Advanced search
Publication Cover
Xenobiotica
the fate of foreign compounds in biological systems
Volume 33, 2003 - Issue 12
Submit an article Journal homepage
50
Views
2
CrossRef citations to date
0
Altmetric
Research Article

Pharmacokinetics and metabolism of NO-1886, a lipoprotein lipase-promoting agent, in cynomolgus monkey

Y. Morioka Division of Pharmacology, Drug Safety and Metabolism, Otsuka Pharmaceutical Factory, Inc., 115 Tateiwa, Muya-cho, Naruto, Tokushima 772-8601, JapanCorrespondence[email protected]
,
M. Harada Division of Pharmacology, Drug Safety and Metabolism, Otsuka Pharmaceutical Factory, Inc., 115 Tateiwa, Muya-cho, Naruto, Tokushima 772-8601, Japan
,
T. Imai Faculty of Pharmaceutical Sciences, Kumamoto University, 5-1 Oe-honmachi, Kumamoto 862-0973, Japan
&
S. Naito Division of Pharmacology, Drug Safety and Metabolism, Otsuka Pharmaceutical Factory, Inc., 115 Tateiwa, Muya-cho, Naruto, Tokushima 772-8601, Japan
Pages 1247-1260 | Received 07 Jul 2003, Published online: 22 Sep 2008

References

  • CHIBA, T., MIURA, S., SAWAMURA, F., UETSUKA, R., TOMITA, I., INouE, Y., TSUTSUMI, K. and TOMITA, T., 1997, Antiatherogenic effects of a novel lipoprotein lipase-enhancing agent in cholesterol-fed New Zealand white rabbits. Arteriosclerosis Thrombosis and Vascular Biology, 17, 2601–2608.
  • EISENBERG, S., 1984, High density lipoprotein metabolism. Journal of Lipid Research, 25, 1017–1058.
  • FRANK, N., CAESAR, R., SCHERF, H. R. and WIESSLER, M., 1986, Influence of the carboxylesterase inhibitor bis-p-nitrophenylphosphate on the rates of hydrolysis of various alpha-esters of 1-(N-methyl-N-nitrosamino)-methanol in vitro and in vivo and on the acute toxicity and carcinogenicity of 1-(N-methyl-N-nitrosamino)-methylacetate. Journal of Cancer Research and Clinical Oncology, 111, 98–102.
  • GORDEN, D. J. and RIFKING, B. M., 1989, Current concepts: high-density lipoprotein: The clinical implications of recent studies. New England Journal of Medicine, 321, 1311–1316.
  • GRABEN, R. D. and PARSONS, D. L., 1988, Effects of a perfluorochemical blood substitute on diazepam binding by human albumin. Journal of Pharmacy and Pharmacology, 40, 684–688.
  • HOSOKAWA, S., TAGAWA, 0., MIKAMI, T., NOZAKI, Y. and KAWAGUCHI, A., 1992, A new rat mutant with chronic conjugated hyperbilirubinemia and renal glomerular lesions. Laboratory Animal Science, 42, 27–34.
  • MORDENTI, J., 1986, Man versus beast: pharmacokinetic scaling in mammals. Journal of Pharmaceutical Sciences, 75, 1028–1040.
  • MORIOKA, Y., OHMIZO, M., HARADA, M., GOTO, K., NAITO, S. and TSUTSUMI, K., 1996, Metabolism of diethyl 4-[(4-bromo-2-cyanopheny1)-carbamoyl] benzyl-phosphonate in the rat. Xenobiotica, 26, 853–861.
  • MORIOKA, Y., OTSU, M., NAITO, S. and Iwo, T., 2002, Phosphonate 0-deethylation of [4-(4-bromo-2-cyano-phenylcarbamoyl) benzyl]-phosphonic acid diethyl ester, a lipoprotein lipase-promoting agent, catalyzed by cytochrome P450 2C8 and 3A4 in human liver microsomes. Drug Metabolism and Disposition, 30, 301–306.
  • SATOH, T. and HOSOKAWA. M., 1998, The mammalian carboxylesterases: from molecule to functions. Annual Review of Pharmacology and Toxicology, 38, 257–288.
  • TSUTSUMI, K., INouE, Y., HAGI, A. and MURASE, T., 1997, The novel compound N0-1886 elevates plasma high-density lipoprotein cholesterol levels in hamsters and rabbits by increasing lipoprotein lipase without any effect on cholesterol ester transfer protein activity. Metabolism: Clinical and Experimental, 46, 257–260.
  • TSUTSUMI, K., INouE, Y., SHIMA, A., IWASAKI, K., KUWAMURA, M. and MURASE, T., 1993, The novel compound NO-1886 increases lipoprotein lipase activity with resulting elevation of high lipoprotein cholesterol, and long-term administration inhibits atherogenesis in the coronary arteries of rats with experimental atherosclerosis. Journal of Clinical Investigation, 92, 411–417.
  • TSUTSUMI, K., INouE, Y., SHIMA, A. and MURASE, T., 1995, Correction of hypertriglyceridemia with low high-density lipoprotein cholesterol by the novel compound NO-1886, a lipoprotein lipase-promoting agent, in STZ-induced diabetic rats. Diabetes, 44, 414–417.
  • YAMAOKA, K., NAKAGAWA, T. and UNO, T., 1978, Statistical moments in pharmacokinetics. Journal of Pharmacokinetics and Biopharmaceutics, 6, 547–558.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.