Advanced search
Publication Cover
Xenobiotica
the fate of foreign compounds in biological systems
Volume 33, 2003 - Issue 6
Submit an article Journal homepage
77
Views
13
CrossRef citations to date
0
Altmetric
Research Article

Pharmacokinetics and metabolism of the cholecystokinin antagonist dexloxiglumide in male human subjects

C. Webber Drug Metabolism and Pharmacokinetics, Huntingdon Life Sciences, Huntingdon PE28 4HS, UK
,
A. Roth Drug Metabolism and Pharmacokinetics, Huntingdon Life Sciences, Huntingdon PE28 4HS, UK
,
S. Persiani Rotta Research Laboratorium, I-20052 Monza, Italy
,
A. J. Peard Drug Metabolism and Pharmacokinetics, Huntingdon Life Sciences, Huntingdon PE28 4HS, UK
,
F. Makovec Rotta Research Laboratorium, I-20052 Monza, Italy
,
R. P. Kapil Forest Laboratories, Inc., Jersey City, NJ 07311, USA
,
B. A. John Drug Metabolism and Pharmacokinetics, Huntingdon Life Sciences, Huntingdon PE28 4HS, UK
,
J. D. Holding Drug Metabolism and Pharmacokinetics, Huntingdon Life Sciences, Huntingdon PE28 4HS, UK
,
M. D'amato Rotta Research Laboratorium, I-20052 Monza, Italy
,
Z. R. Cybulski Drug Metabolism and Pharmacokinetics, Huntingdon Life Sciences, Huntingdon PE28 4HS, UK
,
L. F. Chasseaud Drug Metabolism and Pharmacokinetics, Huntingdon Life Sciences, Huntingdon PE28 4HS, UK
&
L. C. Rovati Rotta Research Laboratorium, I-20052 Monza, Italy
 show all
Pages 625-641 | Published online: 22 Sep 2008

References

  • BRODIE, R., PEARD, A., ROTH, A., PERSIANI, S., MAKOVEC, F. and D'AmATo, M., 2003, Development and validation of a bioanalytical method for the determination of the cholecystokinin type-1 (CCI(i) receptor antagonist dexloxiglumide in human plasma. Journal of Chromatography B, 784, 91–100.
  • D'AmATo, M., MAKOVEC, F. and ROVATI, L. C., 1999b, CCKA-receptors in gastrointestinal disorders. In T. S. Gaginella and A. Guglietta (eds), Drug Development: Molecular Targets for GI Diseases (Totowa: Human Press), pp. 147–175.
  • D'AmATo, M., WHORWELL, P. J., THOMPSON, D. G., SPILLER, R. C., GIACOVELLI, G. and ROVATI, L. C., 1999a, The efficacy and safety of the CCKA-receptor antagonist dexloxiglumide in IBS. Gut, 45 (Suppl. V), A258.
  • D'AmATo, M., WHORWELL, P. J., THOMPSON, D. G., SPILLER, R. C., GIACOVELLI, G., GRIFFIN, P. H., SCHNEIER, H. and ROVATI, L. C., 2001, CCKi-receptor antagonist dexloxiglumide is effective and safe in female patients with constipation predominant irritable bowel syndrome. American Journal of Gastroenterology, 96, S317.
  • DAVIES, B. and MORRIS, T., 1993, Physiological parameters in laboratory animals and humans. Pharmaceutical Research, 10, 1093–1095.
  • FEINLE, C., MEIER, O. and D'AmATo, M., 1999, CCK-A Receptor blockade improves dyspeptic symptoms due to duodenal lipid and gastric distension in functional dyspepsia. Gastroenterology, 116 (Suppl.), A992.
  • FIESER, L. F. and FIESER, M., 1956, Organic Chemistry (New York: Reinhold).
  • FIORAMONTI, J., D'AMATO, M., ROVATI, L. and ButNo, L., 1996, Effects of dexloxiglumide on gastric emptying delayed by colonic distension in dogs. Neurogastroenterology and Motility, 8, 172.
  • GIBSON, G. G. and SKETT, P., 1986, Introduction to Drug Metabolism (London: Chapman & Hall). GRIDER, J. R., 1994, Role of cholecystokinin in the regulation of gastrointestinal motility. Journal of Nutrition, 124 (Suppl. 8), 1334S–1339S.
  • HALL, M., CHEUNG, Y.L., MATTHEWS, A., HOLDING, J. D., CYBULSKI, Z. R., PERSIAN', S., D'AMATO, M. and MAKOVEC, F., 2001, Phase I metabolism of dexloxiglumide (CR 2017) by human liver microsomes. Drug Metabolism Reviews, 33 (Suppl. 1), 91.
  • HIROM, P. C., IDLE, J. R. and MILLBURN, P., 1977, Comparative aspects of the biosynthesis and excretion of xenobiotic conjugates by non-primate mammals. In D. V. Parke and R. L. Smith (eds), Drug Metabolism — From Microbe to Man (London: Taylor & Francis), pp. 299–329.
  • MEIER, R., BEGLINGER, C., GIACOVELLI, G. and D'AMATO, M., 1997, Effect of the CCK-A receptor antagonist dexloxiglumide on postprandial gallbladder emptying and colonic transit time in healthy volunteers, Gastroenterology, 112, A788.
  • PERSIAN', S., D'AMATO, M., MAKOVEC, F., TAVARES, I. A., BISHAI, P. M. and ROVATI, L. C., 2002, Pharmacokinetics of dexloxiglumide after administration of single and repeat oral escalating doses in healthy young males. International Journal of Clinical Pharmacology and Therapeutics, 40, 108–206.
  • REVEL, L., MAKOVEC, F. and CASTANER, J., 1999, Dexloxiglumide — CCKi (CCKA) receptor antagonist treatment of irritable bowel syndrome. Drugs of the Future, 24, 725–728.
  • ROUZADE, M. L. FIORAMONTI, J., D'AMATO, M., ROVATI, L. and ButNo, L., 1996, Inhibitory action of dexloxiglumide on transient lower oesophageal sphincter relaxation in dogs. Neurogastroenter-ology and Motility, 8, 188.
  • SCARPIGNATO, C., KISFALV I., D'AMATO, M. and VARGA, G., 1996, Effect of dexloxiglumide and spiroglumide, two new CCK-receptor antagonists, on gastric emptying and secretion in the rat: evaluation of their receptor selectivity in vivo. Alimentary Pharmacology Therapy, 10, 411–419.
  • SCHELINE, R. R., 1973, Metabolism of foreign compounds by gastrointestinal microorganisms. Pharmacological Reviews, 25, 451–523.
  • WOODRUFF, G. N. and HUGHES, J., 1991, Cholecystokinin antagonists. Annual Review of Pharmacology and Toxicology, 31, 469–501.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.