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Xenobiotica
the fate of foreign compounds in biological systems
Volume 33, 2003 - Issue 2
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Research Article

Serotonin (5-hydroxytryptamine) glucuronidation in vitro : assay development, human liver microsome activities and species differences

S. Krishnaswamy Comparative and Molecular Pharmacogenetics Laboratory, Tufts University School of Medicine, Boston, MA 02111, USA
,
S. X. Duan Comparative and Molecular Pharmacogenetics Laboratory, Tufts University School of Medicine, Boston, MA 02111, USA
,
L. L. Von Moltke Clinical Pharmacology Laboratory, Department of Pharmacology and Experimental Therapeutics, Tufts University School of Medicine, Boston, MA 02111, USA
,
D. J. Greenblatt Clinical Pharmacology Laboratory, Department of Pharmacology and Experimental Therapeutics, Tufts University School of Medicine, Boston, MA 02111, USA
,
J. L. Sudmeier Tufts Biological NMR Center, Tufts University School of Medicine, Boston, MA 02111, USA
,
W. W. Bachovchin Tufts Biological NMR Center, Tufts University School of Medicine, Boston, MA 02111, USA
&
M. H. Court Comparative and Molecular Pharmacogenetics Laboratory, Tufts University School of Medicine, Boston, MA 02111, USA
 show all
Pages 169-180 | Published online: 22 Sep 2008

References

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  • CIOTTI, M., MARRONE, A., POTTER, C. and OWENS, I. S., 1997, Genetic polymorphism in the human UGT1A6 (planar phenol) UDP-glucuronosyltransferase: pharmacological implications. Pharmacogenetics, 7, 485–495.
  • COURT, M. H., 2001, Acetaminophen UDP-glucuronosyltransferase in ferrets: species and gender differences, and sequence analysis of ferret UGT1A6. Journal of Veterinary Pharmacology and Therapeutics, 24, 415–422.
  • COURT, M. H. and GREENBLATT, D. J., 2000, Molecular genetic basis for deficient acetaminophen glucuronidation by cats: UGT1A6 is a pseudogene, and evidence for reduced diversity of expressed hepatic UGT1A isoforms. Pharmacogenetics, 10, 355–369.
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  • LISTON, H. L., MARKOWITZ, J. S. and DEVANE, C. L., 2001, Drug glucuronidation in clinical psychopharmacology. Journal of Clinical Psychopharmacology, 21, 500–515.
  • SUTHERLAND, L., EBNER, T. and BURCHELL, B., 1993, The expression of UDP-glucuronosyltransferases of the UGT1 family in human liver and kidney and in response to drugs. Biochemical Pharmacology, 45, 295–301.
  • TUKEY, R. H. and STRASSBURG, C. P., 2001, Genetic multiplicity of the human UDP-glucuronosyltransferases and regulation in the gastrointestinal tract. Molecular Pharmacology, 59, 405–414.
  • VENKATAKRISHNAN, K., VON MOLTKE, L. L. and GREENBLATT, D. J., 2001, Human drug metabolism and the cytochromes P450: application and relevance of in vitro models. Journal of Clinical Pharmacology, 41, 1149–1179.
  • YEH, S., CHERNOV, H. and WOODS, L., 1971, Metabolism of morphine by cats. Journal of Pharmaceutical Sciences, 60, 469–471.

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