Advanced search
Publication Cover
Xenobiotica
the fate of foreign compounds in biological systems
Volume 31, 2001 - Issue 12
Submit an article Journal homepage
101
Views
38
CrossRef citations to date
0
Altmetric
Research Article

Differential inhibition of human liver and duodenum sulphotransferase activities by quercetin, a flavonoid present in vegetables, fruit and wine

F. Marchetti Departments of Neurosciences, Section of Pharmacology, and Department of Surgery, Medical School, Via Roma 55, I-56126 Pisa, Italy
,
C. De Santi Departments of Neurosciences, Section of Pharmacology, and Department of Surgery, Medical School, Via Roma 55, I-56126 Pisa, Italy
,
M. Vietri Departments of Neurosciences, Section of Pharmacology, and Department of Surgery, Medical School, Via Roma 55, I-56126 Pisa, Italy
,
A. Pietrabissa Departments of Neurosciences, Section of Pharmacology, and Department of Surgery, Medical School, Via Roma 55, I-56126 Pisa, Italy
,
R. Spisni Departments of Neurosciences, Section of Pharmacology, and Department of Surgery, Medical School, Via Roma 55, I-56126 Pisa, Italy
,
F. Mosca Departments of Neurosciences, Section of Pharmacology, and Department of Surgery, Medical School, Via Roma 55, I-56126 Pisa, Italy
&
G. M. Pacifici Departments of Neurosciences, Section of Pharmacology, and Department of Surgery, Medical School, Via Roma 55, I-56126 Pisa, Italy
 show all
Pages 841-847 | Published online: 22 Sep 2008

References

  • ANDERSON, R. J. and WEINSHILBOUM, R. M., 1980, Phenolsulphotransferase in human tissues: radiochemical enzymatic assay and biochemical properties. Clinka Chimica Ada, 103, 79–90.
  • ARAI, Y., WATANABE, S., KIMURA, M., SHIMOI, K., MOCHIZUKI, R. and KINAE, N., 2000, Dietary intakes of flavonols, flavones and isoflavones by Japanese women and the inverse correlation between quercetin intake and plasma LDL cholesterol concentration. Journal of Nutrition, 130, 2243–2250.
  • BONHAM CARTER, S. M., REIN, G., GLOVER, V. and SANDLER, M., 1983, Human platelet phenolsulphotransferase M and P: substrate specificities and correlation with in vivo sulphoconjugation of paracetamol and salicylamide. British Journal of Clinical Pharmacology, 15, 323–330.
  • CAMPBELL, N. R. C, VAN LOON J. A. and WEINSHILBOUM, R. M., 1987, Human liver phenol sulfotransferase: assay conditions, biochemical properties and partial purification of isoenzymes of the thermostable form. Biochemical Pharmacology, 36, 1435–1446.
  • CAPPIELLO, M., GIULIANI, L. and PACIFIC', G. M., 1990, Differential distribution of phenol and catechol sulphotransferase in human liver and intestinal mucosa. Pharmacology, 40, 69–76.
  • CAPPIELLO, M., GIULIANI, L., RANE, A. and PACIFICI, G. M., 1991, Dopamine sulphotransferase is better developed than p-nitrophenol sulphotransferase in the human fetus. Developmental Pharmacology and Therapeutics, 16, 83–88.
  • DE SANTI, C., PIETRABISSA, A., SPINSI, R., MOSCA, F. and PACIFICI, G. M., 2000, Sulphation of resveratrol, a natural product present in grapes and wine, in the human liver and duodenum. Xenobiotica, 30, 609–617.
  • EATON, E. A., WALLE, U. K., LEWIS, A. J., HUDSON, T., WILSON, A. A. and WALLE, T., 1996, Flavonoids, potent inhibitors of the human P-form phenolsulfotransferase. Drug Metabolism and Disposition, 24, 232–237.
  • FOLDES, A. and MEEK, J., 1973, Rat brain phenolsulphotransferase -partial purification and some properties. Biochimica et Biophysica Acta, 327, 365–374.
  • GHAZALI, R. A. and WARING, R. H., 1999, The effects of flavonoids on human phenolsulphotransferases: potential in drug metabolism and chemoprevention. Life Sciences, 65, 1625–1632.
  • GOLDBERG, D. M., TSANG, E., KARUMANCHIRI, A., DIAMANDIS, E. P., SOLEAS, G. and NG, E., 1996, Method to assay the concentrations of phenolic constituents of biological interest in wines. Analytical Chemistry, 68, 1688–1694.
  • HAKKINEN, S. H., KARENLAMPI, S. O., HEINONEN, I. M., MYKKANEN, H. M. and TORRENEN, A. R., 1999, Content of the flavonols quercetin, myricetin, and kaempferol in 25 edible berries. Journal of Agricultural and Food Chemistry, 47, 2274–2279.
  • HOLLMAN, P. C. H., VAN TRIP, J. M. P., BUYSMAN, M. N. C. P., GAAG, M. S. V. D., MENGELERS, M. J. B., DE VRIES, J. H. M. and KATAN, M. B., 1997, Relative bioavailability of the antioxidant flavonoid quercetin from various foods in man. FEBS Letters, 418, 152–156.
  • LOWRY, O. H., ROSEBROUGH, N. J., FAR, A. and RANDALL, R. J., 1951, Protein measurement with Folin phenol reagent. Journal of Biological Chemistry, 193, 265–275.
  • OTAKE, Y., NOLAN, A. L., WALLE, U. K. and WALLE, T., 2000, Quercetin and resveratrol potently reduce estrogen sulfotransferase activity in normal human mammary epithelial cells. Journal of Steroid Biochemistry and Molecular Biology, 73, 265–270.
  • PACIFICI, G. M., GIULIANETTI, B., QUILICI, M., SPISNI, R., NERVI, M., GIULIANI, L. and GOMENI, R., 1997, (—)-Salbutamol sulphation in the human liver and duodenal mucosa: interindividual variability. Xenobiotica, 27, 279–286.
  • PACIFICI, G. M. and DE SANTI, C., 1995, Human sulphotransferase. Classification and metabolic profile of the major isoforms. The point of view of the clinical pharmacologist. In G. M. Pacifici and G. N. Fracchia (eds), Advanced in Drug Metabolism in Man (Luxembourg: European Commission), pp. 311–349.
  • RAFTOGIANIS, R. B., HER C. and WEINSHILBOUM, R. M. 1996 Human phenol suffotransferaw pharmacogenetics: STP1 gene cloning and structural characterisation. Pharmacogenetics, 6, 473–487.
  • REITER, C. and WEINSHILBOUM, R., 1982, Platelet phenol sulfotransferase activity: Correlation with sulfate conjugation of acetaminophen. Clinical Pharmacology and Therapeutics, 32, 612–621.
  • VIETRI, M., PIETRABISSA, A., SPISNI, R., MOSCA, F. and PACIFICI, G. M., 2000, Differential inhibition of hepatic and duodenal sulfation of (—)-salbutamol and minoxidil by mefenamic acid. European Journal of Clinical Pharmacology, 56, 477–479.
  • WEINSHILBOUM, R. M., 1986, Phenol sulphotransferase in humans: properties, regulation, and function. Federation Proceeding, 45, 2223–2228.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.