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Xenobiotica
the fate of foreign compounds in biological systems
Volume 34, 2004 - Issue 7
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Research Article

Cross-talk between xenobiotic detoxication and other signalling pathways: clinical and toxicological consequences

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Pages 633-664 | Received 22 Mar 2004, Published online: 22 Sep 2008

Reference

  • ABDEL-RAZZAK, Z., LOYER, P., FAUTREL, A., GAUTIER, J. C., CORCOS, L., TURLIN, B., BEAUNE, P. and Gun,',ouzo, A., 1993, Cytokines down-regulate expression of major cytochrome P-450 enzymes in adult human hepatocytes in primary culture. Molecular Pharmacology, 44,707–715.
  • ACHATZ, G., HOLZL, B., SPECKMAYER, R., HAUSER, C., SANDHOFER, F. and PAULWEBER, B., 1997, Functional domains of the human orphan receptor ARP-1/COUP-TFII involved in active repression and transrepression. Molecular Cell Biology, 17, 4914–4932.
  • ApcocK, I. M. and CARAMORI, G., 2001, Cross-talk between pro-inflammatory transcription factors and glucocorticoids. Immunology and Cell Biology, 79, 376–384.
  • AKIYAMA, T. E. and GONZALEZ, F. J., 2003, Regulation of P450 genes by liver-enriched transcription factors and nuclear receptors. Biochimica et Biophysica Acta, 1619, 223–234.
  • AKNER, G., WIKSTROM, A. C. and GUSTAFSSON, J. A., 1995, Subcellular distribution of the glucocorticoid receptor and evidence for its association with microtubules. Journal of Steroid Biochemistry and Molecular Biology, 52, 1–16.
  • Aso, T., CONAWAY, J. W. and CONAWAY, R. C., 1995, The RNA polymerase II elongation complex. FASEB Journal, 9, 1419–1428.
  • ASSENAT, E., GERBAL-CHALOIN, S., LARREY, D., SARIC, J., FABRE, J. M., MAUREL, P., VILAREM, M. J. and PASCUSSI, J. M., 2004, Interleukin-113 suppresses CAR-induced expression of hepatic genes involved in drug and bilirubin clearance: role of NFkB in CAR gene repression. Hepatology (in press).
  • AUERBACH, S. S., RAMSDEN, R., STONER, M. A., VERLINDE, C., HASSETT, C. and OMIECINSKI, C. J., 2003, Alternatively spliced isoforms of the human constitutive androstane receptor. Nucleic Acids Research, 31, 3194–3207.
  • AUMAIS, J. P., LEE, H. S., DEGANNES, C., HORSFORD, J. and WHITE, J. H., 1996, Function of directly repeated half-sites as response elements for steroid hormone receptors. Journal of Biological Chemistry, 271, 12568–12577.
  • BABA, T., MIMURA, J., GRADIN, K., KUROIWA, A., WATANABE, T., MATSUDA, Y INAZAWA, J., SOGAWA, K. and FUJII-KURIYAMA, Y., 2001, Structure and expression of the Ah receptor repressor gene. Journal of Biological Chemistry, 276, 33101–33110.
  • BAES, M., GULICK, T., CHOI, H. S., MARTINOLI, M. G., SIMHA, D. and MOORE, D. D., 1994, A new orphan member of the nuclear hormone receptor superfamily that interacts with a subset of retinoic acid response elements. Molecular Cell Biology, 14, 1544–1551.
  • BARKER, C. W., FAGAN, J. B. and PASCO, D. S., 1992, Interleukin-1 beta suppresses the induction of P4501A1 and P4501A2 mRNAs in isolated hepatocytes. Journal of Biological Chemistry, 267, 8050–8055.
  • BEELMAN, C. A. and PARKE R., 1995, Degradation of mRNA in eukaryotes. Cell, 81, 179–183.
  • BEIGNEUX, A. P., MOSER, A. H., SHIGENAGA, J. K., GRUNFELD, C. and FEINGOLD, K. R., 2002, Reduction in cytochrome P-450 enzyme expression is associated with repression of CAR (constitutive androstane receptor) and PXR (pregnane X receptor) in mouse liver during the acute phase response. Biochemical and Biophysical Research Communications, 293, 145–149.
  • BEISCHLAG, T. V., WANG, S., ROSE, D. W., TORCHIA, J., REISZ-PORSZASZ, S., MUHAMMAD, K., NELSON, W. E., PROBST, M. R., ROSENFELD, M. G. and HANKINSON, 0., 2002, Recruitment of the NCoA/ SRC-1/p160 family of transcriptional coactivators by the aryl hydrocarbon receptor/aryl hydrocarbon receptor nuclear translocator complex. Molecular Cell Biology, 22, 4319–4333.
  • BELANDIA, B. and PARKER, M. G., 2003, Nuclear receptors: a rendezvous for chromatin remodeling factors. Cell, 114, 277–280.
  • BEN-CHETRIT, E. and LEVY, M., 1998, Colchicine: 1998 update. Seminars in Arthritis and Rheumatism, 28, 48–59.
  • BERTILSSON, G., HEIDRICH, J., SVENSSON, K., ASMAN, M., JENDEBERG, L., SYDOW-BACKMAN, M., OHLSSON, R., POSTLIND, H., BLOMQUIST, P. and BERKENSTAM, A., 1998, Identification of a human nuclear receptor defines a new signaling pathway for CYP3A induction. Proceedings of the National Academy of Sciences, USA, 95, 12208–12213.
  • BLACKWOOD, E. M. and KADONAGA, J. T., 1998, Going the distance: a current view of enhancer action. Science, 281, 61–63.
  • BLUMBERG, B., KANG, H., BOLADO, J., JR, CHEN, H., CRAIG, A. G., MORENO, T. A., UMESONO, K., PERLMANN, T., DEROBERTIS, E. M. and EVANS, R. M., 1998a, BXR, an embryonic orphan nuclear receptor activated by a novel class of endogenous benzoate metabolites. Genes and Development, 12, 1269–1277.
  • BLUMBERG, B., SABBAGH, W., JR, JUGUILON, H., BOLADO, J., JR, VAN METER, C. M., ONG, E. S. and EVANS, R. M., 1998b, SXR, a novel steroid and xenobiotic-sensing nuclear receptor. Genes and Development, 12, 3195–3205.
  • BOCK, K. W., 1994, Aryl hydrocarbon or dioxin receptor: biologic and toxic responses. Reviews in Physiology, Biochemistry and Pharmacology, 125, 1–42.
  • BOURGUET, W., GERMAIN, P. and GRONEMEYER, H., 2000, Nuclear receptor ligand-binding domains: three-dimensional structures, molecular interactions and pharmacological implications. Trends in Pharmacology Science, 21, 381–388.
  • BRIVANLOU, A. H. and DARNELL, J. E., JR, 2002, Signal transduction and the control of gene expression. Science, 295, 813–818.
  • BRODIE, M. J., BOOBIS, A. R., HILLYARD, C. J., ABEYASEKERA, G., STEVENSON, J. C., MACINTYRE, I. and PARK, B. K., 1982, Effect of rifampicin and isoniazid on vitamin D metabolism. Clinical Pharmacology and Therapy, 32, 525–530.
  • BRZOZOWSKI, A. M., PIKE, A. C., DAUTER, Z., HUBBARD, R. E., BONN, T., ENGSTROM, 0., OHMAN, L., GREENE, G. L., GUSTAFSSON, J. A. and CARLQUIST, M., 1997, Molecular basis of agonism and antagonism in the oestrogen receptor. Nature, 389, 753–758.
  • BURBACH, K. M., POLAND, A. and BRADFIELD, C. A., 1992, Cloning of the Ah-receptor cDNA reveals a distinctive ligand-activated transcription factor. Proceedings of the National Academy of Sciences, USA, 89, 8185–8189.
  • CHAN, T. Y., 1996, Osteomalacia during rifampicin and isoniazid therapy is rare in Hong Kong. International Journal of Clinical Pharmacology and Therapy, 34, 533–534.
  • CHAN, W. K., YAO, G., Gu, Y. Z. and BRADFIELD, C. A., 1999, Cross-talk between the aryl hydrocarbon receptor and hypoxia inducible factor signaling pathways. Demonstration of competition and compensation. Journal of Biological Chemistry, 274, 12115–12123.
  • CHEN, Y., FERGUSON, S. S., NEGISHI, M. and GOLDSTEIN, J. A., 2003, Identification of constitutive androstane receptor and glucocorticoid receptor binding sites in the CYP2C19 promoter. Molecular Pharmacology, 64, 316–324.
  • COMMITTEE, N. R. N., 1999, A unified nomenclature system for the nuclear receptor superfamily. Cell, 97, 161–163.
  • COONEY, A. J., LENG, X., TSAI, S. Y., O'MALLEY, B. W. and TSAI, M. J., 1993, Multiple mechanisms of chicken ovalbumin upstream promoter transcription factor-dependent repression of transactivation by the vitamin D, thyroid hormone, and retinoic acid receptors. Journal of Biological Chemistry, 268, 4152–4160.
  • CRAMER, P., BUSHNELL, D. A. and KORNBERG, R. D., 2001, Structural basis of transcription: RNA polymerase II at 2. 8 angstrom resolution. Science, 292, 1863–1876.
  • CURTIS, D., LEHMANN, R. and ZAMORE, P. D., 1995, Translational regulation in development. Cell, 81, 171–178.
  • DANIELSSON, C., MATHIASEN, I. S., JAMES, S. Y., NAYERI, S., BRETTING, C., HANSEN, C. M., COLSTON, K. W. and CARLBERG, C., 1997, Sensitive induction of apoptosis in breast cancer cells by a novel 1,25-dihydroxyvitamin D3 analogue shows relation to promoter selectivity. Journal of Cell Biochemistry, 66, 552–562.
  • DAUJAT, M., CHARRASSE, S., FABRE, I., LESCA, P., JOUNAIDI, Y., LARROQUE, C., POELLINGER, L. and MAUREL, P., 1996, Induction of CYP1A1 gene by benzimidazole derivatives during Caco-2 cell differentiation. Evidence for an aryl-hydrocarbon receptor-mediated mechanism. European Journal of Biochemistry, 237, 642–652.
  • DEVIrro, M. J., THOMAS, T., MARTIN, E., UMBREIT, T. H. and GALLO, M. A., 1992, Antiestrogenic action of 2,3,7,8-tetrachlorodibenzo-p-dioxin: tissue-specific regulation of estrogen receptor in CD1 mice. Toxicology and Applied Pharmacology, 113, 284–292.
  • DIAZ, D., FABRE, I., DAUJAT, M., Saint AUBERT, B., BORIES, P., MICHEL, H. and MAUREL, P., 1990, Omeprazole is an aryl hydrocarbon-like inducer of human hepatic cytochrome P450. Gastroenterology, 99, 737–747.
  • DOTZLAW, H., LEYGUE, E., WATSON, P. and MURPHY, L. C., 1999, The human orphan receptor PXR messenger RNA is expressed in both normal and neoplastic breast tissue. Clinical Cancer Research, 5, 2103–2107.
  • DROCOURT, L., OURLIN, J. C., PASCUSSI, J. M., MAUREL, P. and VILAREM, M. J., 2002, Expression of CYP3A4, CYP2B6, and CYP2C9 is regulated by the vitamin D receptor pathway in primary human hepatocytes. Journal of Biological Chemistry, 277, 25125–25132.
  • DUAN, R., PORTER, W., SAMUDIO, I., VYHLIDAL, C., KLADDE, M. and SAFE, S., 1999, Transcriptional activation of c-fos protooncogene by 17beta-estradiol: mechanism of aryl hydrocarbon receptor-mediated inhibition. Molecular Endocrinology, 13, 1511–1521.
  • DUSSAULT, I., Yoo, H. D., LIN, M., WANG, E., FAN, M., BATTA, A. K., SALEN, G., ERICKSON, S. K. and FORMAN, B. M., 2003, Identification of an endogenous ligand that activates pregnane X receptor-mediated sterol clearance. Proceedings of the National Academy of Sciences, USA, 100, 833–838.
  • DVORAK, Z., MODRIANSKY, M., PICHARD-GARCIA, L., BALAGUER, P., VILAREM, M. J., ULRICHOVA, J., MAUREL, P. and PASCUSSI, J. M., 2003, Colchicine down-regulates cytochrome P450 2B6, 2C8, 2C9, and 3A4 in human hepatocytes by affecting their glucocorticoid receptor-mediated regulation. Molecular Pharmacology, 64, 160–169.
  • DZELETOVIC, N., McGuIEE, J., DAUJAT, M., THOLANDER, J., EMA, M., FUJII-KURIYAMA, Y., BERGMAN, J., MAUREL, P. and POELLINGER, L., 1997, Regulation of dioxin receptor function by omeprazole. Journal of Biological Chemistry, 272, 12705–12713.
  • EDWARDS, D. P., 1999, Coregulatory proteins in nuclear hormone receptor action. Vitamins and Hormones, 55, 165–218.
  • EcucHI, H., IEuTA, T., TACHIBANA, T., YONEDA, Y. and KAwAimi, K., 1997, A nuclear localization signal of human aryl hydrocarbon receptor nuclear translocator/hypoxia-inducible factor lbeta is a novel bipartite type recognized by the two components of nuclear pore-targeting complex. Journal of Biological Chemistry, 272, 17640–17647.
  • EKINS, S., MIRNY, L. and SCHUETZ, E. G., 2002, A ligand-based approach to understanding selectivity of nuclear hormone receptors PXR, CAR, FXR, LXRalpha, and LXRbeta. Pharmacology Research, 19, 1788–1800.
  • EMA, M., HIROTA, K., MIMURA, J., ABE, H., YODOI, J., SOGAWA, K., POELLINGER, L. and FUJII-KURIYAMA, Y., 1999, Molecular mechanisms of transcription activation by HLF and HIF1 alpha in response to hypoxia: their stabilization and redox signal-induced interaction with CBP/p300. EMBO Journal, 18, 1905–1914.
  • FABER, K. N., MULLER, M. and JANSEN, P. L., 2003, Drug transport proteins in the liver. Advances in Drug Delivery Reviews, 55, 107–124.
  • FERNANDEZ-SALGUERO, P. M., WARD, J. M., SUNDBERG, J. P. and GONZALEZ, F. J., 1997, Lesions of aryl-hydrocarbon receptor-deficient mice. Veterinary Pathology, 34, 605–614.
  • FORMAN, B. M., TZAMELI, I., CHOI, H. S., CHEN, J., SIMHA, D., SEOL, W., EVANS, R. M. and MOORE, D. D., 1998, Androstane metabolites bind to and deactivate the nuclear receptor CAR-beta. Nature, 395, 612–615.
  • FRANCIS, G. A., FAYARD, E., PICARD, F. and AUWERX, J., 2003, Nuclear receptors and the control of metabolism. Annual Reviews in Physiology, 65, 261–311.
  • FRANK, C., GONZALEZ, M. M., OINONEN, C., DUNLOP, T. W. and CARLBERG, C., 2003, Characterization of DNA complexes formed by the nuclear receptor constitutive androstane receptor. Journal of Biological Chemistry, 278, 43299–43310.
  • FRASER, D. J., ZUMSTEG, A. and MEYER, U. A., 2003, Nuclear receptors constitutive androstane receptor and pregnane X receptor activate a drug-responsive enhancer of the murine 5-aminolevulinic acid synthase gene. Journal of Biological Chemistry, 278, 39392–39401.
  • GALIGNIANA, M. D., HOUSLEY, P. R., DEFRANCO, D. B. and PRATT, W. B., 1999, Inhibition of glucocorticoid receptor nucleocytoplasmic shuttling by okadaic acid requires intact cytoskeleton. Journal of Biological Chemistry, 274, 16222–16227.
  • GALIGNIANA, M. D., SCRUGGS, J. L., HERRINGTON, J., WELSH, M. J., CARTER-SU, C., HOUSLEY, P. R. and PRATT, W. B., 1998, Heat shock protein 90-dependent (geldanamycin-inhibited) movement of the glucocorticoid receptor through the cytoplasm to the nucleus requires intact cytoskeleton. Molecular Endocrinology, 12, 1903–1913.
  • GALVA N., JASKULA-SZTUL, R., MACWILLIAMS, P. S., CZUPRYNSKI, C. J. and JEFCOATE, C. R., 2003, Bone marrow cytotoxicity of benzo[a]pyrene is dependent on CYP1B1 but is diminished by Ah receptor-mediated induction of CYP1A1 in liver. Toxicology and Applied Pharmacology, 193, 84–96.
  • GARDNER-STEPHEN, D., HEYDEL, J. M., GOYAL, A., Lu, Y., XIE, W., LINDBLOM, T., MACKENZIE, P. and RADOMINSKA-PANDYA, A., 2004, Human PXR variants and their differential effects on the regulation of human UDP-glucuronosyltransferase gene expression. Drug Metabolism and Disposition, 32, 340–347.
  • GEICK, A., EICHELBAU M. and BURR, 0., 2001, Nuclear receptor response elements mediate induction of intestinal MDR1 by rifampin. Journal of Biological Chemistry, 276, 14581–14587.
  • GERBAL-CHALOIN, S., DAUJAT, M., PASCUSSI, J. M., PICHARD-GARCIA, L., VILAREM, M. J. and MAUREL, P., 2002, Transcriptional regulation of CYP2C9 gene. Role of glucocorticoid receptor and constitutive androstane receptor. Journal of Biological Chemistry, 277, 209–217.
  • GHOSH, S., 1999, Regulation of inducible gene expression by the transcription factor NF-kappaB. Immunology Research, 19, 183–189.
  • GIGUERE, V., 1999, Orphan nuclear receptors: from gene to function. Endocrine Reviews, 20, 689–725. GILLESBY, B. E., STANOSTEFANO, M., PORTER, W., SAFE, S., Wu, Z. F. and ZACHAREWSKI, T. R., 1997, Identification of a motif within the 5' regulatory region of p52 which is responsible for AP–1 binding and TCDD-mediated suppression. Biochemistry, 36, 6080-6089.
  • GLASS, C. K. and ROSENFELD, M. G., 2000, The coregulator exchange in transcriptional functions of nuclear receptors. Genes and Development, 14, 121–141.
  • GNATT, A. L., CRAMER, P., Fu, J., BUSHNELL, D. A. and KORNBERG, R. D., 2001, Structural basis of transcription: an RNA polymerase II elongation complex at 3.3 A resolution. Science, 292, 1876–1882.
  • GONZALEZ, F. J., 1992, Human cytochromes P450: problems and prospects. Trends in Pharmacology Science, 13, 346–352.
  • GONZALEZ, F. J. and Fernandez-SALoumo, P., 1998, The aryl hydrocarbon receptor: studies using the AHR-null mice. Drug Metabolism and Disposition, 26, 1194–1198.
  • GOODBOURN, 1996, Eukaryotic Gene Transcription (Oxford: IRL Press).
  • GOODWIN, B., GAUTHIER, K. C., UMETANI, M., WATSON, M. A., LOCHANSKY, M. I., COLLINS, J. L., LEITERSDORF, E., MANGELSDORF, D. J., KLIEWER, S. A. and REPA, J. J., 2003, Identification of bile acid precursors as endogenous ligands for the nuclear xenobiotic pregnane X receptor. Proceedings of the National Academy of Sciences, USA, 100, 223–228.
  • GOODWIN, B., HODGSON, E. and LIDDLE, C., 1999, The orphan human pregnane X receptor mediates the transcriptional activation of CYP3A4 by rifampicin through a distal enhancer module. Molecular Pharmacology, 56, 1329–1339.
  • GOODWIN, B., HODGSON, E., D'CosTA, D. J., ROBERTSON, G. R. and LIDDLE, C., 2002, Transcriptional regulation of the human CYP3A4 gene by the constitutive androstane receptor. Molecular Pharmacology, 62, 359–365.
  • GOODWIN, B., JONES, S. A., PRICE, R. R., WATSON, M. A., McKEE, D. D., MOORE, L. B., GALARDI, C., WILSON, J. G., LEWIS, M. C., ROTH, M. E., MALONEY, P. R., WILLSON, T. M. and KLIEWER, S. A., 2000, A regulatory cascade of the nuclear receptors FXR, SHP-1, and LRH-1 represses bile acid biosynthesis. Molecular Cell, 6, 517–526.
  • GOODWIN, B., MOORE, L. B., STOLTZ, C. M., MCKEE, D. D. and KLIEWER, S. A., 2001, Regulation of the human CYP2B6 gene by the nuclear pregnane X receptor. Molecular Pharmacology, 60, 427–431.
  • GRADIN, K., McGuirtE, J., WENGER, R. H., KVIETIKOVA, I., FHITELAW, M. L., TOFTGARD, R., TORA, L., GASSMANN, M. and POELLINGER, L., 1996, Functional interference between hypoxia and dioxin signal transduction pathways: competition for recruitment of the Arnt transcription factor. Molecular Cell Biology, 16, 5221–5231.
  • GROZINGER, C. M. and SCHREIBER, S. L., 2002, Deacetylase enzymes: biological functions and the use of small-molecule inhibitors. Chemistry and Biology, 9, 3–16.
  • GUSTAFSSON, J. A., 2003, What pharmacologists can learn from recent advances in estrogen signalling. Trends in Pharmacology Science, 24, 479–485.
  • HAHN, M. E., 1998, The aryl hydrocarbon receptor: a comparative perspective. Comp in Biochemistry and Physiology C: Pharmacology, Toxicology and Endocrinology, 121, 23–53.
  • HANDSCHIN, C., PODVINEC, M., AMHERD, R., LOOSER, R., OURLIN, J. C. and MEYER, U. A., 2002, Cholesterol and bile acids regulate xenosensor signaling in drug-mediated induction of cytochromes P450. Journal of Biological Chemistry, 277, 29561–29567.
  • HANDSCHIN, C., PODVINEC, M., STOCKLI, J., HOFFMANN, K. and MEYER, U. A., 2001, Conservation of signaling pathways of xenobiotic-sensing orphan nuclear receptors, chicken xenobiotic receptor, constitutive androstane receptor, and pregnane X receptor, from birds to humans. Molecular Endocrinology, 15, 1571–1585.
  • HANKINSON, 0., 1995, The aryl hydrocarbon receptor complex. Annual Reviews in Pharmacology and Toxicology, 35, 307–340.
  • HANNA-ROSE, W. and HANSEN, U., 1996, Active repression mechanisms of eukaryotic transcription repressors. Trends in Genetics, 12, 229–234.
  • HERTZ, R., MAGENHEIM, J., BERMAN, I. and BAR-TANA, J., 1998, Fatty acyl-CoA thioesters are ligands of hepatic nuclear factor-4alpha. Nature, 392, 512–516.
  • HILL, D., SHEDLOFSKY, S., MCCLAIN, C., DIEHL, A. M. and TSUKAMOTO, H., 1997, Cytokines in Health and Disease (New York), pp. 401–425.
  • HONKAKOSKI, P., ZELKO, I., SUEYOSHI, T. and NEGISHI, M., 1998, The nuclear orphan receptor CAR-retinoid X receptor heterodimer activates the phenobarbital-responsive enhancer module of the CYP2B gene. Molecular Cell Biology, 18, 5652–5658.
  • HUANG, W., ZHANG, J. and MOORE, D. D., 2004, A traditional herbal medicine enhances bilirubin clearance by activating the nuclear receptor CAR. Journal in Clinical Investigation, 113, 137–143.
  • HUANG, W., ZHANG, J., CHUA, S. S., QATANANI, M., HAN, Y., GRANATA, R. and MOORE, D. D., 2003, Induction of bilirubin clearance by the constitutive androstane receptor (CAR). Proceedings of the National Academy of Sciences, USA, 100, 4156–4161.
  • Huss, J. M. and KASPER, C. B., 1998, Nuclear receptor involvement in the regulation of rat cytochrome P450 3A23 expression. Journal of Biological Chemistry, 273, 16155–16162.
  • HUSTERT, E., ZIBAT, A., PRESECAN-SIEDEL, E., EISELT, R., MUELLER, R., Fuss, C., BREHM, I., BRINKMANN, U., EICHELBAUM, M., WOJNOWSKI, L. and BURR, 0., 2001, Natural protein variants of pregnane X receptor with altered transactivation activity toward CYP3A4. Drug Metabolism and Disposition, 29, 1454–1459.
  • IKUTA, T., EGUCHI, H., TACHIBANA, T., YONEDA, Y. and KAWAJIRI, K., 1998, Nuclear localization and export signals of the human aryl hydrocarbon receptor. Journal of Biological Chemistry, 273, 2895–2904.
  • ISRAEL, D. I., ESTOLANO, M. G., GALEAZZI, D. R. and WHITLOCK, J. P., JR, 1985, Superinduction of cytochrome P1-450 gene transcription by inhibition of protein synthesis in wild type and variant mouse hepatoma cells. Journal of Biological Chemistry, 260, 5648–5653.
  • JANA, N. R., SARKAR, S., ISHIZUKA, M., YONEMOTO, J., TOHYAMA, C. and SONE, H., 1999, Role of estradiol receptor-alpha in differential expression of 2,3,7,8-tetrachlorodibenzo-p-dioxin-inducible genes in the RL95-2 and KLE human endometrial cancer cell lines. Archives in Biochemistry and Biophysics, 368, 31–39.
  • JENUWEIN, T. and Aws, C. D., 2001, Translating the histone code. Science, 293, 1074–1080.
  • JOHANSSON, L., THOMSEN, J. S., DAMDIMOPOULOS, A. E., SPYROU, G., GUSTAFSSON, J. A. and TREUTER, E., 1999, The orphan nuclear receptor SHP inhibits agonist-dependent transcriptional activity of estrogen receptors ERalpha and ERbeta. Journal of Biological Chemistry, 274, 345–353.
  • JovER, R., BORT, R., GOMEZ-LECHON, M. J. and CASTELL, J. V., 2001, Cytochrome P450 regulation by hepatocyte nuclear factor 4 in human hepatocytes: a study using adenovirus-mediated antisense targeting. Hepatology, 33, 668–675.
  • KAMIYA, A., INouE, Y. and GONZALEZ, F. J., 2003, Role of the hepatocyte nuclear factor 4alpha in control of the pregnane X receptor during fetal liver development. Hepatology, 37, 1375-1384. KARIN, M., 1999, How NF-kappaB is activated: the role of the IkappaB kinase (IKK) complex. Oncogene, 18, 6867–6874.
  • KAST, H. R., GOODWIN, B., TARR, P. T., JONES, S. A., ANISFELD, A. M., STOLTZ, C. M., TONTONOZ, P., KLIEWER, S., WILLSON, T. M. and EDWARDS, P. A., 2002, Regulation of multidrug resistance-associated protein 2 (ABCC2) by the nuclear receptors pregnane X receptor, farnesoid X-activated receptor, and constitutive androstane receptor. Journal of Biological Chemistry, 277, 2908–2915.
  • KATO, S., 2000, The function of vitamin D receptor in vitamin D action. Journal of Biochemistry (Tokyo), 127, 717–722.
  • KAWAMOTO, T., SUEYOSHI, T., ZELKO, I., MOORE, R., WASHBURN, K. and NEGISHI, M., 1999, Phenobarbital-responsive nuclear translocation of the receptor CAR in induction of the CYP2B gene. Molecular Cell Biology, 19, 6318–6322.
  • KAWANA, K., IKUTA, T., KOBAYASHI, Y., GOTOH, 0., TAKEDA, K. and KAWAJIRI, K., 2003, Molecular mechanism of nuclear translocation of an orphan nuclear receptor, SXR. Molecular Pharmacology, 63, 524–531.
  • KAZLAUSKAS, A., SUNDSTROM, S., POELLINGER, L. and PONGRATZ, I., 2001, The hsp90 chaperone complex regulates intracellular localization of the dioxin receptor. Molecular Cell Biology, 21, 2594–2607.
  • KE, S., RABSON, A. B., GERMINO, J. F., GALLO, M. A. and TIAN, Y., 2001, Mechanism of suppression of cytochrome P-450 1A1 expression by tumor necrosis factor-alpha and lipopolysaccharide. Journal of Biological Chemistry, 276, 39638–39644.
  • KHATSENKO, 0. G., BOOBIS, A. R. and GROSS, S. S., 1997, Evidence for nitric oxide participation in down-regulation of CYP2B1/2 gene expression at the pretranslational level. Toxicology Letters, 90, 207–216.
  • KLIEWER, S. A., LEHMANN, J. M. and WILLSON, T. M., 1999, Orphan nuclear receptors: shifting endocrinology into reverse. Science, 284, 757–760.
  • KLIEWER, S. A., MOORE, J. T., WADE, L., STAUDINGER, J. L., WATSON, M. A., JoNEs, S. A., McKEE, D. D., OLIVER, B. B., WILLSON, T. M., ZETTERSTROM, R. H., PERLMANN, T. and LEHMANN, J. M., 1998, An orphan nuclear receptor activated by pregnanes defines a novel steroid signaling pathway. Cell, 92, 73–82.
  • KOBAYASHI, A., NUMAYAMA-TSURUTA, K., SOGAWA, K. and FUJII-KURIYAMA, Y., 1997, CBP/p300 functions as a possible transcriptional coactivator of Ah receptor nuclear translocator (Arnt). Journal of Biochemistry (Tokyo), 122, 703–710.
  • KOBAYASHI, K., SUEYOSHI, T., INouE, K., MOORE, R. and NEGISHI, M., 2003, Cytoplasmic accumulation of the nuclear receptor CAR by a tetratricopeptide repeat protein in HepG2 cells. Molecular Pharmacology, 64, 1069–1075.
  • KOYANO, S., KUROSE, K., SAITO, Y., OZAWA, S., HASEGAWA, R., KOMAMURA, K., UENO, K., KAMAKURA, S., KITAKAZE, M., NAKAJIMA, T., MATSUMOTO, K., AKASAWA, A., SAITO, H. and SAWADA, J., 2004, Functional characterization of four naturally occurring variants of human pregnane X receptor (PXR): one variant causes dramatic loss of both DNA binding activity and the transactivation of the CYP3A4 promoter/enhancer region. Drug Metabolism and Disposition, 32, 149–154.
  • KRISHNAN, V., PORTER, W., SANTOSTEFANO, M., WANG, X. and SAFE, S., 1995, Molecular mechanism of inhibition of estrogen-induced cathepsin D gene expression by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in MCF-7 cells. Molecular Cell Biology, 15, 6710–6719.
  • KTISTAKI, E. and TALIANIDIS, I., 1997, Chicken ovalbumin upstream promoter transcription factors act as auxiliary cofactors for hepatocyte nuclear factor 4 and enhance hepatic gene expression. Molecular Cell Biology, 17, 2790–2797.
  • KUMAR, M. B., TARPEY, R. W. and PERDEW, G. H., 1999, Differential recruitment of coactivator RIP140 by Ah and estrogen receptors. Absence of a role for LXXLL motifs. Journal of Biological Chemistry, 274, 22155–22164.
  • Kuo, C. J., CONLEY, P. B., CHEN, L., SLADEK, F. M., DARNELL, J. E., JR and CRABTREE, G. R., 1992, A transcriptional hierarchy involved in mammalian cell-type specification. Nature, 355, 457–461.
  • LECLUYSE, E. L., 2001, Pregnane X receptor: molecular basis for species differences in CYP3A induction by xenobiotics. Chemistry and Biology Interactions, 134, 283–289.
  • LEE, J., OBACH, R. and FISHER, M., 2003, Drug Metabolizing Enzymes. Cytochrome P450 and Other Enzymes in Drug Discovery and Development (Lausanne: FontisMedia SA and New York: Marcel Dekker).
  • LEE, T. I. and YOUNG, R. A., 2000, Transcription of eukaryotic protein-coding genes. Annual Reviews in Genetics, 34, 77–137.
  • LEHMANN, J. M., MCKEE, D. D., WATSON, M. A., WILLSON, T. M., MOORE, J. T. and KLIEWER, S. A., 1998, The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene expression and cause drug interactions. Journal in Clinical Investigation, 102, 1016–1023.
  • LI, J., NING, G. and DUNCAN, S. A., 2000, Mammalian hepatocyte differentiation requires the transcription factor HNF-4alpha. Genes and Development, 14, 464–474.
  • LI-MASTERS, T. and MORGAN, E. T., 2001, Effects of bacterial lipopolysaccharide on phenobarbital-induced CYP2B expression in mice. Drug Metabolism and Disposition, 29, 252–257.
  • LI-MASTERS, T. and MORGAN, E. T., 2002, Down-regulation of phenobarbital-induced cytochrome P4502B mRNAs and proteins by endotoxin in mice: independence from nitric oxide production by inducible nitric oxide synthase. Biochemical Pharmacology, 64, 1703–1711.
  • LIN, J. H. and Lu, A. Y., 1998, Inhibition and induction of cytochrome P450 and the clinical implications. Clinical Pharmacokinetics, 35, 361–390.
  • LIN, T. M., Ko, K., MOORE, R. W., SIMANAINEN, U., OBERLEY, T. D. and PETERSON, R. E., 2002, Effects of aryl hydrocarbon receptor null mutation and in utero and lactational 2,3,7,8-tetrachlorodibenzo-p-dioxin exposure on prostate and seminal vesicle development in C57BL/6 mice. Toxicology Science, 68, 479–487.
  • MA, Q., 2001, Induction of CYP1A1. The AhR/DRE paradigm: transcription, receptor regulation, and expanding biological roles. Current Drug Metabolism, 2, 149–164.
  • MAGLICH, J. M., PARKS, D. J., MOORE, L. B., COLLINS, J. L., GOODWIN, B., BILLIN, A. N., STOLTZ, C.
  • A., KLIEWER, S. A., LAMBERT, M. H., WILLSON, T. M. and MOORE, J. T., 2003, Identification of a novel human constitutive androstane receptor (CAR) agonist and its use in the identification of CAR target genes. Journal of Biological Chemistry, 278, 17277–17283.
  • MAKINEN, J., REINISALO, M., NIEMI, K., VIITALA, P., JYRKKARINNE, J., CHUNG, H., PELKONEN, 0. and HONKAKOSKI, P., 2003, Dual action of oestrogens on the mouse constitutive androstane receptor. Biochemistry Journal, 376, 465–472.
  • MAKISHIMA, M., Lu, T. T., XIE, W., WHITFIELD, G. K., DOMOTO, H., EVANS, R. M., HAUSSLER, M. R. and MANGELSDORF, D. J., 2002, Vitamin D receptor as an intestinal bile acid sensor. Science, 296, 1313–1316.
  • MANGELSDORF, D. J. and EVANS, R. M., 1995, The RXR heterodimers and orphan receptors. Cell, 83, 841–850.
  • MANGELSDORF, D. J., THUMMEL, C., BEATO, M., HERRLICH, P., SCHUTZ, G., UMESONO, K., BLUMBERG, B., KASTNER, P., MARK, M., CHAMBON, P. and EVANS, R. M., 1995, The nuclear receptor superfamily: the second decade. Cell, 83, 835–839.
  • MAUREL, P., 1996, The CYP3 family. In Ioannides, C. (ed.), Cytochromes P450 Metabolic and Toxicological Aspects (Boca Raton: CRC Press), pp. 241–270.
  • MCDONNELL, D. P. and NORRIS, J. D., 2002, Connections and regulation of the human estrogen receptor. Science, 296, 1642–1644.
  • MCINNES, G. T. and BRODIE, M. J., 1988, Drug interactions that matter. A critical reappraisal. Drugs, 36, 83–110.
  • McKAv, L. I. and CIDLowsKI, J. A., 1998, Cross-talk between nuclear factor-kappa B and the steroid hormone receptors: mechanisms of mutual antagonism. Molecular Endocrinology, 12, 45–56.
  • MEYER, B. K., PRAY-GRANT, M. G., VANDEN HEUVEL, J. P. and PERDEW, G. H., 1998, Hepatitis B virus X-associated protein 2 is a subunit of the unliganded aryl hydrocarbon receptor core complex and exhibits transcriptional enhancer activity. Molecular Cell Biology, 18, 978–988.
  • MIMURA, J., EMA, M., SOGAWA, K., FUJII-KURIYAMA, Y. and INAZAWA, J., 1999, Identification of a novel mechanism of regulation of Ah (dioxin) receptor function. Genes and Development, 13, 20–25.
  • MIMURA, J. and FUJII-KURIYAMA, Y., 2003, Functional role of AhR in the expression of toxic effects by TCDD. Biochimica et Biophysica Acta, 1619, 263–268.
  • MIMURA, J., YAMASHITA, K., NAKAMURA, K., MORITA, M., TAKAGI, T. N., NAKAO, K., EMA, M., SOGAWA, K., YASUDA, M., KATSUKI, M. and FUJII-KURIYAMA, Y., 1997, Loss of teratogenic response to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in mice lacking the Ah (dioxin) receptor. Genes and Cells, 2, 645–654.
  • MOOCHHALA, S. M., 1991, Alteration of drug biotransformation by interferon and host defence mechanism. Annals of the Academy of Medicine of Singapore, 20, 13–18.
  • MOORE, L. B., GOODWIN, B., JONES, S. A., WISELY, G. B., SERABJIT-SINGH, C. J., WILLSON, T. M., COLLINS, J. L. and KLIEWER, S. A., 2000a, St. John's wort induces hepatic drug metabolism through activation of the pregnane X receptor. Proceedings of the National Academy of Sciences, USA, 97, 7500–7502.
  • MOORE, L. B., MAGLICH, J. M., MCKEE, D. D., WISELY, B., WILLSON, T. M., KLIEWER, S. A., LAMBERT, M. H. and MOORE, J. T., 2002, Pregnane X receptor (PXR), constitutive androstane receptor (CAR), and benzoate X receptor (BXR) define three pharmacologically distinct classes of nuclear receptors. Molecular Endocrinology, 16, 977–986.
  • MOORE, L. B., PARKS, D. J., JONES, S. A., BLEDSOE, R. K., CONSLER, T. G., STIMMEL, J. B., GOODWIN, B., LIDDLE, C., BLANCHARD, S. G., WILLSON, T. M., COLLINS, J. L. and KLIEWER, S. A., 2000b, Orphan nuclear receptors constitutive androstane receptor and pregnane X receptor share xenobiotic and steroid ligands. Journal of Biological Chemistry, 275, 15122–15127.
  • MORGAN, E. T., 1997, Regulation of cytochromes P450 during inflammation and infection. Drug Metabolism Reviews, 29, 1129–1188.
  • MULLER, M., 2000, Transcriptional control of hepatocanalicular transporter gene expression. Seminars in Liver Disease, 20, 323–337.
  • MUNTANE-RELAT, J., OURLIN, J. C., DOMERGUE, J. and MAUREL, P., 1995, Differential effects of cytokines on the inducible expression of CYP1A1, CYP1A2, and CYP3A4 in human hepatocytes in primary culture. Hepatology, 22, 1143–1153.
  • NAGY, S. R., Liu, G., LAM, K. S. and DENISON, M. S., 2002, Identification of novel Ah receptor agonists using a high-throughput green fluorescent protein-based recombinant cell bioassay. Biochemistry, 41, 861–868.
  • NEBERT, D. W., 1989, The Ah locus: genetic differences in toxicity, cancer, mutation, and birth defects. Critical Reviews in Toxicology, 20, 153–174.
  • NEBERT, D. W. and JONES, J. E., 1989, Regulation of the mammalian cytochrome P1-450 (CYP1A1) gene. International Journal of Biochemistry, 21, 243–252.
  • NISHIKAWA, J., SAITO, K., SASAKI, M., TOMIGAHARA, Y. and NISHIHARA, T., 2000, Molecular cloning and functional characterization of a novel nuclear receptor similar to an embryonic benzoate receptor BXR. Biochemical and Biophysical Research Communications, 277, 209–215.
  • NISHIOKA, K. and REINBERG, D., 2001, Transcription. Switching partners in a regulatory tango. Science, 294, 2497–2498.
  • OGINO, M., NAGATA, K., MIYATA, M. and YAMAZOE, Y., 1999, Hepatocyte nuclear factor 4-mediated activation of rat CYP3A1 gene and its modes of modulation by apolipoprotein AT regulatory protein I and v-ErbA-related protein 3. Archives in Biochemistry and Biophysics, 362, 32–37.
  • OHTAKE, F., TAKEYAMA, K., MATSUMOTO, T., KITAGAWA, H., YAMAMOTO, Y., NOHARA, K., TOHYAMA, C., KRUST, A., MIMURA, J., CHAMBON, P., YANAGISAWA, J., FUJII-KURIYAMA, Y. and KATO, S., 2003, Modulation of oestrogen receptor signalling by association with the activated dioxin receptor. Nature, 423, 545–550.
  • OKEY, A. B., RIDDIcK, D. S. and HARPER, P. A., 1994, Molecular biology of the aromatic hydrocarbon (dioxin) receptor. Trends in Pharmacology Science, 15, 226–232.
  • OREN, A., HERSCHKOVITZ, A., BEN-DROR, I., HOLDENGREBER, V., BEN-SHAUL, Y., SEGER, R. and VARDIMON, L., 1999, The cytoskeletal network controls c-Jun expression and glucocorticoid receptor transcriptional activity in an antagonistic and cell-type-specific manner. Molecular Cell Biology, 19, 1742–1750.
  • OURLIN, J. C., LASSERRE, F., PINEAU, T., FABRE, J. M., SA-CUNHA, A., MAUREL, P., VILAREM, M. J. and PASCUSSI, J. M., 2003, The small heterodimer partner interacts with the pregnane X receptor and represses its transcriptional activity. Molecular Endocrinology.
  • PAHL, H. L. and BAEUERLE, P. A., 1996, Control of gene expression by proteolysis. Current Opinions in Cell Biology, 8, 340–347.
  • PAOLINI, M., POZZETTI, L., PIAZZA, F., GUERRA, M. C., SPERONI, E., CANTELLI-FORTI, G. and RODA, A., 2000, Mechanism for the prevention of cholestasis involving cytochrome P4503A overexpression. Journal of Investigation Medicine, 48, 49–59.
  • PARK, Y., LI, H. and KEMPER, B., 1996, Phenobarbital induction mediated by a distal CYP2B2 sequence in rat liver transiently transfected in situ. Journal of Biological Chemistry, 271, 23725–23728.
  • PARKINSON, A., 1995, Biotransformation of xenobiotics. In C. D. Klaassen (ed.), Casarett and Doull's Toxicology. The Basic Science of Poisons (New York: McGraw-Hill), pp. 113–188.
  • PARKS, D. J., BLANCHARD, S. G., BLEDSOE, R. K., CHANDRA, G., CONSLER, T. G., KLIEWER, S. A., STIMMEL, J. B., WILLSON, T. M., ZAVACKI, A. M., MOORE, D. D. and LEHMANN, J. M., 1999, Bile acids: natural ligands for an orphan nuclear receptor. Science, 284, 1365–1368.
  • PASCUSSI, J., BUSSON-LE CONIAT, M., MAUREL, P. and VILAREM, M., 2003a, Transcriptional analysis of the orphan nuclear receptor constitutive androstane receptor (NR1I3) gene promoter: identification of a distal glucocorticoid response element. Molecular Endocrinology, 17, 42–55.
  • PASCUSSI, J., GERBAL-CHALOIN, S., DAUJAT, M., DROCOURT, L., L., P.-G., M. J., V., P., M., S., K., F., T., M., B., F., G. and G., F., 2003b, CYP gene induction by xenobiotics and drugs. In J. S. 0. R. Lee and M. Fisher (eds), Drug Metabolizing Enzymes. Cytochrome P450 and Other Enzymes in Drug Discovery and Development (Lausanne: FontisMedia SA and New York: Marcel Dekker). pp. 337–374.
  • PASCUSSI, J. M., DROCOURT, L., FABRE, J. M., MAUREL, P. and VILAREM, M. J., 2000a, Dexamethasone induces pregnane X receptor and retinoid X receptor-alpha expression in human hepatocytes: synergistic increase of CYP3A4 induction by pregnane X receptor activators. Molecular Pharmacology, 58, 361–372.
  • PASCUSSI, J. M., DROCOURT, L., GERBAL-CHALOIN, S., FABRE, J. M., MAUREL, P. and VILAREM, M. J., 2001, Dual effect of dexamethasone on CYP3A4 gene expression in human hepatocytes. Sequential role of glucocorticoid receptor and pregnane X receptor. European Journal of Biochemistry, 268, 6346–6358.
  • PASCUSSI, J. M., GERBAL-CHALOIN, S., DROCOURT, L., MAUREL, P. and VILAREM, M. J., 2003c, The expression of CYP2B6, CYP2C9 and CYP3A4 genes: a tangle of networks of nuclear and steroid receptors. Biochimica et Biophysica Acta, 1619, 243–253.
  • PASCUSSI, J. M., GERBAL-CHALOIN, S., FABRE, J. M., MAUREL, P. and VILAREM, M. J., 2000b, Dexamethasone enhances constitutive androstane receptor expression in human hepatocytes: consequences on cytochrome P450 gene regulation. Molecular Pharmacology, 58, 1441–1450.
  • PASCUSSI, J. M., GERBAL-CHALOIN, S., PICHARD-GARCIA, L., DAUJAT, M., FABRE, J. M., MAUREL, P. and VILAREM, M. J., 2000c, Interleukin-6 negatively regulates the expression of pregnane X receptor and constitutively activated receptor in primary human hepatocytes. Biochemical and Biophysical Research Communications, 274, 707–713.
  • PASCUSSI, J. M., JOUNAIDI, Y., DROCOURT, L., DOMERGUE, J., BALABAUD, C., MAUREL, P. and VILAREM, M. J., 1999, Evidence for the presence of a functional pregnane X receptor response element in the CYP3A7 promoter gene. Biochemical and Biophysical Research Communications, 260, 377–381.
  • POLLENZ, R. S., 2002, The mechanism of AH receptor protein down-regulation (degradation) and its impact on AH receptor-mediated gene regulation. Chemistry and Biology Interactions, 141, 41–61.
  • POLLENZ, R. S., DAVARINOS, N. A. and SHEARER, T. P., 1999, Analysis of aryl hydrocarbon receptor-mediated signaling during physiological hypoxia reveals lack of competition for the aryl hydrocarbon nuclear translocator transcription factor. Molecular Pharmacology, 56, 1127–1137.
  • PORTER, W., WANG, F., DUAN, R., QIN, C., CASTRO-RIVERA, E., KIM, K. and SAFE, S., 2001, Transcriptional activation of heat shock protein 27 gene expression by 17beta-estradiol and modulation by antiestrogens and aryl hydrocarbon receptor agonists. Journal of Molecular Endocrinology, 26, 31–42.
  • Ricci, M. S., TOSCANO, D. G., MATTINGLY, C. J. and TOSCANO, W. A., JR, 1999, Estrogen receptor reduces CYP1A1 induction in cultured human endometrial cells. Journal of Biological Chemistry, 274, 3430–3438.
  • ROSENFELD, J. M., VARGAS, R., JR, XIE, W. and EVANS, R. M., 2003, Genetic profiling defines the xenobiotic gene network controlled by the nuclear receptor pregnane X receptor. Molecular Endocrinology, 17, 1268–1282.
  • ROUTLEDGE, E. J., WHITE, R., PARKER, M. G. and SUMPTER, J. P., 2000, Differential effects of xenoestrogens on coactivator recruitment by estrogen receptor (ER) alpha and ERbeta. Journal of Biological Chemistry, 275, 35986–35993.
  • SAFE, S. and WORMKE, M., 2003, Inhibitory aryl hydrocarbon receptor—estrogen receptor alpha cross-talk and mechanisms of action. Chemical Research in Toxicology, 16, 807–816.
  • SAINT, S. P., SONODA, J., XU, L., TOMA, D., UPPAL, H., Mu, Y., REN, S., MOORE, D. D., EVANS, R. M. and XIE, W., 2004, A novel constitutive androstane receptor-mediated and CYP3A-independent pathway of bile acid detoxification. Molecular Pharmacology, 65, 292–300.
  • SCHEIDEREIT, C., 1998, Signal transduction. Docking IkappaB kinases. Nature, 395, 225–226.
  • SCHUETZ, E. G., STROM, S., YASUDA, K., LECUREUR, V., ASSEM, M., BRIMER, C., LAMBA, J., KIM, R. B., RAMACHANDRAN, V., KOMOROSKI, B. J., VENKATARAMANAN, R., CAI, H., SINAL, C. J., GONZALEZ, F. J. and SCHUETZ, J. D., 2001, Disrupted bile acid homeostasis reveals an unexpected interaction among nuclear hormone receptors, transporters, and cytochrome P450. Journal of Biological Chemistry, 276, 39411–39418.
  • SEMENZA, G. L., 2001, Hypoxia-inducible factor 1: oxygen homeostasis and disease pathophysiology. Trends in Molecular Medicine, 7, 345–350.
  • SEOL, W., CHOI, H. S. and MOORE, D. D., 1996, An orphan nuclear hormone receptor that lacks a DNA binding domain and heterodimerizes with other receptors. Science, 272, 1336–1339.
  • SEOL, W., CHUNG, M. and MOORE, D. D., 1997, Novel receptor interaction and repression domains in the orphan receptor SHP. Molecular Cell Biology, 17, 7126–7131.
  • SEWER, M. B. and MORGAN, E. T., 1997, Nitric oxide-independent suppression of P450 2C11 expression by interleukin-lbeta and endotoxin in primary rat hepatocytes. Biochemical Pharmacology, 54, 729–737.
  • SHENOY, S. D., SPENCER, T. A., MERCER-HAINES, N. A., ALIPOUR, M., GARGANO, M. D., RUNGE-MORRIS, M. and KOCAREK, T. A., 2004, CYP3A induction by liver x receptor ligands in primary cultured rat and mouse hepatocytes is mediated by the pregnane X receptor. Drug Metabolism and Disposition, 32, 66–71.
  • SHEPPARD, K. A., PHELPS, K. M., WILLIAMS, A. J., THANOS, D., GLASS, C. K., ROSENFELD, M. G., GERRITSEN, M. E. and COLLINS, T., 1998, Nuclear integration of glucocorticoid receptor and nuclear factor-kappaB signaling by CREB-binding protein and steroid receptor coactivator-1. Journal of Biological Chemistry, 273, 29291–29294.
  • SHIMADA, T., INouE, K., SUZUKI, Y., KAWAI, T., AZUMA, E., NAKAJIMA, T., SHINDO, M., KUROSE, K., SUGIE, A., YAMAGISHI, Y., FUJII-KURIYAMA, Y. and HASHIMOTO, M., 2002, Arylhydrocarbon receptor-dependent induction of liver and lung cytochromes P450 1A1, 1A2, and 1B1 by polycyclic aromatic hydrocarbons and polychlorinated biphenyls in genetically engineered C57BL/6J mice. Carcinogenesis, 23, 1199–1207.
  • SHIMADA, T., YAMAZAKI, H., MIMURA, M., INUI, Y. and GUENGERICH, F. P., 1994, Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: studies with liver microsomes of 30 Japanese and 30 Caucasians. Journal of Pharmacology and Experimental Therapeutics, 270, 414–423.
  • SHIRAKI, T., SAKAI, N., KANAYA, E. and JINGAmi, H., 2003, Activation of orphan nuclear constitutive androstane receptor requires subnuclear targeting by peroxisome proliferator-activated receptor gamma coactivator-1 alpha. A possible link between xenobiotic response and nutritional state. Journal of Biological Chemistry, 278, 11344–11350.
  • SHIVERICK, K. T. and MUTHER, T. F., 1982, Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin on serum concentrations and the uterotrophic action of exogenous estrone in rats. Toxicology and Applied Pharmacology, 65, 170–176.
  • SLADEK, F. M., ZHONG, W. M., LAI, E. and DARNELL, J. E., JR, 1990, Liver-enriched transcription factor HNF-4 is a novel member of the steroid hormone receptor superfamily. Genes and Development, 4, 2353–2365.
  • SOGAWA, K. and FUJII-KURIYAMA, Y., 1997, Ah receptor, a novel ligand-activated transcription factor. Journal of Biochemistry (Tokyo), 122, 1075–1079.
  • SONG, Z. and POLLENZ, R. S., 2002, Ligand-dependent and independent modulation of aryl hydrocarbon receptor localization, degradation, and gene regulation. Molecular Pharmacology, 62, 806–816.
  • SOUTOGLOU, E. and TALIANIDIS, I., 2002, Coordination of PIC assembly and chromatin remodeling during differentiation-induced gene activation. Science, 295, 1901–1904.
  • SPECTOR, D. L., 2003, The dynamics of chromosome organization and gene regulation. Annual Review in Biochemistry, 72, 573–608.
  • ST JOHNSTON, D., 1995, The intracellular localization of messenger RNAs. Cell, 81, 161-170. STALLCUP, M. R., 2001, Role of protein methylation in chromatin remodeling and transcriptional regulation. Oncogene, 20, 3014–3020.
  • STAUDINGER, J. L., GOODWIN, B., JONES, S. A., HAWKINS-BROWN, D., MACKENZIE, K. I., LATouR, A., Liu, Y., KLAASSEN, C. D., BROWN, K. K., REINHARD, J., WILLSON, T. M., KoLLER, B. H. and KLIEWER, S. A., 2001b, The nuclear receptor PXR is a lithocholic acid sensor that protects against liver toxicity. Proceedings of the National Academy of Sciences, USA, 98, 3369–3374.
  • STAUDINGER, J., Liu, Y., MADAN, A., HABEEBU, S. and KLAASSEN, C. D., 2001a, Coordinate regulation of xenobiotic and bile acid homeostasis by pregnane X receptor. Drug Metabolism and Disposition, 29, 1467–1472.
  • STIEGER, B. and MEIER, P. J., 1998, Bile acid and xenobiotic transporters in liver. Current Opinions in Cell Biology, 10, 462–467.
  • SUEYOSHI, T., KAWAMOTO, T., ZELKO, I., HONKAKOSKI, P. and NEGISHI, M., 1999, The repressed nuclear receptor CAR responds to phenobarbital in activating the human CYP2B6 gene. Journal of Biological Chemistry, 274, 6043–6046.
  • SUGATANI, J., KOJIMA, H., UEDA, A., KAKIZAKI, S., YOSHINARI, K., GONG, Q. H., OWENS, I. S., NEGISHI, M. and SUEYOSHI, T., 2001, The phenobarbital response enhancer module in the human bilirubin UDP-glucuronosyltransferase UGT1A1 gene and regulation by the nuclear receptor CAR. Hepatology, 33, 1232–1238.
  • SYNOLD, T. W., DUSSAULT, I. and FORMAN, B. M., 2001, The orphan nuclear receptor SXR coordinately regulates drug metabolism and efflux. Nature Medicine, 7, 584–590.
  • TABB, M. M., KHOLODOVYCH, V., GRUN, F., ZHOU, C., WELSH, W. J. and BLUMBERG, B., 2004, Highly chlorinated PCBs inhibit the human xenobiotic response mediated by the steroid and xenobiotic receptor (SXR). Environmental Health Perspectives, 112, 163–169.
  • THUMMEL, K. E., BRIMER, C., YASUDA, K., THOTTASSERY, J., SENN, T., LIN, Y., IsHizuRA, H., KHARASCH, E., SCHUETZ, J. and SCHUETZ, E., 2001, Transcriptional control of intestinal cytochrome P-4503A by lalpha,25-dihydroxy vitamin D3. Molecular Pharmacology, 60, 1399–1406.
  • TIRONA, R. G., LEE, W., LEAKE, B. F., LAN, L. B., CLINE, C. B., LAMBA, V., PARVIZ, F., DUNCAN, S. A., INouE, Y., GONZALEZ, F. J., SCHUETZ, E. G. and KIM, R. B., 2003, The orphan nuclear receptor HNF4alpha determines PXR- and CAR-mediated xenobiotic induction of CYP3A4. Nature Medicine, 9, 220–224.
  • TRAUNER, M., FICKERT, P. and STAUBER, R. E., 1999, Inflammation-induced cholestasis. Journal of Gastroenterology and Hepatology, 14, 946–959.
  • TROTTIER, E., BELZIL, A., STOLTZ, C. and ANDERSON, A., 1995, Localization of a phenobarbital-responsive element (PBRE) in the 5'-flanking region of the rat CYP2B2 gene. Gene, 158, 263–268.
  • TZAMELI, I., Pissios, P., SCHUETZ, E. G. and MOORE, D. D., 2000, The xenobiotic compound 1,4-bis[2-(3, 5-dichloropyridyloxy)]benzene is an agonist ligand for the nuclear receptor CAR. Molecular Cell Biology, 20, 2951–2958.
  • WANG, H., FAUCETTE, S., SUEYOSHI, T., MOORE, R., FERGUSON, S., NEGISHI, M. and LECLUYSE, E. L., 2003, A novel distal enhancer module regulated by pregnane X receptor/constitutive androstane receptor is essential for the maximal induction of CYP2B6 gene expression. Journal of Biological Chemistry, 278, 14146–14152.
  • WATKINS, R. E., MAGLICH, J. M., MOORE, L. B., WISELY, G. B., NOBLE, S. M., DAVIS-SEARLES, P. R., LAMBERT, M. H., KLIEWER, S. A. and REDINBO, M. R., 2003,2.1 A crystal structure of human PXR in complex with the St. John's wort compound hyperforin. Biochemistry, 42, 1430–1438.
  • WATKINS, R. E., WISELY, G. B., MOORE, L. B., COLLINS, J. L., LAMBERT, M. H., WILLIAMS, S. P., WILLSON, T. M., KLIEWER, S. A. and REDINBO, M. R., 2001, The human nuclear xenobiotic receptor PXR: structural determinants of directed promiscuity. Science, 292, 2329–2333.
  • WAXMAN, D. J., 1999, P450 gene induction by structurally diverse xenochemicals: central role of nuclear receptors CAR, PXR, and PPAR. Archives in Biochemistry and Biophysics, 369, 11–23.
  • WEI, P., ZHANG, J., EGAN-HAFLEY, M., LIANG, S. and MOORE, D. D., 2000a, The nuclear receptor CAR mediates specific xenobiotic induction of drug metabolism. Nature, 407, 920–923.
  • WEI, Y. D., BERGANDER, L., RANNUG, U. and RANNUG, A., 2000b, Regulation of CYP1A1 transcription via the metabolism of the tryptophan-derived 6-formylindolo[3,2-b]carbazole. Archives in Biochemistry and Biophysics, 383, 99–107.
  • WHITLOCK, J. P., JR, 1999, Induction of cytochrome P4501A1 . Annual Reviews in Pharmacology and Toxicology, 39, 103–125.
  • WIJAYARATNE, A. L. and MCDONNELL, D. P., 2001, The human estrogen receptor-alpha is a ubiquitinated protein whose stability is affected differentially by agonists, antagonists, and selective estrogen receptor modulators. Journal of Biological Chemistry, 276, 35684–35692.
  • WOLFFE, A. P., 2001, Chromatin remodeling: why it is important in cancer. Oncogene, 20, 2988–2990.
  • WORMKE, M., STONER, M., SAVILLE, B., WALKER, K., ABDELRAHIM, M., BURGHARDT, R. and SAFE, S., 2003, The aryl hydrocarbon receptor mediates degradation of estrogen receptor alpha through activation of proteasomes. Molecular Cell Biology, 23, 1843–1855.
  • XIE, W., RADOMINSKA-PANDYA, A., SHI, Y., SIMON, C. M., NELSON, M. C., ONG, E. S., WAXMAN, D. J. and EVANS, R. M., 2001, An essential role for nuclear receptors SXR/PXR in detoxification of cholestatic bile acids. Proceedings of the National Academy of Sciences, USA, 98, 3375–3380.
  • XIE, W., YEUH, M. F., RADOMINSKA-PANDYA, A., SAINI, S. P., NEGISHI, Y., BOTTROFF, B. S., CABRERA, G. Y., TUKEY, R. H. and EVANS, R. M., 2003, Control of steroid, heme, and carcinogen metabolism by nuclear pregnane X receptor and constitutive androstane receptor. Proceedings of the National Academy of Sciences, USA, 100, 4150–4155.
  • YOSHINARI, K., KOBAYASHI, K., MOORE, R., KAWAMOTO, T. and NEGISHI, M., 2003, Identification of the nuclear receptor CAR:HSP90 complex in mouse liver and recruitment of protein phosphatase 2A in response to phenobarbital. FEBS Letters, 548, 17–20.
  • ZELKO, I. and NEGISHI, M., 2000, Phenobarbital-elicited activation of nuclear receptor CAR in induction of cytochrome P450 genes. Biochemical and Biophysical Research Communications, 277, 1–6.
  • ZELKO, I., SUEYOSHI, T., KAWAMOTO, T., MOORE, R. and NEGISHI, M., 2001, The peptide near the C terminus regulates receptor CAR nuclear translocation induced by xenochemicals in mouse liver. Molecular Cell Biology, 21, 2838–2846.
  • ZHANG, J., HUANG, W., CHUA, S. S., WEI, P. and MOORE, D. D., 2002, Modulation of acetaminophen-induced hepatotoxicity by the xenobiotic receptor CAR. Science, 298, 422–424.
  • ZHANG, J., KUEHL, P., GREEN, E. D., TOUCHMAN, J. W., WATKINS, P. B., DALY, A., HALL, S. D., MAUREL, P., RELLING, M., BRIMER, C., YASUDA, K., WRIGHTON, S. A., HANCOCK, M., KIM, R. B., STROM, S., THUMMEL, K., RUSSELL, C. G., HUDSON, J. R., JR, SCHUETZ, E. G. and BOGUSKI, M. S., 2001, The human pregnane X receptor: genomic structure and identification and functional characterization of natural allelic variants. Pharmacogenetics, 11, 555–572.
  • ZHou, Z., CORDEN, J. L. and BROWN, T. R., 1997, Identification and characterization of a novel androgen response element composed of a direct repeat. Journal of Biological Chemistry, 272, 8227–8235.

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