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Xenobiotica
the fate of foreign compounds in biological systems
Volume 31, 2001 - Issue 2
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Research Article

Species difference in stereoselective involvement of CYP3A in the mono-N-dealkylation of disopyramide

L. Zhang Metabolism and Safety Evaluation, Pharmacia, Skokie, IL 60077, USA; Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, Chicago, IL 60612-7231, USA
,
J. F. Fitzloff Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, Chicago, IL 60612-7231, USA
,
L. C. Engel Metabolism and Safety Evaluation, Pharmacia, Skokie, IL 60077, USA
&
C. S. Cook Metabolism and Safety Evaluation, Pharmacia, Skokie, IL 60077, USA; Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, Chicago, IL 60612-7231, USA
Pages 73-83 | Published online: 22 Sep 2008

References

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  • LIMA, J. J., BOUDOULAS, H. and SHIELDS, B. J., 1985, Stereoselective pharmacokinetics of disopyramide enantiomers in man. Drug Metabolism and Disposition, 13, 572–577.
  • PAULSON, S. K., ENGEL, L. C., REITZ, B., BOLTEN, S., BURTON, E. G., MAZIASZ, T. J., YAN, B. and SCHOENHARD, G. L., 1999, Evidence for polymorphism in the canine metabolism of the cyclooxygenase 2 inhibitor, celecoxib. Drug Metabolism and Disposition, 27, 1133–1142.
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