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Xenobiotica
the fate of foreign compounds in biological systems
Volume 33, 2003 - Issue 3
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Research Article

mRNA and protein expression of dog liver cytochromes P450 in relation to the metabolism of human CYP2C substrates

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Pages 225-237 | Published online: 22 Sep 2008

References

  • ANDERSSON, T., MINERS, J. O., VERONESE, M. E., TASSANEEYAKUL, W., TASSANEEYAKUL, W., MEYER, U. A. and BIRKETT, D. J., 1993, Identification of human liver cytochrome P450 isoforms mediating omeprazole metabolism. British Journal of Clinical Pharmacology, 36, 521–530.
  • BLAISDELL, J., GOLDSTEIN, J. A. and BAI, S. A., 1998, Isolation of a new canine cytochrome P450 cDNA from the cytochrome P450 2C subfamily (CYP2C41) and evidence for polymorphic differences in its expression. Drug Metabolism and Disposition, 26, 278–283.
  • CHAURET, N., GAUTHIER, A., MARTIN, J. and NICOLL-GRITH, D. A., 1997, In vitro comparison of cytochrome P450-mediated activities in human, dog, cat and horse. Drug Metabolism and Disposition, 25, 1130–1136.
  • CIACCIO, P. J. and HALPERT, J. R., 1989, Characterization of a phenobarbital-inducible dog liver cytochrome P450 structurally related to rat and human enzymes of the P450IIIA (steroid inducible) gene subfamily. Archives of Biochemistry and Biophysics, 271, 284–299.
  • CORNISH-BOWDEN, A., 1995, Fundamentals of Enzyme Kinetics (London: Portland), p. 207.
  • COURT, M. H., VON MOLTKE, L. L., SHADER, R. I. and GREENBLATT, D. J., 1997, Biotransformation of chlorzoxazone by hepatic microsomes from humans and ten other mammalian species. Biopharmaceutics and Drug Disposition, 18, 213–226.
  • FRASER, D. J., FEYEREISEN, R., HARLOW, G. R. and HALPERT, J. R., 1997, Isolation heterologous expression and functional characterization of a novel cytochrome P450 3A enzyme from a canine liver cDNA library. Journal of Pharmacology and Experimental Therapeutics, 283, 1425–1432.
  • GEE, S. J., GREEN, C. E. and TYSON, C. A., 1984, Comparative metabolism of tolbutamide by isolated hepatocytes from rat rabbit, dog and squirrel monkey. Drug Metabolism and Disposition, 12, 174–178.
  • GRAVES, P. E., ELHAG, G. A., CIACCIO, P. J., BOURQUE, D. P. and HALPERT, J. R., 1990, cDNA and deduced amino acid sequence of a dog hepatic cytochrome P450IIB responsible for the metabolism of 2,2',4,4',5,5'-hexachlorobiphenyl. Archives of Biochemistry and Biophysics, 281, 106–115.
  • GUENGERICH, F. P., 1997, Comparison of catalytic selectivity of cytochrome P450 subfamily enzymes from different species. Chemico-Biological Interactions, 106, 161–182.
  • OHTA, K., MOTOYA, M., MIURA, T., KITADA, M. and KAMATAKI, T., 1989, A novel form of cytochrome P450 in Beagle dogs. Biochemical Pharmacology, 38, 91–96.
  • PAULSON, S. K., ENGEL, L., REITZ, B., BOLTEN, S., BURTON, E. G., MAZIASZ, T. J., YAN, B. and SCHOENHARD, G. L., 1999, Evidence for polymorphism in the canine metabolism of the cyclooxygenase inhibitor, celecoxib. Drug Metabolism and Disposition, 27, 1133–1142.
  • PRIEKSARITANONT, T., GORHAM, L. M., HOCHMAN, J. H., TRAN, L. O. and VYAS, K. P., 1996, Comparative studies of drug metabolising enzymes in dog, monkey, and human small intestines and in Caco-2 cells. Drug Metabolism and Disposition, 24, 634–642.
  • ROUSSEL, F., DUIGNAN, D. B., LAWTON, M. P., OBAC, R. S., STRICK, C. A. and TWEEDIE, D. J., 1998, Expression and characterization of canine cytochrome P450 2D15. Archives of Biochemistry and Biophysics, 357, 27–36.
  • SAKAMOTO, K., SHIROU, K., BABA, T., NAKAMURA, Y., YAMAZOE, Y., KATO, R., TANAKA, A. and MATSUBARA, T., 1995, A new cytochrome P450 form belonging to the CYP2D in dog liver microsomes: purification, cDNA cloning and enzyme characterization. Archives of Biochemistry and Biophysics, 319, 372–382.
  • SCHMIDER, J., GREENBLATT, D. J., FOGELMAN, S. M., VON MOLTKE, L. L. and SHADER, R. I., 1997b, Metabolism of dextromethorphan in vitro: involvement of cytochromes P450 2D6 and 3A3/4, with a possible role of 2E1. Biopharnzacology and Drug Disposition, 18, 227–240.
  • SCHMIDER, J., GREENBLATT, D. J., VON MOLTKE, L. L., KARSOV, D. and SHADER, R. I., 1997a, Inhibition of CYP2C9 by selective serotonin reuptake inhibitors in vitro: studies of phenytoin p-hydroxylation. British Journal of Clinical Pharmacology, 44, 495–498.
  • SHARER, J., SHIPLEY, L. A., VANDENBRANDEN, M. R., BINKLEY, S. N. and WRIGHTON, S. A., 1995, Comparisons of Phase I and Phase II in vitro hepatic enzyme activities of human, dog, rhesus monkey and cynomolgus monkey. Drug Metabolism and Disposition, 23, 1231–1241.
  • SHAW, L., LENNARD, M. S., TUCKER, G. T., BAx, N. D. S. and WOODS, H. F., 1987, Irreversible binding and metabolism of propranolol by human liver microsomes — relationship to polymorphic oxidation. Biochemical Pharmacology, 36, 2283–2288.
  • SHIMADA, T., MIMURA, M., INOUE, K., NAKAMURA, S., ODA, H., OHMORI, S. and YAMAZAKI, H., 1997, Cytochrome P450-dependent drug oxidation activities in liver microsomes of various animal species including rats, guinea pigs, dogs, monkeys, and humans. Archives in Toxicology, 71, 401–408.
  • SHIMADA, T., YAMAZAKI, H., MIMURA, M., INUI, Y. and GUENGERICH, F. P., 1994, Interindividual variations in human liver cytochrome P450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: studies with liver microsomes of 30 Japanese and 30 Caucasians. Journal of Pharmacology and Experimental Therapeutics, 270, 414–423.
  • TANAKA, E., NARISAWA, C., NAKAMURA, H., SAWA, Y., ETOH, H., TADANO, K., HORIE, T., OHKAWA, H. and MISAWA, S., 1998, Changes in the enzymatic activities of beagle liver during maturation as assessed both in vitro and in vivo. Xenobiotica, 28, 795–802.
  • UCHIDA, T., KOMORI, M., KITADA, M. and KAMATAKI, T., 1990, Isolation of cDNAs for three different forms of liver microsomal cytochrome P450 from polychlorinated biphenyl-treated dogs. Journal of Pharmacology and Experimental Therapeutics, 38, 644–651.
  • VON MOLTKE, L. L., GREENBLATT, D. G., GRASSI, J. M., GRANDA, B. W., VENKATARISHNAN, K., SCHMIDER, J., HARMATZ, J. S. and SHADER, R. I., 1998, Multiple human cytochromes contribute to biotransformation of dextromethorphan in vitro, role of CYP2C9, CYP2C19, CYP2D6 and CYP3A4. Journal of Pharmaceutics and Pharmacology, 50, 997–1004.
  • WILKINSON, G. R., GUENGERICH, F. P. and BRANCH, R. A., 1989, Genetic polymorphism of S-mephenytoin hydroxylation. Pharmacology and Therapeutics, 43, 53–76.
  • YAMAOKA, K., NAKAGAWA, T. and UNO, T., 1978, Application of Akaike information criteria (AIC) in the evaluation of linear pharmacokinetic equations. Journal of Pharmacokinetics and Biopharmaceutics, 6, 165–175.
  • YAMAZAKI, H. and SHIMADA, T., 1997, Human liver cytochrome P450 enzymes involved in the 7-hydroxylation of R- and S-warfarin enantiomers. Biochemical Pharmacology, 54, 1195–1203.
  • YASUMORI, T., CHEN, L., Li, Q., NAGATA, K., YAMAZOE, Y. and KATO, R., 1993, Species differences in stereoselective metabolism of mephenytoin by cytochrome P450 (CYP2C and CYP3A)Journal of Pharmacology and Experimental Therapeutics, 264, 89–94.
  • YASUMORI, T., CHEN, L., Li, Q., UEDA, M., TSUZUKI, T., GOLDSTEIN, J. A., KATO, R. and YAMAZOE, Y., 1999, Human CYP2C-mediated stereoselective phenytoin hydroxylation in Japanese: difference in chiral preference of CYP2C9 and CYP2C19. Biochemical Pharmacology, 57, 1297–1303.
  • ZHAO, X.-J. and IsHizAxi, T., 1997, The in vitro hepatic metabolism of quinine in mice, rats and dogs: comparison with human liver microsomes. Journal of Pharmacology and Experimental Therapeutics, 283, 1168–1176.

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