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Xenobiotica
the fate of foreign compounds in biological systems
Volume 31, 2001 - Issue 11
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Research Article

Evaluation of the absorption, excretion and metabolism of [14 C] etoperidone in man

G. W. Caldwell Division of Drug Discovery and Division of Preclinical Development, R. W. Johnson Pharmaceutical Research Institute, Spring House, PA 19477, USA
,
W. N. Wu Division of Drug Discovery and Division of Preclinical Development, R. W. Johnson Pharmaceutical Research Institute, Spring House, PA 19477, USA
&
J. A. Masucci Division of Drug Discovery and Division of Preclinical Development, R. W. Johnson Pharmaceutical Research Institute, Spring House, PA 19477, USA
Pages 823-839 | Published online: 22 Sep 2008

References

  • BECKER, E. D., 1969, High Resolution NMR (New York: Academic Press).
  • BOLDEN-WATSON, C. and RICHELSON, E., 1993, Blockade by newly-developed antidepressants of biogenic amine uptake into rat brain synaptosomes. Life Sciences, 52, 1023.
  • BROGDEN, R. N., HEEL, R. C., SPEIGHT, T. M. and AVERY, G. S., 1981, Trazodone: A review of its pharmacological properties and therapeutic use in depression and anxiety. Drugs, 21, 401.
  • DAVIS, R., WHITTINGTON, R. and BRYSON, H. M., 1997, Nefazodone: a review of its pharmacology and clinical efficacy in the management of major depression. Drugs, 53, 608.
  • GIBALDI, M. and PERRIER, D., 1982, Pharmacokinetics (New York: Marcel Dekker).
  • GREENE, D. S. and BARBHAIYA, R. H., 1997, Clinical pharmacokinetics of nefazodone. Clinical Pharmacokinetics, 33, 260.
  • HOLLAND, M. L. and HEEBNER, E. T., 1991, High-performance liquid chromatographic assay with ultraviolet detection for the determine of etoperizone and two active metabolites, 5-(1-hydroxyethyl)etoperidone and 1 -(3-chlorophenyl)piperazine, in plasma, Journal of Chromato-graphy, 567, 433.
  • MAES, M., WESTENBERG, H., VANDOOLAEGHE, E., DEMEDTS, P., WAUTERS, A., NEELS, H. and MELTZER, H. Y., 1997, Effects of trazodone and fluoxetine in the treatment of major depression: therapeutic pharmacokinetic and pharmacodynamic interactions through formation of meta-chlorophenylpiperazine. Journal of Clinical Psychopharmacology, 17, 358.
  • MAYOL, R. F., COLE, C. A., LUKE, G. M., COLSON, K. L. and KERNS, E. H., 1994, Characterization of the metabolites of the antidepressant drug nefazodone in human urine and plasma. Drug Metabolism and Disposition, 22, 304.
  • NILSEN, 0. G. and DALE, 0., 1992, Single dose pharmacokinetics of trazodone in healthy subjects. Pharmacology and Toxicology (Copenhagen), 71, 150.
  • RAFFA, R. B., SHANK, R. P. and VAUGHT, J. L., 1992, Etoperidone, trazodone and MCPP: in vitro and in vivo identification of serotonin 5-HT1A (antagonistic) activity. Psychopharmacology (Berlin), 108, 320.
  • RAMACCI M. T., GHI RARDI 0 MACCARI, F., PACIFICI, L. and SALE, P., 1979, Pharmacological evaluation of A2, 1,2, 4 -triazolin - 5 -one [1, 3(4 -m - chlorophenyl-1 -piperazinyl) -propyl] -3,4-diethyl-hydrochloride (etoperidone), a new potential antidepressant drug. Arzneim.-Forsch. Drug Research, 29, 294.
  • Wu, W. N., CALDWELL, G. W. and UETZ, J. A., 1991, Biotransformation of etoperidone in man. Pharmacologist, 33, 208.
  • Wu, W. N., MA SUCCI, J. A., McKowN, L. A. and RODGERS, J. D., 1995, Identification of four plasma metabolites of Etoperidone in dogs. Journal of Pharmacology and Biomedical Analysis, 13, 177.

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