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Xenobiotica
the fate of foreign compounds in biological systems
Volume 30, 2000 - Issue 7
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Research Article

Investigation of the metabolism of 14C/13C-practolol in rat using directly coupled radio-HPLC-NMR-MS

G. B. Scarfe Biological Chemistry, Biomedical Sciences Division, Imperial College of Science, Technology and Medicine, Sir Alexander Fleming Building, South Kensington, London SW7 2AZ, UK
,
J. C. Lindon Drug Metabolism and Pharmacokinetics Department, AstraZeneca Pharmaceuticals, Mereside, Alderley Park, Macclesfield SK10 4TG, UK
,
J. K. Nicholson Biological Chemistry, Biomedical Sciences Division, Imperial College of Science, Technology and Medicine, Sir Alexander Fleming Building, South Kensington, London SW7 2AZ, UK
,
P. Martin Drug Metabolism and Pharmacokinetics Department, AstraZeneca Pharmaceuticals, Mereside, Alderley Park, Macclesfield SK10 4TG, UK
,
B. Wright Biological Chemistry, Biomedical Sciences Division, Imperial College of Science, Technology and Medicine, Sir Alexander Fleming Building, South Kensington, London SW7 2AZ, UK
,
S. Taylor Drug Metabolism and Pharmacokinetics Department, AstraZeneca Pharmaceuticals, Mereside, Alderley Park, Macclesfield SK10 4TG, UK
,
E. Lenz Biological Chemistry, Biomedical Sciences Division, Imperial College of Science, Technology and Medicine, Sir Alexander Fleming Building, South Kensington, London SW7 2AZ, UK
&
I. D. Wilson Drug Metabolism and Pharmacokinetics Department, AstraZeneca Pharmaceuticals, Mereside, Alderley Park, Macclesfield SK10 4TG, UK
 show all
Pages 717-729 | Published online: 22 Sep 2008

References

  • NICHOLLS, A. W., FARRANT, R. D., SHOCKCOR, J. P., UNGER, S. E., WILSON, I. D., LINDON, J. C. and NICHOLSON, J. K., 1997a, NMR and HPLC-NMR spectroscopic studies on the metabolism and futile deacetylation of paracetamol metabolites in rat and man. Biochemical Pharmacology, 49, 1155–1164.
  • NICHOLLS, A. W., LINDON, J. C., CADDICK, S., FARRANT, R. D., WILSON, I. D. and NICHOLSON, J. K., 1997b, NMR spectroscopic studies on the metabolism and futile deacetylation of phenacetin in the rat. Xenobiotica, 27, 1175–1186.
  • NICHOLLS, A. W., LINDON, J. C., FARRANT, R. D., SHOCKOR, J. P., WILSON, I. D. and NICHOLSON, J. K., 1999, Directly coupled HPLC-NMR spectroscopic studies of metabolism and futile deacetylation of phenacetin in the rat. Journal of Pharmaceutics and Biomedical Annals, 20, 865–873.
  • REEVES, P. R., CASE, D. E, JEPSON, H. T., McCoRmicK, D. J., NICHOLLS, J. T., FELIX, R. H., HOLT, P. J. L., ZACHARIAS, F. J. and FLUKE, R. W., 1978, Practolol metabolism. II. Metabolism in human subjects. Journal of Pharmacology and Experimental Therapeutics, 205, 489–498.
  • REEVES, P. R., McCoRmicK, D. J. and JEPSON, H. T., 1979, Practolol metabolism in various small animal species. Xenobiotica, 9, 453–458.
  • SCALES, B. and COSGROVE, M. B., 1970, The metabolism and distribution of the selective adrenergic beta blocking agent, Practolol. Journal of Pharmacology and Experimental Therapeutics, 175, 338–347.
  • SCARFE, G. B., LINDON, J. C., NICHOLSON. J. K., WRIGHT, B., CLAYTON, E. and WILSON, I. D., 1999c, Investigation of the quantitative metabolic fate and urinary excretion of 3 -methyl-4-trifluoro-aniline and 3-methyl-4-trifluroacetanilide in the rat. Drug Metabolism and Disposition, 27, 1171–1178.
  • SCARFE G. B., TUGNAIT, M., WILSON, I. D. and NICHOLSON, J. K., 1999b, Studies on the metabolism of 4-fluoroaniline and 4-fluoroacetanilide in the rat: formation of 4-acetamidophenol (paracetamol) and its metabolites via defluorination and N-acetylation. Xenobiotica, 29, 205–216.
  • SCARFE G. B., WRIGHT, B., CLAYTON., TAYLOR, S., WILSON, I. D., LINDON, J. C. and NICHOLSON, J., 1999a, Quantitative studies on the urinary metabolic fate of 2-chloro-4-trifluormethylaniline in the rat using 19, NMR spectroscopy and directly coupled HPLC-NMR-MS. Xenobiotica, 29, 77–91.

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