Transport, transformation and distribution space of propofol in the rat liver studied by means of the indicator-dilution technique

Reference

• BARON, E., AHUMADA, F., LeDERS, C., SAAVEDRA, I. and ZAMBUCETTI, R., 2000, Farmacocinetica de propofol en potrillos de 10 a 15 dias de edad. Archivos de Medicina Veterinaria, 32, 193–200. BJöRcK, . and DAHLQUIST, G., 1972, Numerische Methoden (Munich: Oldenburg).
   Google Scholar
• BRACHT, A., IsHII-IwAmoTo, E. L. and SALGUEIRO-PAGADIGORRIA, C., 2003b, Tecnicas de centrifugaçâo e fracionamento celular. In A. Bracht and E. L. Ishii-Iwamoto (eds), Metodos de Laboratório em Bioquimica (S5o Paulo: Manole), pp. 77–101.
   Google Scholar
• BRACHT, A., IsFm-IwAmoTo, E. L. and SALGUEIRO-PAGADIGORRIA, C. L., 2003a, 0 estudo do metabolismo energetic° em mitocndrias isoladas de tecido animal. In A. Bracht and E. L. Ishii-Iwamoto (eds), Metodos de Laboratório em Bioquimica (S5o Paulo: Manole), pp. 227–247.
   Google Scholar
• BRACHT, A., SCHWAB, A. J. and ScHoLz, R., 1980, Untersuchung von Flugeschwindigkeiten in der isoliert perfundierten Rattenleber durch Pulsmarkierung mit radioaktiven Substraten und mathematischer Analyse der Auswaschkinetiken. Hoppe—Seyler's Zeitschrift fur Physiologische Chemie, 361, 357–377.
   PubMedGoogle Scholar
• BRANCA, D., ROBERT, M. S., LORENZIN, P., VINCENT, E. and SCUTARI, G., 1991b, Influence of the anaesthetic 2,6-diisopropylphenol on the oxidative phosphorylation of isolated rat liver mitochondria. Biochemical Pharmacology, 42, 87–90.
   Google Scholar
• BRANCA, D., ROBERT, M. S., VINCENT, E. and SCUTARI, G., 1991a, Uncoupling effect of the general anaesthetic 2,6-diisopropylphenol in isolated rat liver mitochondria. Archives of Biochemistry and Biophysics, 290, 517–521.
   Google Scholar
• COURT, M. H., DUAN, S. X., HESSE, L. M., VENKATAKRISHNAN, K. and GREENBLATT, D. J., 2001, Cytochrome P-450 2B6 is responsible for interindividual variability of propofol hydroxylation by human liver microsomes. Anesthesiology, 94, 110–119.
   PubMed Web of Science ®Google Scholar
• COURT, M. H., Hay-KRAus, B. L., HILL, D. W., KIND, A. J. and GREEBBLATT, D. J., 1999, Propofol hydroxylation by dog liver microsomes: assay development and dog breed differences. Drug Metabolism and Disposition, 27, 1293–1299.
   Google Scholar
• ENGDAHL, 0., ABRAHAMS, M., BJORNSSON, A., VEGFORS, M., NORLANDER, B., AHLNER, J. and EINTREI, C., 1998, Cerebrospinal fluid concentrations of propofol during anaesthesia in humans. British Journal of Anaesthesia, 81, 957–959.
   Google Scholar
• FAVETTA, P., GUITTON, J., DEGOUTE, C. S., VAN DAELE, L. and BOULIEU, R., 2000, High-performance liquid chromatographic assay to detect hydroxylate and conjugate metabolites of propofol in human urine. Journal of Chromatography B, 742, 25–35.
   PubMed Web of Science ®Google Scholar
• FERRARESI-FILHO, 0., FERRARESI, M. L., CONSTANTIN, J., IsFm-IwAmoTo, E. L., SCHWAB, A. J. and BRACHT, A., 1992, Transport and metabolism of palmitate in the rat liver. Net flux and unidirectional fluxes across the cell membrane. Biochimica et Biophysica Acta, 1103, 239–249.
   Google Scholar
• GORESKY, C. A., BACH, G. G. and ROSE, C. P., 1983b, Effects of saturating metabolic uptake on space profiles and tracer kinetics. American Journal of Physiology, 244, G215—G232.
   Google Scholar
• GORESKY, C. A., GORDON, E. R. and BACH, G. G., 1983a, Uptake of monohydric alcohols by liver: demonstration of a shared enzymic space. American Journal of Physiology, 244, G198—G214. GORESKY, C. A., ZIEGLER, W. H. and BACH, G. G., 1970, Capillary exchange modelling. Barrier-limited and flow-limited distribution. Circulation Research, 27, 739–764.
   Google Scholar
• Ism', E. L., SCHWAB, A. J. and BRACHT, A., 1987, Inhibition of monosaccharide transport in the intact rat liver by stevioside. Biochemical Pharmacology, 36, 1417–1433.
   Google Scholar
• ITINOSE, A. M., DOI-SAKUNO, M. L. and BRACHT, A., 1989, Metabolic effects of acetaminophen. Studies in the isolated perfused rat liver. Cell Biochemistry and Function, 7, 263–273.
   Google Scholar
• ITINOSE, A. M., DOI-SAKUNO, M. L. and BRACHT, A., 1995, Induction of paracetamol biotrans-formation in the rat liver by ry-hexachlorocyclohexane. Research Communications in Alcohol and Substances of Abuse, 16, 177–188.
   Google Scholar
• KANTO, J. and GEPTS, E., 1989, Pharmacokinetic implications for the clinical use of propofol. Clinical Pharmacokinetics, 17, 308–206.
   PubMed Web of Science ®Google Scholar
• KELMER-BRACHT, A. M., IsFm-IwAmoTo, E. L. and BRACHT, A., 1993, Transport, distribution space and intracellular concentration of the anti-inflammatory drug niflumic acid in the perfused rat liver. Biochemical Pharmacology, 45, 1863–1871.
   Google Scholar
• LARIJANI, G. E., GRATZ, I., AFSHAR, M. and JAcom, A. G., 1989, Clinical pharmacology of propofol: an intravenous anaesthetic agent. DICP: the Annals of Pharmacotherapy, 23, 743–749.
   Google Scholar
• LOPEZ, M. M. and KosK-KosicKA, D., 1997, Entropy-driven interactions of anaesthetics with membrane proteins. Biochemistry, 36, 8864–8872.
   Google Scholar
• LOWRY, 0. H., ROSEBROUGH, N. J., FARR, A. L. and RANDALL, R. J., 1951, Protein measurement with the Folin reagent. Journal of Biological Chemistry, 193, 265–275.
   Google Scholar
• McGurac, K., BRIERLEY, C. H. and BURCHELL, B., 1998, Drug glucuronidation by human renal UDP-glucuronosyltransferases. Biochemical Pharmacology, 55, 1005–1012.
   Google Scholar
• MEIER, P. and ZIERLER, K. L., 1954, On the theory of the indicator dilution method for measurement of blood flow and volume. Journal of Applied Physiology, 6, 731–744.
   PubMed Web of Science ®Google Scholar
• MIRENDA, J. and BROYLES, G., 1995, Propofol as used for sedation in the ICU. Chest, 108, 539–548.
   Google Scholar
• MOORE, L., CHEN, T., KNAPP, R. and LONDON, E. J., 1975, Energy-dependent calcium sequestration activity in rat liver microsomes. Journal of Biological Chemistry, 250, 4562–4568.
   PubMed Web of Science ®Google Scholar
• RAOOF, A. A., AUGUSTIJNS, P. F. and VERBEECK, R. K., 1996a, In vivo assessment of intestinal, hepatic and pulmonary first pass metabolism of propofol in the rat. Pharmacological Research, 13, 891–895.
   Google Scholar
• RAOOF, A. A., OBBERGH, L. J. VAN, VILLE DE GOYET, J. DE and VERBEECK, R. K., 1996b, Extrahepatic glucuronidation of propofol in man: possible contribution of gut wall and kidney. European Journal of Clinical Pharmacology, 50, 91–96.
   Google Scholar
• SCHOLZ, R. and BUCHER, T., 1965, Hemoglobin-free perfusion of rat liver. In B. Chance, R. W. Estabrook and J. R. Williamson (eds), Control of Energy Metabolism (New York: Academic Press), pp. 393–414.
   Google Scholar
• SERVIN, F., DESMONTS, J. M., HABERER, J. P., COCKSHOTT, I. D., PLUMMER, G. F. and FARINOTTI, R., 1988, Pharmacokinetics and protein binding of propofol in patients with cirrhosis. Anesthesiology, 69, 887–891.
   PubMed Web of Science ®Google Scholar
• SHAFER, S. L., 1993, Advances in propofol pharmacokinetics and pharmacodynamics. Journal of Clinical Anesthesia, 5, 14S–21S.
   Google Scholar
• SHAFER, A., DOZE, V. A., SHAFER, S. L. and WHITE, P. F., 1988, Pharmacokinetics and pharmaco-dynamics of propofol infusions during general anesthesia. Anesthesiology, 69, 348–356.
   PubMed Web of Science ®Google Scholar
• SHIMIZU, M., MATSUMOTO, Y., TATSUNO, M. and FUKUOKA, M., 2003, Glucuronidation of propofol and its analogs by human and rat liver microsomes. Biological and Pharmaceutical Bulletin, 26, 216–219.
   PubMed Web of Science ®Google Scholar
• SIMONS, P. J., COCKSHOTT, I. D., DOUGLAS, E. J., GORDON, E. A., KNOTT, S. and RUANE, R. J., 1991, Distribution in females of an anaesthetic intravenous dose of 14C-propofol. Xenobiotica, 21, 1325–1335.
   PubMed Web of Science ®Google Scholar
• TONNER, P. H., POPPERS, D. M. and MILLER, K. W., 1992, The general anesthetic potency of propofol and its dependence on hydrostatic pressure. Anesthesiology, 77, 926–931.
   Google Scholar
• TSUCHIYA, H., 2001, Structure-specific membrane-fluidizing effect of propofol. Clinical and Experimental Pharmacology and Physiology, 28, 292–299.
   PubMed Web of Science ®Google Scholar
• Voss, D. 0., CAMPELLO, A. P. and BACILA, M., 1961, The respiratory chain and the oxidative phosphorylation of rat brain mitochondria. Biochemical and Biophysical Research Communica-tions, 4, 48–51.
   Google Scholar
• VREE, T. B., LAGERWERF, A. J., BLEEKER, C. P. and DE GROOD, P. M., 1999, Direct high-performance liquid chromatography determination of propofol and its metabolite quinol with their glucuronide conjugates and preliminary pharmacokinetics in plasma and urine of man. Journal of Chromatography B, 721, 217–228.
   PubMed Web of Science ®Google Scholar
• WEAVER, B. M. Q., STADDON, G. E. and MAPLEsoN, W. W., 2001, Tissue/blood and tissue/water partition coefficients for propofol in sheep. British Journal of Anaesthesia, 86, 693–703. WILKINSON, G. N., 1961, Statistical estimations in enzyme kinetics. Biochemical Journal, 80, 423–332.
   Google Scholar
• ZORAN, D. L., RIEDESEL, D. H. and DYER, D. C., 1993, Pharmacokinetics of propofol in mixed-breed dogs and Greyhounds. American Journal of Veterinary Research, 54, 755–760.
   PubMed Web of Science ®Google Scholar