Publication Cover
Xenobiotica
the fate of foreign compounds in biological systems
Volume 33, 2003 - Issue 11
171
Views
19
CrossRef citations to date
0
Altmetric
Research Article

Sulfation of apomorphine by human sulfotransferases: evidence of a major role for the polymorphic phenol sulfotransferase, SULT1A1

&
Pages 1139-1148 | Received 30 May 2003, Published online: 22 Sep 2008

References

  • ARGIOLAS, A. and HEDLUND, H., 2001, The pharmacology and clinical pharmacokinetics of apomorphine SL. BJU International, 88(Suppl 3), 18–21.
  • BRADFORD, M. M., 1976, A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein—dye binding. Analytical Biochemistry, 72, 248–254.
  • COUGHTRIE, M. W. H., 2002, Sulfation through the looking glass — recent advances in sulfotransferase research for the curious. Pharmacogenomics Journal, 2, 297–308.
  • COUGHTRIE, M. W. H., GILISSEN, R. A. H. J., SHEK, B., STRANGE, R. C., FRYER, A. A., JONES, P. W. and BAMBER, D. E., 1999, Phenol sulphotransferase SULT1A1 polymorphism: molecular diagnosis and allele frequencies in Caucasian and African populations. Biochemical Journal, 337, 45–49.
  • DAJANI, R., CLEASBY, A., NEU, M., WONACOTT, A. J., JHuri, H., HOOD, A. M., Mom, S., HERSEY, A., TASKINEN, J., COOKE, R. M., MANCHEE, G. R. and COUGHTRIE, M. W. H., 1999a, X-ray crystal structure of human dopamine sulfotransferase, SULT1A3: Molecular modelling and QSAR analysis demonstrate a molecular basis for sulfotransferase substrate specificity. Journal of Biological Chemistry, 274, 37862–37868.
  • DAJANI, R., HOOD, A. M. and COUGHTRIE, M. W. H., 1998, A single amino acid, G1u14.6, governs the substrate specificity of a human dopamine sulfotransferase, SULT1A3. Molecular Pharmacology, 54, 942–948.
  • DAJANI, R., SHARP, S., GRAHAM, S., BETHELL, S. S., COOKE, R. M., JAMIESON, D. J. and COUGHTRIE, M. W. H., 1999b, Kinetic properties of human dopamine sulfotransferase (SULT1A3) expressed in prokaryotic and eukaryotic systems: comparison with the recombinant enzyme purified from Escherichia coli. Protein Expression and Purification, 16, 11–18.
  • DOOLEY, T. P., Haldeman-CAHILL, R., JOINER, J. and WILBORN, T. W., 2000, Expression profiling of human sulfotransferase and sulfatase gene superfamilies in epithelial tissues and cultured cells. Biochemical and Biophysical Research Communications, 277, 236–245.
  • FOLDES, A. and MEEK, J. L., 1973, Rat brain phenolsulfotransferase — partial purification and some properties. Biochimica et Biophysica Acta, 327, 365–374.
  • GANCHER, S. T., NUTT, J. G. and WOODWARD, W. R., 1991, Absorption of apomorphine by various routes in Parkinsonism. Movement Disorders, 6, 212–216.
  • GANCHER, S. T., WOODWARD, W. R., BOUCHER, B. and NUTT, J. G., 1989, Peripheral pharmacokinetics of apomorphine in humans. Annals of Neurology, 26, 232–238.
  • HEROUX, J. A., FALANY, C. N. and ROTH, J. A., 1989, Immunological characterization of human phenol sulfotransferase. Molecular Pharmacology, 36, 29–33.
  • HONMA, W., SHIMADA, M., SASANO, H., OZAWA, S., MIYATA, M., NAGATA, K., IKEDA, T. and YAMAZOE, Y., 2002, Phenol sulfotransferase, ST1A3, as the main enzyme catalyzing sulfation of troglitazone in human liver. Drug Metabolism and Disposition, 30, 944–949.
  • JANKOVIC, J. and MARSDEN, D., 1998, Therapeutic strategies in Parkinson's disease. In J. Jankovic and E. Tolosa (eds), Parkinson's Disease and Movement Disorders, 3rd edn (Baltimore: Williams & Wilkins), pp. 191–220.
  • JONES, A. L., ROBERTS, R. C. and COUGHTRIE, M. W. H., 1993, The human phenolsulfotransferase polymorphism is determined by the level of expression of the enzyme protein. Biochemical Journal, 296, 287–290.
  • O'SULLIVAN, J. D. and LEES, A. J., 1999, Use of apomorphine in Parkinson's disease. Hospital Medicine, 60, 816–820.
  • PIETZ, K., HAGELL, P. and ODIN, P., 1998, Subcutaneous apomorphine in late stage Parkinson's disease: a long term follow up. Journal of Neurology, Neurosurgery and Psychiatry, 65, 709-716. RAFTOGIANIS, R. B., 2001, Human sulfotransferases and cellular response to estrogens and antiestrogens. Drug Metabolism Reviews, 33(Suppl 1), 10.
  • RAFTOGIANIS, R. B., WOOD, T. C., OTTERNESS, D. M., Van LOON, J. A. and WEINSHILBOUM, R. M., 1997, Phenol sulfotransferase pharmacogenetics in humans: Association of common SULT1A1 alleles with TS PST phenotype. Biochemical and Biophysical Research Communications, 239, 298–304.
  • RAFTOGIANIS, R. B., WOOD, T. C. and WEINSHILBOUM, R. M., 1999, Human phenol sulfotransferases SULT1A2 and SULT1A1. Genetic polymorphisms, allozyme properties, and human liver genotype-phenotype correlations. Biochemical Pharmacology, 58, 605–616.
  • RICHARD, K., HUME, R., KAPTEIN, E., STANLEY, E. L., VISSER, T. J. and COUGHTRIE, M. W. H., 2001, Sulfation of thyroid hormone and dopamine during human development — ontogeny of phenol sulfotransferases and arylsulfatase in liver, lung and brain. Journal of Clinical Endocrinology and Metabolism, 86, 2734–2742.
  • RUBIN, G. L., HARROLD, A. J., MILLS, J. A., FALANY, C. N. and COUGHTRIE, M. W. H., 1999, Regulation of sulfotransferase expression in the endometrium during the menstrual cycle, by oral contraceptives and during early pregnancy. Molecular Human Reproduction, 5, 995–1002.
  • RUBIN, G. L., SHARP, S., JONES, A. L., GLATT, H., MILLS, J. A. and COUGHTRIE, M. W. H., 1996, Design, production and characterisation of antibodies discriminating between the phenol- and monoamine-sulphating forms of human phenol sulphotransferase. Xenobiotica, 26, 1113–1119.
  • STANLEY, E. L., HUME, R., VISSER, T. J. and COUGHTRIE, M. W. H., 2001, Differential expression of sulfotransferase enzymes involved in thyroid hormone metabolism during human placental development. Journal of Clinical Endocrinology and Metabolism, 86, 5944–5955.
  • STROTT, C. A., 2002, Sulfonation and molecular action. Endocrine Reviews, 23, 703–732.
  • TASKINEN, J., ETHELL, B., LAUTALA, P., HOOD, A. M., BURCHELL, B. and COUGHTRIE, M. W. H., 2003, Conjugation of catechols by recombinant human sulfotransferases, UDP-glucuronosyltrans-ferases and soluble catechol 0-methyltransferase. Drug Metabolism and Disposition, 31, 1187–1197.
  • VIETRI, M., VAGLINI, F., CANTINI, R. and PACIFICI, G. M., 2003, Quercetin inhibits the sulfation of R(—)-apomorphine in human brain. International Journal of Clinical Pharmacology and Therapeutics, 41, 30–35.
  • VIETRI, M., VAGLINI, F., PIETRABISSA, A., SPISNI, R., MOSCA, F. and PACIFICI, G. M., 2002, Sulfation of R(—)-apomorphine in the human liver and duodenum, and its inhibition by mefenamic acid, salicylic acid and quercetin. Xenobiotica, 32, 587–594.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.