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Xenobiotica
the fate of foreign compounds in biological systems
Volume 33, 2003 - Issue 7
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Research Article

Use of cultured precision-cut rat lung slices to study the in vitro induction of pulmonary cytochrome P450 forms

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Pages 691-702 | Published online: 02 Jul 2010

References

  • ARINC, E., 1993, Extrahepatic microsomal forms: lung microsomal cytochrome P450 isozymes. In J. B. Schenkman and H. Greim (eds), Cytochrome P450, Handbook of Experimental Pharmacology, Vol. 105 (Heidelberg: Springer), pp. 373–386.
  • BACH, P. H., VICKERS, A. E. M., FISHER, R., BAUMANN, A., BRITTEBO, E., CARLILE, D. J., KOSTER, H. J., LAKE, B. G., SALMON, F., SAWYER, T. W. and SKIBINSKI, G., 1996, The use of tissue slices for pharmacotoxicology studies. The report and recommendations of ECVAM Workshop 20. Alternatives to Laboratory Animals, 24, 893–923.
  • BARON, J. and VOIGT, J. M., 1993, Localization, distribution and induction of xenobiotic-metabolizing enzymes and aryl hydrocarbon hydroxylase activity within lung. In T. E. Gram (ed.), Metabolic Activation and Toxicity of Chemical Agents to Lung Tissue and Cells (Oxford: Pergamon), pp. 41–75.
  • BEAMAND, J. A., PRICE, R. J., CUNNINGHAME, M. E. and LAKE, B. G. 1993, Culture of precision-cut liver slices: effect of some peroxisome proliferators. Food and Chemical Toxicology, 31, 137–147.
  • COECKE, S., ROGIERS, V., BAYLISS, M., CASTELL, J., DOEHMER, J., FABRE, G., FRY, J., KERN, A. and WESTMORELAND, C., 1999, The use of long-term hepatocyte cultures for detecting induction of drug metabolising enzymes: the current status. Alternatives to Laboratory Animals, 27, 579–638.
  • CONNEY, A. H., 1986, Induction of microsomal cytochrome P-450 enzymes: the first Benard B. Brodie lecture at Pennsylvania State University. Life Sciences, 39, 2493–2518.
  • DEKANTER, R., DE JAGER, M. H., DRAAISMA, A. L., juRvA, J. U., OLINGA, P., MEIJER, D. K. F. and GROOTHUIS, G. M. M., 2002, Drug-metabolizing activity of human and rat liver, lung, kidney and intestine slices. Xenobiotica, 32, 349–362.
  • DE KANTER, R., OLINGA, P., DE JAGER, M. H., MEREMA, M. T., MEIJER, D. K. F. and GROOTHIUS, G. M. M., 1999, Organ slices as an in vitro test system for drug metabolism in human liver, lung and kidney. Toxicology in Vitro, 13, 737–744.
  • DEBRI, K., BOOBIS, A. R., DAVIES, D. S. and EDWARDS, R. J., 1995, Distribution and induction of CYP3A1 and CYP3A2 in rat liver and extrahepatic tissues. Biochemical Pharmacology, 50, 2047–2056.
  • DEVEREUX, T. R., DOMIN, B. A. and PHILPOT, R. M., 1993, Xenobiotic metabolism by isolated pulmonary bronchiolar and alveolar cells. In T. E. Gram (ed.), Metabolic Activation and Toxicity of Chemical Agents to Lung Tissue and Cells (Oxford: Pergamon), pp. 25–40.
  • EDWARDS, R. F., 1998, Targetting antipeptide antibodies towards cytochrome P450 enzymes. In I. R. Phillips and E. A. Shephard (eds), Methods in Molecular Biology, Vol. 107: Cytochrome P450 Protocols (Totowa: Humana), pp. 239–249.
  • GODDEN, P. M. M., KASS, G., MAYER, R. T. and BURKE, M. D., 1987 The effect of cigarette smoke compared to 3-methylcholanthrene and phenobarbitone on alkoxyresorufin metabolism by lung and liver microsomes from rats. Biochemical Pharmacology, 36, 3393–3398.
  • HAND, J. A., MCGARRIGLE, B. P., MACCUBBIN, A. E. and OLSON, J. R., 2000, Expression of cytochrome P-450 1A1 (CYP1A1) and DNA adduct formation in rat liver and lung slices incubated with benzo(a)pyrene (BAP) in dynamic organ culture. Toxicological Sciences, 54 (Suppl. 1), 350.
  • HOET, P. H. M., DEMEDTS, M. and NEMERY, B., 1997, In vitro modulation of the P450 activities of hamster and human lung slices. Cell Biology and Toxicology, 13, 185–192.
  • IMAOKA, S., TERANO, Y. and FUNAE, Y., 1989, Expression of four phenobarbital-inducible cytochrome P-450s in liver, kidney, and lung of rats. Yourna/ of Biochemistry, 105, 939–945.
  • KEITH, I. M., OLSON, E. B., JR, WILSON, N. M. and JEFCOATE, C. R., 1987, Immunological identification and effects of 3-methylcholanthrene and phenobarbital treatment on rat pulmonary cytochrome P-450. Cancer Research, 47, 1878–1882.
  • LAKE, B. G., CHARZAT, C., TREDGER, J. M., RENWICK, A. B., BEAMAND J. A. and PRICE, R. J., 1996, Induction of cytochrome P450 isoenzymes in cultured precision-cut rat and human liver slices. Xenobiotica, 26, 297–306.
  • LAKE, B. G. and LEWIS, D. F. V., 1996, The CYP4 family. In C. Ioannides (ed.), Cytochromes P450 Metabolic and Toxicologic Aspects (Boca Raton: CRC Press), pp. 271–297.
  • LAKE, B. G., PRICE, R. J., RENWICK, A. B. and BEAMAND, J. A., 1998, Maintenance of intracellular organization in liver slices: importance in studies of drug metabolism. In A. R. BOOBIS, P. KREMERS, 0. Pelkonen and K. Pithan (eds), European Symposium on the Prediction of Drug Metabolism in Man: Progress and Problems (Luxembourg: European Communities), pp. 61–76.
  • LECLUYSE, E. L., BULLOCK, P. L. and PARKINSON, A., 1996, Strategies for restoration and maintenance of normal hepatic structure and function in long-term cultures of rat hepatocytes. Advanced Drug Delivery Reviews, 22, 133–186.
  • LEE, C., WATT, K. C., CHANG, A.-M., PLOPPER, C. G., BUCICPITT, A. R. and PINKERTON, K. E., 1998, Site-selective differences in cytochrome P450 isoform activities. Comparison of expression in rat and Rhesus monkey lung and induction in rats. Drug Metabolism and Disposition, 26, 396–400.
  • LERCHE-LANGRAND, C. and TOUTAIN, H. J., 2000, Precision-cut liver slices: characteristics and use for in vitro pharmaco-toxicology. Toxicology, 153, 221–253. 702C YP induction in rat lung slices
  • LOWRY, 0. H., ROSEBROUGH, N. J., FARR, A. L. and RANDALL, R. J., 1951, Protein measurement with the Folin phenol reagent. Journal of Biological Chemistry, 193, 265–275.
  • NELSON, D. R., KOYMANS, L., KAMATAKI, T., STEGEMAN, J. J., FEYEREISEN, R., WAXMAN, D. J., WATERMAN, M. R., GOTOH, 0., COON, M. J., ESTABROOK, R. W., GuNsALus, I. C. and NEBERT, D. W., 1996, P450 superfamily: update on new sequences, gene mapping, accession numbers and nomenclature. Pharmacogenetics, 6, 1–42.
  • NEMERY, B. and HOET, P. H. M., 1993, Use of isolated lung cells in pulmonary toxicology. Toxicology in Vitro, 7, 359–364.
  • Ntms, R. W. and LUBET, R. A., 1996, The CYP2B subfamily. In C Ioannides (ed.), Cytochromes P450 Metabolic and Toxicological Aspects (Boca Raton: CRC Press), pp. 135–160.
  • OKEY, A. B., 1990, Enzyme induction in the cytochrome P-450 system. Pharmacology and Therapeutics, 45, 241–298.
  • PARRISH, A. R., GANDOLFI, A. J. and BRENDEL, K., 1995, Precision-cut tissue slices: applications in pharmacology and toxicology. Life Sciences, 57, 1887–1901.
  • PLACKE, M. E. and FISHER, G. L., 1987, Adult peripheral lung organ culture — a model for respiratory tract toxicology. Toxicology and Applied Pharmacology, 90, 284–298.
  • PRICE, R. J., RENWICK, A. B., BARTON, P. T., HOUSTON, J. B. and LAKE, B. G., 1998, Influence of slice thickness and culture conditions on the metabolism of 7-ethoxycoumarin in precision-cut rat liver slices. Alternatives to Laboratory Animals, 26, 541–548.
  • PRICE, R. J., RENWICK, A. B., BEAMAND, J. A., ESCLANGON, F., WIELD, P. T., WALTERS, D. G. and LAKE, B. G., 1995, Comparison of the metabolism of 7-ethoxycoumarin and coumarin in precision-cut rat liver and lung slices. Food and Chemical Toxicology, 33, 233–237.
  • SLEZAK, B. P., HAND, J., MCGARRIGLE, B. P., JEFCOATE, C. R. and OLSON, J. R., 1998, Human lung and kidney slices in dynamic organ culture as an in vitro model for studying CYP1A1 and CYP1B1 modulation by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Toxicological Sciences, 42 (Suppl. 1), 387.
  • STEFANIAK, M. S., KRUMDIECK, C. L., SPALL, R. D., GANDOLFI, A. J. and BRENDEL, K., 1992, Biochemical and histological characterization of agar-filled precision-cut rat lung slices in dynamic organ culture as an in vitro tool. In Vitro Toxicology, 5, 7–19.
  • TöRNQUIST, S., SUNDIN, M., MOLLER, L., GUSTAESSON, J.-À. and TOFTGARD, R., 1988, Age dependent expression of cytochrome P-450b and metabolism of the potent carcinogen 2-nitrofluorene in the rat lung. Carcinogenesis, 9, 2209–2214.
  • VERSCHOYLE, R. D., DINSDALE, D. and WOLF, C. R., 1993, Inhibition and induction of cytochrome P450 isoenzymes in rat lung. Journal of Pharmacology and Experimental Therapeutics, 265, 386–391.
  • VOIGT, J. M., KAWABATA, T. T., BURKE, J. P., MARTIN, M. V., GUENGENICH, F. P. and BARON, J., 1990, In situ localization and distribution of xenobiotic-activating enzymes and aryl hydrocarbon hydroxylase activity in lungs of untreated rats. Molecular Pharmacology, 37, 182–191.

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