Publication Cover
Xenobiotica
the fate of foreign compounds in biological systems
Volume 34, 2004 - Issue 2
99
Views
9
CrossRef citations to date
0
Altmetric
Research Article

Pharmacokinetics and metabolism of 14C-1,3-dichloropropene in the Fischer 344 rat and the B6C3F1 mouse

, , , , , & show all
Pages 193-213 | Received 07 Jul 2003, Published online: 22 Sep 2008

Reference

  • BANIJAMALI, A. R., Xu, Y., STRUNK, R. J., GAY, M. H., ELLIS, M. C., PUTTERMAN, G. J. and SUMNER, S. J., 1999, Identification of metabolites of [1,2,3-13C]propargyl alcohol in rat urine by 13C NMR and mass spectrometry. Journal of Agriculture and Food Chemistry, 47, 1717–1729.
  • BARTELS, M. J., BRZAK, K. A., MENDRALA, A. M. and STOTT, W. T., 2000, Mechanistic aspects of the metabolism of 1,3-dichloropropene in the rat and mouse. Chemical Research in Toxicology, 13, 1096–1102.
  • BOND, J. A., MEDINSKY, M. A., DUTCHER, J. S., HENDERSON, R. F., CHENG, Y. S., MEWHINNEY, J. A. and BIRNBAUM, L. S., 1985, Disposition and metabolism of 2,3114C]dichloropropene in rats after inhalation. Toxicology and Applied Pharmacology, 78, 47–54.
  • BUDAVARI, S., 1996, In The Merck Index: An Encyclopedia of Chemicals, Drugs and Biologicals (Whitehouse Station: Merck), p. 520.
  • CLIMIE, I., HUTSON, D., MORRISON, B. and STOYDIN, G., 1979, Glutathione conjugation in the detoxification of (Z)-1,3-dichloropropene (a component of the nematocide D-D) in the rat. Xenobiotica, 9, 149–156.
  • DOMORADZKI, J. Y., STEWART, H. S., MENDRALA, A. L., GILBERT, J. R. and MARKHAM, D. A., 1996, Comparison of the metabolism and tissue distribution of 14C-labeled spinosyn A and 14C-labeled spinosyn D in Fischer 344 rats. Toxicologist, 30, 35.
  • EDER, E. and DORNBUSCH, K., 1988, Metabolism of 2,3-dichloro-1-propene in the rat. Drug Metabolism and Disposition, 16, 60–68.
  • FISHER, G. D. and KILGORE, W. W., 1988, Mercapturic acid excretion by rats following inhalation exposure to 1,3-dichloropropene. Fundamentals in Applied Toxicology, 11, 300–307.
  • GINGELL, R., MITSCHKE, H. R., DZIDIC, I., BEATTY, P. W., SAWIN, V. L. and PAGE, A. C., 1985, Disposition and metabolism of [2-14C]epichlorohydrin after oral administration to rats. Drug Metabolism and Disposition, 13, 333–341.
  • HUTSON, D. H., Moss, J. A. and PICKERING, B. A., 1971, The excretion and retention of components of the soil fumigant D-D* and their metabolites in the rat. Fundamentals in Cosmetic Toxicology, 9, 677–680.
  • KAYE, C. M., CLAPP, J. J. and YOUNG, L., 1972, The metabolic formation of mercapturic acids from allyl halides. Xenobiotica, 2, 129–139.
  • KE2it, S., MONSTER, A. C., VERPLANKE, J. W. and DE WOLFF, F. A., 1996, Dermal absorption of cis-1,3-dichloropropene vapour: human experimental exposure. Human Experimental Toxicology, 15, 396–399.
  • MUTLIB, A. E., CHEN, H., NEMETH, G., GAN, L.-S. and CHRIST, D. D., 1999, Liquid chromatography/ mass spectrometry and high-field nuclear magnetic resonance characterization of novel mixed diconjugates of the non-nucleoside human immunodeficiency virus-1 reverse transcriptase inhibitor, efavirenz. Drug Metabolism and Disposition, 27, 1045–1056.
  • NATARAJAN, V., SCHMID, H. H. and SASTRY, P. S., 1984, Biosynthesis of long-chain alcohols by developing and regenerating rat sciatic nerve. Journal of Neurochemistry, 43, 328–334.
  • ONKENHOUT, W., MULDER, P. P. J., BOOGARD, P. J., BUIJS, W. and VERMEULEN, N. P. E., 1986, Identification and quantitative determination of mercapturic acids formed from Z- and E-1,3-dichloropropene by the rat, using gas chromatography with three different detection techniques. Archives in Toxicology, 59, 235–224.
  • OSTERLOH, J. D., COHEN, B.-S., POPENDORF, W. and POND, S. M., 1984, Urinary excretion of the N-acetyl cysteine conjugate of cis-1,3-dichloropropene by exposed individuals. Archives of Environmental Health, 39, 271–275.
  • SCHNEIDER, M., QUISTAD, G. B. and CASIDA, J. E., 1998, 1,3-Dichloropropene epoxides: intermediates in the bioactivation of the promutagen 1,3-dichloropropene. Chemical Research in Toxicology, 11, 1137–1144.
  • TIMCHALK, C., SMITH, F. A. and BARTELS, M. J., 1994, Route-dependent comparative metabolism of 14C]toluene 2,4-diisocyanate and [14C]toluene 2,4-diamine in Fischer 344 rats. Toxicology and Applied Pharmacology, 124, 181–190.
  • VAN WELIE, R. T. H., VAN DUYN, P., BROUWER, D. H., VAN HEMMEN, J. J., BROUWER, E. J. and VERMEULEN, N. P. E., 1991, Inhalation exposure to 1,3-dichloropropene in the Dutch flower-bulb culture. Part II. Biological monitoring by measurement of urinary excretion of two mercapturic acid metabolites. Archives in Environmental Contamination and Toxicology, 20, 6–12.
  • WORLD HEALTH ORGANIZATION, 1993, 1,3-Dichloropropene, 1,2-Dichloropropane and Mixtures. Environmental Health Criteria 146 (Geneva: WHO).

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.