Advanced search
Publication Cover
Xenobiotica
the fate of foreign compounds in biological systems
Volume 32, 2002 - Issue 9
Submit an article Journal homepage
57
Views
2
CrossRef citations to date
0
Altmetric
Research Article

Pharmacokinetic and mass balance study of unlabelled and 14 C-labelled emedastine difumarate in healthy volunteers

M. Brunner Department of Clinical Pharmacology, Division of Clinical Pharmacokinetics, University of Vienna Medical School, Allgemeines Krankenhaus, Währinger Gürtel 18-20, A-1090 Vienna, Austria
,
K. Kletter Department of Clinical Pharmacology, Division of Clinical Pharmacokinetics, University of Vienna Medical School, Allgemeines Krankenhaus, Währinger Gürtel 18-20, A-1090 Vienna, Austria
,
A. Assandri Department of Clinical Pharmacology, Division of Clinical Pharmacokinetics, University of Vienna Medical School, Allgemeines Krankenhaus, Währinger Gürtel 18-20, A-1090 Vienna, Austria
,
M. Ermanno Corrado Department of Clinical Pharmacology, Division of Clinical Pharmacokinetics, University of Vienna Medical School, Allgemeines Krankenhaus, Währinger Gürtel 18-20, A-1090 Vienna, Austria
,
H. G. Eichler Department of Clinical Pharmacology, Division of Clinical Pharmacokinetics, University of Vienna Medical School, Allgemeines Krankenhaus, Währinger Gürtel 18-20, A-1090 Vienna, Austria
&
M. Müller Department of Clinical Pharmacology, Division of Clinical Pharmacokinetics, University of Vienna Medical School, Allgemeines Krankenhaus, Währinger Gürtel 18-20, A-1090 Vienna, Austria
Pages 761-770 | Published online: 22 Sep 2008

References

  • AMADA, T. and AWATA, N., 1990, Metabolism of a new antiallergic agent, emedastine difumarate, in human. Xenobiotics Metabolism and Disposition, 5, 871–881.
  • AWATA, N. and SATOMI, O., 1986, Synthesis of 1-(2-ethoxyethyl)-2-(4-methyl-1-homopiperaziny1)-[2- ([14 c.-] 14c] benzimidazole difumarateKB-2413). Journal of Labelled Compounds and Radiopharmaceuticals, 24, 331–338.
  • FUKUDA, T., MoRiEvEro, Y., ImiuRA, R., KAWASHIMA, T., TSUKAMOTO, G. and Fro, K., 1984b, Effect of 1-(2-ethoxyethyl)-2-(4-methy1-1-homopiperaziny1)-benzimidazole (KB-2413), a new antialler-gic, on chemical mediators. Arzneimittelforschung, 34, 801–805.
  • FUKUDA, T., SAITO, T., TAJIMA, S., SHIMOHARA, K. and Pro, K., 1984a, Antiallergic effect of 1-(2-ethoxyethyl)-2-(4-methyl-l-homopiperazinyl)benzimidazole difumarate (KB-2413). Arzneimit-telforschung, 34, 805–810.
  • HAMADA, T., KADOWAKI, M. and AWATA, N., 1987, Radioreceptor assay for a new antiallergic agent, 1-(2-ethoxyethyl)-2-(4-methy1-1-homopiperazinyl)benzimidazole difumarate (KB-2413), in plasma. Chemical and Pharmaceutical Bulletin ( Tokyo), 35, 3329–3335.
  • HERRANZ, U., RUSCA, A. and ASSANDRI, A., 2001, Emedastine—ketoconazole: pharmacokinetic and pharmacodynamic interactions in healthy volunteers. International Journal of Clinical Pharmacology and Therapeutics, 39, 102–109.
  • JANSEN, B., GRASELLI, U., DALLINGER, S., KISS, B., WACHECK, V., SCHLAGBAUER-WADL, H., ASSANDRI, A. and MULLER, M., 2000, Pharmacokinetics and pharmacodynamics of the novel Hi-receptor antagonist emedastine in healthy volunteers. European Journal of Clinical Pharmacology, 55, 837–841.
  • JOUKHADAR, C., HERRANZ, U., PERNERSTORFER, T., ASSANDRI, A., KLEIN, N., SCHROLNBERGER, C., LACKNER, E., EICHLER, H. G. and MULLER, M., 2001, Pharmacokinetics of emedastine difumarate, a new anti-histaminic agent in patients with renal impairment. European Journal of Clinical Pharmacology, 56, 905–910.
  • NAKAJIMA, S., TSUTANI, Y., OHISHI, M., Doi, Y., YAMAZAKI, K. and OHBA, Y., 1989, Phase I study on emedastine difumarate (KG-2413). Single and consecutive administration with KG-2413 tablets. Kiso to Rinsho, 23, 5419–5430.
  • SAITO, T., FUKUDA, T., SUKAMOTO, T., YOSHIDOMI, M., MORIMOTO, Y., SHIMOHARA, K. and Pro, K., 1988a, General pharmacology of 1-(2-ethoxyethyl)-2-(4-methyl-l-homopiperazinybbenzirnida-zole difumarate. 1st Communication: Effects on the central nervous system. Arzneimittel-forschung, 38, 66–69.
  • SAITO, T., FUKUDA, T., TAJIMA, S., SUKAMOTO, T., YAMASHITA, A., KANAZAWA, T., MORIMOTO, Y., SHIMOHARA, K., NISHIMURA, N., YOKOTA, K. et at. 1988b, General pharmacology of 1-(2-ethoxyethyl)-2-(4-methyl-l-homopiperazinyl) benzimidazole difumarate. 2nd Communication: Effects on the circulation and the other systems. Arzneimitte/forschung, 38, 267–272.
  • SAITO, T., NISHIMURA, N., DWAIN., S., FUKUDA, T. and Ho, K., 1987, Anti-allergic effects of 1-(2-ethoxyethyl)-2- (4- methyl-1 -homopiperazinyl)benzimidazole fumarate (KB-2413). Nippon Yakurigaku Zasshi, 89, 55–62.
  • SAKAI, T., 1987, The biological fate of emedastine difumarate. Absorption and excretion after oral administration to rats and guinea pigs. Xenobiotics Metabolism and Disposition, 2, 123–131.
  • SLATER, J. W., ZECHNICH, A. D. and HANBY, D. G., 1999, Second-generation antihistamines: a comparative review. Drugs, 57, 31–47.
  • TASAKA, K., KAMEI, C., KATAYAMA, S., KITAZUMI, K., AKAHORI, H. and HOKONOHARA, T., 1986, Comparative study of various Hi-blockers on neuropharmacological and behavioral effects including 1-(2-ethoxethyl)-2-(4-methyl-l-homopiperazinyl) benzimidazole difumarate (KB-2413), a new antiallergic agent. Archives of International Pharmacodynamics, 280, 275–291.
  • WADA, Y., 1989, Absorption, metabolism and excretion of an antiallergic agent, emedastine difumarate, in dogs. Xenobiotics Metabolism and Disposition, 4, 471–480.
  • WADA, Y., HAMADA, T., KAWASHIMA, T. and AWATA, N., 1990, In vitro metabolism of an antiallergic agent, emedastine difumarate, in rats and guinea pigs. Yakugaku Zasshi, 10, 40–48.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.