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Xenobiotica
the fate of foreign compounds in biological systems
Volume 35, 2005 - Issue 1
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Research Article

Identification of glutathione conjugates and mercapturic acids of 1,2-dibromopropane in female BALB/c mice by liquid chromatography-electrospray ionization tandem mass spectrometry

S. K. Lee College of Pharmacy, Yeungnam University, Kyungsan, Korea
,
C. H. Jin College of Pharmacy, Yeungnam University, Kyungsan, Korea
,
S. H. Hyun College of Pharmacy, Yeungnam University, Kyungsan, Korea
,
D. W. Lee College of Pharmacy, Yeungnam University, Kyungsan, Korea
,
G. H. Kim College of Pharmacy, Yeungnam University, Kyungsan, Korea
,
T. W. Jeon College of Pharmacy, Yeungnam University, Kyungsan, Korea
,
J Lee College of Pharmacy, Yeungnam University, Kyungsan, Korea
,
D. H. Kim Bioanalysis and Biotransformation Research Center, Korea Institute of Science and Technology, Chungryang, Seoul, Korea
,
H. G. Jeong College of Pharmacy, Chosun University, Gwangju, KoreaCorrespondence[email protected]
,
E. S. Lee College of Pharmacy, Yeungnam University, Kyungsan, Korea
&
T. C. Jeong College of Pharmacy, Yeungnam University, Kyungsan, Korea
 show all
Pages 97-105 | Received 19 Aug 2004, Published online: 22 Sep 2008

Reference

  • Barnsley EA, Grenby TH, Young L. 1966. Biochemical studies of toxic agents: the metabolism of 1- and 2-bromopropane in rats. Biochemical Journal 100:282–288.
  • James SP, Pue MA, Richards DH. 1981. Metabolism of 1,3-dibromoproprane. Toxicology Letters 8:7–15.
  • Kim DH, Guengerich FP. 1990. Formation of the DNA adduct S12-(N7-guanypethyl]glutathione from ethylene dibromide: effects of modulation of glutathione and glutathione S-transferase levels and lack of a role for sulfation. Carcinogenesis 11:419–424.
  • Kim DH, Humphreys WG, Guengerich FP. 1990. Characterization of S12-(N'-adenypethyl]glutathione as an adduct formed in RNA and DNA from 1,2-dibromoethane. Chemical Research in Toxicology 3:587–594.
  • Kim NH, Hyun SH, Jin CH, Lee SK, Lee DW, Jeon TW, Choi CB, Lee ES, Chae W, Jeong TC. 2003. Acute effects of 2-bromopropane and 1,2-dibromopropane on hepatotoxic and immunotoxic parameters in female BALB/c mice. Archives of Pharmacal Research 26:943–950.
  • Lag M, Omichinski JG, Brunborg G, Dybing E, Nelson SD, Soderlund EJ. 1994. Mutagenic activity of halogenated propanes and propenes: effect of bromine and chlorine positioning. Chemico-Biological Interactions 93:73–84.
  • Lag M, Soderlund EJ, Omichinski JG, Brunborg G, Holme JA, Dahl JE, Nelson SD, Dybing E. 1991. Effect of bromine and chlorine positioning in the induction of renal and testicular toxicity by halogenated propanes. Chemical Research in Toxicology 4:528–534.
  • Loughlin AF, Skiles GL, Alberts DW, Schaefer WH. 2001, An ion exchange liquid chromatography/mass spectrometry method for the determination of reduced and oxidized glutathione and glutathione conjugates in hepatocytes. Journal of Pharmaceutical and Biomedical Analysis 26:131–142.
  • Prabhu S, Fackett A, Lloyd S, McClellan HA, Terrell CM, Silber PM, Li AP. 2002. Identification of glutathione conjugates of troglitazone in human hepatocytes. Chemico-Biological Interactions 142:83–97.
  • Stolzenberg SJ, Hine CH. 1980. Mutagenicity of 2- and 3-carbon halogenated compounds in the Salmonellal mammalian-microsome test. Environmental and Molecular Mutagenesis 2:59–66.
  • Volgel E, Chandler JLR. 1974. Mutagenicity testing of cyclamate and some pesticides in Drosophila melanogaster. Experientia 30:621–623.
  • Zhu M, Decaprio AP, Hauer CR, Spink DC. 1997. Characterization of glutathione conjugates of pyrrolylated amino acids and peptides by liquid chromatography-mass spectrometry and tandem mass spectrometry with electrospray ionization. Journal of Chromatography B 688:187–196.
  • Zoetemelk CEM, Oei IHB, Van Meeteren-Walchli, Onkenhout W, Van der A. Gen, Breimer DD. 1986. Biotransformation of 1,2-dibromopropane in rats into four mercapturic acid derivatives. Drug Metabolism and Disposition 14:601–607.

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