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Xenobiotica
the fate of foreign compounds in biological systems
Volume 30, 2000 - Issue 5
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Research Article

Effect of diet and gavage on the dose- and dose-mode-dependent absorption and metabolism of bidisomide in rat

C. S. Cook Metabolism and Safety Evaluation, G. D. Searle & Co., 4901 Searle Parkway, Skokie, IL 60077, USA
,
M. Lonien Metabolism and Safety Evaluation, G. D. Searle & Co., 4901 Searle Parkway, Skokie, IL 60077, USA
&
J. Hribar Metabolism and Safety Evaluation, G. D. Searle & Co., 4901 Searle Parkway, Skokie, IL 60077, USA
Pages 523-533 | Published online: 22 Sep 2008

References

  • COOK, C. S., Avis, G. B., Smut', M. E., KOWALSKI, K. G. and KARIM, A., 1993a, Absorption and disposition of a new antiarrhythmic agent bidisomide in man. Pharmaceutical Research, 10, 1675–1681.
  • COOK, C. S., HAUSWALD, C., OPPERMANN, J. A. and SCHOENHARD, G. L., 1993b, Involvement of cytochrome P-450 MA in mechanism of inhibition of the epoxide formation by spironolactone and its sulfur-containing metabolite. Journal of Pharmacology Experimental and Therapeutics, 266, 1–7.
  • COOK, C. S., ZHANG, L., Osis, J., SCHOENHARD, G. L. and KARIM, A., 1998, Mechanism of compound-and species-specific food effects of structurally related antiarrhythmic drugs, disopyramide and bidisomide. Pharmaceutical Research, 15, 429–433.
  • DAIN, J. D. and JAFFE, J. M., 1988, Effect of diet and gavage on the absorption and metabolism of fluperlapine in the rat. Drug Metabolism Disposition, 16, 238–242.
  • FREDERICK, L. G., MCDONALD, S. J. and GARTHWAITE, S. M., 1989, Cardiovascular profile of a new antiarrhythmic agent, SC-40230. Cardiovascular Research, 23, 897–903.
  • GARTHWAITE, S., HASHEVIOTO K., KAIUM, A., COOK, C. S., DESAI, D., TooL, J., ANDRESS, J. and FERRO, L., 1995, Bidisomide : an investigational antiarrhythmic agent. Cardiovascular Drug Review, 13, 19–32.
  • HATLEY, F., GARTHWAITE, S., FREDERICK, L., RUBY, J., OTTINGER, J., COOK, C. and MAHONEY, R., 1987, Antiarrhythmic profile of SC-40230. Federation Proceedings, 46, 871.
  • LEE, K. H., Xu, G. X., SCHOENHARD, G. L. and COOK, C. S., 1997, Mechanisms of food effects of structurally related antiarrhythmic drugs, disopyramide and bidisomide in the rat. Pharmaceutical Research, 14, 1032–1040.
  • PAO, L. H., ZHOU, S. Y., COOK, C. S., KARARLI, T., KIRCHHOFF, C., TRUELOVE, J., KARIM, A. and FLEISHER, D., 1998, Reduced systemic availability of antiarrhythmic drugs, bidisomide, with meal co-administration: relationship with region-dependent intestinal absorption. Pharmaceutical Research, 15, 221–227.
  • SMYTH, R. D., GAYER, R. C., DANDEKAR, K. A. VAN HARKEN, D. R. and HOTTENDORF, G. H., 1979, Evaluation of the availability of drugs incorporated in rat laboratory diet. Toxicology and Applied Pharmacology, 50, 493–499.
  • VANDENBERGHE, Y., MASSON, M., PALATE, B. and ROSA. J., 1995, Effect of folate supplementation on clinical chemistry and hematologic changes related to bidisomide administration in the rat. Drug Chemical Toxicology, 18, 235–270.
  • VANHARKEN, D. R. and HOTTENDORF, G. H., 1978, Comparative absorption following the adminis-tration of a drug to rats by oral gavage and incorporation in the diet. Toxicology Applied Pharmacology, 43, 407–410.

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