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Xenobiotica
the fate of foreign compounds in biological systems
Volume 33, 2003 - Issue 11
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Research Article

Application of structure–metabolism relationships in the identification of a selective endothelin A antagonist, BMS-193884, with favourable pharmacokinetic properties

W. G. Humphreys Department of Metabolism and Pharmacokinetics, Preclinical Candidate Optimization, PO Box 5400, Princeton, NJ, 08543, USA; Department of Chemistry, Bristol-Myers Squibb Pharmaceutical Research Institute, PO Box 5400, Princeton, NJ, 08543, USACorrespondence[email protected]
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M. T. Obermeier Department of Metabolism and Pharmacokinetics, Preclinical Candidate Optimization, PO Box 5400, Princeton, NJ, 08543, USA; Department of Chemistry, Bristol-Myers Squibb Pharmaceutical Research Institute, PO Box 5400, Princeton, NJ, 08543, USA
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J. C. Barrish Department of Metabolism and Pharmacokinetics, Preclinical Candidate Optimization, PO Box 5400, Princeton, NJ, 08543, USA; Department of Chemistry, Bristol-Myers Squibb Pharmaceutical Research Institute, PO Box 5400, Princeton, NJ, 08543, USA
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S. Chong Department of Metabolism and Pharmacokinetics, Preclinical Candidate Optimization, PO Box 5400, Princeton, NJ, 08543, USA; Department of Chemistry, Bristol-Myers Squibb Pharmaceutical Research Institute, PO Box 5400, Princeton, NJ, 08543, USA
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A. M. Marino Department of Metabolism and Pharmacokinetics, Preclinical Candidate Optimization, PO Box 5400, Princeton, NJ, 08543, USA; Department of Chemistry, Bristol-Myers Squibb Pharmaceutical Research Institute, PO Box 5400, Princeton, NJ, 08543, USA
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N. Murugesan Department of Metabolism and Pharmacokinetics, Preclinical Candidate Optimization, PO Box 5400, Princeton, NJ, 08543, USA; Department of Chemistry, Bristol-Myers Squibb Pharmaceutical Research Institute, PO Box 5400, Princeton, NJ, 08543, USA
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D. Wang-Iverson Department of Metabolism and Pharmacokinetics, Preclinical Candidate Optimization, PO Box 5400, Princeton, NJ, 08543, USA; Department of Chemistry, Bristol-Myers Squibb Pharmaceutical Research Institute, PO Box 5400, Princeton, NJ, 08543, USA
&
R. A. Morrison Department of Metabolism and Pharmacokinetics, Preclinical Candidate Optimization, PO Box 5400, Princeton, NJ, 08543, USA; Department of Chemistry, Bristol-Myers Squibb Pharmaceutical Research Institute, PO Box 5400, Princeton, NJ, 08543, USA
 show all
Pages 1109-1123 | Received 11 Apr 2003, Published online: 22 Sep 2008

References

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