Reference
- ABOU-SHAKRA, F., SAGE, A. B., CASTRO-PEREZ, J., NICHOLSON, J. K. LINDON, J. C., SCARFE, G. B and WILSON, I. D., 2002, High-performance liquid chromatography-UV diode array, inductively coupled plasma mass spectrometry (ICPMS) and orthogonal acceleration time-of-flight mass spectrometry (oa-TOF-MS) applied to the simultaneous detection and identification of metabolites of 4-bromoaniline in rat urine. Chromatographia, 55, S9—S13.
- BAILLIE, T. A., CAYEN, M. N., FOUDA, H., GERSON, R. J., GREEN, J. D., GROSSMAN, S. J., KLUNK, L. J., LEBLANC, B., PERKINS, D. G. and SHIPLEY, L. A., 2002, Drug metabolites in safety testing, Toxicology and Applied Pharmacology, 182, 188–196.
- DAVY, H., 1840, Collected Works, vol. IV (London).
- HUCKER, H. B., KWAN, K. C. and DUGGAN, D. E., 1980, Pharmacokinetics and metabolism of non-steroidal anti-inflammatory agents. In J. W. Bridges and L. F. Chasseaud (eds), Progress in Drug Metabolism (Chichester: Wiley), vol. 5, pp. 165–253.
- LI, A. P., 2002, A review of the common properties of drugs with idiosyncratic hepatoxicity and the 'multiple determinant hypothesis' for the manifestation of idiosyncratic drug toxicity, 142, 7–23.
- MAJOR, H., CASTRO-PEREZ, J., NICHOLSON, J. and WILSON, I. D., In press, Detection of mono- and di-hexoses as metabolites of 4-bromoaniline using exact mass neutral loss acquisitions by HPLC-TOF-MS/MS. Xenobiotica.
- MAJOR, H., CASTRO-PEREZ, J., NICHOLSON, J. K. and WILSON, I. D., 2002, Characterisation of putative pentose-containing conjugates as minor metabolites of 4-bromoaniline present in the urine of rats following intraperitoneal administration. Rapid Communications in Mass Spectrometry, 17, 76–80.
- NICHOLLS, A. W., FARRANT, R. D., SHOCKOR, J. P., UNGER, S. E., WILSON, I. D., LINDON, J. C. and NICHOLSON, J. K., 1997, NMR and HPLC-NMR studies on the metabolism and futile deacetylation of paracetamol metabolites in rat and man, Biochemical Pharmacology, 49, 1155–1164.
- NICHOLSON, J. K., CONNELLY, J. LINDON J. C. and HOLMES, E., 2002, Metabonomics a platform for studying drug toxicity and gene function. Nature Reviews, Drug Discovery, 1, 153–161.
- NICHOLSON, J. K., LINDON, J. C., SCARFE, G., WILSON, I. D., ABOU-SHAKRA, F., CASTR-PEREZ, J., EATON, A and PREECE, S., 2000, High-performance liquid chromatography and inductively coupled plasma mass spectrometry (HPLC-ICPMS) for the analysis of xenobiotic metabolites in rat urine: application to the metabolites of 4-bromoaniline. Analyst, 125, 235–236.
- SCARFE, G. B., NICHOLSON, J. K., LINDON, J. C., WILSON, I. D., TAYLOR, S., CLAYTON, E. and WRIGHT, B., 2002, Identification of the urinary metabolites of 4-bromoaniline and 4-bromo-[carbony/-13C]-acetanilide in rat. Xenobiotica, 32, 325–337.
- TESTA, B. and JENNER, P., 1978, Novel drug metabolites produced by functionalisation reactions: chemistry and toxicology. Drug Metabolism Reviews, 7, 325–369.
- WILLIAMS, R. T., 1947, Detoxication Mechanisms (London: Chapman & Hall).