Publication Cover
Xenobiotica
the fate of foreign compounds in biological systems
Volume 33, 2003 - Issue 5
379
Views
61
CrossRef citations to date
0
Altmetric
Research Article

Studies on the induction of rat hepatic CYP1A, CYP2B, CYP3A and CYP4A subfamily form mRNAs in vivo and in vitro using precision-cut rat liver slices

, , , &
Pages 511-527 | Published online: 22 Sep 2008

References

  • BARS, R. G., BELL, D. R. and ELCOMBE, C. R., 1993, Induction of cytochrome P450 and peroxisomal enzymes by clofibric acid in vivo and in vitro. Biochemical Pharmacology, 45, 2045–2053.
  • BARS, R. G., MITCHELL, A. M., WOLF, C. R. and ELCOMBE, C. R., 1989, Induction of cytochrome P-450 in cultured rat hepatocytes. The heterogeneous localization of specific isoenzymes using immunocytochemistry. Biochemical Journal, 262, 151–158.
  • BEAMAND, J. A., PRICE, R. J., CUNNINGHAME, M. E. and LAKE, B. G., 1993, Culture of precision-cut liver slices: effect of some peroxisome proliferators. Food and Chemical Toxicology, 31, 137–147.
  • BURCZYNSKI, M. E., MCMILLIAN, M., PARKER, J. B., BRYANT, S., LEONE, A., GRANT, E. R., THORNE, J. M., ZHONG, Z., ZIVIN, R. A. and JOHNSON, M. D., 2001, Cytochrome P450 induction in rat hepatocytes assessed by quantitative real-time reverse-transcription polymerase chain reaction and the RNA invasive cleavage assay. Drug Metabolism and Disposition, 29, 1243–1250.
  • COECKE, S., ROGIERS, V., BAYLISS, M., CASTELL, J., DOEHMER, J., FABRE, G., FRY, J., KERN, A. and WESTMORELAND, C., 1999, The use of long-term hepatocyte cultures for detecting induction of drug metabolising enzymes: the current status. ECVAM Hepatocytes and Metabolically Competent Systems Task Force Report 1. Alternatives to Laboratory Animals, 27, 579–638.
  • CONNEY, A. J., 1986, Induction of microsomal cytochrome P-450 enzymes: the first Bernard B. Brodie Lecture at Pennsylvania State University. Life Sciences, 39, 2493–2518.
  • DAVILA, J. C. and MORRIS, D. L., 1999, Analysis of cytochrome P450 and phase II conjugating enzyme expression in adult male rat hepatocytes. In Vitro Cellular and Developmental Biology, 35, 120–130.
  • DEBRI, K., BOOB'S, A. R., DAVIES, D. S. and EDWARDS, R. J., 1995, Distribution and induction of CYP3A1 and CYP3A2 in rat liver and extrahepatic tissues. Biochemical Pharmacology, 50, 2047–2056.
  • DRAHUSHUK, A. T., MC GARRIGLE, B. P., TAI, H.-L. KITAREEWAN, S ., GOLDSTEIN, J. A. and OLSON, J. R, 1996, Validation of precision-cut liver slices in dynamic organ culture as an in vitro model for studying CYP1A1 and CYP1A2 induction. Toxicology and Applied Pharmacology, 140, 393–403.
  • GERBAL- CHALOIN, S., PASCUSSI. J . M., P 'CHARD -GARCIA, L., DAUJAT, M., WAECHTER, F., FABRE, J . -M. CARRERE, N. and MAUREL, P., 2001, Induction of CYP2C genes in human hepatocytes in primary culture. Drug Metabolism and Disposition, 29, 242–251.
  • GRASSO, P. and HINTON, R. H., 1991, Evidence for and possible mechanisms of non-genotoxic carcinogenesis in rodent liver. Mutation Research, 248, 271–290.
  • GRAY, T. J. B., LAKE, B. G., BEAMAND, J. A., FOSTER, J. R. and GANGOLLI, S. D., 1983, Peroxisome proliferation in primary cultures of rat hepatocytes. Toxicology and Applied Pharmacology, 67, 15–25.
  • JAPENGA, A. C., DAVIES, S., PRICE, R. J. and LAKE, B. G., 1993, Effect of treatment with pyrazine and some derivatives on cytochrome P450 and some enzyme activities in rat liver. Xenobiotica, 23, 169–179.
  • KOMORI, M. and ODA, Y., 1994, A major glucocorticoid-inducible P450 in rat liver is not P450 3A1. Journal of Biochemistry, 116, 114–120.
  • LAKE, B. G., 1987, Preparation and characterisation of microsomal fractions for studies of xenobiotic metabolism. In K. Snell and B. Mullock (eds), Biochemical Toxicology: A Practical Approach (Oxford: IRL Press), pp. 183–215.
  • LAKE, B. G., BEAMAND, J. A., JAPENGA, A. C., RENVVICK, A., DAVIES, S. and PRICE, R. J., 1993, Induction of cytochrome P-450-dependent enzyme activities in cultured rat liver slices. Food and Chemical Toxicology, 31, 377–386.
  • LAKE, B. G., CHARZAT, C., TREDGER, J. M., RENVVICK, A. B., BEAMAND, J. A. and PRICE, R. J., 1996, Induction of cytochrome P450 isoenzymes in cultured precision-cut rat and human liver slices. Xenobiotica, 26, 297–306.
  • LAKE, B. G. and LEWIS, D. F. V., 1996, The CYP4 family. In C. Ioannides (ed.), Cytochromes P450: Metabolic and Toxicological Aspects (Boca Raton: CRC Press), pp. 271–297.
  • LAKE, B. G., PRICE, R. J., RENWICK, A. B. and BEAMAND, J. A., 1998a, Maintenance of intracellular organization in liver slices: importance in studies of drug metabolism. In A. R. Boobis, P. Kremers, O. Pelkonen and K. Pithan (eds), COST B1 European Symposium on the Prediction of Drug Metabolism in Man: Progress and Problems (Luxembourg: European Communities), pp. 61–76.
  • LAKE, B. G., RENVVICK, A. B., CUNNINGHAME, M. E., PRICE, R. J., SURRY, D. and EVANS, D. C., 1998b, Comparison of the effects of some CYP3A and other enzyme inducers on replicative DNA synthesis and cytochrome P450 isoforms in rat liver. Toxicology, 131, 9–20.
  • LECLUYSE, E. L., BULLOCK, P. L. and PARKINSON, A., 1996, Strategies for restoration and maintenance of normal hepatic structure and function in long-term cultures of rat hepatocytes. Advanced Drug Delivery Reviews, 22, 133–186.
  • LERCHE- LANGRAND, C. and TOUTA IN, H. J., 2000, Precision-cut liver slices: characteristics and Use for in vitro pharmaco-toxicology. Toxicology, 153, 221–253.
  • LIN, J. H. and Lu, A. Y. H., 1998, Inhibition and induction of cytochrome P450 and the clinical implications. Clinical Pharmacokinetics, 35, 361–390.
  • LOWRY, O. H., ROSEBROUGH, N. J., FARR, A. L. and RANDALL, R. J., 1951, Protein measurement with the Folin phenol reagent. Journal of Biological Chemistry, 193, 265–275.
  • MAHNKE, A., STROTKAMP, D., Roos, P. H., HANSTEIN, W. G., CHABOT, G. G. and NE P., 1997, Expression and inducibility of cytochrome P450 3A9 (CYP3A9) and other members of the CYP3A subfamily in rat liver. Archives of Biochemistry and Biophysics, 337, 62–68.
  • MAUREL, P., 1996, The CYP3 family. In C. Ioannides (ed.), Cytochromes P450: Metabolic and Toxicological Aspects (Boca Raton: CRC Press), pp. 241–270.
  • MOLLER, D., GLGCKNER, R., ROST, M. and STEINMETZER, P., 1998, Monooxygenation, cytochrome P450-mRNA expression and other functions in precision-cut rat liver slices. Experimental Toxicology and Pathology, 50, 507–513.
  • MOLLER, D., STEINMETZER, P., PISSOWOTZKI, K. and GLDCKNE R., 2000, Induction of cytochrome P450 2B1-mRNA and pentoxyresorufin O-depentylation after exposure of precision-cut rat liver slices to phenobarbital. Toxicology, 44, 93–97.
  • NELSON, D. R., KOYMANS, L., KAMATAKI, T., STEGEMAN, J. J., FEYEREISEN, R., WAXMAN, D. J., WATERMAN, M. R., GOTOH, O., COON, M. J., ESTABROOK, R. W., GUNSALUS, I. C. and NEBERT, D. W., 1996, P450 superfamily: update on new sequences, gene mapping, accession numbers and nomenclature. Pharmacogenetics, 6, 1–42.
  • Nims, R. W. and LUBET, R. A., 1996, The CYP2B subfamily. In C. Ioannides (ed.), Cytochromes P450: Metabolic and Toxicological Aspects (Boca Raton: CRC Press), pp. 135–160.
  • OKEY, A. B., 1990, Enzyme induction in the cytochrome P-450 system. Pharmacology and Therapeutics, 45, 241–298.
  • PAN, J., XIANG, Q., RENVVICK, A. B., PRICE, R. J., BALL, S. E., KAO, J., SCATINA, J. A. and LAKE, B. G., 2002, Use of a quantitative real-time reverse transcription-polymerase chain reaction method to study the induction of CYP1A, CYP2B and CYP4A forms in precision-cut rat liver slices. Xenobiotica, 32, 739–747.
  • PARKINSON, A., 1996, Biotransformation of xenobiotics. In C. D. Klaassen (ed.), Casarett and Doull's
  • Toxicology: The Basic Science of Poisons, 5th edn (New York: McGraw-Hill) pp. 113–186.
  • PELKONEN, O., MAENP/Aik, J., TAAVITSAINEN, P., RAUTIO, A. and RAUNIO, H., 1998, Inhibition and induction of cytochrome P450 (CYP) enzymes. Xenobiotica, 28, 1203–1253.
  • PRICE, R. J., RENWICK, A. B., BARTON, P. T., HOUSTON, J. B. and LAKE, B. G., 1998, Influence of slice thickness and culture conditions on the metabolism of 7-ethoxycoumarin in precision-cut rat liver slices. Alternatives to Laboratory Animals, 26, 541–548.
  • SIDHU, J. S., FARIN, F. M. and OMIECINSKI, C. J., 1993, Influence of extracellular matrix overlay on phenobarbital-mediated induction of CYB2B1, 2B2, and 3A1 genes in primary adult rat hepatocyte cultures. Archives of Biochemistry and Biophysics, 301, 103–113.
  • SINCLAIR, P. R., BEMENT, W. J., HAUGEN, S. A., SINCLAIR, J. F. and GUZELIAN, P. S., 1990, Induction of cytochrome P-450 and 5-aminolevulinate synthase activities in cultured rat hepatocytes. Cancer Research, 50, 5219–5224.
  • TOUTAIN, H. J., MORANVALLE-HALLEY, V., SARSAT, J. P., CHELIN, C., HOET, D. and LEROY, D., 1998, Morphological and functional integrity of precision-cut rat liver slices in rotating organ culture and multiwell plate culture: effects of oxygen tension. Cell Biology and Toxicology, 14, 175–190.
  • WAXMAN, D. J., MORRISSEY, J. J., NAIK, S. and JAUREGUI, H. O., 1990, Phenobarbital induction of cytochromes P–450.
  • High-level long-term responsiveness of primary rat hepatocyte cultures to drug induction, and glucocorticoid dependence of the phenobarbital response. Biochemical Journal, 271, 113–119.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.