A pilot study comparing the effect of orally administered esomeprazole and omeprazole on gastric fluid pH in horses

References

• Andersson T, Hassan-Alin M, Hasselgren G, Rhoss K, Weidolf L. Pharmacokinetic studies with esomeprazole, the (S)-isomer of omeprazole. Clinical Pharmacokinetics 40, 411–26, 2001 doi: 10.2165/00003088-200140060-00003
   PubMed Web of Science ®Google Scholar
• Andrews FM, Frank N, Sommardahl CS, Buchannan BR, Elliott SB, Allen VA. Effects of intravenously administered omeprazole in gastric juice pH and gastric ulcer scores in adult horses. Journal of Veterinary Internal Medicine 20, 1202–6, 2006 doi: 10.1111/j.1939-1676.2006.tb00723.x
   PubMed Web of Science ®Google Scholar
• Bell NJV, Burget D, Howden CW, Wilkinson J, Hunt RH. Appropriate acid suppression for the management of gastro-oesophageal reflux disease. Digestion 51, 59–67, 1992 doi: 10.1159/000200917
   PubMed Web of Science ®Google Scholar
• *Habershon-Butcher JL, Hallowell GD, Bowen IM, Sykes BW. Prevalence and risk factors for ulceration of the gastric glandular mucosa in thoroughbred racehorses in training in the UK and Australia. Journal of Veterinary Internal Medicine 26, 731, 2012
   Web of Science ®Google Scholar
• Kendall MJ. Esomeprazole – the first proton pump inhibitor to be developed as an isomer. Alimentary Pharmacology and Therapeutics 17, 1–4, 2003 doi: 10.1046/j.1365-2036.17.s1.1.x
   PubMed Web of Science ®Google Scholar
• MacAllister CG, Stifferman RL, McClure SR, White GW. Effects of omeprazole paste on healing of spontaneous gastric ulcers in horses and foals: a field trial. Equine Veterinary Journal 29, 77–80, 1999
   Google Scholar
• McClure SR, White GW, Sifferman RL, Bernard W, Doucet MY, Vrins A, Holste JE, Fleishman C, Alva R, Cramer LG. Efficacy of omeprazole paste for prevention of gastric ulcers in horses in race training. Journal of the American Veterinary Medical Association 226, 1681–84, 2005a doi: 10.2460/javma.2005.226.1681
   PubMed Web of Science ®Google Scholar
• McClure SR, White GW, Sifferman RL, Bernard W, Hughes FE, Hoste JE, Fleishman C, Alva R, Cramer LG. Efficacy of omeprazole paste for prevention of recurrence of gastric ulcers in horses in race training. Journal of the American Veterinary Medical Association 226, 1685–88, 2005b doi: 10.2460/javma.2005.226.1685
   PubMed Web of Science ®Google Scholar
• McConaghy FF, Hodgson DR, Perkins NR. Comparison of the effect of omoguard and gastroshield on gastric pH in fasted horses, and effects of differing doses of the generic omeprazole paste gastrozol. Australian Equine Veterinarian 30, 64–70, 2011
   Google Scholar
• Merritt AM. The equine stomach: a personal perspective (1963–2003). Proceedings of the American Association of Equine Practitioners Meeting 49, 75–102, 2003
   Google Scholar
• Murray MJ. Equine model of inducing ulceration in the alimentary squamous epithelial mucosa. Digestive Diseases and Sciences 39, 2530–5, 1994 doi: 10.1007/BF02087686
   PubMed Web of Science ®Google Scholar
• Nieto JE, Spier SJ, Van Hoogmoed L, Pipers F, Timmerman B, Snyder JR. Comparison of paste and suspension formulations of omeprazole in the healing of gastric ulcers and prevention of gastric ulcers in racehorses in active training. Journal of the American Veterinary Medicine Association 221, 1139–43, 2002 doi: 10.2460/javma.2002.221.1139
   PubMed Web of Science ®Google Scholar
• Pereira MC, Levy FL, Valadao CAA, Ferraz GC, Queiroz-Neto A. Preliminary study of the gastric acidity in thoroughbred horses at rest after enteral administration of esomeprazole magnesium (Nexium). Journal of Equine Veterinary Science 29, 791–94, 2009 doi: 10.1016/j.jevs.2009.10.006
   Web of Science ®Google Scholar
• Pike N. Using false discover rates for multiple comparisons in ecology and evolution. Methods in Ecology and Evolution 2, 278–2, 2011 doi: 10.1111/j.2041-210X.2010.00061.x
   Web of Science ®Google Scholar
• Rohss K, Lind T, Wilder-Smith C. Esomeprazole 40 mg provides more effective intragastric acid control than lansoprazole 30 mg, omeprazole 20 mg, pantoprazole 40 mg and rabeprazole 20 mg in patients with gastro-oesophageal reflux symptoms. European Journal of Clinical Pharmacology 60, 531–39, 2004 doi: 10.1007/s00228-004-0804-6
   PubMed Web of Science ®Google Scholar
• Sykes BW, Jokisalo JM. Rethinking equine gastric ulcer syndrome: part 2 – equine squamous gastric ulcer syndrome (ESGUS). Equine Veterinary Education 27, 264–8, 2015 doi: 10.1111/eve.12277
   Web of Science ®Google Scholar
• Sykes BW, Sykes KM, Hallowell GD. Comparison of the effect of two doses of omeprazole on the squamous gastric mucosa in thoroughbred racehorses. Veterinary Record 175, 249, 2014 doi: 10.1136/vr.102622
   PubMed Web of Science ®Google Scholar
• Sykes BW, Hewetson M, Hepburn RJ, Luthersson N, Tamzali Y. European College of Equine Internal Medicine Consensus Statement – equine gastric ulcer syndrome in adult horses. Journal of Veterinary Internal Medicine 29, 1288–99, 2015a doi: 10.1111/jvim.13578
   PubMed Web of Science ®Google Scholar
• Sykes BW, Underwood C, Greer R, McGowan CM, Mills PC. Pharmacokinetics and bioequivalence testing of five commercial formulation of omeprazole in the horse. Journal of Veterinary Pharmacology and Therapeutics 39, 78–83, 2015b doi: 10.1111/jvp.12240
   PubMed Web of Science ®Google Scholar
• Sykes BW, Underwood C, McGowan CM, Mills PC. The effect of feeding on the pharmacokinetic variables of two commercially available formulations of omeprazole. Journal of Veterinary Pharmacology and Therapeutics 38, 500–3, 2015c doi: 10.1111/jvp.12210
   PubMed Web of Science ®Google Scholar
• Sykes BW, Underwood C, McGowan CM, Mills PC. The effects of dose and diet on the pharmacokinetics of omeprazole in the horse. Journal of Veterinary Pharmacology and Therapeutics 40, 172–8, 2017 doi: 10.1111/jvp.12345
   PubMed Web of Science ®Google Scholar
• Videla R, Sommardahl CS, Elliott SB, Vasili A, Andrews FM. Effects of intravenously administered esomeprazole sodium on gastric juice pH in adult female horses. Journal of Veterinary Internal Medicine 25, 558–62, 2011 doi: 10.1111/j.1939-1676.2011.0716.x
   PubMed Web of Science ®Google Scholar
• *Wilder-Smith C, Claar-Nilsson C, Hasselgren G, Rohss K. Esomeprazole 40 mg provides faster and more effective acid control than rabeprazole 20 mg in patients with symptoms of GERD. Gastroenterology and Hepatology 17, 612, 2002
   Google Scholar