Publication Cover
Xenobiotica
the fate of foreign compounds in biological systems
Volume 33, 2003 - Issue 12
51
Views
4
CrossRef citations to date
0
Altmetric
Research Article

Altered expression of sulfotransferases, glucuronosyltransferases and mrp transporters in FVB/mrp1–/– mice

&
Pages 1173-1183 | Received 02 May 2003, Published online: 22 Sep 2008

References

  • ANDERSON, M. E., 1985, Determination of glutathione and glutathione disulfide in biological samples. Methods in Enzymology, 113, 548–555.
  • BALDWIN, W. S. and LEBLANC, G. A., 1992, The anti-carcinogenic plant compound indole-3-carbinol differentially modulates P450-mediated steroid hydroxylase activities in mice. Chemico-Biological Interactions, 83, 155–169.
  • BELINSKY, M. G., BAIN, L. J., BALSARA, B. B., TESTA, J. R. and KRUH, G. D., 1998, Characterization of MOAT-C and MOAT-D new members of the MRP/cMOAT subfamily of transporter proteins. Journal of the National Cancer Institute, 90, 1735–1741.
  • BOCK, K. W., GSCHAIDMEIER, H., HEEL, H., LEHMKOSTER, T., MUNZEL, P. A., RASCHKO, F. and BOCK-HENNING, B., 1998, AH receptor-controlled transcriptional regulation and function of rat and human UDP-glucuronosyltransferase isoforms. Advances in Enzyme Regulation, 38, 207–222.
  • BORST, P., EVERS, R., KooL, M. and WIJNHOLDS, J., 1999, The multidrug resistance protein family. Biochimica et Biophysica Acta, 1461, 347–357.
  • BRADFORD, M. M., 1976 A rapid and sensitive method for the quantitation of microgram quantities of protein using the principle of protein dye binding. Analytical Biochemistry, 72, 248–254.
  • CHEN, Z.-S., MUTOH, M., SUMIZAWA, T., FURUKAWA, T., HARAGUCHI, M., TANI, A. and AKIYAMA, S., 1997, Reversal of heavy metal resistance in multidrug-resistant human KB carcinoma cells. Biochemical and Biophysical Research Communications, 236, 586–590.
  • COFFMAN, B. L., Rios, G. R. and TEPHLY, T. R., 1999, Measurements of UDP-glucuronosyltransferase (UGT) activities. Current Protocols in Toxicology, 4.3, 4.3.1–4.3.15.
  • ENOMOTO, A., Prox, K., NAGAYOSHI, E., HARUTA, J., KIMURA, T., O'CONNOR, T., HARADA, T. and YAMAMOTO, M., 2001, High sensitivity of Nrf2 knockout mice to acetaminophen hepatotoxicity associated with decreased expression of ARE-regulated drug metabolizing enzymes and antioxidant genes. Toxicological Sciences, 59, 169–177.
  • FLENS, M. J., ZAMAN, G. J. R., VAN DER VALK, P., IZQUIERDO, M. A., SCHROEIJERS, A. B., SCHEFFER, G. L., VAN DER GROEP, P., DE HAAS, M., MEIJER, C. J. L. M. and SCHEPER, R. J., 1996, Tissue distribution of the multidrug resistance protein. American Journal of Pathology, 148, 1237–1247.
  • GRANCHAROV, K., NAYDENOVA, Z., LOZEVA, S. and GOLOVINSKY, E., 2001, Natural and synthetic inhibitors of UDP-glucuronosyltransferase. Pharmacology and Therapeutics, 89, 171–186.
  • HABIG, W. H., PABST, M. J. and JAKosv, W. B., 1974, Glutathione S-transferases. The first enzymatic step in mercapturic acid formation. Journal of Biological Chemistry, 249, 7130–7139.
  • HIROHASHI, T., SUZUKI, H., ITo, K., OGAWA, K., KUME, K., SHIMIZU, T. and SUGIYAMA, Y., 1998, Hepatic expression of multidrug resistance-associated protein-like proteins maintained in Eisai hyperbilirubinemic rats. Molecular Pharmacology, 53, 1068–1075.
  • HIROHASHI, T., SUZUKI, H., TAKIKAWA, J. and SUGIYAMA, Y., 2000, ATP-dependent transport of bile salts by rat multidrug resistance-associated protein 3 (mrp3). Journal of Biological Chemistry, 275, 2905–2910.
  • HUANG, W., ZHANG, J., CHUA, S. S., QATANANI, M., HAN, Y., GRANATA, R. and MOORE, D. D., 2003, Induction of bilirubin clearance by the constitutive androstane receptor (CAR). Proceedings of the National Academy of Sciences, USA, 100, 4156–4161.
  • JEDLITSCHKY, G., LEIER, I., BUCHHOLZ, U., HUMMEL-EISENBEISS, J., BURCHELL, B. and KEPPLER, D., 1997, ATP-dependent transport of bilirubin glucuronides by the multidrug resistance protein MRP1 and its hepatocyte canalicular isoform MRP2. Biochemical Journal, 327, 305–310.
  • KONIG, J., NIES, A. T., Cm, Y., LEIER, I. and KEPPLER, D., 1999a, Conjugate export pumps of the multidrug resistance protein (MRP) family: localization, substrate specificity, and MRP2-mediated drug resistance. Biochimica et Biophysica Acta, 1461, 377–394.
  • KONIG, J., ROST, D., Cm, Y. and KEPPLER, D., 1999b, Characterization of the human multidrug resistance protein isoform MRP3 localized to the basolateral hepatocyte membrane. Hepatology, 29, 1156–1163.
  • KRUH, G. D., ZENG, H., REA, P. A., Liu, G., CHEN, Z.-S., LEE, K. and BELINSKY, M. G., 2001, MRP subfamily transporters and resistance to anticancer agents. Journal of Bioenergetics and Biomembranes, 33, 493–501.
  • LEE, K., BELINSKY, M. G., BELL, D. W., TESTA, J. R. and KRUH, G. D., 1998, Isolation of MOAT-B, a widely expressed multidrug resistance-associated protein/canalicular multispecific organic anion transporter-related transporter. Cancer Research, 58, 2741–2747.
  • LOE, D. W., ALMQUIST, K. C., DEELEY, R. G. and COLE, S. P. C., 1996, Multidrug resistance protein (MRP)-mediated transport of leukotriene C4 and chemotherapeutic agents in membrane vesicles. Journal of Biological Chemistry, 271, 9675–9682.
  • LOE, D. W., DEELEY, R. G. and COLE, S. P., 1998, Characterization of vincristine transport by the M(r) 190,000 multidrug resistance protein (MRP): evidence for cotransport with reduced glutathione. Cancer Research, 58, 5130–5136.
  • LORICO, A., RAPPA, G., FINCH, R. A., YANG, D., FLAVELL, R. A. and SARTORELLI, A. C., 1997, Disruption of the murine MRP (multidrug resistance protein) gene leads to increased sensitivity to etoposide (VP-16) and increased levels of glutathione. Cancer Research, 57, 5238–5242.
  • PAULUSMA, C. C., KOOL, M., BOSMA, P. J., SCHEFFER, G. L., TER BORG, F., SCHEPER, R. J., TYTGAT, G. N., BORST, P., BAAS, F. and OUDE ELFERINK, R. P., 1997, A mutation in the human canalicular multispecific organic anion transporter gene causes the Dubin—Johnson Syndrome. Hepatology, 25, 1539–1542.
  • PEI, Q.-L., KOBAYASHI, Y., TANAKA, Y., TAGUCHI, Y., HIGUCHI, K., KAITO, M., MA, N., SEMBA, R., KAmismco, T. and ADACHI, Y., 2002, Increased expression of multidrug resistance-associated protein 1 (mrpl) in hepatocyte basolateral membrane and renal tubular epithelia after bile duct ligation in rats. Hepatology Research, 22, 58–64.
  • PENG, K.-C., CLUZEAUD, F., BENS, M., VAN HUYEN, J. P., WIOLAND, M. A., LACAVE, R. and VANDEWALLE, A., 1999, Tissue and cell distribution of the multidrug resistance-associated protein (MRP) in mouse intestine and kidney. Journal of Histochemistry and Cytochemistry, 47, 757–768.
  • PETERS, W. H. M., JANSEN, P. L. M. and NAUTA, H., 1984, The molecular weights of UDP-glucuronyltransferase determined with radiation-inactivation analysis. Journal of Biological Chemistry, 259, 11701–11705.
  • RUNGE-MORRIS, M., 1998, Regulation of sulfotransferase gene expression by glucocorticoid hormones and xenobiotics in primary rat hepatocyte culture. Chemico-Biological Interactions, 109, 315–327.
  • RUNGE-MORRIS, M., ROSE, K., FALANY, C. N. and KOCAREK, T. A., 1998, Differential regulation of individual sulfotransferase isoforms by phenobarbital in male rat liver, Drug Metabolism and Disposition, 26, 795–801.
  • SCHUETZ, E. G., STROM, S., YASUDA, K., LECUREUR, V., ASSEM, M., BRIMER, C., LAMBA, J., KIM, R. B., RAMACHANDRAN, V., KOMOROSKI, B. J., VENKATARAMANAN, R., CAI, H., SINAL, C. J., GONZALEZ, F. J. and SCHUETZ, J. D., 2001, Disrupted bile acid homeostasis reveals an unexpected interaction among nuclear hormone receptors, transporters, and cytochrome P450. Journal of Biological Chemistry, 276, 39411–39418.
  • SCHUETZ, E. G., UMBENHAUER, D. R., YASUDA, K., BRIMER, C., NGUYEN, L., RELLING, M. V., SCHUETZ, J. D. and SCHINKEL, A., 2000, Altered expression of hepatic cytochromes P-450 in mice deficient in one or more mdrl genes. Molecular Pharmacology, 57, 188–197.
  • SHENG, J. J., SHARMA, V. and DUFFEL, M. W., 2001, Measurement of aryl and alcohol sulfotransferase activity. Current Protocols in Toxicology, 4.5, 4.5.1–4.5.9.
  • SONODA, J., XIE, W., ROSENFELD, J. M., BARWICK, J. L., GUZELLAN, P. S. and EVANS, R. M., 2002, Regulation of a xenobiotic sulfonation cascade by nuclear pregnane X receptor (PXR). Proceedings of the National Academy of Sciences, USA, 99, 13801–13806.
  • STRASSER, S. I., MASHFORD, M. L. and DESMOND, P. V., 1998, Regulation of uridine diphosphate glucuronosyltransferase during the acute-phase response, Journal of Gastroenterology and Hepatology, 13, 88–94.
  • THIEBAUT, F., TSURUO, T., HAMADA, H., GOTTESMAN, M. M., PASTAN, I. and WILLINGHAM, M. C., 1987, Cellular localization of the multidrug resistance gene product in normal human tissues. Proceedings of the National Academy of Sciences, USA, 84, 7735–7738.
  • TRIBULL, T. E., BRUNER, R. H. and BAIN, L. J., 2003, The multidrug resistance-associated protein 1 (MRP1/ABCC1) transports methoxychlor and protects the seminiferous epithelium from injury. Toxicology Letters, 142, 61–70.
  • WAXMAN, D. J., Ko, A. and WALSH, C., 1983, Regioselectivity and stereoselectivity of androgen hydroxylations catalyzed by cytochrome P450 isozymes purified from phenobarbital-induced rat liver. Journal of Biological Chemistry, 258, 11937–11947.
  • WIJNHOLDS, J., EVERS, R., VAN LEUSDEN, M. R., MOL, C. A. A. M., ZAMAN, G. J. R., MAYER, U., BEIJNEN, J. H., VAN DER VALK, M., KRIMPENFORT, P. and BORST, P., 1997, Increased sensitivity to anticancer drugs and decreased inflammatory response in mice lacking the multidrug resistance-associated protein. Nature Medicine, 3, 1275–1279.
  • WIJNHOLDS, J., MOL, C. A. A. M., VAN DEEMTER, L., DE HAAS, M., SCHEFFER, G. L., BAAS, F., BEIJNEN, J. H., SCHEPER, R. J., HATSE, S., DE CLERCQ, E., BALZARINI, J. and BORST, P., 2000, Multidrug-resistance protein 5 is a multispecific organic anion transporter able to transport nuclotide analogs. Proceedings of the National Academy of Sciences, USA, 97, 7476–7481.
  • WIJNHOLDS, J., SCHEFFER, G. L., VANDER VALK, M., VAN DER VALK, P., BEIJNEN, J. H., SCHEPER, R. J. and BORST, P., 1998, Multidrug resistance protein 1 protects the oropharyngeal mucosal layer and the testicular tubules against drug-induced damage. Journal of Experimental Medicine, 188, 797–808.
  • XIE, W., YEUH, M.-F., RADOMINSKA-PANDYA, A., SAINT, S. P. S., NEGISHI, Y., BOTTROFF, B. S., CABRERA, G. Y., TUKEY, R. H. and EVANS, R. M., 2003, Control of steroid, heme, and carcinogen metabolism by nuclear pregnane X receptor and constitutive androstane receptor. Proceedings of the National Academy of Sciences, USA, 100, 4150–4155.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.