Characterization of transgenic mouse strains using six human hepatic cytochrome P450 probe substrates

References

• ADAMS, M., LENNARD, M. S., OTTON, S. V., TUCKER, G. T. and WOODS, H. F., 1991, Assessment of the mouse as an experimental model for studying polymorphic oxidation of the sparteine/ debrisoquine type. Biochemical Pharmacology, 42, 947–949.
   PubMedGoogle Scholar
• CHEMIN, I., TAKAHASHI, S., BELLOC, C., LANG, M. A., ANDO, K., GUIDOTTI, L. G., CHIZARI, F. V. and WILD, C. P., 1996, Differential induction of carcinogen metabolizing enzymes in a transgenic mouse model of fulminant hepatitis. Hepatology, 24, 649–656.
   PubMedGoogle Scholar
• CHERIATHUNDAM, E., Doi, S. Q., KNAPP, J. R., JASSER, M. Z., KOPCHICK, J. J. and ALVARES, A. P., 1998, Consequences of overexpression of growth hormone in transgenic mice on liver cytochrome P450 enzymes. Biochemical Pharmacology, 55, 1481–1487.
   PubMedGoogle Scholar
• CHRISTOPHERSON, P. A., MANKOWSKI, D. C., TWEEDIE, D. J. and LAWTON, M. P., 1995, Expression of human cytochromes P450 in insect cells. /SSX Proceedings, 8, 358.
   Google Scholar
• COURJAULT-GAUTIER, F., ANTOINE, B., BENS, M., VALLET, V., CLUZEAUD, F., PRINGAULT, E., KAHN, A., TOUTAIN, H. and VANDEWALLE, A., 1997, Activity and inducibility of drug-metabolizing enzymes in immortalized hepatocyte-like cells (mhPKT) derived from a L-PK/Tag1 transgenic mouse. Experimental Cell Research, 234, 362–372.
   PubMed Web of Science ®Google Scholar
• EKIN S., 1996a, Maintenance and cryopreservation of xenobiotic metabolism in precision-cut liver slices. Evaluation of an alternative in vitro model to isolated hepatocytes. PhD thesis, University of Aberdeen.
   Google Scholar
• EKIN S., 1996b, Past, present, and future applications of precision-cut liver slices for in vitro xenobiotic metabolism. Drug Metabolism Reviews, 28, 591–624.
   PubMed Web of Science ®Google Scholar
• EKINS, S., MÄENPÄÄ, J. and WRIGHTON, S. A., 1999, In vitro metabolism: subcellular fractions. In T. F. Wolff (ed.), Handbook of Drug Metabolism (New York: Marcel Dekker), pp. 363–399.
   Google Scholar
• EKINS, S., VANDENBRANDEN, M., RING, B. J. and WRIGHTON, S. A., 1997, Examination of purported probes of human CYP2B6. Pharmacogenetks, 7, 165–179.
   PubMedGoogle Scholar
• GHOKALE, M. S., BUNTON, T. E., ZURLO, J. and YAGER, J. D., 1997, Cytochrome P450 isozyme activities in cultured rat and mouse liver slices. Xenobiotka, 27, 341–355.
   PubMedGoogle Scholar
• GUENGERICH, F. P., 1977, Separation and purification of multiple forms of cytochrome P450. journal of Biological Chemistry, 252, 3970–3979.
   PubMed Web of Science ®Google Scholar
• JACQZ-AIGRAIN, E., FUNCK-BRENTANO, C. and CRESTEIL, T., 1993, CYP2D6- and CYP3A-dependent metabolism of dextromethorphan in humans. Pharmacogenetics, 3, 197–204.
   PubMedGoogle Scholar
• KARVONEN, I., SORMUNEN, R., HUUPPONEN, R. and SOTANIEMI, E. A., 1990, Reduced glucose-6-phosphorylase and NADPH generating enzyme activities associated with glibenclamide induced hypoglycemia and hypoinsulinemia in genetically obese mice. Biomedicine and Pharmacotherapy, 44, 307–316.
   PubMedGoogle Scholar
• KNODELL, R. G., HANDWERGER, B. S., MORLEY, J. E., LEVINE, A. S. and BROWN, D. M., 1984, Separate influences of insulin and hyperglycemia on hepatic drug metabolism in mice with genetic and chemically induced diabetes mellitus. Journal of Pharmacology and Experimental Therapeutics, 230, 256–262.
   PubMedGoogle Scholar
• LEEMAN, T., BONNABRY, P. and DAYER, P., 1994, Selective inhibition of major drug-metabolizing cytochrome P450 isoenzymes in human liver microsomes by carbon monoxide. Life Sciences, 54, 951–956.
   PubMedGoogle Scholar
• LEEMAN, T., TRANSON, C. and DAYER, P., 1993, Cytochrome P450TB (CYP2C): a major monoxygenase catalyzing diclofenac 4'-hydroxylation in human liver. Life Sciences, 52, 29–34.
   PubMedGoogle Scholar
• LOWN, K. S., KOLARS, J. C., THUMMEL, K. E., BARNETT, J. L., KUNZE, K. L., WRIGHTON, S. A. and WATKINS, P. B., 1994, Interpatient heterogeneity in expression of CYP3A4 and CYP3A5 in small bowel. Drug Metabolism and Disposition, 22, 947–955.
   PubMed Web of Science ®Google Scholar
• MANKOWSKI, D. C., 1999, The role of CYP2C19 in the metabolism of ( + 1—) bufuralol, the prototypic substrate of CYP2D6. Drug Metabolism and Disposition, 27, 1024–1028.
   PubMed Web of Science ®Google Scholar
• MANKOWSKI, D. C., ELSENBOSS, L., CHRISTOPHERSON, P., LAWTON, M. P. and TWEEDIE, D. J., 1996, Characterization of baculovirus-expressed human cytochromes P450. Paper presented at the 11th International Symposium on Microsomes and Drug Oxidations, 21-24 July, University of California, Los Angeles.
   Google Scholar
• MASUBUCHI, Y., IwAsA, T., HOSOKAWA, S., SUZUKI, T., HORIE, T., IMAOKA, S., FUNAE, Y. and NARIMATSU, S., 1997, Selective deficiency of debrisoquine 4-hydroxylase activity in mouse liver microsomes. Journal of Pharmacology and Experimental Therapeutics, 282, 1435–1441.
   PubMed Web of Science ®Google Scholar
• MEIER, U. T., KRONBACH, T. and MEYER, U. A., 1985, Assay of mephenytoin metabolism in human liver microsomes by high-performance liquid chromatography. Annals of Biochemistry, 151,286–291.
   Google Scholar
• MUGFORD, C. A. and KEDDERIS, G. L., 1998, Sex-dependent metabolism of xenobiotics. Drug Metabolism Reviews, 30, 441–498.
   PubMed Web of Science ®Google Scholar
• NELSON, D. R., KOYMANS, L., KAMATAKI, T., STEGEMAN, J. J., FEYEREIZEN, R., WAXMAN, D. J., WATERMAN, M. R., GOTOH, O., COON, M. J., ESTABROOK, R. W., GUNSALUS, I. C. and NEBERT, D. W., 1996, P450 superfamily: update on new sequences, gene mapping, accession numbers and nomenclature. Pharmacogenetks, 6, 1–42.
   PubMedGoogle Scholar
• OMURA, T. and SATO, R., 1964, The carbon monoxide-binding pigment of human liver microsomes. I. Evidence for its hemoprotein nature. Journal of Biological Chemistry, 239, 2370–2378.
   PubMed Web of Science ®Google Scholar
• PELKONEN, O., MAENPAA, J., TAAVITSAINEN, P., RAUTIO, A. and RAUNIO, H., 1998, Inhibition and induction of human cytochrome P450 (CYP) enzymes. Xenobiotica, 28, 1203–1253.
   PubMed Web of Science ®Google Scholar
• PERLOFF, M. D., VON MOLTKE, L. L., COTREAU, M. M. and GREENBLATT, D. J., 1999, Unchanged cytochrome P450 3A (CYP3A) expression and metabolism of midazolam, triazolam, and dexamethasone in mdr ( — / —) mouse liver microsomes. Biochemical Pharmacology, 57, 1227–1232.
   PubMedGoogle Scholar
• PRUEKSARITANONT, T., GORHAM, L. M., HOCHMAN, J. H., TRAN, L. O. and VYAS, K. P., 1996, Comparative studies of drug-metabolizing enzymes in dog, monkey and human small intestines, and in Caco-2 cells. Drug Metabolism and Disposition, 24, 634–642.
   PubMed Web of Science ®Google Scholar
• ROE, A. L., HOWARD, G., BLOUIN, R. and SNAWDER, J. E., 1999, Characterization of cytochrome P450 and glutathione S-transfera activity and expression in male and female ob/ob mice. International Journal of Obesity, 23, 48–53.
   PubMed Web of Science ®Google Scholar
• ROSENBERG, D. W. and MANKOWSKI, D. C., 1994, Induction of cyp2e1 protein in mouse colon. Carcinogenesis, 15, 73–78.
   PubMed Web of Science ®Google Scholar
• SCHUETZ, E. G., SCHINKEL, A. H., RELLING, M. V., SCHUETZ, J. D., 1996, P-glycoprotein: a major determinant of rifampicin-inducible expression of cytochrome P4503A in mice and humans. Proceedings of the National Academy of Sciences, USA, 93, 4001–4005.
   PubMed Web of Science ®Google Scholar
• SCHUETZ, E. G., YASUDA, K., ARIMORI, K. and SCHGETZ, J. D., 1998, Human MDR1 and mouse mdr1a P-glycoprotein alter the cellular retention and disposition of erythromycin, but not of retinoic acid or benzo(a)pyrene. Archives of Biochemistry and Biophysics, 350, 340–347.
   PubMed Web of Science ®Google Scholar
• SESARDIC, D., BOOBIS, A. R., EDWARDS, R. J. and DAVIES, D. S., 1988, A form of cytochrome P450 in man orthologous to form d in the rat, catalyses the 0-deethylation of phenacetin and is inducible by cigarette smoking. British Journal of Clinical Pharmacology, 26, 363–372.
   PubMed Web of Science ®Google Scholar
• SHARER, J. E., SHIPLEY, L. A., VANDENBRANDEN, M., BINKLEY, S. N. and WRIGHTON, S. A., 1995, Comparisons of phase I and Phase II in vitro hepatic enzyme activities of human, dog rhesus monkey and cynomolgus monkey. Drug Metabolism and Disposition, 23, 1231–1241.
   PubMed Web of Science ®Google Scholar
• SONDERFAN, A. J., ARLOTTO, M. P., DUTTON, D. R., MCMILLEN, S. K. and PARKINSON, A., 1987, Regulation of testosterone hydroxylation by rat liver microsomal cytochrome P450. Archives of Biochemistry and Biophysics, 255,27–41.
   PubMed Web of Science ®Google Scholar
• STENGARD, J. H., SAARNI, H. U., KARVONEN, R. I., LAHTELA, J. T., KARKI, N. T., STENBACK, F. and SOTANIEMI, E. A., 1987, Hepatic drug metabolism and the activities of NADPH generating enzymes and glucose-6-phosphata in phenobarbital treated genetically obese (ob/ob) mice. Biomedical Pharmacotherapy, 41, 389–396.
   PubMed Web of Science ®Google Scholar
• STEVENS, J. C., SHIPLEY, L. A., CASHMAN J. R., VANDENBRANDEN, M. and WRIGHTON, S. A., 1993, Comparison of human and rhesus monkey in vitro phase I and II hepatic drug metabolism activities. Drug Metabolism and Disposition, 21, 753–760.
   Google Scholar
• STOHS, S. J., GRAFSON, R. C., BURKE, M. D., MOLDEUS, P. W. and ORRENIUS, S. G., 1976, The isolation of rat intestinal microsomes with stable cytochrome P-450 and their metabolism of benzo(a)pyrene. Archives of Biochemistry and Biophysics, 177, 105–116.
   PubMed Web of Science ®Google Scholar
• WATSON, A. M., POLOYAC, S. M., HOWARD, G. and BLOUIN, R. A., 1999, Effect of leptin on cytochrome P-450, conjugation, and antioxidant enzymes in the ob/ob mouse. Drug Metabolism and Disposition, 27, 695–700.
   PubMed Web of Science ®Google Scholar
• WRIGHTON, S. A., STEVENS, J. C., BECICER, G. W. and VANDENBRANDEN, M., 1993, Isolation and characterization of human liver cytochrome P4502C19: Correlation between 2C19 and S-mephenytoin 4'-hydroxylation. Archives of Biochemistry and Biophysics, 306, 240–245.
   PubMed Web of Science ®Google Scholar
• ZHANG, Q.-Y., DUNBAR, D., OSTROWSKA, A., ZEISLOFT, S., YANG, J. and KAMINSKY, L. S., 1999, Characterization of human small intestinal cytochromes P450. Drug Metabolism and Dispositicn, 27, 804–809.
   PubMed Web of Science ®Google Scholar