Publication Cover
Xenobiotica
the fate of foreign compounds in biological systems
Volume 34, 2004 - Issue 9
146
Views
36
CrossRef citations to date
0
Altmetric
Research Article

Identification of the novel canine CYP1A2 1117 C>T SNP causing protein deletion

, , &
Pages 835-846 | Received 29 Apr 2004, Published online: 22 Sep 2008

References

  • AKLILLU, E., CARRILLO, J. A., MAKONNEN, E., HELLMAN, K., PITARQUE, M., BERTILSSON, L. and INGELMAN-SUNDBERG, M., 2003, Genetic polymorphism of CYP1A2 in Ethiopians affecting induction and expression: characterization of novel haplotypes with single-nucleotide polymorphisms in intron 1. Molecular Pharmacology, 64, 659–669.
  • ALLORGE, D., CHEVALIER, D., Lo-GumicE, J. M., CAUFFIEZ, C., SUARD, F., BAUMANN, P., EAP, C. B. and BROLY, F., 2003, Identification of a novel splice-site mutation in the CYP1A2 gene. British Journal of Clinical Pharmacology, 56, 341–344.
  • AZUMA, R., KOMURO, M., KAWAGUCHI, Y., OKUDAIRA, K., HAYASHI, M. and KIWADA, H., 2002, Comparative analysis of in vitro and in vivo pharmacokinetic parameters related to individual variability of GTS-21 in canine. Drug Metabolism Pharmacokinetics, 17, 75–82.
  • BERTZ, R. J. and GRANNEMAN, G. R., 1997, Use of in vitro and in vivo data to estimate the likelihood of metabolic pharmacokinetic interactions. Clinical Pharmacokinetics, 32, 210–258.
  • BLAISDELL, J., GOLDSTEIN, J. A. and BAI, S. A., 1998, Isolation of a new canine cytochrome P450 cDNA from the cytochrome P450 2C subfamily (CYP2C41) and evidence for polymorphic differences in its expression. Drug Metabolism and Disposition, 26, 278–283.
  • CIACCIO, P. J., GRAVES, P. E., BOURQUE, D. P., GLINSMANN-GIBSON, B. and HALPERT, J. R., 1991, cDNA and deduced amino acid sequences of a dog liver cytochrome P-450 of the IIIA gene subfamily. Biochimica et Biophysica Acta, 1088, 319–322.
  • COLEMAN, T., ELLIS, S. W., MARTIN, I. J., LENNARD, M. S. and TUCKER, G. T., 1996, 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) is N-demethylated by cytochromes P450 2D6, 1A2 and 3A4 - implications for susceptibility to Parkinson's disease. Journal of Pharmacology and Experimental Therapeutics, 277, 685–690.
  • FRASER, D. J., FEYEREISEN, R., HARLOW, G. R. and HALPERT, J. R., 1997, Isolation, heterologous expression and functional characterization of a novel cytochrome P450 3A enzyme from a canine liver cDNA library. Journal of Pharmacology and Experimental Therapeutics, 283, 1425–1432.
  • FURUTA, T., OHASHI, K., KOSUGE, K., ZHAO, X. J., TAKASHIMA, M., KIMURA, M., NISHIMOTO, M., HANAI, H., KANEKO, E. and IsHiz.ARI, T., 1999, CYP2C19 genotype status and effect of omeprazole on intragastric pH in humans. Clinical Pharmacology and Therapeutics, 65, 552–561.
  • GOODERHAM, N. J., MURRAY, S., LYNCH, A. M., EDWARDS, R. J., YADOLLAHI-FARSANI, M., BRATT, C., RICH, K. J., ZHAO, K., MURRAY, B. P., BHADRESA, S., CROSBIE, S. J., BOOBIS, A. R. and DAVIES, D. S., 1996, Heterocyclic amines: evaluation of their role in diet associated human cancer. British Journal of Clinical Pharmacology, 42, 91–98.
  • GRAHAM-LORENCE, S. E. and PETERSON, J. A., 1996, Structural alignments of P450s and extrapolations to the unknown. Methods in Enzymology, 272, 315–326.
  • GRAVES, P. E., ELHAG, G. A., CIACCIO, P. J., BOURQUE, D. P. and HALPERT, J. R., 1990, cDNA and deduced amino acid sequences of a dog hepatic cytochrome P450IIB responsible for the metabolism of 2,2',4,4',5,5'-hexachlorobiphenyl. Archives of Biochemistry and Biophysics, 281, 106–115.
  • IWATA, M., TAKAYAMA, K., HISAMICHI, H., KUBOTA, H., KAWANO, N., AOKI, M. and IsomuRA, Y., 1998, Synthetic studies on selective type IV phosphodiesterase (PDEIV) inhibitors. III. In 216th American Chemical Society National Meeting Book of Abstracts Part 2 Medical Chemistry Division 47 (ACS).
  • KAGIMOTO, M., HEIM, M., KAGIMOTO, K., ZEUGIN, T. and MEYER, U. A., 1990, Multiple mutations of the human cytochrome P450IID6 gene (CYP2D6) in poor metabolizers of debrisoquine. Study of the functional significance of individual mutations by expression of chimeric genes. Journal of Biological Chemistry, 265, 17209–17214.
  • LANKFORD, S. M., BAI, S. A. and GOLDSTEIN, J. A., 2000, Cloning of canine cytochrome P450 2E1 cDNA: Identification and characterization of two variant alleles. Drug Metabolism and Disposition, 28, 981–986.
  • MISE, M., YADERA, S., MATSUDA, M., HASHIZUME, T., MATSUMOTO, S., TERAUCHI, Y. and FUJII, T., 2004, Polymorphic expression of CYP1A2 leading to interindividual variability in metabolism of a novel benzodiazepine receptor partial inverse agonist in dogs. Drug Metabolism and Disposition, 32, 240–245.
  • MURAYAMA, N., SOYAMA, A., SAITO, Y., NAKAJIMA, Y., KOMAMURA, K., UENO, K., KAMAKURA, S., KITAKAZE, M., KIMURA, H., GOTO, Y., SAITOH, O., KATOH, M., OHNUMA, T., KAWAI, M., SUGAI, K., OHTSUKI, T., SUZUKI, C., MINAMI, N., OZAWA, S. and SAWADA, J., 2004, Six novel nonsynonymous CYP1A2 gene polymorphisms: catalytic activities of the naturally occurring variant enzymes. Journal of Pharmacology and Experimental Therapeutics, 308, 300–306.
  • NAKAJIMA, M., YOKOI, T., MIZUTANI, M., KINOSHITA, M., FUNAYAMA, M. and KAMATAKI, T., 1999, Genetic polymorphism in the 5'-flanking region of human CYP1A2 gene: effect on the CYP1A2 inducibility in humans. Journal of Biochemistry, 125, 803–808.
  • NEBERT, D. W., 2000, Suggestions for the nomenclature of human alleles: relevance to ecogenetics, pharmacogenetics and molecular epidemiology. Pharmacogenetics, 10, 279–290.
  • NELSON, D. R., KOYMANS, L., KAMATAKI, T., STEGEMAN, J. J., FEYEREISEN, R., WAXMAN, D. J., WATERMAN, M. R., GOTOH, O., COON, M. J., ESTABROOK, R. W., GUNSALUS, I. C. and NEBERT, D. W., 1996, P450 superfamily: update on new sequences, gene mapping, accession numbers and nomenclature. Pharmacogenetics, 6, 1–42.
  • PAULSON, S. K., ENGEL, L., REITZ, B., BOLTEN, S., BURTON, E. G., MAZIASZ, T. J., YAN, B. and SCHOENHARD, G. L., 1999, Evidence for polymorphism in the canine metabolism of the cyclooxygenase 2 inhibitor, celecoxib. Drug Metabolism and Disposition, 27, 1133–1142.
  • PELKONEN, O., MAENPAA, J., TAAVITSAINEN, P., RAUTIO, A. and RAUNIO, H., 1998, Inhibition and induction of human cytochrome P450 (CYP) enzymes. Xenobiotica, 28, 1203–1253.
  • SAKAMOTO, K., KIRITA, S., BABA, T., NAKAMURA, Y., YAMAZOE, Y., KATO, R., TAKANAKA, A. and MATSUBARA, T., 1995, a new cytochrome P450 form belonging to the CYP2D in dog liver microsomes: purification, cDNA cloning, and enzyme characterization. Archives of Biochemistry and Biophysics, 319, 372–382.
  • SALAVAGGIONE, O. E., KIDD, L., PRONDZINSKI, J. L., SZUMLANSKI, C. L., PANKRATZ, V. S., WANG, L., TREPANIER, L. and WEINSHILBOUM, R. M., 2002, Canine red blood cell thiopurine S-methyltransferase: companion animal pharmacogenetics. Pharmacogenetics, 12, 713–724.
  • SHOU, M., NORCROSS, R., SANDIG, G., Lu, P., Li, Y., LIN, Y., MEI, Q., RODRIGUES, A. D. and RUSHMORE, T. H., 2003, Substrate specificity and kinetic properties of seven heterologously expressed dog cytochromes p450. Drug Metabolism and Disposition, 31, 1161–1169.
  • SULLIVAN-KLOSE, T. H., GHANAYEM, B. I., BELL, D. A., ZHANG, Z. Y., KAMINSKY, L. S., SHENFIELD, G. M., MINERS, J. O., BIRKETT, D. J. and GOLDSTEIN, J. A., 1996, The role of the CYP2C9-Leu359 allelic variant in the tolbutamide polymorphism. Pharmacogenetics, 6, 341–349.
  • TENMIZU, D., FUKUNAGA, Y., NOGUCHI, K. and KAMIMURA, H., 2004, Simultaneous determination of YM-64227, a phosphodiesterase type 4 inhibitor, and its five metabolites in dog plasma by high-performance liquid chromatography with fluorescence detection. Biomedical Chromatog-raphy (in press).
  • TIRONA, R. G., LEAKE, B. F., MERINO, G. and Kim, R. B., 2001, Polymorphisms in OATP-C. Identification of multiple allelic variants associated with altered transport activity among European- and African-Americans. Journal of Biological Chemistry, 276, 35669–35675.
  • UCHIDA, T., KOMORI, M., KITADA, M. and KAMATAKI, T., 1990, Isolation of cDNAs coding for three different forms of liver microsomal cytochrome P-450 from polychlorinated biphenyl-treated beagle dogs. Molecular Pharmacology, 38, 644–651.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.