Pharmacokinetics, toxicokinetics, distribution, metabolism and excretion of linezolid in mouse, rat and dog

References

• BOXENBAUM, H., 1980, Interspecies variation in liver weight, hepatic blood flow, and antipyrine intrinsic clearance: extrapolation of data to benzodiazepines and phenytoin. Journal of Pharmacokine tics and Biopharmaceutics, 8, 165–176.
   PubMedGoogle Scholar
• BRATTON, C. and MARSHALL, E. K., 1939, A new coupling agent for sulfanilamide determination. Journal of Biological Chemistry, 128, 537–539.
   Google Scholar
• CHIBA, K., FEENSTRA, K. L., SLATTER, J. G., DALEY-YATES, P., DUNCAN, J. N., FAGERNESS, P. E., HOWARD, M. R., MARTIN, I. J., OZAWA, N., PASSINGHAM, B. J., PARKS, H. G., PENG, G. W., SIMMONDS, R. J., SPEED, W., YALLOP, D. and YAMAZAKI, S., 1998, Absorption, distribution, metabolism and excretion of the oxazolidinone antibiotic linezolid (PNU-100766) in the Sprague—Dawley rat. Poster at the 38th Interscience Conference on Antimicrobial Agents and Chemotherapy, San Diego, CA, USA, Poster A–123.
   Google Scholar
• DEMYAN, W. F., SWANEY, S. M. and SHINABARGER, D. L., 1997, The oxazolidinone linezolid inhibits translation initiation in bacteria. In Proceedings of the 37th Interscience Conference on Antimicrobial Agents and Chemotherapy, Toronto, Canada, Abstract 5375.
   Google Scholar
• HEINZEL, G., WOLOSCZAK, R. and THOMMAN, P., 1993, TOPFIT 2.0. Pharmacokinetk and Pharmacodynamic Data Analysis System for the PC (Stuttgart: Gustav Fischer).
   Google Scholar
• HEYROVSKY, A., 1956, A new method for the determination of inulin in plasma and urine. Clinica Chimica Acta, 1, 470.
   PubMed Web of Science ®Google Scholar
• JAUCIT, R., GRIESSER, E., OESTERHELT, G., ARNOLD, W., MEISTER, W., ZIEGLER, W. H. and GUENTERT, T. W., 1990, Biotransformation of moclobemide in humans. Ada Psychiatrka Scandinavica Supplement, 360, 87–90.
   PubMedGoogle Scholar
• KOIKE, S., MIURA, H., NAKAMURA, R., CHIBA, K. and MOE, J. B., 1995, Drug safety studies with a novel oxazolidinone U-100766. In Proceedings of the 35th Interscience Conference on Antimicrobial Agents and Chemotherapy, San Francisco, CA, USA, Abstract 5375.
   Google Scholar
• LIN, A. H., MURRAY, R. W., VIDMAR, T. J. and MAROTTI, K. R., 1997, The oxazolidinone eperezolid binds to the 50S ribosomal subunit and competes with the binding of chloramphenicol and lincomycin. Antimicrobial Agents and Chemotherapy, 41, 2127–2131.
   PubMed Web of Science ®Google Scholar
• NICHOLLS, A. W., LINDON, J. C., FARRANT, R. D., SHOCKCOR, J. P., WILSON, I. D. and NICHOLSON, J. K. 1999, Directly-coupled HPLC-NMR spectroscopic studies of metabolism and futile deacetylation of phenacetin in the rat. Journal of Pharmaceutical and Biomedical Analysis, 20, 865–873.
   PubMed Web of Science ®Google Scholar
• ORLOFF, J. and BERLINER, R. W., 1973, Handbook of Physiology, Section 8, Renal Physiology (Washington, DC: American Physiological Society), p. 229.
   Google Scholar
• PAWSEY, S. D., DALEY-YATES, P. T., WAJSZCZUK, C. P. and STALKER, D. J., 1996, U-100766 Safety, toleration and pharmacokinetics after oral and intravenous administration. In Proceedings of the European Congress of Antimicrobial Chemotherapy, Abstract F151.
   Google Scholar
• PENG, G. W., STRYD, R. P., MURATA, S., IGARASHI, M., CHIBA, K., AOYAMA, H., AOYAMA, M., ZENKI, T. and OZAWA, N., 1999, Determination of linezolid in plasma by reversed-phase high-performance liquid chromatography. Journal of Pharmaceutical and Biomedical Analysis, 20, 65–73.
   PubMed Web of Science ®Google Scholar
• PHARMACIA CORP., 2000, Zyvox package insert. In Physicians' Desk Reference (Montvale: Medical Economics) [http: //www.pdrel.com].
   Google Scholar
• SHINABARGER, D. L., MAROTTI, K. R., MURRAY, R. W., LIN, A. H. and MELCHIOR, E. P., 1997, Mechanism of action of oxazolidinones: effects of linezolid and eperezolid on translation reactions. Antimicrobial Agents and Chemotherapy, 41, 2132–2136.
   PubMed Web of Science ®Google Scholar
• SISSON, T. A., JUNGBLUTH, G. L. and HOPKINS, N. K., 1999, Effect of age and gender on linezolid pharmacokinetics. In Proceedings of the 39th Interscience Conference on Antimicrobial Agents and Chemotherapy, San Francisco, CA, USA, Abstract 32.
   Google Scholar
• SLATTER, J. G., STALKER, D. J., FEENSTRA, K. L., WELSHMAN, I. R., BRUSS, J. B., SAMS, J. P., JOHNSON, M. G., SANDERS, P. E., HAUER, M. J., EAGERNESS, P. E., STRYD, R. P., PENG, G. W. and SHOBE, E. M., 2001, Pharmacokinetics, metabolism, and excretion of linezolid following an oral dose of [14C] linezolid to healthy human subjects. Drug Metabolism and Disposition, 29, 1136–1145.
   PubMed Web of Science ®Google Scholar
• STALKER, D. J., WAJSZCZUK, C. P. and BATTS, D. H., 1997a, Linezolid safety, tolerance, and pharmacokinetics following oral dosing twice daily for 14.5 days. In Proceedings of the 37th Interscience Conference on Antimicrobial Agents and Chemotherapy, Toronto, Canada.
   Google Scholar
• STALKER, D. J., WAJSZCZUK, C. P. and BATTS, D. H., 1997b, Linezolid safety, tolerance, and pharmacokinetics after intravenous dosing twice daily for 7.5 days. In Proceedings of the 37th Interscience Conference on Antimicrobe Agents and Chemotherapy, Toronto, Canada.
   Google Scholar
• SUN, J. X. S., EMBIL, K., CHOW, D. S. L. and LEE, C. C. S., 1987, High-performance liquid chromatographic analysis, plasma protein binding and red blood cell partitioning of phenprobamate. Biopharmaceutics and Drug Disposition, 8, 341–351.
   Google Scholar
• SWANEY, S. M. and SHINABARGER, D. L, 1997, Oxazolidinone mechanism of action: eperezolid inhibits the initiation event of protein synthesis in bacteria. In Proceedings of the 97th General Meeting of the American Society for Microbiology, Miami Beach, FL, USA, Abstract A–57.
   Google Scholar
• TANNI, E, REKKA, E. and KOUROUNAKIS, P. N., 1994, Synthesis and effect on free radical processes of some substituted morpholine derivatives with potential biological activity. Arzeimittel Forschungl Drug Research, 44, 992–994.
   PubMedGoogle Scholar
• TOCCO, D. J., DUNCAN, A. E., DELUNA, F. A., SMITH, J. L., WALKER, R. W. and VANDENHEUVEL, W. J., 1980, Timolol metabolism in man and laboratory animals. Drug Metabolism and Disposition, 8, 236–240.
   PubMed Web of Science ®Google Scholar
• VICKERS, S. and POLSKY, S. L., 2000, The biotransformation of nitrogen containing xenobiotics to lactams. Current Drug Metabolism, 1, 357–389.
   PubMed Web of Science ®Google Scholar
• WIENKERS, L. C., WYNALDA, M. A., FEENSTRA, K. L., GAO, P. and SLATTER, J. G., 1999, In vitro metabolism of linezolid (PNU-100766): lack of induction or inhibition of cytochrome P450 enzymes and studies on the mechanism of formation of the major human metabolite, PNU-142586. In Proceedings of the 39th Interscience Conference on Antimicrobial Agents and Chemotherapy, San Francisco, CA, USA.
   Google Scholar
• WYNALDA, M. A., HAUER, M. J. and WIENKERS, L. C., 2000, Oxidation of the novel oxazolidinone antibiotic linezolid in human liver microsomes. Drug Metabolism and Disposition, 28, 1014–1017.
   PubMed Web of Science ®Google Scholar