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REVIEW ARTICLE

The effects of raw-meat diets on the gastrointestinal microbiota of the cat and dog: a review

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Pages 1-9 | Received 25 Jan 2021, Accepted 26 Aug 2021, Published online: 19 Sep 2021

References

  • *AAFCO. American Association of Feed Control Officials 2020 Official Publication. AAFCO Publications, Champaign, IL, USA. 2020
  • Alessandri G, Argentini C, Milani C, Turroni F, Cristina Ossiprandi M, van Sinderen D, Ventura M. Catching a glimpse of the bacterial gut community of companion animals: a canine and feline perspective. Microbial Biotechnology 13, 1708–32, 2020
  • Alessandri G, Milani C, Mancabelli L, Mangifesta M, Lugli GA, Viappiani A, Duranti S, Turroni F, Ossiprandi MC, van Sinderen D, et al. Metagenomic dissection of the canine gut microbiota: insights into taxonomic, metabolic and nutritional features. Environmental Microbiology 21, 1331–43, 2019
  • Anderson RC, Armstrong KM, Young W, Maclean P, Thomas DG, Bermingham EN. Effect of kibble and raw meat diets on peripheral blood mononuclear cell gene expression profile in dogs. The Veterinary Journal 234, 7–10, 2018
  • Andrés-Lasheras S, Martín-Burriel I, Mainar-Jaime RC, Morales M, Kuijper E, Blanco JL, Chirino-Trejo M, Bolea R. Preliminary studies on isolates of Clostridium difficile from dogs and exotic pets. BMC Veterinary Research 14, 77, 2018
  • Anturaniemi J, Barrouin-Melo SM, Zaldivar-López S, Sinkko H, Hielm-Björkman A. Owners’ perception of acquiring infections through raw pet food: a comprehensive internet-based survey. Veterinary Record 185, 658, 2019
  • AVMA. Recalls and Safety Alerts. https://www.avma.org/news/recalls-alerts (accessed 22 December 2020) American Veterinary Medical Association, Schaumburg, IL, USA, 2020
  • Axelsson E, Ratnakumar A, Arendt ML, Maqbool K, Webster MT, Perloski M, Liberg O, Arnemo JM, Hedhammar A, Lindblad-Toh K. The genomic signature of dog domestication reveals adaptation to a starch-rich diet. Nature 495, 360–4, 2013
  • Baede VO, Broens EM, Spaninks MP, Timmerman AJ, Graveland H, Wagenaar JA, Duim B, Hordijk J. Raw pet food as a risk factor for shedding of extended-spectrum beta-lactamase-producing Enterobacteriaceae in household cats. PLoS One 12, e0187239, 2017
  • Bakken V, Högh BT, Jensen HB. Utilization of amino acids and peptides by Fusobacterium nucleatum. European Journal of Oral Sciences 97, 43–53, 1989
  • Beloshapka AN, Dowd SE, Suchodolski JS, Steiner JM, Duclos L, Swanson KS. Fecal microbial communities of healthy adult dogs fed raw meat-based diets with or without inulin or yeast cell wall extracts as assessed by 454 pyrosequencing. FEMS Microbiology Ecology 84, 532–41, 2013
  • Bermingham EN, Maclean P, Thomas DG, Cave NJ, Young W. Key bacterial families (Clostridiaceae, Erysipelotrichaceae and Bacteroidaceae) are related to the digestion of protein and energy in dogs. PeerJ 5, e3019, 2017
  • Bischoff K, Rumbeiha WK. Pet food recalls and pet food contaminants in small animals: an update. The Veterinary Clinics of North America: Small Animal Practice 48, 917–31, 2018
  • Bosch G, Hagen-Plantinga EA, Hendriks WH. Dietary nutrient profiles of wild wolves: insights for optimal dog nutrition? British Journal of Nutrtion 113(Suppl), S40–54, 2015.
  • Brosey BP, Hill RC, Scott KC. Gastrointestinal volatile fatty acid concentrations and pH in cats. American Journal of Veterinary Research 61, 359–61, 2000
  • Butowski CF, Thomas DG, Young W, Cave NJ, McKenzie CM, Rosendale DI, Bermingham EN. Addition of plant dietary fibre to a raw red meat high protein, high fat diet, alters the faecal bacteriome and organic acid profiles of the domestic cat (Felis catus). PLoS One 14, e0216072, 2019
  • Carriere F, Raphel V, Moreau H, Bernadac A, Devaux MA, Grimaud R, Barrowman JA, Benicourt C, Junien JL, Laugier R, et al. Dog gastric lipase: stimulation of its secretion in vivo and cytolocalization in mucous pit cells. Gastroenterology 102, 1535–45, 1992
  • Çatak J. Determination of niacin profiles in some animal and plant based foods by high performance liquid chromatography: association with healthy nutrition. Journal of Animal Science and Technology 61, 138–46, 2019
  • Citron DM. Update on the taxonomy and clinical aspects of the genus Fusobacterium. Clinical Infectious Diseases 35, S22–S7, 2002
  • Cruz-Morales P, Orellana CA, Moutafis G, Moonen G, Rincon G, Nielsen LK, Marcellin E. Revisiting the evolution and taxonomy of Clostridia, a phylogenomic update. Genome Biology and Evolution 11, 2035–44, 2019
  • Davies M, Alborough R, Jones L, Davis C, Williams C, Gardner DS. Mineral analysis of complete dog and cat foods in the UK and compliance with European guidelines. Scientific Reports 7, 17107, 2017
  • Davies RH, Lawes JR, Wales AD. Raw diets for dogs and cats: a review, with particular reference to microbiological hazards. The Journal of Small Animal Practice 60, 329–39, 2019
  • de Bruijne JJ, van den Brom WE. The effect of long-term fasting on ketone body metabolism in the dog. Comparative Biochemistry and Physiology B 83, 391–5, 1986
  • Diakite A, Dubourg G, Dione N, Afouda P, Bellali S, Ngom II, Valles C, Tall Ml, Lagier J-C, Raoult D. Optimization and standardization of the culturomics technique for human microbiome exploration. Scientific Reports 10, 9674, 2020
  • Dillitzer N, Becker N, Kienzle E. Intake of minerals, trace elements and vitamins in bone and raw food rations in adult dogs. British Journal of Nutrition 106(Suppl 1), S53–6, 2011
  • Fauth E, Freeman LM, Cornjeo L, Markovich JE, Janecko N, Weese JS. Salmonella bacteriuria in a cat fed a Salmonella-contaminated diet. Journal of the American Veterinary Medical Association 247, 525–30, 2015
  • *FEDIAF. Nutritional Guidelines for Complete and Complementary Pet Food for Cats and Dogs. http://www.fediaf.org/images/FEDIAF_Nutritional_Guidelines_2020_20200917.pdf (accessed 9 October 2020). European Pet Food Industry Federation, Brussels, Belgium, 2020
  • Finley R, Reid-Smith R, Weese JS, Angulo FJ. Human health implications of Salmonella-contaminated natural pet treats and raw pet food. Clinical Infectious Diseases 42, 686–91, 2006
  • Finley R, Ribble C, Aramini J, Vandermeer M, Popa M, Litman M, Reid-Smith R. The risk of salmonellae shedding by dogs fed Salmonella-contaminated commerical raw food diets. Canadian Veterinary Journal 48, 69–75, 2007
  • Flint HJ, Scott KP, Louis P, Duncan SH. The role of the gut microbiota in nutrition and health. Nature Reviews in Gastroenterology and Hepatology 9, 577–89, 2012
  • Garcia-Mazcorro JF, Minamoto Y. Gastrointestinal microorganisms in cats and dogs: a brief review. Achivos de Medicina Veterinaria 45, 111–24, 2013
  • Guard BC, Barr JW, Reddivari L, Klemashevich C, Jayaraman A, Steiner JM, Vanamala J, Suchodolski JS. Characterization of microbial dysbiosis and metabolomic changes in dogs with acute diarrhea. PLoS One 10, e0127259, 2015
  • *Guy RCE. Pet foods. In: Reference Module in Food Science. doi:https://doi.org/10.1016/B978-0-08-100596-5.00140-2, Elsevier, Amsterdam, The Netherlands, 2016
  • Hewson-Hughes AK, Hewson-Hughes VL, Colyer A, Miller AT, Hall SR, Raubenheimer D, Simpson SJ. Consistent proportional macronutrient intake selected by adult domestic cats (Felis catus) despite variations in macronutrient and moisture content of foods offered. Journal of Comparative Physiology B: Biochemical, Systemic, and Environmental Physiology 183, 525–36, 2013a
  • Hewson-Hughes AK, Hewson-Hughes VL, Colyer A, Miller AT, McGrane SJ, Hall SR, Butterwick RF, Simpson SJ, Raubenheimer D. Geometric analysis of macronutrient selection in breeds of the domestic dog, Canis lupus familiaris. Behavioural Ecology 24, 293–304, 2013b
  • Hiney K, Sypniewski L, Rudra P, Pezeshki A, McFarlane D. Clinical health markers in dogs fed raw meat based or commercial extruded kibble diets. Journal of Animal Science 99, skab133, 2021
  • Hiskett EK, Suwitheechon O-u, Lindbloom-Hawley S, Boyle DL, Schermerhorn T. Lack of glucokinase regulatory protein expression may contribute to low glucokinase activity in feline liver. Veterinary Research Communications 33, 227–40, 2009
  • Honneffer JB, Minamoto Y, Suchodolski JS. Microbiota alterations in acute and chronic gastrointestinal inflammation of cats and dogs. World Journal of Gastroenterology 20, 16489–97, 2014
  • How KL, Hazewinkel HA, Mol JA. Dietary vitamin D dependence of cat and dog due to inadequate cutaneous synthesis of vitamin D. General and Comparative Endocrinology 96, 12–8, 1994
  • Jones JL, Wang L, Ceric O, Nemser SM, Rotstein DS, Jurkovic DA, Rosa Y, Byrum B, Cui J, Zhang Y, et al. Whole genome sequencing confirms source of pathogens associated with bacterial foodborne illness in pets fed raw pet food. The Journal of Veterinary Diagnostic Investigation 31, 235–40, 2019
  • Kerr KR, Dowd SE, Swanson KS. Faecal microbiota of domestic cats fed raw whole chicks v. an extruded chicken-based diet. Journal of Nutrition Science 3, e22, 2014
  • Kienzle E. Carbohydrate metabolism of the cat 1. activity of amylase in the gastrointestinal tract of the cat1. Journal of Animal Physiology and Animal Nutrition 69, 92–101, 1993
  • Kim J, An J-U, Kim W, Lee S, Cho S. Differences in the gut microbiota of dogs (Canis lupus familiaris) fed a natural diet or a commercial feed revealed by the Illumina MiSeq platform. Gut Pathogens 9, 68, 2017
  • Kim S, Cho YS, Kim H-M, Chung O, Kim H, Jho S, Seomun H, Kim J, Bang WY, Kim C, et al. Comparison of carnivore, omnivore, and herbivore mammalian genomes with a new leopard assembly. Genome Biology 17, 211, 2016
  • Knospe C, Plendl J. Histochemical demonstration of lipase activity in the gastric mucosa of the cat. Anatomia, Histologia, Embryologia 26, 303–4, 1997
  • Laflamme DP, Abood SK, Fascetti AJ, Fleeman LM, Freeman LM, Michel KE, Bauer C, Kemp BL, Doren JR, Willoughby KN. Pet feeding practices of dog and cat owners in the United States and Australia. Journal of the American Veterinary Medical Association 232, 687–94, 2008
  • Lagier J-C, Dubourg G, Million M, Cadoret F, Bilen M, Fenollar F, Levasseur A, Rolain J-M, Fournier P-E, Raoult D. Culturing the human microbiota and culturomics. Nature Reviews Microbiology 16, 540–50, 2018
  • Li X, Li W, Wang H, Cao J, Maehashi K, Huang L, Bachmanov AA, Reed DR, Legrand-Defretin V, Beauchamp GK, et al. Pseudogenization of a sweet-receptor gene accounts for cats’ indifference toward sugar. PLoS Genetics 1, 27–35, 2005
  • Ma J, Li Z, Zhang W, Zhang C, Zhang Y, Mei H, Zhuo N, Wang H, Wang L, Wu D. Comparison of gut microbiota in exclusively breast-fed and formula-fed babies: a study of 91 term infants. Scientific Reports 10, 15792, 2020
  • McGeachin RL, Akin JR. Amylase levels in the tissues and body fluids of the domestic cat (Felis catus). Comparative Biochemistry & Physiology B 63, 437–9, 1979
  • Moon CD, Young W, Maclean PH, Cookson AL, Bermingham EN. Metagenomic insights into the roles of Proteobacteria in the gastrointestinal microbiomes of healthy dogs and cats. Microbiologyopen 7, e00677, 2018
  • Morelli G, Bastianello S, Catellani P, Ricci R. Raw meat-based diets for dogs: survey of owners’ motivations, attitudes and practices. BMC Veterinary Research 15, 74, 2019
  • National Research Council. Nutrient Requirements of Dogs and Cats. National Academies Press, Washington DC, USA. 2006
  • Nüesch-Inderbinen M, Treier A, Zurfluh K, Stephan R. Raw meat-based diets for companion animals: a potential source of transmission of pathogenic and antimicrobial-resistant Enterobacteriaceae. Royal Society Open Science 6, 191170, 2019
  • O’Halloran C, Tornqvist-Johnsen C, Woods G, Mitchell J, Reed N, Burr P, Gascoyne-Binzi D, Wegg M, Beardall S, Hope J, et al. Feline tuberculosis caused by Mycobacterium bovis infection of domestic UK cats associated with feeding a commercial raw food diet. Transboundary and Emerging Diseases 68, 2308–20, 2020
  • Oliphant K, Allen-Vercoe E. Macronutrient metabolism by the human gut microbiome: major fermentation by-products and their impact on host health. Microbiome 7, 91, 2019
  • Olkkola S, Kovanen S, Roine J, Hänninen M-L, Hielm-Björkman A, Kivistö R. Population genetics and antimicrobial susceptibility of canine Campylobacter isolates collected before and after a raw feeding experiment. PLoS One 10, e0132660, 2015
  • Pacheco AR, Barile D, Underwood MA, Mills DA. The impact of the milk glycobiome on the neonate gut microbiota. Annual Review of Animal Biosciences 3, 419–45, 2015
  • Pallotto MR, de Godoy MRC, Holscher HD, Buff PR, Swanson KS. Effects of weight loss with a moderate-protein, high-fiber diet on body composition, voluntary physical activity, and fecal microbiota of obese cats. American Journal of Veterinary Research 79, 181–90, 2018
  • Pawlosky R, Barnes A, Salem N, Jr. Essential fatty acid metabolism in the feline: relationship between liver and brain production of long-chain polyunsaturated fatty acids. Journal of Lipid Research 35, 2032–40, 1994
  • Pilla R, Suchodolski JS. The role of the canine gut microbiome and metabolome in health and gastrointestinal disease. Frontiers in Veterinary Science 6, 498, 2019
  • Potrykus J, Mahaney B, White RL, Bearne SL. Proteomic investigation of glucose metabolism in the butyrate-producing gut anaerobe Fusobacterium varium. ProteomicS 7, 1839–53, 2007
  • Raila J, Buchholz I, Aupperle H, Raila G, Schoon HA, Schweigert FJ. The distribution of vitamin A and retinol-binding protein in the blood plasma, urine, liver and kidneys of carnivores. Veterinary Research 31, 541–51, 2000
  • Ramezani M, MacIntosh SE, White RL. Utilization of D-amino acids by Fusobacterium nucleatum and Fusobacterium varium. Amino Acids 17, 185–93, 1999
  • Reese AT, Dunn RR. Drivers of microbiome biodiversity: a review of general rules, feces, and ignorance. MBio 9, e01294–18, 2018
  • Remillard RL. Homemade diets: attributes, pitfalls, and a call for action. Topics in Companion Animal Medicine 23, 137–42, 2008
  • Roberts MT, Bermingham EN, Cave NJ, Young W, McKenzie CM, Thomas DG. Macronutrient intake of dogs, self-selecting diets varying in composition offered ad libitum. Journal of Animal Physiology and Animal Nutrition 102, 568–75, 2018
  • Rubinstein MR, Baik JE, Lagana SM, Han RP, Raab WJ, Sahoo D, Dalerba P, Wang TC, Han YW. Fusobacterium nucleatum promotes colorectal cancer by inducing Wnt/β-catenin modulator Annexin A1. EMBO Reports 20, e47638, 2019
  • Runesvärd E, Wikström C, Fernström L-L, Hansson I. Presence of pathogenic bacteria in faeces from dogs fed raw meat-based diets or dry kibble. Veterinary Record 187, e71, 2020
  • Sabshin SJ, Levy JK, Tupler T, Tucker SJ, Greiner EC, Leutenegger CM. Enteropathogens identified in cats entering a Florida animal shelter with normal feces or diarrhea. Journal of the American Veterinary Medical Association 241, 331–7, 2012
  • Salaun F, Blanchard G, Le Paih L, Roberti F, Niceron C. Impact of macronutrient composition and palatability in wet diets on food selection in cats. Journal of Animal Physiology and Animal Nutiriton 101, 320–8, 2017
  • Sandri M, Dal Monego S, Conte G, Sgorlon S, Stefanon B. Raw meat based diet influences faecal microbiome and end products of fermentation in healthy dogs. BMC Veterinary Research 13, 65, 2017
  • Schlegel BJ, Van Dreumel T, Slavić D, Prescott JF. Clostridium perfringens type A fatal acute hemorrhagic gastroenteritis in a dog. The Canadian Veterinary Journal 53, 555–7, 2012
  • Schmidt M, Unterer S, Suchodolski JS, Honneffer JB, Guard BC, Lidbury JA, Steiner JM, Fritz J, Kolle P. The fecal microbiome and metabolome differs between dogs fed bones and raw food (BARF) diets and dogs fed commercial diets. PLoS One 13, e0201279, 2018
  • Schweigert FJ, Raila J, Wichert B, Kienzle E. Cats absorb beta-carotene, but it is not converted to vitamin A. The Journal of Nutrition 132, 1610S–2S, 2002
  • Signat B, Roques C, Poulet P, Duffaut D. Fusobacterium nucleatum in periodontal health and disease. Current Issues in Molecular Biology 13, 25–36, 2011
  • Stockman J, Fascetti AJ, Kass PH, Larsen JA. Evaluation of recipes of home-prepared maintenance diets for dogs. Journal of the American Veterinary Medical Association 242, 1500–5, 2013
  • Stogdale L. One veterinarian’s experience with owners who are feeding raw meat to their pets. The Canadian Veterinary Journal 60, 655–8, 2019
  • Suchodolski JS, Foster ML, Sohail MU, Leutenegger C, Queen EV, Steiner JM, Marks SL. The fecal microbiome in cats with diarrhea. PLoS One 10, e0127378, 2015
  • Suchodolski JS, Markel ME, Garcia-Mazcorro JF, Unterer S, Heilmann RM, Dowd SE, Kachroo P, Ivanov I, Minamoto Y, Dillman EM, et al. The fecal microbiome in dogs with acute diarrhea and idiopathic inflammatory bowel disease. PLoS One 7, e51907, 2012
  • Summers SC, Quimby JM, Isaiah A, Suchodolski JS, Lunghofer PJ, Gustafson DL. The fecal microbiome and serum concentrations of indoxyl sulfate and p-cresol sulfate in cats with chronic kidney disease. Journal of Veterinary Internal Medicine 33, 662–9, 2019
  • Thomas M, Feng Y. Risk of foodborne illness from pet food: assessing pet owners’ knowledge, behavior, and risk perception. Journal of Food Protection 83, 1998–2007, 2020
  • van Bree FPJ, Bokken GCAM, Mineur R, Franssen F, Opsteegh M, van der Giessen JWB, Lipman LJA, Overgaauw PAM. Zoonotic bacteria and parasites found in raw meat-based diets for cats and dogs. Veterinary Record 182, 50, 2018
  • Vital M, Gao J, Rizzo M, Harrison T, Tiedje JM. Diet is a major factor governing the fecal butyrate-producing community structure across Mammalia, Aves and Reptilia. International Society for Microbial Ecology Journal 9, 832–43, 2015
  • Washizu T, Tanaka A, Sako T, Washizu M, Arai T. Comparison of the activities of enzymes related to glycolysis and gluconeogenesis in the liver of dogs and cats. Research in Veterinary Science 67, 205–6, 1999
  • Ziese AL, Suchodolski JS. Impact of changes in gastrointestinal microbiota in canine and feline digestive diseases. Veterinary Clinics of North America: Small Animal Practice 51, 155–69, 2021
  • * Non-peer-reviewed

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