Biochemical profile of heifers with spontaneous humeral fractures suggest that protein-energy malnutrition could be an important factor in the pathology of this disease

References

• Agenäs S, Heath M, Nixon R, Wilkinson J, Phillips C. Indicators of undernutrition in cattle. Animal Welfare 15, 149–60, 2006
   Web of Science ®Google Scholar
• *Anonymous. Fractured legs in heifers? Think copper deficiency! https://www.thevetgroup.com.au/fractured-legs-in-heifers-think-copper-deficiency/ (accessed April 29, 2022). The Vet Group, Victoria, Australia, 2020
   Google Scholar
• Brunner N, Groeger S, Canelas Raposo J, Bruckmaier R, Gross J. Prevalence of subclinical ketosis and production diseases in dairy cows in Central and South America, Africa, Asia, Australia, New Zealand, and Eastern Europe. Translational Animal Science 3, 84–92, 2019. https://doi.org/10.1093/tas/txy102
   PubMed Web of Science ®Google Scholar
• Compton C, McDougall S, Young L, Bryan M. Prevalence of subclinical ketosis in mainly pasture-grazed dairy cows in New Zealand in early lactation. New Zealand Veterinary Journal 62, 30–7, 2014. https://doi.org/10.1080/00480169.2013.823829
   PubMed Web of Science ®Google Scholar
• *Constable P, Hinchcliff K, Done S, Grünberg W. Diseases of the musculoskeletal system. Veterinary Medicine: a Textbook of the Diseases of Cattle, Horses, Sheep, Pigs and Goats. 11th Edtn. Pp 1372–534. Elsevier Health Sciences, St. Louis, MO, USA, 2016
   Google Scholar
• Cozzi G, Ravarotto L, Gottardo F, Stefani A, Contiero B, Moro L, Brscic M, Dalvit P. Reference values for blood parameters in Holstein dairy cows: effects of parity, stage of lactation, and season of production. Journal of Dairy Science 94, 3895–901, 2011. https://doi.org/10.3168/jds.2010-3687
   PubMed Web of Science ®Google Scholar
• *Craig L, Dittmer K, Thompson K. Bone and joints. In: Maxie MG (ed). Pathology of Domestic Animals. 6th Edtn. Pp 16–163. Elsevier, St. Louis, MO, USA, 2016
   Google Scholar
• Dittmer K, Hitchcock B, McDougall S, Hunnam J. Pathophysiology of humeral fractures in a sample of dairy heifers. New Zealand Veterinary Journal 64, 230–7, 2016. https://doi.org/10.1080/00480169.2016.1171173
   PubMed Web of Science ®Google Scholar
• Ensley S. Evaluating mineral status in ruminant livestock. Veterinary Clinics of North America: Food Animal Practice 36, 525–46, 2020. https://doi.org/10.1016/j.cvfa.2020.08.009
   PubMed Web of Science ®Google Scholar
• Gibson M, Dittmer K, Hickson R, Back P, Wehrle-Martinez A, Rogers C. The mid-diaphysis Is a poor predictor of humeral fracture risk indicating that predisposing factors are recent. Ruminants 1, 23–30, 2021. https://doi.org/10.3390/ruminants1010002
   Google Scholar
• Graham TW. Trace element deficiencies in cattle. Veterinary Clinics of North America: Food Animal Practice 7, 153–215, 1991. https://doi.org/10.1016/S0749-0720(15)30816-1
   PubMed Web of Science ®Google Scholar
• Horst R, Goff J, Reinhardt T. Adapting to the transition between gestation and lactation: differences between rat, human and dairy cow. Journal of Mammary Gland Biology and Neoplasia 10, 141–56, 2005. https://doi.org/10.1007/s10911-005-5397-x
   PubMed Web of Science ®Google Scholar
• McArt J, Nydam D, Oetzel G, Overton T, Ospina P. Elevated non-esterified fatty acids and β-hydroxybutyrate and their association with transition dairy cow performance. Veterinary Journal 198, 560–70, 2013. https://doi.org/10.1016/j.tvjl.2013.08.011
   PubMed Web of Science ®Google Scholar
• Megahed A, Hiew M, Ragland D, Constable P. Changes in skeletal muscle thickness and echogenicity and plasma creatinine concentration as indicators of protein and intramuscular fat mobilization in periparturient dairy cows. Journal of Dairy Science 102, 5550–65, 2019. https://doi.org/10.3168/jds.2018-15063
   PubMed Web of Science ®Google Scholar
• Mills C, Dalgarno A, Wenham G. Biochemical and pathological changes in tissues of Friesian cattle during the experimental induction of copper deficiency. British Journal of Nutrition 35, 309–31, 1976. https://doi.org/10.1079/BJN19760039
   PubMed Web of Science ®Google Scholar
• National Research Council. Minerals. In: Nutrient Requirements of Dairy Cattle. 7th Edtn. Pp 105–61. National Academic Press, Washington, DC, USA, 2001
   Google Scholar
• Rakestraw P. Fractures of the humerus. Veterinary Clinics of North America: Food Animal Practice 12, 153–68, 1996. https://doi.org/10.1016/S0749-0720(15)30440-0
   PubMed Web of Science ®Google Scholar
• Russell K, Roussel A. Evaluation of the ruminant serum chemistry profile. Veterinary Clinics of North America: Food Animal Practice 23, 403–26, 2007. https://doi.org/10.1016/j.cvfa.2007.07.003
   PubMed Web of Science ®Google Scholar
• Suttle N, Angus K. Effects of experimental copper deficiency on the skeleton of the calf. Journal of Comparative Pathology 88, 137–48, 1978. https://doi.org/10.1016/0021-9975(78)90070-1
   PubMed Web of Science ®Google Scholar
• Wehrle-Martinez A, Lawrence K, Back P, Rogers C, Gibson M, Dittmer K. Osteoporosis is the cause of spontaneous humeral fracture in dairy cows from New Zealand. Veterinary Pathology, 2022. https://doi.org/10.1177/03009858221122500
   PubMed Web of Science ®Google Scholar
• *Weston J. An outbreak of humeral fractures among dairy heifers. Proceedings of the Society of Dairy Cattle Veterinarians of the New Zealand Veterinary Association. Pp 241–3, 2008
   Google Scholar
• *Weston J, Thompson K, Dittmer K, Rashid Z. Humeral fractures in dairy heifers. Proceedings of the Dairy Cattle Veterinarians of the New Zealand Veterinary Association. Pp 2.18.11–12, 2012
   Google Scholar
• *Non-peer-reviewed
   Google Scholar