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Xenobiotica
the fate of foreign compounds in biological systems
Volume 34, 2004 - Issue 3
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Research Article

Comparative pharmacokinetics and metabolism of levetiracetam, a new anti-epileptic agent, in mouse, rat, rabbit and dog

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Pages 281-300 | Received 16 Oct 2003, Published online: 22 Sep 2008

Reference

  • ADUSUMALLI, V. E., YANG, J. T., WONG, K. K., KUCHARCZYK, N. and SOFIA, R. D., 1991, Felbamate pharmacokinetics in the rat, rabbit and dog. Drug Metabolism and Disposition, 19, 1116–1125.
  • ALT, B. and KAUR, S., 1983a, Mammalian tissue acetylsalicylic acid esterases: identification, distribution and discrimination from other esterases. Journal of Pharmacology and Experimental Therapeutics, 226, 589–594.
  • ALT, B. and KAUR, S., 1983b, The effects of phenobarbital, 3-metrhylcholanthrene and benzo(a)pyrene on the hydrolysis of xenobiotics in the rats. Biochemical Pharmacology, 32, 3479–3480.
  • BOXENBAUM, H. and RONFELD, R., 1983, Interspecies pharmacokinetic scaling and the Dedrick's plot. American Journal of Physiology, 245, R768—R775.
  • DOHENY, H. C., RATNARAJ, N., WHITTINGTON, M. A., JEFFERYS, J. G. R. and PATSALOS, P. N., 1999, Blood and cerebrospinal fluid pharmacokinetics of the novel anticonvulsant levetiracetam (ucb L059) in the rat. Epilepsy Research, 34, 161–168.
  • DOHENY, M. H., ALAVIJEH, M. S., RATNARAJ, N. and PATSALOS, P. N., 1994, Piracetam kinetics in blood and cerebrospinal fluid. Epilepsia, 35, 85.
  • EFTHYMIOPOULOS, C., BATTAGLIA, R. and STROLIN BENEDETTI, M., 1991, Animal pharmacokinetics and interspecies scaling of FCE 22101, a penem antibiotic. Journal of Antimicrobial Chemotherapy, 27, 517–526.
  • GOBERT, J., 1975, Le piracétam: pharmacocinétique et biochimie. Paper presented at the Symposium Nootropil, UCB S. A. Brussels, 10 October, Bucarest, Romania, pp. 1–6.
  • GONZALEZ, M. A., TOZER, T. N. and CHANG, D. T. T., 1975, Nonlinear tissue disposition: salicylic acid in rat brain. Journal of Pharmaceutical Sciences, 64, 99–103.
  • GOWER, A. J., HIRSCH, E., BOEHRER, A., NOYER, M. and MAREscAux, C., 1995, Effects of levetiracetam, a novel antiepileptic drug, on convulsant activity in two genetic rat models of epilepsy. Epilepsy Research, 22, 207–213.
  • GOWER, A. J., NOYER, M., VERLOES, R., GOBERT, J. and WÜLFERT, E., 1992, ucb L059, a novel anti-convulsant drug: pharmacological profile in animals. European Journal of Pharmacology, 222, 193–203.
  • KLITGAARD, H., MATAGNE, A., GOBERT, J. and WÜLFERT, E., 1998, Evidence for a unique profile of levetiracetam in rodent models of seizures and epilepsy. European Journal of Pharmacology, 353, 191–206.
  • LAPKA, R., REJHOLEC, V. and SmouR, S., 1990, Pharmacokinetics of piracetam in plasma and brain. Activas Nervosas Superior, 32, 58–59.
  • LöSCHER, W. and HoNACK, D., 1993, Profile of ucb L059, a novel anticonvulsant drug, in models of partial and generalized epilepsy in mice and rats. European Journal of Pharmacology, 232, 147–158.
  • LöSCHER, W., HöNACK, D. and RUNDFELDT, C., 1998, Antiepileptogenic effects of the novel anticonvulsant levetiracetam (ucb L059) in the kindling model of temporal lobe epilepsy. Journal of Pharmacology and Experimental Therapeutics, 284, 474–479.
  • LUKYANETZ, E. A., SHKRYL, V. M. and KOSTYUK, P. G., 2002, Selective blockade of N-type calcium channels by levetiractam. Epilepsia, 43, 9–18.
  • MARGINEANU, D. G. and KLITGAARD, H., 2002, Levetiracetam: mechanisms of action. In R. H. Levy, R. H. Mattson, B. S. Meldrum and E. Puracca (eds), Antiepileptic drugs, 5th edn (Philadelphia: Lippincott, Williams & Wilkins), pp. 419–427.
  • MORGAN, E. W., YAN, B., GREENWAY, D., PETERSEN, D. R. and PARKINSON, A., 1994, Purification and characterization of two rat liver microsomal carboxylesterases (hydrolase A and B). Archives of Biochemistry and Biophysics, 315, 495–512.
  • NICOLAS, J. M., COLLART, P., GERIN, B., MATHER, G., TRAGER, W., LEVY, R. and ROBA, J., 1999, Levetiracetam: in vitro metabolism assays and prediction of drug—drug interaction. In A. R. Boobis, P. Kremers, 0. Pelkonen and K. Pithan (eds), Proceedings of the European Symposium on the Prediction of Drug Metabolism in Man: Progress and Problems, 19–20 May, Liege, Belgium. Cost B1 EUR 18569 EN, Luxembourg: Office for Official Publications of the European Communities, pp. 193–195.
  • NIESPODZIANY, I., KLITGAARD, H. and MARGINEANU, D. G., 2001, Levetiracetam inhibits the high-voltage-activated Ca2± current in pyramidal neurons of rat hippocampal slices. Neuroscience Letters, 306, 5–8.
  • NOUSIAINEN, U. and HANNINEN, 0., 1981, On the inducibility of cystolic and microsomal carboxyesterase by phenobarbital in rat tissues [Letter to the Editor]. Acta Pharmacologica et Toxicologica, 49, 77–80.
  • NOYER, M., GILLARD, M., MATAGNE, A., HENICHART, J. P. and W0FLERT, E., 1995, The novel antiepileptic drug levetiracetam (ucb L059) appears to act via a specific binding site in CNS membranes. European Journal of Pharmacology, 286, 137–146.
  • OSTROWSKI VON, J., KEIL, M. and SCHRAVEN, E., 1975, Autoradiographische Untersuchungen zur Verteilung von Piracetam-14C bei Ratte und Hund. Arzneimittel-ForschunglDrug Research, 25, 589–596.
  • RIGO, J. M., HANS, G., NGUYEN, L., ROCHER, V., BELACHEW, S., MALGRANGE, B., LEPRINCE, P., MOONEN, G., SELAK, I., MATAGNE, A. and KLITGAARD, H., 2002, The anti-epileptic drug levetiracetam reverses the inhibition by negative allosteric modulators of neuronal GABA- and glycine-gated currents. British Journal of Pharmacology, 136, 659–672.
  • SCHWARK, W. S. and ECOBICHON, D. J., 1968, Subcellular localization and drug-induced changes of rat liver and kidney esterases. Canadian Journal of Physiology and Pharmacology, 46, 207–212.
  • STROLIN BENEDETTI, M., WHOMSLEY, R., NICOLAS, J. M., YOUNG, C. and BALTES, E., 2003, Pharmacokinetics and metabolism of 14C-levetiracetam, a new antiepileptic agent, in healthy volunteers. European Journal of Clinical Pharmacology, 59, 621–630.
  • TACCONI, M. T. and WURTMAN, R. J., 1984, Physiological disposition of oral piracetam in Sprague—Dawley rats. Journal of Pharmaceutics and Pharmacology, 36, 659–662.

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