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Xenobiotica
the fate of foreign compounds in biological systems
Volume 32, 2002 - Issue 5
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Research Article

Microsomal metabolism and enyzme kinetics of the terpene p-cymene in the common brushtail possum (Trichosurus vulpecula), koala (Phascolarctos cinereus) and rat

G. J. Pass School of Pharmacy, University of Tasmania, Hobart 7001, Australia
,
S. McLean School of Pharmacy, University of Tasmania, Hobart 7001, Australia
,
I. Stupans School of Pharmacy, University of Tasmania, Hobart 7001, Australia
&
N. W. Davies School of Pharmacy, University of Tasmania, Hobart 7001, Australia
Pages 383-397 | Published online: 22 Sep 2008

References

  • BOLAND, K. J. and BROPHY, J. J., 1991, Eucalyptus Leaf Oils: Use, Chemistry, Distillation and Marketing (Melbourne: Inkata).
  • BOYLE, R. R., MCLEAN, S. and DAVIES, N., 2000b, Biotransformation of 1,8-cineole in the brushtail possum (Trichosurus vulpecula). Xenobiotica, 30, 915–932.
  • BOYLE, R. R., MCLEAN, S., FOLEY, W. J. and DAVIES, N., 1999, Comparative metabolism of dietary terpene, p-cymene, in generalist and specialist folivorous marsupials. Journal of Chemical Ecology, 25, 2109–2126.
  • BOYLE, R., MCLEAN, S., FOLEY, W. J., DAVIES, N. W., PEACOCK, E. J. and MOORE, B. D., 2001, Metabolites of dietary 1,8- cineole in the male koala (Phascolarctos cinereus). Comparative Biochemistry and Physiology Part C, 129, 385–395.
  • BOYLE, R., MCLEAN, S., FOLEY, W. J., MOORE, B. D., DAVIES, N. W. and BRANDON, S., 2000a, Fate of the dietary terpene, p-cymene, in the male koala. Journal of Chemical Ecology, 25, 1095–1111.
  • FOLEY, W. J., JASON, G. R. and Mcflurniutt, C., 1999, Nutritional ecology of herbivores. In H.-J. G. Jung and G. C. Fahey (eds), Proceedings of the 5th International Symposium of the Nutrition of Herbivores (San Antonio: American Society of Animal Science), pp. 130–209.
  • FREELAND, W. J. and JANZEN, D. H., 1974, Strategies in herbivory by mammals: the role of plant secondary compounds. American Naturalist, 108, 269–287.
  • HUME, I. D., 1982, Digestive Physiology and Nutrition of Marsupials (Melbourne: Cambridge University Press).
  • ISHIDA, T., ASAKAWA, Y., TAKEMOTO, T. and ÄRATANI, T., 1981, Terpenoid biotransformation in mammals. III: Biotransformation of oc-pinene, O.pinene, pinane, 3-carene, carane, myrcene, and p-cymene in rabbits. Journal of Pharmaceutical Sciences, 70, 406–415.
  • KELLY, S., 1969, Eucalypts (Melbourne: Nelson).
  • KIM, H., WANG, R. S., ELOVAARA, E., RAUNIO, H., PELKONEN, O., filOYAMA, T., VAINIO, H. and NAKAJIMA, T., 1997, Cytochrome P450 isozymes responsible for the metabolism of toluene and styrene in human liver microsomes. Xenobiotica, 27, 657–665.
  • LI, H., 1993, Phytochemistry of Eucalyptus spp. and its role in insect-host-tree selection. PhD thesis, University of Tasmania, Hobart.
  • McMANUS, M. E. and km, K. F., 1976, Mixed function oxidase activity in a marsupial, the quokka (Setonix brachyurus). Drug Metabolism and Disposition, 4, 199–202.
  • MCMANUS, M. E. and ILETT, K. F., 1977, Microsomal xenobiotic metabolism in marsupials. Drug Metabolism and Disposition, 5, 503–510.
  • MCMANUS, M. E., McGuAcms, J. K. and ILETT, K. F., 1978, Development of the hepatic mixed function oxidase system in a marsupial, the quokka (Setonix brachyurus). Toxicology and Applied Pharmacology, 46, 117–124.
  • MIYAZAWA, M., SHINDO, M. and SHIMADA, T., 2001, Oxidation of 1,8-cineole, the monoterpene cyclic ether originated from Eucalyptus polybractea, by cytochrome P450 3A enzymes in rat and human liver microsomes. Drug Metabolism and Disposition, 29, 200–205.
  • NAKAJIMA, M., 1997, Cytochrome P450 isoforms and the metabolism of volatile hydrocarbons of low relative molecular mass. Journal of Occupational Health, 39, 83–91.
  • PASS, G. J., MCLEAN, S. and STUPANS, I., 1999, Induction of xenobiotic metabolising enzymes in the common brushtail possum, Trichosurus vu/pecu/a, by Eucalyptus terpenes. Comparative Biochemistry and Physiology Part C, 124, 239–246.
  • PASS, G. J., MCLEAN, S., STCPANS, I. and DAVIES, N., 2001, Microsomal metabolism of the terpene, 1,8-cineole, in the common brushtail possum (Trichosurus vu/pecu/a), koala (Phascolarctos cinereus), rat and human. Xenobiotica, 31, 205–221.
  • RIVEROS-ROSAS, H., JULIAN-SANCHEZ, A. and PINA, E., 1997, Enzymology of ethanol and acetaldehyde metabolism in mammals. Archives of Medical Research, 28, 453–471.
  • SOUTHWELL, I. A., FLYNN, T. M. and DEGABRIELE, R., 1980, Metabolism of- and O.pinene, p-cymene and 1,8-cineole in the brushtail possum, Trichosurus vulpecula. Xenobiotica, 10, 17–23.
  • TASSANEEYAKUL, W., BIRKETT, D. J., EDWARDS, J. W., VERONESE, M. E., TASSANEEYAKUL, W., TUKEY, R. H. and MINERS, J. O., 1996, Human cytochrome P450 isoform specificity in the regioselective metabolism of toluene and o-, m- and p-xylene. Journal of Pharmacology and Experimental Therapeutics, 276, 101–108.
  • WALDE, A., VE, B., SCHELINE, R. R. and MONGE, P., 1983, p-Cymene metabolism in rats and guinea-pigs. Xenobiotica, 13, 503–512.

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