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Xenobiotica
the fate of foreign compounds in biological systems
Volume 34, 2004 - Issue 7
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Research Article

Differences in the metabolism and pharmacokinetics of two structurally similar PPAR agonists in dogs: involvement of taurine conjugation

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Pages 665-674 | Received 20 Apr 2004, Published online: 22 Sep 2008

Reference

  • BERGER, J. and MOLLER, D., 2002, The mechanisms of action of PPARs. Annual Review of Medicine, 53, 409–435.
  • CALDWELL, J., 1982, Metabolism of functional groups. In W. B. Jakoby, J. R. Bend and J. Caldwell (eds), Metabolic Basis of Detoxication (New York: Academic Press), pp. 271–290.
  • CALDWELL, J., EMUDIANUGHE, T. S. and SMITH, R. L., 1979, Species variation in the taurine conjugation of clofibric acid. British Journal of Pharmacology, 66, 421P–422P.
  • DESVERGENE, B. and WAHLI, W., 1999, Peroxisome proliferator-activated receptors: nuclear control of metabolism. Endocrinology Review, 20, 649–688.
  • DIXON, P. A., CALDWELL, J. and SMITH, R. L., 1977, Metabolism of arylacetic acids. The fate of 1-naphthylacetic acid and its variation with species and dose. Xenobiotica, 7, 695–706.
  • EMUDIANUGHE, T. S., CALDWELL, J., SINCLAIR, K. A. and SMITH, R. L., 1983, Species differences in the metabolic conjugation of clofibric acid and clofibrate in laboratory animals and man. Drug Metabolism and Disposition, 11, 97–102.
  • EMUDIANUGHE, T. S., CALDWELL, J. and SMITH, R. L., 1987, Comparative metabolic conjugation of 1- and 2-naphthylacetic acids in the guinea pig, mouse, hamster and gerbil. Xenobiotica, 17, 15–21.
  • EZZET, F., KRISHNA, G., WEXLER, D. B., STATKEVICH, P., KOSOGLOU, T. and BATRA, V. K., 2001, A population phamacokinetic model that describes multiple peaks due to enterohepatic recirculation of ezetimibe. Clinical Therapeutics, 23, 871–885.
  • HUTT, A. J. and CALDWELL, J., 1990, Amino acid conjugation. In G. J. Mulder (ed.), Conjugation Reactions in Drug Metabolism (London: Taylor & Francis), pp. 273–305.
  • KERSTEN, 5, DESVERGENE, B. and WAHLI, W., 2000, Roles of PPARs in health and disease. Nature, 405,421–423.
  • KILLENBERG, P. G. and WEBSTER, L. T., 1980, In W. B. Jakoby (ed.), Enzymatic Basis of Detoxication II (New York: Academic Press), pp. 141–167.
  • KOYAMA, H., MILLER, D. J., BOUERES, J. K., DESAI, R. C., JONES, A. B., BERGER, J. P., MACNAUL, K. L., KELLY, L. J., DOEBBER, T. W., Wu, M. S., ZHOU, G., WANG, P.-R., IPPOLITO, M. C., CHAO, Y.-S., AGRAWAL, A. K., FRANKLIN, R., HECK, J. V., WRIGHT, S. D., MOLLER, D. E. and SAHOO, S. P., 2004, (2R)-2-ethylchromane-2-carboxylic acids: discovery of novel PPARa/y dual agonists as antihyperglycemic and hypolipidemic agents. Journal of Medicinal Chemistry, 47, 3255–3263.
  • LEVY, G. and GIACOMINI, K. M., 1978, Rational aspirin dosage regimens. Clinical Pharmacology and Therapeutics, 23, 247–252.
  • LEVY, G., 1965a, Salicylurate formation — demonstration of Michaelis—Menten kinetics in man. Journal of Pharmaceutical Sciences, 54, 96.
  • LEVY, G., 1965b, Pharmacokinetics of salicylate elimination in man. Journal of Pharmaceutical Sciences, 54, 959–967.
  • LEVY, G., TSUCHIYA, T. and AMSEL, L. P., 1972, Limited capacity for salicyl phenolic glucuronide formation and its effect on the kinetics of salicylate elimination in man. Clinical Pharmacology and Therapeutics, 13, 258–268.
  • GUELLET, D. M. C. and POLLACK, G. M., 1995 Biliary excretion and enterohepatic recirculation of morphine-3-glucuronide in rats. Drug Metabolism and Disposition, 23, 487–494.
  • PATRICK, J. E., KOSOGLOU, T., STAUBER, K. L., ALTON, K. B., MAXWELL, S. E., ZHU, Y. L., STATKEVICH, P., IANNUCCI, R., CHOWDHURY, S., AFFRIME, M. and CAYEN, M. N., 2002, Disposition of the selective cholesterol absorption inhibitor ezetimibe in healthy male subjects. Drug Metabolism and Disposition, 30, 430–437.
  • ROBERTS, M. S., MAGNUSSON, B. M., BURCZYNSKI, F. J. and WEISS, M., 2002, Enterohepatic circulation — physiological, pharmacokinetic and clinical implications. Clinical Pharmaco-kinetics, 41, 751–790.
  • SCHOONJANS, K., STAELA, B. and AUWERX, J., 1996, The peroxisome proliferator activated receptors (PPARs) and their effects on lipid metabolism and adipocyte differentiation. Biochimica et Biophysica Acta, 1302, 93–109.
  • WAHLI,W., BRAISSANT, 0. and DESVERGNE, B., 1995, Peroxisome proliferator activated receptors: transcriptional regulators of adipogenesis, lipid metabolism and more. Chemistry and Biology, 2, 261–266.

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