Advanced search
Publication Cover
Xenobiotica
the fate of foreign compounds in biological systems
Volume 34, 2004 - Issue 11-12
Submit an article Journal homepage
157
Views
22
CrossRef citations to date
0
Altmetric
Research Article

Identification of the cytochrome P450 enzymes involved in the metabolism of domperidone

C. Simard Faculté de Pharmacie, Université Laval, Québec, Canada; Faculté de Pharmacie, Université de Montréal, C.P. 6128, Succursale Centre-ville, Montréal, QC, Canada H3C 3J7Correspondence[email protected]
,
V. Michaud Faculté de Pharmacie, Université de Montréal, C.P. 6128, Succursale Centre-ville, Montréal, QC, Canada H3C 3J7
,
B. Gibbs MDS Pharma Services, St-Laurent, Canada
,
R. Massé MDS Pharma Services, St-Laurent, Canada
,
É Lessard AstraZeneca R&D Montréal, St-Laurent, Canada
&
J. Turgeon Faculté de Pharmacie, Université de Montréal, C.P. 6128, Succursale Centre-ville, Montréal, QC, Canada H3C 3J7
Pages 1013-1023 | Received 07 Oct 2004, Published online: 22 Sep 2008

Reference

  • BALDWIN, S. J., BLOOMER, J. C., SMITH, G. J., AYRTON, A. D., CLARKE, S. E. and CHENERY, R. J., 1995, Ketoconazole and sulphaphenazole as the respective selective inhibitors of P4503A and 2C9. Xenobiotica, 25, 261–270.
  • BARONE, J. A., 1999, Domperidone: a peripherally acting dopamine2-receptor antagonist. Annals of Pharmacotherapy, 33, 429–440.
  • BROGDEN, R. N., CARMINE, A. A., HEEL, R. C., SPEIGHT, T. M. and AVERY, G. S., 1982, Domperidone, A review of its pharmacological activity, pharmacokinetics and therapeutic efficacy in the symptomatic treatment of chronic dyspepsia and as an antiemetic. Drugs, 24, 360–400.
  • CAMERON, H. A., REYNTJENS, A. J. and LAKE-BAKAAR, G., 1985, Cardiac arrest after treatment with intravenous domperidone. British Medical Journal, 290, 160.
  • CHou, F., TZENG, S. and HUANG, J., 2001, Genetic polymorphism of cytochrome P450 3A5 in Chinese. Drug Metabolism and Disposition, 29, 1205–1209.
  • CLARKE, S. E., 1998, In vitro assessment of human cytochrome P450. Xenobiotica, 28, 1167-1202. DROLET, B., ROUSSEAU, G., DALEAU, P., CARDINAL, R. and TURGEON, J., 2000, Domperidone should not be considered a no-risk alternative to cisapride in the treatment of gastrointestinal motility disorders. Circulation, 102, 1883–1885.
  • HEYKANTS, J., HENDRICKX, R., MEULDERMANS, W., MICHIELS, M., SCHEYGROND, H. and REYNTJENS, H., 1981, On the pharmacokinetics of domperidone in animals and man IV. The pharmacokinetics of intravenous domperidone and its bioavailability in man following intramuscular, oral and rectal administration. European Journal of Drug Metabolism and Pharmacokinetics, 6, 61–70.
  • KUEHL, P., ZHANG, J., LIN, Y., LAMBA, J., ASSEM, M., SCHUETZ, J., WATKINS, P. B., DALY, A., WRIGHTON, S. A., HALL, S. D., MAUREL, P., RELLING, M., BRIMER, C., YASUDA, K., VENKATARAMANAN, R., STROM, S., THUMMEL, K., BOGUSKI, M. and SCHUETZ, E., 2001, Sequence diversity in CYP3A promoters and characterization of the genetic basis of polymorphic CYP3A5 expression. Nature Genetics, 27, 383–391.
  • LESSARD, E., HAMELIN, B. A., LABBE, L., O'HARA, G. E., BELANGER, P. and TURGEON, J., 1999, Involvement of CYP2D6 activity in the N-oxidation of procainamide in man. Pharmacogenetics, 9, 683–696.
  • MEULDERMANS, W., HURKMANS, R., SWYSEN, E., HENDRICKX, J., MICHIELS, M., LAUWERS, W. and HEYKANTS, J., 1981, On the pharmacokinetics of domperidone in animals and man III. Comparative study on the excretion and metabolism of domperidone in rats, dogs and man. European Journal of Drug Metabolism and Pharmacokinetics, 6, 49–60.
  • NEWTON, D., WANG, R. and Lu, A. H. Y., 1995. Cytochrome P450 inhibitors: Evaluation of specificities in the in vitro metabolism of therapeutic agents by human liver microsomes. Drug Metabolism and Disposition, 23, 154–158.
  • OSBORNE, R. J., SLEVIN, M. L., HUNTER, R. W. and HAMER, J., 1985a, Cardiac arrhythmias during cytotoxic chemotherapy: role of domperidone. Human Toxicology, 4, 617–626.
  • OSBORNE, R. J., SLEVIN, M. L., HUNTER, R. W. and HAMER, J., 1985b, Cardiotoxicity of intravenous domperidone. Lancet, ii, 385.
  • PRAKASH, A. and WAGSTAFF, A. J., 1998, Domperidone: A review of its use in diabetic gastropathy. Drugs, 56, 429–445.
  • QUINN, N., PARKES, D., JACKSON, G. and UPWARD, J., 1985, Cardiotoxicity of domperidone. Lancet, 28, 724.
  • ROUSSAK, J. B., CAREY, P. and PARRY, H., 1984, Cardiac arrest after treatment with intravenous domperidone. British Medical Journal, 289, 1579.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.