Advanced search
Publication Cover
Xenobiotica
the fate of foreign compounds in biological systems
Volume 31, 2001 - Issue 7
Submit an article Journal homepage
316
Views
73
CrossRef citations to date
0
Altmetric
Research Article

Metabolism of the analgesic drug, tramadol hydrochloride, in rat and dog

W. N. Wu Divisions of Preclinical Development and Drug Discovery, The R. W. Johnson Pharmaceutical Research Institute, Spring House, PA 19477, USA
,
L. A. McKown Divisions of Preclinical Development and Drug Discovery, The R. W. Johnson Pharmaceutical Research Institute, Spring House, PA 19477, USA
,
A. D. Gauthier Divisions of Preclinical Development and Drug Discovery, The R. W. Johnson Pharmaceutical Research Institute, Spring House, PA 19477, USA
,
W. J. Jones Divisions of Preclinical Development and Drug Discovery, The R. W. Johnson Pharmaceutical Research Institute, Spring House, PA 19477, USA
&
R. B. Raffa Divisions of Preclinical Development and Drug Discovery, The R. W. Johnson Pharmaceutical Research Institute, Spring House, PA 19477, USA
Pages 423-441 | Published online: 22 Sep 2008

References

  • ABEL, S. R., 1995, Tramadol: an alternative analgesic to traditional opioids and NSAIDs. Journal Pharmaceutical Care in Pain and Symptom Control, 3, 5–29.
  • DAYER, P., DE SMEULES, J. and COLLART, L., 1997, Pharmacologie du tramadol. Drugs, 53 (suppl. 2), 18–24.
  • FLICK, K., FRANKUS, E. and FRIDERICHS, E. 1978, Studies on chemical structure and analgesic activity of phenyl substituted aminomethylcyclohexanols. Arzneim-ForschlDrug Research, 28, 107–113.
  • FLOHE', L., AREND, I., COGAL, A., RICHTER, W. and SIMON, W., 1978, Klinische Prüfung der Abhängigkeitsentwicklung nach Langzeitapplikation von Tramadol. Arzneim-ForschlDrug Research, 28, 213–217.
  • FRANKUS, E., FRIDERICHS, E., KIM, S. M. and OSTERLOH, G., 1978, On separation of isomers, structural elucidation and pharmacological characterization of 1-(m-methoxypheny1)-2-(dimethylamino-methyl)-cyclohexan-1-ol. Arzneim-ForschlDrug Research, 28, 114–121.
  • FRIDERICHS, E., FELGENHAUER, F., JONSCHAAP, P. and OSTERLOH, G., 1978, Pharmakologische Untersuchungen zur Analgesie, Abhängigkeits- und Toleranzentwicklung von Tramadol, einem stark wirkenden Analgetikum. Arzneim-ForschlDrug Research, 28, 122–134.
  • HENNIES, H. H., FRIDERICHS, E. and SCHNEIDER, J., 1988, Receptor binding analgesic and antitussive potency of tramadol and other selected opioids. Arzneim-ForschlDrug Research, 38, 877–880.
  • HILLS, J. F., LIAO, S. and NAYAK, R. K., 1992, The effect of food on the bioavailability of tramadol. In 1992 AAPS Eastern Regional Meeting, abst., 32.
  • LEE, R. C., McTAvisit, D. and SORKIN, E. M., 1993, Tramadol, a preliminary review of its pharmacodynamic and pharmacokinetic properties, and therapeutic potential in acute and chronic pain states. Drugs, 46, 313–340.
  • LINTZ, W. and BESKE R., 1986, Determination of tramadol in human serum by capillary gas chromatography with nitrogen-selective detection. journal of Chromatography, 377, 213–220.
  • LINTZ, W., ERLACIN, S., FRANKUS, E. and URAGG, H., 1981, Metabolismus von Tramadol bei Mensch und Tier. Arzneim-ForschlDrug Research, 31, 1932–1943.
  • PAAR, W. D., FRANKUS, P. and DENGLER, H. J., 1992, The metabolism of tramadol by human liver microsomes. Clinical Investigation, 70, 708–710.
  • PAAR, W. D., POCHE, S., GERLOFF, J. and DENGLER, H. J., 1993, In vivo investigation of the metabolism of tramadol — further evidence for O-demethylation polymorphism. Naunyn-Schmiedeberg's Archives of Pharmacology, 347 (suppl. R39), 154.
  • RAFFA, R. B., FRIDERICHS, E., REIMANN, W., SHANK, R. P., CODD, E. E. and VAUGHT, J. L., 1992, Opioid and nonopioid components independently contribute to the mechanism of action of tramadol, an 'atypical' opioid analgesic. Journal of Pharmacology and Experimental Therapeutics, 260, 275–285.
  • RAFFA, R. B., FRIDERICHS, E., REIMANN, W., SHANK, R. P., CODD, E. E., VAUGHT, J. L., JACOBY, H. I. and SELVE, N., 1993, Complementary and synergistic antinociceptive interaction between the enantiomers of tramadol. Journal of Pharmacology and Experimental Therapeutics, 267, 331–340.
  • RAFFA, R. B., NAYAK, R. K. and LIAO, S., 1995, The mechanism(s) of action and pharmacokinetics of tramadol. Review of Contemporary Pharmacotherapeutks, 6, 485–497.
  • Wu, W. N., DESAI, D., McKowN, L. A., GAUTHIER, A. D., JONES, W. J., TAKACS, A. R., SCOTT, L., SORGI, K. L. and RAFFA, R. B., 1997a, Metabolism of Ultrame(tramadol) in the dog. In ISSX Proceedings of the 6th European ISSX Meeting, 11, abst. 160.
  • Wu, W. N., LIAO, S., MCKOWN, L. A. and TAKACS, A. R., 1997c, Metabolism of Ultrame(tramadol) in the human. ISSX Proceedings of the 6th European ISSX Meeting, 11, abst. 159.
  • Wu, W. N., McKowN, L. A., JONES, W. J., GAUTHIER, A. D. and TAKACS, A. R., 1997b, Metabolism of Ultrame(tramadol) in the rat. In ISSX Proceedings of the 8th North American ISSX Meeting, 12, abst. 107.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.