References
- BURKE, M. D., THOMPSON, S., ELCOMBE, C. R., HALPERT, J., HAAPARANTA, T. and MAYER R. T., 1985, Ethoxy-, pentoxy- and benzyloxyphenoxazones and homologues: a series of substrates to distinguish between different induced cytochromes P-450. Biochemical Pharmacology, 34, 3337–3345.
- BURKE, M. D., THOMPSON, S., WEAVER, R. J., WOLF, C. R. and MAYER, R. T., 1994, Cytochrome P450 specificities of alkoxyresorufin 0-dealkylation in human liver microsomes. Biochemical Pharmacology, 48, 923–936.
- BUTERS, J. T. M., SCHILLER, C. D. and Cliou, R. C., 1993, A highly sensitive tool for the assay of cytochrome P450 enzyme activity in rat, dog and man. Direct fluorescence monitoring of the deethylation of 7-ethoxy-4-trifluoromethylcoumarin. Biochemical Pharmacology, 46, 1577–1584.
- CHAURET, N., TREMBLAY, N., LACKMAN, R. L., GAUTHIER, J.-Y., SILVA, J. M., MAROIS, J., YERGEY, J. A. and NIC,OLL -GRIFFITH, D. A., 1999, Description of a 96-well plate assay to measure cytochrome P4503A inhibition in human liver microsomes using a selective fluorescent probe. Analytical Biochemistry, 276, 215–226.
- CLARKE, S. E., 1998, In vitro assessment of human cytochrome P450. Xenobiotica, 28, 1167–1202.
- CONNEY, A. J., 1986, Induction of microsomal cytochrome P-450 enzymes: the first Bernard B Brodie lecture at Pennsylvania State University. Life Sciences, 39, 2493–2518.
- CRESPI, C. L., MILLER, V. P. and PENMAN, B. W., 1997, Microtiter plate assays for inhibition of human, drug-metabolizing cytochromes P450. Analytical Biochemistry, 248, 188–190.
- CRESPI, C. L., MILLER, V. P. and PENMAN, B. W., 1998, High throughput screening for inhibition of cytochrome P450 metabolism. Medical Chemistry Research, 8, 457–471.
- DELucA, J. G., DYSART, G. R., RASNICK, D. and BRADLEY, M. O., 1988, A direct, highly sensitive assay for cytochrome P-450 catalyzed O-deethylation using a novel coumarin analog. Biochemical Pharmacology, 37, 1731–1739.
- DONATO, M. T., GômEz-LEciiON, M. J. and CASTELL, J. V., 1993, A microassay for measuring cytochrome P4501A1 and P45011B1 activities in intact human and rat hepatocytes cultured on 96-well plates. Analytical Biochemistry, 213, 29–33.
- GOmEz-LEctiON, M. J., DONATO, M. T., PONSODA, X., FABRA, R., TRULLENQUE, R. and CASTELL, J. V., 1997, Isolation, culture and use of human hepatocytes in drug research. In J. V. Casten and M. J. Gómez-LechOn (eds), In Vitro Methods in Pharmaceutical Research (London: Academic Press), pp. 129–153.
- GRASSO, P. and HINTON, R. H., 1991, Evidence for and possible mechanisms of non-genotoxic carcinogenesis in rodent liver. Mutation Research, 248, 271–290.
- GRAY, T. J. B., LAKE, B. G., BEAMAND, J. A., FOSTER, J. R. and GANGOLLI, S. D., 1983, Peroxisome proliferation in primary cultures of rat hepatocytes. Toxicology and Pharmacology, 67, 15–25.
- JAPENGA, A. C., DAVIES, S., PRICE, R. J. and LAKE, B. G., 1993, Effect of treatment with pyrazine and some derivatives on cytochrome P450 and some enzyme activities in rat liver. Xenobiotica, 23, 169–179.
- LAKE, B. G., 1987, Preparation and characterisation of microsomal fractions for studies of xenobiotic metabolism. In K. Snell and B. Mullock (eds), Biochemical Toxicology: A Practical Approach (Oxford: IRL), pp. 183–215.
- LAKE, B. G., 1995, Mechanisms of hepatocarcinogenicity of peroxisome-proliferating drugs and chemicals. Annual Review of Pharmacology and Toxicology, 35, 483–507.
- LAKE, B. G., 1997, In vitro methods. In R. S. McCuskey and D. L. Earnest (eds), Comprehensive Toxicology, vol. 9: Hepatic and Gastrointestinal Toxicology (Oxford: Pergamon), pp. 233–249.
- LAKE, B. G. and LEWIS, D. F. V., 1996, The CYP4 family. In C. Ioannides (ed.), Cytochromes P450: Metabolic and Toxicological Aspects (Boca Raton: CRC Press), pp. 271–297.
- LAKE, B. G., RENWICK, A. B., CUNNINGHAME, M. E., PRICE, R. J., SURRY, D. and EVANS, D. C., 1998, Comparison of the effects of some CYP3A and other enzyme inducers on replicative DNA synthesis and cytochrome P450 isoforms in rat liver. Toxicology, 131, 9–20.
- LIN, J. H. and Lu, A. Y. H., 1998, Inhibition and induction of cytochrome P450 and the clinical implications. Clinical Pharmacokinetks, 35, 361–390.
- LOWRY, O. H., ROSEBROUGH, N. J., FR, A. L. and RANDALL, R. J. 1951, Protein measurement with the Folin phenol reagent. Journal of Biological Chemistry, 193, 265–275.
- LUBET, R. A., SYI, J.-L., NELSON, J. O. and Nims, R. W., 1990, Induction of hepatic cytochrome P-450 mediated alkoxyresorufin 0-dealkylase activities in different species by prototype P-450 inducers. Chemko-Biological Interactions, 75, 325–399.
- MAUREL, P., 1996, The CYP3 family. In C. Ioannides (ed.), Cytochromes P450: Metabolic and Toxicological Aspects (Boca Raton: CRC Press), pp. 241–270.
- MAYER, R. T., NETTER, K. J., HEUBEL, F., HAHNEMANN, B., BUCHHEISTER, A., MAYER, G. K. and BURKE, M. D., 1990, 7-Alkoxyquinolines: new fluorescent substrates for cytochrome P450 monooxygenases. Biochemical Pharmacology, 40, 1645–1655.
- NELSON, D. R., KOYMANS, L., KAMATAKI, T., STEGEMAN, J. J., FEYEREISEN, R., WAXMAN, D. J., WATERMAN, M. R., GOTOH, O., COON, M. J., ESTABROOK, R. W., GUNSALUS, I. C. and NEBERT, D. W., 1996, P450 superfamily: update on new sequences, gene mapping, accession numbers and nomenclature. Pharmacogenetics, 6, 1–42.
- NERURKAR, P. V., PARK, S. S., THOMAS, P. E., Nims, R. W. and LUBET, R. A., 1993, Methoxyresorufin and benzyloxyresorufin: substrates preferentially metabolised by cytochromes P4501A2 and 2B, respectively, in the rat and mouse. Biochemical Pharmacology, 46, 933–943.
- Nims, R. W. and LUBET, R. A., 1996, The CYP2B subfamily. In C. Ioannides (ed.), Cytochromes P450: Metabolic and Toxicological Aspects (Boca Raton: CRC press), pp. 135–160.
- Nims, R. W., DEVOR, D. E., HENNEMAN, J. R. and LUBET, R. A., 1987, Induction of alkoxyresorufin 0-dealkylases, epoxide hydrolase, and liver weight gain: correlation with tumor-promoting potential in a series of barbiturates. Carcinogenesis, 8, 67–71.
- OKEY, A. B., 1990, Enzyme induction in the cytochrome P-450 system. Pharmacology and Therapeutics, 45, 241–298.
- PARKINSON, A., 1996, Biotransformation of xenobiotics. In C. D. Klaassen (ed.), Casarett and Doull's Toxicology: The Basic Science of Poisons, 5th edn (New York: McGraw-Hill) pp. 113–186.
- PELKONEN, O., MAENpAA, J., TAAVITSAINEN, P., RAUTIO, A. and RAUNIO, H., 1998, Inhibition and induction of human cytochrome P450 (CYP) enzymes. Xenobiotica, 28, 1203–1253.
- PRICE, R. J., SURRY, D., RENWICK, A. B., MENESES-LORENTE, G., LAKE, B. G. and EVANS, D. C., 2000, CYP isoforrn induction screening in 96-well plates: use of 7-benzyloxy-4-trifluoromethyl-coumarin as a substrate for studies with rat hepatocytes. Xenobiotica, 30, 781–795.
- REINKE, L. A., SEXTER, S. H. and RIKANS, L. E., 1985, Comparison of ethanol and imidazole pretreatments on hepatic monooxygenase activities in the rat. Research Communications in Chemistry, Pathology and Pharmacology, 47, 97–106.
- RENWICK, A. B., LEWIS, D. F. V., FULFORD, S., SURRY, D., WILLIAMS, B., WORBOYS, P. D., CAI, X., WANG, R. W., PRICE, R. J., LAKE, B. G. and EVANS, D. C., 2001, Metabolism of 2,5-bis(trifluoromethyl)-7-benzyloxy-4-triliuoromethylcoumarin by human hepatic CYP isoforms: evidence for selectivity towards CYP3A4. Xenobiotica, 31, 187–204.
- RENWICK, A. B., SURRY, D., PRICE, R. J., LAKE, B. G. and EVANS, D. C., 2000, Metabolism of 7-benzyloxy-4-trifluoromethylcoumarin by human hepatic cytochrome P450 isoforms. Xenobiotica, 30, 955–969.
- RODRIGUES, A. D., 1999, Integrated cytochrome P450 reaction phenotyping. Attempting to bridge the gap between cDNA-expressed cytochromes P450 and native human liver microsomes. Biochemical Pharmacology, 57, 465–480.
- SONDERFAN, A. J., ÄRLOTTO, M. P., DUTTON, M. R., MCMILLEN, S. K. and PARKINSON, A., 1987, Regulation of testosterone hydroxylation by rat liver microsomal cytochrome P450. Archives of Biochemistry and Biophysics, 255, 27–41.
- TANAKA, E., 1998, Clinically important drug—drug interactions: role of cytochrome P450 enzymes. Journal of Clinical Pharmacology and Therapeutics, 23, 403–416.
- WHITE, I. N. H., 1988, A continuous fluorimetric assay for P-450-dependent mixed function oxidases using 3-cyano-7-ethoxycoumarin. Analytical Biochemistry, 172, 304–310.
- WHYSNER, J., Ross, P. M. and WILLIAMS, G. M., 1996, Phenobarbital mechanistic data and risk assessment: enzyme induction, enhanced cell proliferation, and tumor promotion. Pharmacology and Therapeutics, 71, 153–191.
- WRIGHTON, S. A., VANDENBRANDEN, M., STEVENS, J. C., SHIPLEY, LA., RING, B. J., RETTIE, A. E. and CASHMAN, J. R., 1993, In vitro methods for assessing human hepatic drug metabolism: their use in drug development. Drug Metabolism Reviews, 25, 453–484.