rottinghaus , G E , Cornell , C N and Testereci , H . 1993 . “ Chemistry of compounds associated with endophyte/grass interaction: ergovaline and ergopeptine-related alkaloids ” . In Acremonium/Grass Interactions. Agriculture, Ecosystems and Environment Edited by: Quisenberry , S and Joost , R . Vol. 44 , 65 – 80 .
   Google Scholar
• *Garthwaite , I , Miles , C O and Towers , N R . 1993 . “ Immunological detection of the indole diterpenoid tremorgenic mycotoxins ” . In Proceedings of the 2nd International Symposium on Acremonium/Grass Interactions , Edited by: Hume , D E , Latch , G CM and Easton , H S . 77 – 79 . New Zealand : AgResearch, Palmerston North .
   Google Scholar
• Gatenby , W A , Munday-Finch , S C , Wilkins , A L and Miles , C O. 1999 . Terpendole M, a novel indole-diterpenoid isolated from Lolium perenne infected with the endophytic fungus Neotyphodium lolii . Journal of Agricultural and Food Chemistry , 47 : 1092 – 7 .
   PubMed Web of Science ®Google Scholar
• Gaynor , D L , Rowan , D D , Latch , G CM and Pilkington , S . 1983 . Preliminary results on the biochemical relationship between adult Argentine stem weevil and two endophytes in ryegrass . Proceedings 36th New Zealand Weed and Pest Control Conference , : 220 – 4 .
   Google Scholar
• Gilruth , J A . 1906 . Meningo-encephalitis (stomach staggers) in horses, cattle and sheep . Annual Report of the New Zealand Department of Agriculture. Appendix VIII. Division of Veterinary Science , : 293 – 7 .
   Google Scholar
• Glenn , A E , Bacon , C W , Price , R and Hanlin , R T . 1996 . Molecular phylogeny of Acremonium and its taxonomic implications . Mycologia , 88 : 369 – 83 .
   Web of Science ®Google Scholar
• Guy , P L. 1992 . Incidence of Acremonium lolii and lack of correlation with barley yellow dwarf viruses in Tasmanian perennial ryegrass pastures . Plant Pathology , 41 : 29 – 34 .
   Web of Science ®Google Scholar
• Gwinn , K D , Collins-ShepardM , H and Reddick , B B . 1991 . Tissue print-immunoblot: an accurate method for the detection of Acremonium coenophialum in tall fescue . Phytopathology , 81 : 747 – 8 .
   Web of Science ®Google Scholar
• Hahn , H , McManus , M T , Warnstorff , K , Monahan , B J , Young , C A , Davies , E , Tapper , B A and Scott , B. 2008 . Neotyphodium fungal endophytes confer physiological protection to perennial ryegrass (Lolium perenne L.) subjected to a water deficit . Environmental and Experimental Botany , 63 : 183 – 99 .
   Web of Science ®Google Scholar
• Harvey , I C , Fletcher , L R and Emms , L M . 1982 . Effects of several fungicides on the Lolium endophyte in ryegrass plants, seeds, and in culture . New Zealand Journal of Agricultural Research , 25 : 601 – 6 .
   Web of Science ®Google Scholar
• Hesse , U and Latch , G CM. 1999 . Influence of Neotyphodium lolii and barley yellow dwarf virus, individually and combined, on the growth of Lolium perenne . Australasian Plant Pathology , 28 : 240 – 7 .
   Web of Science ®Google Scholar
• Hewett , R L . 1983 . Breeding for resistance to ryegrass staggers, the inflation-proof long-term solution? . Proceedings of the New Zealand Grassland Association , 44 : 244 – 7 .
   Google Scholar
• Holzhauer , M and Westerhout , A C . 2004 . (Perennial ryegrass staggers in a young dairy herd.) . Tijdschrift voor Diergeneeskunde , 129 : 298 – 300 .
   PubMedGoogle Scholar
• Hopkirk , C SM . 1935 . Staggers in livestock . New Zealand Journal of Agriculture , 52 : 18 – 21 .
   Google Scholar
• Hovermale , J T and Craig , A M . 2001 . Correlation of ergovaline and lolitrem B levels in endophyte-infected perennial ryegrass (Lolium perenne) . Journal of Veterinary Diagnostic Investigation , 13 : 323 – 7 .
   PubMed Web of Science ®Google Scholar
• Hume , D E . 1999 . “ Establishing and maintaining a toxin-free pasture: a review ” . In Ryegrass Endophyte: An Essential New Zealand Symbiosis. Grassland Research and Practice Series 7 , Edited by: Woodfield , D R and Matthew , C . 123 – 32 . New Zealand : New Zealand Grassland Association, Palmerston North .
   Google Scholar
• Hume , D E , Rolston , M P , Baird , D B , Archie , W J and March , M R . 1999 . “ Survival of endophyte-infected ryegrass seed buried in soil ” . In Ryegrass Endophyte: An Essential New Zealand Symbiosis. Grassland Research and Practice Series 7 , Edited by: Woodfield , D R and Matthew , C . 151 – 6 . New Zealand : New Zealand Grassland Association, Palmerston North .
   Google Scholar
• Hume , D E , Hickey , M J and Tapper , B A . 2007a . “ Degradation of endophyte alkaloids in field-dried cut ryegrass herbage ” . In Proceedings of the 6th InternationalSymposium on Fungal Endophytes of Grasses. Grassland Research and Practice Series No. 13 , 167 – 70 . Dunedin, New Zealand : New Zealand Grassland Association .
   Google Scholar
• Hume , D E , Ryan , D L , Cooper , B M and Popay , A J . 2007b . Agronomic performance of AR37-infected ryegrass in northern New Zealand . Proceedings of the New Zealand Grassland Association , 69 : 201 – 6 .
   Google Scholar
• Imlach , W L , Finch , S C , Dunlop , J , Meredith , A L , Aldrich , R W and Dalziel , J E . 2008 . The molecular mechanism of “ryegrass staggers”, a neurological disorder of K+ channels . The Journal of Pharmacology and Experimental Therapeutics , 327 : 657 – 64 .
   PubMed Web of Science ®Google Scholar
• Imlach , W L , Finch , S C , Dunlop , J and Dalziel , J E . 2009 . Structural determinants of lolitrems for inhibition of BK large conductance Ca2+-activatedK+ channels . European Journal of Pharmacology , 605 : 36 – 45 .
   PubMed Web of Science ®Google Scholar
• Jensen , J G and Popay , A J . 2004 . Perennial ryegrass infected with AR37 endophyte reduces survival of porina larvae . New Zealand Plant Protection , 57 : 323 – 8 .
   Google Scholar
• Kain , W M , Ritchie , I M , Crouchley , C G , Smith , R G and Atkinson , D S . 1977 . Effects of stem weevil on grazed swards of perennial ryegrass in Wairarapa and Manawatu . Proceedings of the 30thNew Zealand Weed and Pest Control Conference , : 192 – 7 .
   Google Scholar
• Keogh , R G . 1973 . Induction and prevention of ryegrass staggers in grazing sheep . New Zealand Journal of Experimental Agriculture , 1 : 55 – 57 .
   Google Scholar
• Keogh , R G . 1978 . Development and control of ryegrass staggers in sheep . Proceedings of the New Zealand Society of Animal Production , 38 : 47 – 52 .
   Google Scholar
• Keogh , R G . 1984 . Grazing behaviour of sheep and ryegrass staggers . Proceedings of the New Zealand Society of Animal Production , 44 : 189 – 92 .
   Google Scholar
• Keogh , R G , Tapper , B A and Fletcher , R H . 1996 . Distributions of the fungal endophyte Acremonium lolii, and of the alkaloids lolitrem B and peramine, within perennial ryegrass . New Zealand Journal of Agricultural Research , 39 : 121 – 7 . *Non-peer-reviewed
   Web of Science ®Google Scholar
• Knaus , H-G , McManus , O B , Lee , S H , Schmalhofer , W A , Garcia-Calvo , M , HelmsLM , H , Sanchez , M , Giangiacomo , K , Reuben , J P Smith , A B III . 1994 . Tremorgenic indole alkaloids potently inhibit smooth muscle high-conductance calcium-activated potassium channels . Biochemistry , 33 : 5819 – 28 .
   PubMed Web of Science ®Google Scholar
• *Lane , G A , Tapper , B A , Davies , E , Hume , D E , Latch , G CM , Barker , D J , Easton , H S and Rolston , M P . 1997 . “ Effect of growth conditions on alkaloid concentrations in perennial ryegrass naturally infected with endophyte ” . In Third international Symposium on Neotyphodium/Grass Interactions , Edited by: Bacon , C W and Hill , N S . 179 – 82 . New York : Plenum Press .
   Google Scholar
• Lane , G A , Christensen , M J and Miles , C O . 2000 . “ Coevolution of fungal endophytes with grasses: the significance of secondary metabolites ” . In Microbial Endophytes , Edited by: Bacon , C W and White , J F Jr. 341 – 88 . New York : Marcel Dekker Inc .
   Google Scholar
• Latch , G CM. 1994 . Influence of Acremonium endophytes on perennial grass improvement . New Zealand Journal of Agricultural Research , 37 : 311 – 8 .
   Web of Science ®Google Scholar
• Latch , G CM and Christensen , M J . 1982 . Ryegrass endophyte, incidence and control . New Zealand Journal of Agricultural Research , 25 : 443 – 8 .
   Web of Science ®Google Scholar
• Latch , G CM and Christensen , M J . 1985 . Artificial infection of grasses with endophytes . Annals of Applied Biology , 107 : 17 – 24 .
   Web of Science ®Google Scholar
• Latch , G CM , Christensen , M J and Samuels , G J . 1984 . Five endophytes of Lolium and Festuca in New Zealand . Mycotaxon , 20 : 535 – 50 .
   Web of Science ®Google Scholar
• Latch , G CM , Christensen , M J and Gaynor , D L . 1985 . Aphid detection of endophyte infection in tall fescue . New Zealand Journal of Agricultural Research , 28 : 129 – 32 .
   Web of Science ®Google Scholar
• Latch , G CM , Potter , L R and Tyler , B F . 1987 . Incidence of endophytes in seeds from collections of Lolium and Festuca species . Annals of Applied Biology , 111 : 59 – 64 .
   Web of Science ®Google Scholar
• Lean , I J . 2001 . Association between feeding perennial ryegrass (Lolium perenne cultivar Grasslands Impact) containing high concentrations of ergovaline and helth and productivity in a herd of lactating dairy cows . Australian Veterinary Journal , 79 : 262 – 4 .
   PubMed Web of Science ®Google Scholar
• Leuchtmann , A and Clay , K . 1990 . Isozyme variation in the Acremonium/Epichloë fungal endophyte complex . Phytopathology , 80 : 1133 – 9 .
   Web of Science ®Google Scholar
• Lewis , G C and Clements , R O . 1986 . A survey of ryegrass endophyte (Acremonium loliae) in the UK and its apparent ineffectuality on a seedling pest . TheJournal of Agricultural Science , 107 : 633 – 8 .
   Web of Science ®Google Scholar
• Lewis , G C , Ravel , C , Naffaa , W , Astier , C and Charmet , G. 1997 . Occurrence of Acremonium endophytes in wildpopulations of Lolium spp. in European countries and a relationship between level of infection and climate in France . Annals of Applied Biology , 130 : 227 – 38 .
   Web of Science ®Google Scholar
• Lloyd , A B . 1959 . The endophytic fungus of perennial ryegrass . New Zealand Journal of Agricultural Research , 2 : 1187 – 94 .
   Google Scholar
• Lowe , K F , Bowdler , T M , Hume , D E , Casey , N D and Tapper , B A . 2008 . The effect of endophyte on the performance of irrigated perennial ryegrasses in subtropical Australia . Australian Journal of Agricultural Research , 59 : 567 – 77 .
   Google Scholar
• McLeay , L M and Smith , B L . 1999 . “ Effects of the mycotoxins lolitrem B and paxilline on gastrointestinal smooth muscle, the cardiovascular and respiratory systems, and temperature in sheep ” . In Ryegrass Endophyte: an Essential New Zealand Symbiosis. Grassland Research and Practice Series. No. 7 , Edited by: Woodfield , D R and Matthew , C . 69 – 76 . New Zealand : New Zealand Grassland Association, Palmerston North .
   Google Scholar
• McLeay , L M and Smith , B L . 2006 . Effects of ergotamine and ergovaline on the electromyographic activity of smooth muscle of the reticulum and rumen of sheep . American Journal of Veterinary Research , 67 : 707 – 14 .
   PubMed Web of Science ®Google Scholar
• McLeay , L M , Smith , B L and Munday-Finch , S C . 1999 . Tremorgenic mycotoxins paxilline, penitrem and lolitrem B, the non-tremorgenic 31-epilolitrem B and electromyographic activity of the reticulum and rumen of sheep . Research in Veterinary Science , 66 : 119 – 27 .
   PubMed Web of Science ®Google Scholar
• McLeay , L M , Smith , B L and Reynolds , G W . 2002 . Cardiovascular, respiratory and body temperature responses of sheep to the ergopeptides ergotamine and ergovaline . American Journal of Veterinary Research , 63 : 387 – 93 .
   PubMed Web of Science ®Google Scholar
• McLennan , E . 1920 . The endophytic fungus of Lolium. I . Proceedings of the Royal Society of Victoria , 32 ( NS ) : 252 – 301 .
   Google Scholar
• Marshall , G AK. 1938 . New Curculionidae (Col.) from New Zealand . Transactions and Proceedings of the Royal Society of New Zealand , 67 : 316 – 40 .
   Google Scholar
• Mason , R W . 1968 . Axis cylinder degeneration associated with ryegrass staggers in sheep and cattle . Australian Veterinary Journal , 44 : 428
   Web of Science ®Google Scholar
• May , K J , Bryant , M K , Zhang , X , Ambrose , B and Scott , B . 2008 . Patterns of expression of a lolitrem biosynthetic gene in the Epichloë festucae-perennial ryegrass symbiosis . Molecular Plant-Microbe Interactions , 21 : 188 – 97 .
   PubMed Web of Science ®Google Scholar
• Miles , C O , Munday , S C , Wilkins , A L , Ede , R M and Towers , N R . 1994 . Large scale isolation of lolitrem B and structure determination of lolitrem E . Journal of Agricultural and Food Chemistry , 42 : 1488 – 92 .
   Web of Science ®Google Scholar
• Miyazaki , S , Fukumura , M , Yoshioka , M and Yamanaka , N . 2001 . Detection of endophyte toxins in the imported perennial ryegrass straw . Journal of Veterinary Medical Science , 63 : 1013 – 5 .
   PubMed Web of Science ®Google Scholar
• Moon , C D , Tapper , B A and Scott , B. 1999 . Identification of Epichloë endophytes in planta by a microsatellite-based PCR fingerprinting assay with automated analysis . Applied and Environmental Microbiology , 65 : 1268 – 79 .
   PubMed Web of Science ®Google Scholar
• Moon , C D , Craven , K D , Leuchtmann , A , Clement , S L and Schardl , C L . 2004 . Prevalence of interspecific hybrids amongst asexual fungal endophytes of grasses . Molecular Ecology , 13 : 1455 – 67 .
   PubMed Web of Science ®Google Scholar
• Morris , C A and Amyes , N C . 2007 . “ Progress in breeding sheep for resistance to ryegrass staggers ” . In Proceedings of the 6th International Symposium on Fungal Endophytes of Grasses. Grassland Research and Practice Series No. 13 , Edited by: Popay , A J and Thom , E R . 431 – 3 . Dunedin, New Zealand : New Zealand Grassland Association .
   Google Scholar
• Mortimer , P H and di Menna , M E . 1983 . Ryegrass staggers: further substantiation of a Lolium endophyte aetiology and the discovery of weevil resistance of ryegrass pastures infected with Lolium endophyte . Proceedings of the New Zealand Grassland Association , 44 : 240 – 3 .
   Google Scholar
• Munday , B L , Monkhouse , I M and Gallagher , R T . 1985 . Intoxication of horses by lolitrem B in ryegrass seed cleanings . Australian Veterinary Journal , 62 : 207
   PubMed Web of Science ®Google Scholar
• Munday-Finch , S C , Miles , C O , Wilkins , A L and Hawkes , A D . 1995 . Isolation and structure elucidation of lolitrem A, a tremorgenic mycotoxin from perennial ryegrass infected with Acremonium lolii . Journal of Agricultural and Food Chemistry , 43 : 1283 – 8 .
   Web of Science ®Google Scholar
• Munday-Finch , S C , Wilkins , A L , Miles , C O , Ede , R M and Thomson , R A . 1996 . Structure elucidation of lolitrem F, a naturally occurring stereoisomer of the tremorgenic mycotoxin lolitrem B, isolated from Lolium perenne infected with . Acremonium lolii. Journal of Agricultural and Food Chemistry , 44 : 2782 – 8 .
   Web of Science ®Google Scholar
• Munday-Finch , S C , Wilkins , A L , Miles , C O , Tomoda , H and Omura , S . 1997 . Isolation and structure elucidation of lolilline, a possible biosynthetic precursor of the lolitrem family of tremorgenic mycotoxins . Journal of Agricultural and Food Chemistry , 45 : 199 – 204 .
   Web of Science ®Google Scholar
• Munday-Finch , S C , Wilkins , A L and Miles , C O . 1998 . Isolation of lolicine A, lolicine B, lolitriol and lolitrem N from Loliumperenne infected with Neotyphodium lolii and evidence for the natural occurrence of 31-epilolitrem N and 31-epilolitrem F . Journal of Agricultural and Food Chemistry , 46 : 590 – 8 .
   PubMed Web of Science ®Google Scholar
• Musgrave , D R . 1984 . Detection of an endophytic fungus of Lolium perenne using enzyme-linked immunosorbent assay (ELISA) . New Zealand Journal of Agricultural Research , 27 : 283 – 8 .
   Web of Science ®Google Scholar
• Neill , J C . 1940 . The endophyte of ryegrass (Lolium perenne) . New Zealand Journal of Science and Technology Section A , 21 : 280 – 91 .
   Google Scholar
• Neill , J C . 1941 . The endophytes of Lolium and Festuca . New Zealand Journal of Science and Technology , 23A : 185 – 93 .
   Google Scholar
• Nicholson , M J , Koulman , A , Monahan , B J , Pritchard , B L , Payne , G A and Scott , B . 2009 . Identification of two aflatrem biosynthesis gene loci in Aspergillus flavus and metabolic engineering of Penicillium paxilli to elucidate their function . Applied and Environmental Microbiology , 75 : 7469 – 81 .
   PubMed Web of Science ®Google Scholar
• Nollet , H , Vanschandevijl , K , Lefere , L and Deprez , P . 2007 . First confirmed case of ryegrass staggers in horses in Belgium . Vlaams Diergeneeskundig Tijdschrift , 76 : 355 – 8 .
   Google Scholar
• Odriozola , E , Lopez , T , Campero , C and Gimenes Placeres , C . 1993 . Ryegrass staggers in heifers: a new mycotoxicosis in Argentina . Veterinary and Human Toxicology , 35 : 144 – 6 .
   PubMedGoogle Scholar
• Oldenburg , E . 1997 . Endophytic fungi and alkaloid production in perennial ryegrass in Germany . Grass and Forage Science , 52 : 425 – 31 .
   Web of Science ®Google Scholar
• *O'Sullivan , B D and Latch , G CM . 1993 . “ Infection of plantlets, derived from ryegrass and tall fescue meristems, with Acremonium endophytes ” . In Proceedings of the 2nd International Symposium on Acremonium/Grass Interactions , Edited by: Hume , D E , Latch , G CM and Easton , H S . 16 – 17 . New Zealand : AgResearch, Palmerston North .
   Google Scholar
• *Pearson , W D . 1989 . “ The pasture mealy bug Balanococcus poae (Maskell) in Canterbury: a preliminary report ” . In Proceedings of the 5th Australasian Conference of Grassland Invertebrate Ecology , Edited by: Stahle , P P . 297 – 303 . Australia : D&D Printing, Victoria .
   Google Scholar
• *Penn , J , Garthwaite , I , Christensen , M J , Johnson , C M and Towers , N R . 1993 . “ The importance of paxilline in screening for potentially tremorgenic Acremonium isolates ” . In Proceedings of the 2nd International Symposium on Acremonium/Grass Interactions , Edited by: Hume , D E , Latch , G CM and Easton , H S . 88 – 93 . New Zealand : AgResearch, Palmerston North .
   Google Scholar
• Pennell , C GL , Popay , A J , Ball , OJ-P , Hume , D E and Baird , D B . 2005 . Occurrence and impact of pasture mealy bug (Balanococcus poae) and root aphid (Aploneura lentisci) on ryegrass (Lolium spp.) with and without infection by Neotyphodium fungal endophytes . New Zealand Journal of Agricultural Research , 48 : 329 – 38 . *Non-peer-reviewed
   Web of Science ®Google Scholar
• Philipson , M N . 1989 . A symptomless endophyte of ryegrass (Lolium perenne) that spores on its host – a light microscope study . New Zealand Journal of Botany , 27 : 513 – 9 .
   Web of Science ®Google Scholar
• Philipson , M N and Christey , M C . 1986 . The relationship of host and endophyte during flowering, seed formation, and germination of Lolium perenne . New Zealand Journal of Botany , 24 : 125 – 34 .
   Web of Science ®Google Scholar
• Poole , D P , Littler , R A , Smith , B L and McLeay , L M . 2009 . Effects and mechanisms of action of the ergopeptides ergotamine and ergovaline and the effects of peramine on reticulum motility of sheep . American Journal of Veterinary Research , 70 : 270 – 6 .
   PubMed Web of Science ®Google Scholar
• Popay , A J and Baltus , J G . 2001 . Black beetle damage to perennial ryegrass infected with AR1 endophyte . Proceedings of New Zealand Grassland Association , 63 : 267 – 71 .
   Google Scholar
• Popay , A J and Gerard , P J . 2007 . Cultivar and endophyte effects on a root aphid, Aploneura lentisci, in perennial ryegrass . New Zealand Plant Protection , 60 : 223 – 7 .
   Google Scholar
• Popay , A J and Hume , D E . 2011 . “ Endophytes improve ryegrass persistence by controlling insects ” . In Pasture Persistence Symposium. Grassland Research and Practice Series , Edited by: Mercer , C F . 149 – 56 . New Zealand : New Zealand Grassland Association, Dunedin .
   Google Scholar
• Popay , A J and Thom , E R . 2009 . Endophyte effects on major insect pests in Waikato dairy pasture . Proceedings of the New Zealand Grassland Association , 71 : 121 – 6 .
   Google Scholar
• Popay , A J and Wyatt , R T . 1995 . Resistance to Argentine stem weevil in perennial ryegrass infected with endophytes producing different alkaloids . Proceedings of the 48th New Zealand Plant Protection Conference , : 229 – 36 .
   Google Scholar
• *Popay , A J , Prestidge , R A , Rowan , D D and Dymock , J J . 1990 . “ The role of Acremonium lolii mycotoxins in insect resistance of perennial ryegrass (Lolium perenne) ” . In Proceedings of the International Symposium on Acremonium/Grass Interactions , Edited by: Quisenberry , S S and Joost , R E . 44 – 48 . Baton Rouge .
   Google Scholar
• Popay , A J , Hume , D E , Baltus , J G , Latch , G CM , Tapper , B A , Lyons , T B , Cooper , B M , Pennell , C G , Eerens , J PJ and Marshall , S L . 1999 . “ Field performance of perennial ryegrass (Lolium perenne) infected with toxin-free fungal endophytes (Neotyphodium spp.) ” . In Ryegrass Endophyte: An Essential New Zealand Symbiosis. GrasslandResearch and Practice Series 7 , Edited by: Woodfield , D E and Matthew , C . 113 – 22 . New Zealand : New Zealand Grassland Association, Palmerston North .
   Google Scholar
• *Popay , A J , Silvester , W B and Gerard , P J . 2004 . “ New endophyte isolate suppresses root aphid, Aploneura lentisci, in perennial ryegrass ” . In Proceedings of the 5^th International Symposium on Neotyphodium/Grass Interactions , Edited by: Kallenbach , R , Rosenkrans , C and Lock , T R . Arkansas : Poster No. 301. University of Arkansas, Lafayetteville .
   Google Scholar
• Prestidge , R A and Gallagher , R T . 1985 . Lolitrem B – A stem weevil toxin isolated from Acremonium-infected ryegrass . Proceedings of the 38th New Zealand Weed and Pest Control Conference , : 38 – 40 .
   Google Scholar
• Prestidge , R A , Pottinger , R P and Barker , G M . 1982 . An association of Lolium endophyte with ryegrass resistance to Argentine stem weevil . Proceedings of the 35th New Zealand Weed and Pest Control Conference , : 119 – 22 .
   Google Scholar
• Prestidge , R A , van der Zijpp , S and Badan , D. 1984 . Effects of Argentine stem weevil on pastures in the Central Volcanic Plateau . New Zealand Journal of Experimental Agriculture , 12 : 323 – 31 .
   Web of Science ®Google Scholar
• Prestidge , R A , Lauren , D R , van der Zijpp , S G and di Menna , M E . 1985 . Isolation of feeding deterrents to Argentine stem weevil in cultures of endophytes of perennial ryegrass and tall fescue . New Zealand Journal of Agricultural Research , 28 : 87 – 92 .
   Web of Science ®Google Scholar
• Pritchard , G C and Lewis , G C. 1995 . Ryegrass staggers . Veterinary Record , 28 : 471 – 2 .
   Web of Science ®Google Scholar
• Reed , K FM , Leonforte , A , Cunningham , P J , Walsh , J R , Allen , D I , Johnstone , G R and Kearney , G . 2000 . Incidence of ryegrass endophyte (Neotyphodium lolii) and diversity of associated alkaloid concentrations among naturalised populations of perennial ryegrass (Lolium perenne L.) . Australian Journal of Agricultural Research , 51 : 569 – 78 .
   Google Scholar
• Reed , K FM , Scrivener , C J , Rainsford , K A and Walker , L V. 2005 . “ Neotyphodium research and application in Australia ” . In Neotyphodiumin Cool-Season Grasses , Edited by: Roberts , C A , West , C P and Spiers , D E . 43 – 54 . Oxford, England : Blackwell Publishing .
   Google Scholar
• Reed , K FM , Vaughan , J L , Cummins , L J and Moore , D D . 2010 . Impact of mycotoxins and of a mycotoxin deactivatoron alpacas grazing perennial ryegrass infected with wild endophyte (Neotyphodium spp.) . Animal Production Science , 50 : 902 – 8 .
   Web of Science ®Google Scholar
• Rolston , M P , Hare , M D , Moore , K K and Christensen , M J. 1986 . Viability of Lolium endophyte fungus in seed stored at different moisture contents and temperatures . New Zealand Journal of Experimental Agriculture , 14 : 297 – 300 .
   Web of Science ®Google Scholar
• *Rolston , M P , Fletcher , L R , Fletcher , C G and Archies , W J . 2000 . “ The viability of perennial ryegrass seed andits endophyte in sheep faeces ” . In Proceedings of the 4th International Symposium on Neotyphodium/Grass Interactions , Edited by: Paul , V H and Dapprich , P D . 405 – 8 . Germany : University of Paderborn .
   Google Scholar
• Rowan , D D . 1993 . Lolitrems, peramine and paxilline: mycotoxins of the ryegrass/endophyte interaction . Agriculture, Ecosystems and Environment , 44 : 103 – 22 .
   Web of Science ®Google Scholar
• Rowan , D D and Gaynor , D L . 1986 . Isolation of feeding deterrents against Argentine stem weevil from ryegrass infected with the endophyte Acremonium loliae . Journal of Chemical Ecology , 12 : 647 – 58 .
   PubMed Web of Science ®Google Scholar
• Rowan , D D and Shaw , G J . 1987 . Detection of ergopeptine alkaloids in endophyte infectedperennial ryegrass by tandem massspectrometry . New Zealand Veterinary Journal , 35 : 197 – 8 .
   PubMed Web of Science ®Google Scholar
• Rowan , D D , Hunt , M B and Gaynor , D L . 1986 . Peramine, a novel insect feeding deterrent from ryegrass infected with the endophyte Acremonium loliae . Journal of the Chemical Society, Chemical Communications , : 935 – 6 .
   Google Scholar
• Rowan , D D , Dymock , J J and Brimble , M A . 1990a . Effect of fungal metabolite peramine and analogs on feeding development of Argentine stem weevil (Listronotus bonariensis) . Journal of Chemical Ecology , 16 : 1683 – 95 .
   PubMed Web of Science ®Google Scholar
• *Rowan , D D , Tapper , B A and Sergejew , N L . 1990b . “ Latch GCMErgopeptine alkaloids in endophyte-infected ryegrass in New Zealand ” . In Proceedings of the International Symposium on Acremonium/Grass Interactions , Edited by: Quisenberry , S S and Joost , R E . 97 – 99 . Baton Rouge, Louisiana : Louisiana Agricultural Experiment Station .
   Google Scholar
• Saikia , S , Parker , E J , Koulman , A and Scott , B . 2007 . Defining paxilline biosynthesis in Penicillium paxilli: functional characterization of two cytochrome P450 monooxygenases . Journal of Biological Chemistry , 282 : 16829 – 37 .
   PubMed Web of Science ®Google Scholar
• Saikia , S , Nicholson , M J , Young , C A , Parker , E J and Scott , B . 2008 . The genetic basis for indole-diterpene chemical diversity in filamentous fungi . Mycological Research , 112 : 184 – 99 .
   PubMed Web of Science ®Google Scholar
• Sampaio , N , Gishen , M , Reed , K , Brown , M , Gregory , D and Munyard , K . 2008 . The occurrence and severity of grass toxicoses in Australian alpaca (Vicugna pacos) herds . Australian Journal of Experimental Agriculture , 48 : 1099 – 104 .
   Google Scholar
• Sampson , K . 1935 . The presence and absence of an endophytic fungus in Lolium temulentum and L. perenne . Transactions of the British Mycological Society , 19 : 337 – 43 .
   Google Scholar
• Schardl , C L , Leuchmann , A , Tsai , H-F , Collett , M A , Watt , D M and Scott , D B . 1994 . Origin of a fungal symbiont of perennial ryegrass by interspecific hybridization of a mutualist with the ryegrass choke pathogen . Epichloë typhina. Genetics , 136 : 1307 – 17 .
   PubMed Web of Science ®Google Scholar
• Siegel , M R and Latch , G CM . 1991 . Expression of antifungal activity in agar culture by isolates of grass endophytes . Mycologia , 83 : 529 – 37 .
   Web of Science ®Google Scholar
• Smith , B L , McLeay , L M and Embling , P P . 1997 . Effect of the mycotoxins penitrem, paxilline and lolitrem B on the electromyographic activity of skeletal and gastrointestinal smooth muscle of sheep . Research in Veterinary Science , 62 : 111 – 6 .
   PubMed Web of Science ®Google Scholar
• Spiering , M J , Greer , D H and Schmid , J . 2006 . Effects of the fungal endophyte, Neotyphodium lolii, on net photosynthesis and growth rates of perennial ryegrass (Lolium perenne) are independent of in planta endophyte concentration . Annals of Botany , 98 : 379 – 87 .
   PubMed Web of Science ®Google Scholar
• Stewart , A V . 1986 . Effect on the Lolium endophyte of nitrogen applied to perennial ryegrass seed crops . New Zealand Journal of Experimental Agriculture , 14 : 393 – 7 .
   Web of Science ®Google Scholar
• Sugawara , K , Ohkubo , H , Yamashita , M and Mikoshiba , Y. 2004 . Flowers for Neotyphodium endophytes detection: a new observation method using flowers of host grasses . Mycoscience , 45 : 222 – 6 .
   Google Scholar
• Sutherland , B L and Hoglund , J H . 1989 . Effects of ryegrass containing the endophyte Acremonium lolii on the performance of associated white clover and subsequent crops . Proceedings of the New Zealand Grassland Association , 50 : 265 – 9 .
   Google Scholar
• Takemoto , D , Tanaka , A and Scott , B . 2007 . NADPH oxidases in fungi: diverse roles of reactive oxygen species in fungal cellular differentiation . Fungal Genetics and Biology , 44 : 1065 – 76 .
   PubMed Web of Science ®Google Scholar
• Tan , Y Y , Spiering , M J , Scott , V , Lane , G A , Christensen , M J and Schmid , J. 2001 . In planta regulation of extension of an endophytic fungus and maintenance of high metabolic rates in its mycelium in the absence of apical extension . Applied and Environmental Microbiology , 67 : 5377 – 83 .
   PubMed Web of Science ®Google Scholar
• Tanaka , A , Tapper , B A , Popay , A J , Parker , E J and Scott , B . 2005 . A symbiosis expressed non-ribosomal peptide synthetase from a mutualistic fungal endophyte of perennial ryegrass confers protection to the symbiotum from insect herbivory . Molecular Microbiology , 57 : 1036 – 50 .
   PubMed Web of Science ®Google Scholar
• Tanaka , A , Christensen , M J , Takemoto , D , Park , P and Scott , B . 2006 . Reactive oxygen species play a role in regulating a fungus-perennial ryegrass mutualistic interaction . The Plant Cell , 18 : 1052 – 66 .
   PubMed Web of Science ®Google Scholar
• Tanaka , A , Takemoto , D , Hyon , G-S , Park , P and Scott , B . 2008 . NoxA activation by the small GTPase RacA is required to maintain a mutualistic symbiotic association between Epichloë festucae and perennial ryegrass . Molecular Microbiology , 68 : 1165 – 78 . *Non-peer-reviewed
   PubMed Web of Science ®Google Scholar
• *Tapper , B A . 1993 . “ A New Zealand perspective on endophyte metabolites ” . In Proceedings of the 2nd International Symposium on Acremonium/Grass Interactions. Plenary papers , Edited by: Hume , D E , Latch , G CM and Easton , H S . 89 – 93 . New Zealand : AgResearch, Palmerston North .
   Google Scholar
• *Tapper , B A and Lane , G A . 2004 . “ Janthitrems found in a Neotyphodium endophyte of perennial ryegrass ” . In Proceedings of the 5th International Symposium on Neotyphodium/Grass Interactions , Edited by: Kallenbach , R , Rosencransz , C and Lock , T R . Arkansas : Poster B No. 301. University of Arkansas, Lafeyetteville .
   Google Scholar
• Tapper , B A and Latch , G CM . 1999 . “ Selection against toxin production in endophyte-infected perennial ryegrass ” . In Ryegrass Endophyte: An Essential New Zealand Symbiosis. Grassland Research and Practice Series 7 , Edited by: Woodfield , D R and Matthew , C . 107 – 11 . New Zealand : New Zealand Grassland Association, Palmerston North .
   Google Scholar
• Tapper , B A , Rowan , D D and Latch , G CM . 1989 . Detection and measurement of the alkaloid peramine in endophyte-infected grasses . Journal of ChromatographyA , 463 : 133 – 18 .
   Web of Science ®Google Scholar
• Thom , E R , Clark , D A , Prestidge , R A , Clarkson , F H and Waugh , C D . 1994 . Ryegrass endophyte, cow health and milk solids production for the 1993/94 season . Proceedings of the New Zealand Grassland Association , 56 : 259 – 64 .
   Google Scholar
• *Thom , E R , Waugh , C D and Minnee , E MK . 2010 . Dairy cow response to the wild-type endophyte in perennial ryegrass . Proceedings of the 4th Australasian Dairy Science Symposium , : 370 – 5 .
   Google Scholar
• Tor-Agbidye , J , Blythe , L L and Craig , A M . 2001 . Correlation of endophyte toxins (ergovaline and lolitrem B) with clinical disease: fescue foot and perennial ryegrass staggers . Veterinary and Human Toxicology , 43 : 140 – 6 .
   PubMedGoogle Scholar
• *Turner , B , Conklin , F , Carroll , D , DelCurto , T and Cross , T . 1995 . Special Report952 , 719 – 22 . Oregon : Agricultural Experimental Station Oregon State University .
   Google Scholar
• *Valentine , S C , Bartsch , B D and Carroll , P D . 1993 . “ Production and composition of milk by dairy cattle grazing high and low endophyte cultivars of perennial ryegrass ” . In Proceedings of the 2nd International Symposium on Acremonium/Grass Interactions , Edited by: Hume , D E , Latch , G CM and Easton , H S . 138 – 41 . New Zealand : AgResearch, Palmerston North .
   Google Scholar
• van Zijll de Jong , E , Guthridge , K M , Spangenberg , G C and Forster , J W . 2003 . Development and characterization of EST-derived simple sequence repeat (SSR) markers for pasture grass endophytes . Genome , 46 : 277 – 90 .
   PubMed Web of Science ®Google Scholar
• van Zijll de Jong , E , Dombrowolski , M P , Sandford , A , Smith , K F , Willocks , M J , Spangenberg , G C and Forster , J W . 2008 . Detection and characterisation of novel fungal endophyte genotypic variation in cultivars of perennial ryegrass (Lolium perenne L.) . Australian Journal of Agricultural Research , 59 : 214 – 21 .
   Google Scholar
• Wang , L , Cross , A L , Allen , K L , Smith , B L and McLeay , L M . 2003 . Tremorgenic mycotoxins increase gastric smooth muscle activity of sheep reticulum and rumen in vitro . Research in Veterinary Science , 74 : 93 – 100 .
   PubMed Web of Science ®Google Scholar
• Wedderburn , M E , Pengelly , W J , Tucker , M A and di Menna , M E . 1989 . Description of ryegrass removed from New Zealand North Island hill country . New Zealand Journal of Agricultural Research , 32 : 521 – 29 .
   Web of Science ®Google Scholar
• Weedon , C M and Mantle , P G . 1987 . Paxilline biosynthesis by Acremonium loliae; a step towards defining the origin of lolitrem neurotoxins . Phytochemistry , 26 : 969 – 71 .
   Web of Science ®Google Scholar
• Welty , R E , Azevedo , M D and Cook , K L. 1986 . Detecting viable Acremonium endophytes in leaf sheaths and meristems of tall fescue and perennial ryegrass . Plant Disease , 70 : 431 – 5 .
   Web of Science ®Google Scholar
• Welty , R E , Azevedo , M D and Cooper , T M . 1987 . Influence of moisture content, temperature and length of storage on seed germination and survival of endophytic fungi in seeds of tall fescue and perennial ryegrass . Phytopathology , 77 : 893 – 900 .
   Web of Science ®Google Scholar
• White , J F and Cole , G T . 1985 . Endophyte-host associations in forage grasses. III. In vitro inhibition of fungi by . Acremonium coenophialum. Mycologia , 77 : 487 – 9 .
   Web of Science ®Google Scholar
• White , E P , Smith , G S , di Menna , M E and Mortimer , P H . 1980 . Absorption and translocation of Penicillium by ryegrass plants . New Zealand Veterinary Journal , 28 : 123 – 4 .
   Web of Science ®Google Scholar
• Widdup , K H and Ryan , D L . 1992 . Forage potential of wild populations of perennial ryegrass collected from southern New Zealand farms . Proceedings of the New Zealand Grassland Association , 54 : 161 – 5 .
   Google Scholar
• Yates , S G , Plattner , R D and Garner , G B . 1985 . Detection of ergopeptine alkaloids in endophyte-infected, toxic Ky-31 tall fescue by mass spectrometry/mass spectrometry . Journal of Agricultural and Food Chemistry , 33 : 719 – 22 .
   Web of Science ®Google Scholar
• Young , C A , Felitti , S , Shields , K , Spangenberg , G , Johnson , R D , Bryan , G T , Saikia , S and Scott , B . 2006 . A complex gene cluster for indole-diterpene biosynthesis in the grass endophyte Neotyphodium lolii . Fungal Genetics and Biology , 43 : 679 – 93 .
   PubMed Web of Science ®Google Scholar
• Young , C A , Tapper , B A , May , K , Moon , C D , Schardl , C L and Scott , B . 2009 . Indole-diterpene biosynthetic capability of Epichloë endophytes as predicted by ltm gene analysis . Applied and Environmental Microbiology , 75 : 2200 – 11 . *Non-peer-reviewed
   PubMed Web of Science ®Google Scholar