Uptake–toxicity relationships of a series of N-substituted N′-(4-imidazole-ethyl)thiourea in precision-cut rat liver slices

References

• Carlile DJ, Hakooz N, Houston BJ. 1999. Kinetics of drug metabolism in rat liver slices: IV. Comparison of ethoxycoumarin clearance by liver slices, isolated hepatocytes, and hepatic microsomes from rats pretreated with known modifiers of cytochrome P-450 activity. Drug Metabolism and Disposition 27:526–532.
   Google Scholar
• Dogterom P. 1993. Development of a simple incubation system for metabolism studies with precision-cut liver slices. Drug Metabolism and Disposition 21:699–704.
   PubMed Web of Science ®Google Scholar
• Dresser MJ, Gray AT, Giacomini KM. 2000. Kinetic and selectivity differences between rodent, rabbit, and human organic cation transporters (OCT1) Journal of Pharmacology and Experimental Therapeutics 292:1146–1152.
   Google Scholar
• Ekins S, Murray GI, Burke MD, Williams JA, Marchant NC, Hawksworth GM. 1995. Quantitative differences in phase I and II metabolism between rat precision-cut liver slices and isolated hepatocytes. Drug Metabolism and Disposition 23:1275–1279.
   Google Scholar
• Gorboulev V, Ulzheimer JC, Akhoundova A, Ulzheimer-Teuber I, Karbach U, Quester S, Baumann C, Lang F, Busch AE, Koepsell H. 1997. Cloning and characterization of two human polyspecific organic cation transporters. DNA Cell Biology 16:871–881.
   PubMed Web of Science ®Google Scholar
• Henderson MC, Krueger SK, Stevens JF, Williams DE. 2004. Human flavin-containing monooxygenase form 2 S-oxygenation: sulfenic acid formation from thioureas and oxidation of glutathione. Chemical Research in Toxicology 17:633–640.
   PubMed Web of Science ®Google Scholar
• Jonker JW, Schinkel AH. 2004. Pharmacological and physiological functions of the polyspecific organic cation transporters: OCT1,2, and 3 (SLC22A1-3). Journal of Pharmacology and Experimental Therapeutics 308:2-9. Koepsell H, Endou H. 2004. The 5LC22 drug transporter family. Pflugers Archives 447:666–676.
   PubMedGoogle Scholar
• Nakamura H, Sano H, Yamazaki M, Sugiyama Y. 1994. Carrier-mediated active transport of histamine H2 receptor antagonists, cimetidine and nizatidine, into isolated rat hepatocytes: contribution of type 1 system. Journal of Pharmacology and Experimental Therapeutics 269:1220–1227.
   PubMedGoogle Scholar
• Olinga P, Hof IH, Merema MT, Smit M, de Jager MH, Swart PJ, Slooff MJ, Meijer DK, Groothuis GM. 2001. The applicability of rat and human liver slices to the study of mechanisms of hepatic drug uptake. Journal of Pharmacology and Toxicology Methods 45:55–63.
   PubMed Web of Science ®Google Scholar
• Onderwater RCA, Commandeur JNM, Groot EJ, Sitters A, Menge WMPB, Vermeulen NPE. 1998. Cy-totoxicity of a series of mono- and di-substituted thiourea in freshly isolated rat hepatocytes: a preliminary structure-toxicity relationship study. Toxicology 125:117–129.
   PubMedGoogle Scholar
• Onderwater RCA, Commandeur JNM, Menge WMPB, Vermeulen NPE. 1999. Activation of microsomal glutathione S-transferase and inhibition of cytochrome P450 1A1 activity as a model system to detect protein alkylation by thiourea-containing compounds in rat liver microsomes. Chemical Research in Toxicology 12:396–402.
   PubMed Web of Science ®Google Scholar
• Onderwater RCA, Commandeur JNM, Vermeulen NPE. 2004. Comparative cytotoxicity of N-substituted K-(4-imidazole-ethyl)thiourea towards precision-cut rat liver slices. Toxicology 197,81–91.
   PubMedGoogle Scholar
• Poulsen LL, Hyslop RM, Ziegler DM. 1979. S-oxygenation of N-substituted thioureas catalyzed by the pig liver microsomal FAD-containing monooxygenase. Archives in Biochemistry and Biophysics 198:78–88.
   Google Scholar
• Proost JH, Roggeveld J, Wierda JMKH, Meijer DKF. 1997. Relationship between chemical structure and physiochemical properties of series of bulky organic cations and their hepatic uptake and biliary excretion rates. Journal of Pharmacology and Experimental Therapeutics 282:715–726.
   PubMedGoogle Scholar
• Rekker RF, Mannhold R. 1992. Calculation of drug lipophilicity. The hydrophobic fragmental constant approach. Weinheim: VCH Verlagsgesellschaft mbH.
   Google Scholar
• Skellern GG. 1989. Thiocarbamides. In Damani LA, editor. Sulphur containing drugs and related organic compounds. Chemistry, biology, toxicity. Chichester: Ellis Horwood, part 1B, p. 49.
   Google Scholar
• Smith PB, Crespi C. 2002. Thiourea toxicity in mouse C3H/10T1/2 cells expressing human flavin dependent monooxygenase 3. Biochemistry and Pharmacology 63:1941–1948.
   PubMed Web of Science ®Google Scholar
• Tchercansky DM, Rubio MC, Acevedo C. 1999. [3H]tyramine uptake by rat liver slices. Pharmacology Research 39:479–486.
   Google Scholar
• Van Montfoort JE, Hagenbusch B, Groothuis GM, Koepsell H, Meier PJ, Meijer DK. 2003. Drug uptake systems in liver and kidney. Current Drug Metabolism 4:185–211.
   PubMed Web of Science ®Google Scholar
• Worboys PD, Bradbury A, Houston JB. 1995. Kinetics of drug metabolism in rat liver slices. Rates of oxidation of ethoxycoumarin and tolbutamide, examples of high- and low-clearance compounds. Drug Metabolism and Disposition 23:393–397.
   Google Scholar
• Worboys PD, Bradbury A, Houston JB. 1996. Kinetics of drug metabolism in rat liver slices. II. Comparison of clearance by liver slices and freshly isolated hepatocytes. Drug Metabolism and Disposition 24:677–681.
   Google Scholar
• Worboys PD, Bradbury A, Houston JB. 1997. Kinetics of drug metabolism in rat liver slices. III. Relationship between metabolic clearance and slice uptake rate. Drug Metabolism and Disposition 25:460–467.
   Google Scholar
• You G. 2004. The role of organic ion transporters in drug disposition: an update. Current Drug Metabolism 5:55–62.
   PubMedGoogle Scholar
• Zhang L, Gorset W, Dresser MJ, Giacomini KM. 1999. The interaction of n-Tetraalkylammonium compounds with a human cation transporter, hOCT1. Journal of Pharmacology and Experimental Therapeutics 288: 1192–1198.
   PubMed Web of Science ®Google Scholar
• Zhang L, Dresser MJ, Gray AT, Yost SC, Terashita S, Giacomini KM. 1997. Cloning and functional expression of a human liver organic cation transporter. Molecular Pharmacology 51:913–921.
   PubMed Web of Science ®Google Scholar