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Xenobiotica
the fate of foreign compounds in biological systems
Volume 35, 2005 - Issue 4
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Research Article

Identification of metabolites of [14C]zonampanel, an α-amino-3-hydroxy-5-methylisoxazole-4-propionate receptor antagonist, following intravenous infusion in healthy volunteers

T. Minematsu Drug Metabolism Laboratories, Yamanouchi Pharmaceutical, Co. Ltd, Tokyo, JapanCorrespondence[email protected]
,
K.-Y. Sohda Drug Metabolism Laboratories, Yamanouchi Pharmaceutical, Co. Ltd, Tokyo, Japan
,
T. Hashimoto Drug Metabolism Laboratories, Yamanouchi Pharmaceutical, Co. Ltd, Tokyo, Japan
,
H. Imai Drug Metabolism Laboratories, Yamanouchi Pharmaceutical, Co. Ltd, Tokyo, Japan
,
T. Usui Drug Metabolism Laboratories, Yamanouchi Pharmaceutical, Co. Ltd, Tokyo, Japan
&
H. Kamimura Drug Metabolism Laboratories, Yamanouchi Pharmaceutical, Co. Ltd, Tokyo, Japan
Pages 359-371 | Received 08 Nov 2004, Published online: 22 Sep 2008

References

  • Buist SC, Cherrington NJ, Choudhuri S, Hartley DP, Klaassen CD. 2002. Gender-specific and developmental influences on the expression of rat organic anion transporters. Journal of Pharmacology and Experimental Therapeutics 301:145–151.
  • Cha SH, Sekine T, Kusuhara H, Yu E, Kim JY, Kim DK, Sugiyama Y, Kanai Y, Endou H. 2000. Molecular cloning and characterization of multispecific organic anion transporter 4 expressed in the placenta. Journal of Biological Chemistry 275:4507–4512.
  • Davies B, Morris T. 1993. Physiological parameters in laboratory animals and humans. Pharmaceutical Research 10:1093–1095.
  • Gabrielsson J, Weiner D. 2000. Non-compartmental analysis. In: Gabrielsson J, Weiner D (Eds) Pharmacokinetic and pharmacodynamic data analysis: Concepts and applications, 3rd edn. Stockholm: Swedish Pharmaceutical Press. pp. 141–153.
  • Hashimoto T, Narikawa S, Huang XL, Minematsu T, Usui T, Kamimura H, Endou H. 2004. Characterization of the renal tubular transport of zonampanel, a novel alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptor antagonist, by human organic anion transporters. Drug Metabolism and Disposition 32:1096–1102.
  • Ingwersen SH, Ohrstrom JK, Petersen P, Drustrup J, Bruno L, Nordholm L. 1994. Human pharmacokinetics of the neuroprotective agent NBQX. American Journal of Therapeutics 1:296–303.
  • Kawasaki-Yatsugi S, Yatsugi S, Takahashi M, Toya T, Ichiki C, Shimizu-Sasamata M, Yamaguchi T, Minematsu K. 1998. A novel AMPA receptor antagonist, YM872, reduces infarct size after middle cerebral artery occlusion in rats. Brain Research 793:39–46.
  • Kusuhara H, Sekine T, Utsunomiya-Tate N, Tsuda M, Kojima R, Cha SH, Sugiyama Y, Kanai Y, Endou H. 1999. Molecular cloning and characterization of a new multispecific organic anion transporter from rat brain. Journal of Biological Chemistry 274:13675–13680.
  • Masereeuw R, Russel FG. 2001. Mechanisms and clinical implications of renal drug excretion. Drug Metabolism Review 33:299–351.
  • Race JE, Grassl SM, Williams WJ, Holtzman EJ. 1999. Molecular cloning and characterization of two novel human renal organic anion transporters (hOAT1 and hOAT3). Biochemical and Biophysical Research Communication 255:508–514.
  • Sohda KY, Minematsu T, Hashimoto T, Suzumura K, Funatsu M, Suzuki K, Imai H, Usui T, Kamimura H. 2004. Application of LC-NMR for characterization of rat urinary metabolites of zonampanel monohydrate (YM872). Chemical and Pharmaceutical Bulletin (Tokyo) 52:1322–1325.
  • Takahashi M, Ni JW, Kawasaki-Yatsugi S, Toya T, Yatsugi SI, Shimizu-Sasamata M, Koshiya K, Shishikura JI, Sakamoto S, Yamaguchi T. 1998. YM872, a novel selective alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptor antagonist, reduces brain damage after permanent focal cerebral ischemia in cats. Journal of Pharmacology and Experimental Therapeutics 284:467–473.
  • Umemura K, Kondo K, Ikeda Y, Teraya Y, Yoshida H, Homma M, Uematsu T, Nakashima M. 1997. Pharmacokinetics and safety of the novel amino-3-hydroxy-5-methylisoxazole-4-propionate receptor antagonist YM9OK in healthy men. Journal of Clinical Pharmacology 37:719–727.

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