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Xenobiotica
the fate of foreign compounds in biological systems
Volume 33, 2003 - Issue 7
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Research Article

Relative receptor expression is a determinant in xenobiotic-mediated CYP3A induction in rat and human cells

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Pages 703-716 | Published online: 02 Jul 2010

References

  • BARWICK, J. L., QUATTROCHI, L. C., MILLS, A. S., PoTENzA, C., TUKEY, R. H. and GUZELIAN, P. S., 1996, Trans-species gene transfer for analysis of glucocorticoid-inducible transcriptional activation of transiently expressed human CYP3A4 and rabbit CYP3A6 in primary cultures of adult rat and rabbit hepatocytes. Molecular Pharmacology, 50, 10–16.
  • BEURTON, F., BANDY0PADIIYAY, U., DI ECMFGARD, B., BAROUKI, R. and AGGERBECK, M., 1999, Delineation of the insulin-responsive sequence in the rat cytosolic aspartate aminotransferase gene: binding sites for hepatocyte nuclear factor-3 and nuclear factor I. Biochemical Journal, 343, 687–695.
  • BROWN, S. E. S., QUATTROCHI, L. C. and GliZELIAN, P. S., 1997, Characterization of a pretranscriptional pathway for induction by phenobarbital of cytochrome P450 3A23 in primary cultures of adult rat hepatocytes. Archives of Biochemistry and Biophysics, 342, 134–142.
  • CHOLERTON, S., DALY, A. K. and IDLE, J. R., 1992, The role of individual human cytochromcs P450 in drug-metabolism and clinical-response. Trends in Pharmacological Sciences, 13, 434–439.
  • COSTE.KS, P. A. and CHINSKY, J. M., 2000, Glucocorticoid regulation of branched-chain alpha-ketoacid dehydrogenase E2 subunit gene expression. Biochemical Journal, 347, 449–457.
  • E1-SANKARY, W., 130MBAIL, V., GIBSON, G. G. and PLANT, N., 2002, Glucocorticoid-mediated induction of CYP3A4 is decreased by disruption of a protein: DNA interaction distinct from the pregnane X receptor response element. Drug Metabolism and Disposition, 30, 1029–1034.
  • E1-SANKARY, W., GIBSON, G., AYRTON, A. and PLANT, N., 2001, Use of a reporter gene assay to predict and rank the potency and efficacy of CYP3A4 inducers. Drug Metabolism and Disposition, 29, 1499–1504.
  • GRIOSAL, A., SADRIEH, N., REEK, L., LEVIN, W. and THOMAS, P. E., 1996, Induction of the male-specific cytochrome P450 3A2 in female rats by phenytoin. Archives of Biochemistry and Biophysics, 332, 153–162.
  • HOG I ,NO, M., GISSELSSON, D., SALL, T. and MEEELmAN, F., 2002, Coping with complexity. Multivariate analysis of tumor karyotypes. Cancer Genetics and Cytogenetics, 135, 103–109.
  • JORDAN, M., SCHALI.HORN, A. and WORM, F. M., 1996, Transfecting mammalian cells: optimization of critical parameters affecting calcium-phosphate precipitate formation. Nucleic Acids Research, 24, 596–601.
  • KLIEWER, S. A., MooRE, J. T., WADE, L., STAUDINGER, J. L., WATSON, M. A., JONES, S. A., McKEE, D. D., OLIVER, B. B., WILLSON, T. M., ZETTERSTROM, R. H., PERLMANN, T. and LEHMANN, J. M., 1998, An orphan nuclear receptor activated by pregnanes defines a novel steroid signaling pathway. Cell, 92, 73–82.
  • KOCAREK, T. A., SCHUETZ, E. G., STuom, S. C., FISIIER, R. A. and GUZELIAN, P. S., 1993, Comparative-analysis of cytochrome P4503A induction in primary cultures of rat, rabbit, and human hepatocytes. Drug Metabolism and Disposition, 23, 415–421.
  • ROLLS, J., DEININGER, P., COHEN, J. and LARSON, J., 1993, cDN A equalisation for reverse transcription polymerase chain-reaction quantitiation. Analytical Biochemistry, 208, 264–269.
  • LEHMANN, J. M., NIcKEE, D. D., WATsox, M. A., WILLSON, T. M., MooRE, J. T. and KLIEwER, S. A., 1998, The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene expression and cause drug interactions. Journal of Clinical Investigation, 102, 1016–1023.
  • MOOUE, L. B., PARKS, D. J., JONES, S. A., BLEDSOE, R. K., CONSLER, T. G., STIMMEL, J. B., GOODWIN, B., LIDDLE, C., BLANCHARD, S. G., WILLSON, T. NI., COLLINS, J. L. and KLIEWF.R, S. A., 2000, Orphan nuclear receptors constitutive androstane receptor and pregnane X receptor share xenobiotie and steroid ligands. Journal of Biological Chemistry, 275, 15122–15127.
  • NELSON, D. R., KovmAxs, L., KAMATAKI, T., STEGEMAN, J. j., FEYEREISEN, R., WAxmAN, D. J., WATERMAN, M. R., CoTorl, O., COON, M. J., ESTABROOK, R. W., GUNSALUS, I. C. and NEBERT, D. W., 1996, P450 superfamily: update on new sequences, gene mapping, accession numbers and nomenclature. Pharmacogenetics, 6, 1–42.
  • OGG, M. S., WILLIAMS, J. Ni., TARBIT, Ni., GOLDFARB, P. S., GRAY, T. J. B. and GIBSON, G. G., 1999, A reporter gene assay to assess the molecular mechanisms of xenobiotic-dependent induction of the human CYP3A4 gene in vitro. Xenobiotica, 29, 269–279.
  • PASCUSS J.-M., DROCOURT, L., FABRE, J.-M., MAUREL, P. and VILAREM, M.-J., 2000a, Dexamethasone induces pregnane X receptor and retinoicl X receptor-a expression in human hepatocytes: Synergistic increase of CYP3A4 induction by pregnane X receptor. Molecular Pharmacology, 58, 361–372.
  • PASCUSSI, J.-M., Gerbal-CHALOIN, S., FABRE, J.-M., MAUREL, P. and VILAREM, M.-J., 2000b, Dexamethasone enhances constitutive androstane receptor expression in human hepatocytes: Consequences on cytochrome P450 gene regulation. Molecular Pharmacology, 58, 1441–1450.
  • PLANT, N., OGG, M., CuownEy., NI. and GIBSON, G., 2000, Control and statistical analysis of in vitro reporter gene assays. Analytical Biochemistry, 278, 170–174.
  • SCHUETZ, E. G., SCIIUETZ, J. D., STROM, S. C., THOMPSON, M. T., FISHER, R. A., MoLowA, D. T., Li, D. and GUZELIAN, P. S., 1993, Regulation of human liver cytochromes P-450 in family 3a in primary and continuous-culture of human hepatocytes. Hepatology, 18, 1254–1262.
  • SUEYOSHI, T., KAWAMOTO, T., ZELEo, I., HONKAKOSKI, P. and NEGISHI, M., 1999, The repressed nuclear receptor CAR responds to phenobarbital in activating the human CYP2B6 gene. journal of Biological Chemistry, 274, 6043–6046.
  • TIRONA, R. G., LEE, W., LEAKE, B. F., LAN, L. B., CLINE, C. B., LAMBA, V., PARVIZ, F., DUNCAN, S. A., INouE, Y., GONZALEZ, F. J., SCHUETZ, E. G. and Kim, R. B., 2003, The orphan nuclear receptor HNF4alpha determines PXR- and CAR-mediated xenobiotic induction of CYP3A4. Nature Medicine, 6, 6.
  • WATKINS, P., 1992, Drug metabolism by cytochromes P450 in the liver and small bowel. Gastrointestinal Pharmacology, 21, 511–526.
  • WAXMAN, D. J. and AZAROFF, L., 1992, Phenobarbital induction of cytochrome P-450 gene expression. Biochemical journal, 281, 577–592.
  • WRIGHTON, S., SCHEUTZ, E., WATKINS, P., MAuREL, P., BARWICK, J., BAILEY, B., HARI'LE, H., YouNG, B. and GUZELIAN, P., 1985, Demonstration in multiple species on inducible hepatic cytochrome P450 and their mRNA's related to the glucocorticoid inducible cytochrome P450 of the rat. Molecular Pharmacology, 28, 312–321.
  • XIE, W., BARWICK, J., DOWNES, M., BLUMBERG, B., SIMON, C., NELSON, M., NeUSChWander-TETRI, B., BRUNT, E., GUZELIAN, P. and EVANS, R., 2000a, Humanized xenobiotic in mice expressing nuclear receptor SXR. Nature, 406, 435–438.
  • XIE, W., BARWICK, J., SIMMON, C., PIERCE, A., SAFE, S., BLUMBERG, B., GUZELIAN, P. and EVANS, R., 2000b, Reciprocal activation of xenobiotic response genes by nuclear receptors SXR/PXR and CAR. Genes and Development, 14, 3014–3023.

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