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Xenobiotica
the fate of foreign compounds in biological systems
Volume 33, 2003 - Issue 12
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Research Article

LC-MS-MS analysis of 2-pyridylacetic acid, a major metabolite of betahistine: application to a pharmacokinetic study in healthy volunteers

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Pages 1261-1271 | Received 28 Jul 2003, Published online: 22 Sep 2008

References

  • BOTTA, L., MIRA, E., VALLI, S., ZUCCA, G., BENVENUTI, C., FOSSATI, A., SOTO, E., GUTH, P. and VALLI, P., 2001, Effects of betahistine and of its metabolites on vestibular sensory organs. Acta Otorhinolaryngolica Italica, 21, 24-30.
  • CHAVEZ, H., VEGA, R., VALLI, P., MIRA, E., BENVENUTI, C., GUTH, P. S. and SOTO, E., 2001, Action mechanism of betahistine in the vestibular end organs. Acta Otorhinolaryngolica Italica, 21, 8-15.
  • CHEN, X. Y., ZHONG, D. F., HAN, Y. and XIE, Z. Y., Determination of carbocysteine in human plasma by liquid chromatography/tandem mass spectrometry employing pre-column derivatization. Rapid Communications in Mass Spectrometry, 17, 192-196.
  • DOUGLAS, J. F. and HOHING, T. L., 1978, GLC determination of betahistine in serum. Experientia, 34, 499-500.
  • FOSSATI, A., BARONE, D. and BENVENUTI, C., 2001, Binding affinity profile of betahistine and its metabolites for central histamine receptors of rodents. Pharmacology Research, 43, 389-392.
  • GATER, P. R., WEBBER, S. E., GUI, G. P., JORDAN, C. C., HAYES, N. A. and ASHFORD, J. J. and FOREMAN, J. C., 1986, Some studies of the action of betahistine at H1 and H2 receptors for histamine. Agents Actions, 18, 342-350.
  • JIMENEZ, I., ANTON, E., PICANS, I. and JEREZ, J., 1996, Betahistine-induced bronchospasm. Allergy, 51, 185-188.
  • LACOUR,M. and STERKERS, O., 2001, Histamine and betahistine in the treatment of vertigo: elucidation of mechanisms of action. CNS Drugs, 15, 853-870.
  • MIRA, E., GUIDETTI, G., GHILARDI, L., FATTORI, B., MALANNINO, N., MAIOLINI, L., MORA, R., OTTOBONI, S., PAGNINI, P., LEPRINI, M., PALLESTRINI, E., PASSALI, D., NUTI, D., RUSSOLO, M., TIRELLI, G., SIMONCELLI, C., BRIZI, S., VINCI, C. and FRASCONI, P., 2003, Betahistine dihydrochloride in the treatment of peripheral vestibular vertigo. European Archives in Otorhinolaryngology, 260, 73-77.
  • STERNSON, L. A., TOBIA, A. J., WALSH, G. M. and STERNSON A. W., 1974, The metabolism of betahistine in the rat. Drug Metabolism and Disposition, 2, 123-128.

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