Prediction of whole-body metabolic clearance of drugs through the combined use of slices from rat liver, lung, kidney, small intestine and colon

Reference

• ANDERSSON, T. B., SJOBERG, H., HOFFMANN, K. J., BOOBIS, A. R., WATTS, P., EDWARDS, R. J., LAKE, B. G., PRICE, R. J., RENWICK, A. B., GOMEZ-LECHON, M. J., CASTELL, J. V., INGELMAN-SUNDBERG, M., HIDESTRAND, M., GOLDFARB, P. S., LEWIS, D. F., CORCOS, L., GUILLOUZO, A., TAAVITSAINEN, P. and PELKONEN, 0., 2001, An assessment of human liver-derived in vitro systems to predict the in vivo metabolism and clearance of almokalant. Drug Metabolism and Disposition, 29, 712–720.
   Google Scholar
• CARLILE, D. J., HAKOOZ, N. and HOUSTON, J. B., 1999, Kinetics of drug metabolism in rat liver slices: IV. Comparison of ethoxycoumarin clearance by liver slices, isolated hepatocytes, and hepatic microsomes from rats pretreated with known modifiers of cytochrome P-450 activity. Drug Metabolism and Disposition, 27, 526–532.
   PubMed Web of Science ®Google Scholar
• CARLILE, D. J., STEVENS, A. J., ASHFORTH, E. I., WAGHELA, D. and HOUSTON, J. B., 1998, In vivo clearance of ethoxycoumarin and its prediction from in vitro systems. Use of drug depletion and metabolite formation methods in hepatic microsomes and isolated hepatocytes. Drug Metabolism and Disposition, 26, 216–221.
   PubMed Web of Science ®Google Scholar
• CLARKE, S. E. and JEFFREY, P., 2001, Utility of metabolic stability screening: comparison of in vitro and in vivo clearance. Xenobiotica, 31, 591–598.
   PubMed Web of Science ®Google Scholar
• DE GRAAF, I. A., VAN MEIJEREN, C. E., PEKTAS, F. and KOSTER, H. J., 2002, Comparison of in vitro preparations for semi-quantitative prediction of in vivo drug metabolism. Drug Metabolism and Disposition, 30, 1129–1136.
   PubMed Web of Science ®Google Scholar
• DE KANTER, R., DE JAGER, M. H., DRAAISMA, A. L., JuRvA, J. U., OLINGA, P., MEIJER, D. K. F. and GROOTHUIS, G. M. M., 2002a, Drug metabolizing activity of human and rat liver, lung, kidney and intestine slices. Xenobiotica, 32, 349–362.
   Google Scholar
• DE KANTER, R., MONSHOUWER, M., MEIJER, D. K. F. and GROOTHUIS, G. M. M., 2002b, Precision-cut organ slices as a tool to study toxicity and metabolism of xenobiotics with special reference to non-hepatic tissues. Current Drug Metabolism, 3,39–59.
   Google Scholar
• DE KANTER, R., OLINGA, P., DE JAGER, M. H., MEREMA, M. T., MEIJER, D. K. F. and GROOTHUIS, G. M. M., 1999, Organ slices as an in vitro test system for drug metabolism in human liver, lung and kidney. Toxicology In Vitro, 13, 737–744.
   Google Scholar
• DE KANTER, R., OLINGA, P., HOF, I., DE JAGER, M., VERWILLEGEN, W. A., SLOOFF, M. J. H., KOSTER, H. J., MEIJER, D. K. F. and GROOTHUIS, G. M. M., 1998, A rapid and simple method for cryopreservation of human liver slices. Xenobiotica, 28, 225–234.
   Google Scholar
• EKINS, S., MURRAY, G. I., BURKE, M. D., WILLIAMS, J. A., MARCHANT, N. C. and HAWKSWORTH, G. M., 1995, Quantitative differences in phase I and II metabolism between rat precision-cut liver slices and isolated hepatocytes. Drug Metabolism and Disposition, 23, 1274–1279.
   PubMed Web of Science ®Google Scholar
• GRAM, T. E., 1997, Chemically reactive intermediates and pulmonary xenobiotic toxicity. Pharmacological Reviews, 49, 297–341.
   PubMed Web of Science ®Google Scholar
• HAENEN, B., ROMPELBERG, C., VAN TWILLERT, K., HAMZINK, M., DORMANS, J. and VAN EIJKEREN, J., 2002, Utility of rat liver slices to estimate hepatic clearance for application in physiologically based pharmacokinetic modeling: a study with tolbutamide, a compound with low extraction efficiency. Drug Metabolism and Disposition, 30, 307–313.
   PubMed Web of Science ®Google Scholar
• HOUSTON, J. B., 1981, Drug metabolite kinetics. Pharmacology and Therapeutics, 15, 521-552. HOUSTON, J. B., 1994, Utility of in vitro drug metabolism data in predicting in vivo metabolic clearance. Biochemical Pharmacology, 47, 1469–1479.
   Google Scholar
• HOUSTON, J. B. and CARLILE, D. J., 1997, Prediction of hepatic clearance from microsomes, hepatocytes, and liver slices. Drug Metabolism Reviews, 29, 891–922.
   PubMed Web of Science ®Google Scholar
• ITo, K., IWATSUBO, T., KANAMITSU, S., NAKAJIMA, Y. and SUGIYAMA, Y., 1998, Quantitative prediction of in vivo drug clearance and drug interactions from in vitro data on metabolism, together with binding and transport. Annual Review of Pharmacology and Toxicology, 38, 461–499.
   PubMed Web of Science ®Google Scholar
• LIN, J. H., CHIBA, M. and BAILLIE, T. A., 1997, In vivo assessment of intestinal drug metabolism. Drug Metabolism and Disposition, 25, 1107–1109.
   PubMed Web of Science ®Google Scholar
• LIN, J. H., CHIBA, M. and BAILLIE, T. A., 1999, Is the role of the small intestine in first-pass metabolism overemphasized? Pharmacological Reviews, 51, 135–158.
   Google Scholar
• NARITOMI, Y., TERASHITA, S., KIMURA, S., SUZUKI, A., KAGAYAMA, A. and SUGIYAMA, Y., 2001, Prediction of human hepatic clearance from in vivo animal experiments and in vitro metabolic studies with liver microsomes from animals and humans. Drug Metabolism and Disposition, 29, 1316–1324.
   PubMed Web of Science ®Google Scholar
• NEYRINCK, A., EECKHOUDT, S. L., MEUNIER, C. J., PAMPFER, S., TAPER, H. S., VERBEECK, R. K. and DELZENNE, N., 1999, Modulation of paracetamol metabolism by Kupffer cells: a study on rat liver slices. Life Sciences, 65, 2851–2859.
   PubMed Web of Science ®Google Scholar
• OBACH, R. S., 1999, Prediction of human clearance of twenty-nine drugs from hepatic microsomal intrinsic clearance data: an examination of in vitro half-life approach and nonspecific binding to microsomes. Drug Metabolism and Disposition, 27, 1350–1359.
   PubMed Web of Science ®Google Scholar
• OBACH, R. S., BAXTER, J. G., LISTON, T. E., SILBER, B. M., JONES, B. C., MACINTYRE, F., RANCE, D. J. and WASTALL, P., 1997, The prediction of human pharmacokinetic parameters from preclinical and in vitro metabolism data. Journal of Pharmacology and Experimental Therapeutics, 283, 46–58.
   PubMed Web of Science ®Google Scholar
• OLINGA, P., MEREMA, M. T., MEIJER, D. K. F., SLOOFF, M. J. H. and GROOTHUIS, G. M. M., 1993, Human liver slices express the same lidocaine biotransformation rate as isolated human hepatocytes. Alternatives to Laboratory Animals, 21, 466–468.
   Google Scholar
• OLINGA, P., MEREMA, M., HOF, I. H., DE JONG, K. P., SLOOFF, M. J. H., MEIJER, D. K. F. and GROOTHUIS, G. M. M., 1998, Effect of human liver source on the functionality of isolated hepatocytes and liver slices. Drug Metabolism and Disposition, 26, 5–11.
   Google Scholar
• PARDRIDGE, W. M., 1986, Serum bioavailability of sex steroid hormones. Clinics in Endocrinology and Metabolism, 15, 259–278.
   PubMedGoogle Scholar
• Powis, G., MELDER, D. C. and WILKE, T. J., 1989, Human and dog, but not rat, isolated hepatocytes have decreased foreign compound-metabolizing activity compared to liver slices. Drug Metabolism and Disposition, 17, 526–531.
   PubMed Web of Science ®Google Scholar
• RICHTER, S., MUCKE, I., MENGER, M. D. and VOLLMAR, B., 2000, Impact of intrinsic blood flow regulation in cirrhosis: maintenance of hepatic arterial buffer response. American Journal of Physiology—Gastrointestinal and Liver Physiology, 279, G454—G462.
   Web of Science ®Google Scholar
• RITSCHEL, W. A., JOHNSON, R. D., VACHHARAJANI, N. N. and HUSSAIN, A. S., 1992, Prediction of the volume of distribution of 7-hydroxycoumarin in man from in vitro and ex vivo data obtained in rat. Biopharmaceutics and Drug Disposition, 13, 389–402.
   PubMed Web of Science ®Google Scholar
• SHIBATA, Y TAKAHASHI, H. and Ism', Y., 2000, A convenient In vitro screening method for predicting in vivo drug metabolic clearance using isolated hepatocytes suspended in serum. Drug Metabolism and Disposition, 28, 1518–1523.
   Google Scholar
• SHIMADA, T., TSUMURA, F. and YAMAZAKI, H., 1999, Prediction of human liver microsomal oxidations of 7-ethoxycoumarin and chlorzoxazone with kinetic parameters of recombinant cytochrome P-450 enzymes. Drug Metabolism and Disposition, 27, 1274–1280.
   PubMed Web of Science ®Google Scholar
• TAKEMOTO, K., YAMAZAKI, H., TANAKA, Y., NAKAJIMA, M. and YOKOI, T., 2003, Catalytic activities of cytochrome P450 enzymes and UDP-glucuronosyltransferases involved in drug metabolism in rat everted sacs and intestinal microsomes. Xenobiotica, 33, 43–55.
   PubMed Web of Science ®Google Scholar
• VICKERS, A. E., FISCHER, V., CONNORS, S., FISHER, R. L., BALDECK, J. P., MAURER, G. and BRENDEL, K., 1992, Cyclosporin A metabolism in human liver, kidney, and intestine slices. Comparison to rat and dog slices and human cell lines. Drug Metabolism and Disposition, 20, 802–809.
   PubMed Web of Science ®Google Scholar
• VICKERS, A. E., ZOLLINGER, M., DANNECKER, R., TYNES, R., HEITZ, F. and FISCHER, V., 2001, In vitro metabolism of tegaserod in human liver and intestine: assessment of drug interactions. Drug Metabolism and Disposition, 29, 1269–1276.
   PubMed Web of Science ®Google Scholar
• WALSH, J. S., PATANELLA, J. E., HALM, K. A. and FACCHINE, K. L., 1995, An improved HPLC assay for the assessment of liver slice metabolic viability using 7-ethoxycoumarin. Drug Metabolism and Disposition, 23, 869–874.
   PubMed Web of Science ®Google Scholar
• WORBOYS, P. D., BRADBURY, A. and HOUSTON, J. B., 1995, Kinetics of drug metabolism in rat liver slices. Rates of oxidation of ethoxycoumarin and tolbutamide, examples of high- and low-clearance compounds. Drug Metabolism and Disposition, 23, 393–397.
   PubMed Web of Science ®Google Scholar
• WORBOYS, P. D., BRADBURY, A. and HOUSTON, J. B., 1996a, Kinetics of drug metabolism in rat liver slices. II. Comparison of clearance by liver slices and freshly isolated hepatocytes. Drug Metabolism and Disposition, 24, 676–681.
   PubMed Web of Science ®Google Scholar
• WORBOYS, P. D., BRADBURY, A. and HOUSTON, J. B., 1997, Kinetics of drug metabolism in rat liver slices. III. Relations between metabolic clearance and slice uptake rate. Drug Metabolism and Disposition, 25, 460–467.
   PubMed Web of Science ®Google Scholar
• WORBOYS, P. D., BRENNAN, B., BRADBURY, A. and HOUSTON, J. B., 1996b, Metabolic kinetics of ondansetron in rat. Comparison of hepatic microsomes, isolated hepatocytes and liver slices with in vivo disposition. Xenobiotica, 26, 897–907.
   PubMed Web of Science ®Google Scholar
• ZHANG, Q. Y., DUNBAR, D., OSTROWSKA, A., ZEISLOFT, S., YANG, J. and KAMINSKY, L. S., 1999, Characterization of human small intestinal cytochromes P-450. Drug Metabolism and Disposition, 27, 804–809.
   PubMed Web of Science ®Google Scholar