Evaluation of mRNA expression of human drug-metabolizing enzymes and transporters in chimeric mouse with humanized liver

eferences

• Baliharová V, Skálová L, Maas RF, De Vrieze G, Bull S, Fink-Gremmels J. The effects of mebendazole on P4501A activity in rat hepatocytes and HepG2 cells. Comparison with tiabendazole and omeprazole. Journal of Pharmacy and Pharmacology 2003; 55: 773–781
   PubMed Web of Science ®Google Scholar
• Borst P, Evers R, Kool M, Wijnholds J. A family of drug transporters: The multidrug resistance-associated proteins. Journal of the National Cancer Institute 2000; 92: 1295–1302
   PubMed Web of Science ®Google Scholar
• Bowen WP, Carey JE, Miah A, McMurray HF, Munday PW, James RS, Coleman RA, Brown AM. Measurement of cytochrome P450 gene induction in human hepatocytes using quantitative real-time reverse transcriptase-polymerase chain reaction. Drug Metabolism and Disposition 2000; 28: 781–788
   PubMed Web of Science ®Google Scholar
• Chang TJ, Juan CC, Yin PH, Chi CW, Tsay HJ. Up-regulation of beta-actin, cyclophilin and GAPDH in N1S1 rat hepatoma. Oncology Reports 1998; 5: 469–471
   PubMed Web of Science ®Google Scholar
• Clark MA, Bing BA, Gottschall PE, Williams JF. Differential effect of cytokines on the phenobarbital or 3-methylcholanthrene induction of P450 mediated monooxygenase activity in cultured rat hepatocytes. Biochemical Pharmacology 1995; 49: 97–104
   PubMed Web of Science ®Google Scholar
• Corchero J, Granvil CP, Akiyama TE, Hayhurst GP, Pimprale S, Feigenbaum L, Idle JR, Gonzalez FJ. The CYP2D6 humanized mouse: Effect of the human CYP2D6 transgene and HNF4alpha on the disposition of debrisoquine in the mouse. Molecular Pharmacology 2001; 60: 1260–1267
   PubMed Web of Science ®Google Scholar
• Dandri M, Burda MR, Torok E, Pollok JM, Iwanska A, Sommer G, Rogiers X, Rogler CE, Gupta S, Will H, et al. Repopulation of mouse liver with human hepatocytes and in vivo infection with hepatitis B virus. Hepatology 2001; 33: 981–988
   PubMed Web of Science ®Google Scholar
• Dean M, Rzhetsky A, Allikmets R. The human ATP-binding cassette (ABC) transporter superfamily. Genome Research 2001; 11: 1156–1166
   PubMed Web of Science ®Google Scholar
• Garcia M, Rager J, Wang Q, Strab R, Hidalgo IJ, Owen A, Li J. Cryopreserved human hepatocytes as alternative in vitro model for cytochrome P450 induction studies. In Vitro Cellular & Developmental Biology Animal 2003; 39: 283–287
   PubMed Web of Science ®Google Scholar
• Glare EM, Divjak M, Bailey MJ, Walters EH. β-Actin and GAPDH housekeeping gene expression in asthmatic airways is variable and not suitable for normalising mRNA levels. Thorax 2002; 57: 765–770
   PubMed Web of Science ®Google Scholar
• Gomez-Lechon MJ, Donato MT, Castell JV, Jover R. Human hepatocytes as a tool for studying toxicity and drug metabolism. Current Drug Metablism 2003; 4: 292–312
   PubMed Web of Science ®Google Scholar
• Hesse LM, Sakai Y, Vishnuvardhan D, Li AP, von Moltke LL, Greenblatt DJ. Effect of bupropion on CYP2B6 and CYP3A4 catalytic activity, immunoreactive protein and mRNA levels in primary human hepatocytes: Comparison with rifampicin. Journal of Pharmacy and Pharmacology 2003; 55: 1229–1239
   PubMed Web of Science ®Google Scholar
• Iyer KR, Sinz MW. Characterization of phase I and phase II hepatic drug metabolism activities in a panel of human liver preparations. Chemico-Biological Interactions 1999; 118: 151–169
   PubMed Web of Science ®Google Scholar
• Katoh M, Matsui T, Nakajima M, Tateno C, Kataoka M, Soeno Y, Horie T, Iwasaki K, Yoshizato K, Yokoi T. Expression of human CYPs in chimeric mice with humanized liver. Drug Metabolism and Disposition 2004; 32: 1402–1410
   PubMed Web of Science ®Google Scholar
• Li AP, Gorycki PD, Hengstler JG, Kedderis GL, Koebe HG, Rahmani R, de Sousas G, Silva JM, Skett P. Present status of the application of cryopreserved hepatocytes in the evaluation of xenobiotics: Consensus of an international expert panel. Chemico-Biological Interactions 1999; 121: 117–123
   PubMed Web of Science ®Google Scholar
• Li-Masters T, Morgan ET. Effects of bacterial lipopolysaccharide on phenobarbital-induced CYP2B expression in mice. Drug Metabolism and Disposition 2001; 29: 252–257
   PubMed Web of Science ®Google Scholar
• Lindley C, Hamilton G, McCune JS, Faucette S, Shord SS, Hawke RL, Wang H, Gilbert D, Jolley S, Yan B, et al. The effect of cyclophosphamide with and without dexamethasone on cytochrome P450 3A4 and 2B6 in human hepatocytes. Drug Metabolism and Disposition 2002; 30: 814–822
   PubMed Web of Science ®Google Scholar
• Lu C, Li AP. Species comparison in P450 induction: Effects of dexamethasone, omeprazole, and rifampin on P450 isoforms 1A and 3A in primary cultured hepatocytes from man Sprague-Dawley rat, minipig, and beagle dog. Chemico-Biological Interactions 2001; 134: 271–281
   PubMed Web of Science ®Google Scholar
• Mercer DF, Schiller DE, Elliott JF, Douglas DN, Hao C, Rinfret A, Addison WR, Fischer KP, Churchill TA, Lakey JR, et al. Hepatitis C virus replication in mice with chimeric human livers. Nature Medicine 2001; 7: 927–933
   PubMed Web of Science ®Google Scholar
• Miyano J, Yamamoto S, Hanioka N, Narimatsu S, Ishikawa T, Ogura K, Watabe T, Nishimura M, Ueda N, Naito S. Involvement of SULT1A3 in elevated sulfation of 4-hydroxypropranolol in Hep G2 cells pretreated with beta-naphthoflavone. Biochemical Pharmacology 2005; 69: 941–950
   PubMed Web of Science ®Google Scholar
• Nishimura M, Imai T, Morioka Y, Kuribayashi S, Kamataki T, Naito S. Effects of NO-1886 (Ibrolipim), a lipoprotein lipase-promoting agent, on gene induction of cytochrome P450s, carboxylesterases, and sulfotransferases in primary cultures of human hepatocytes. Drug Metabolism and Pharmacokinetics 2004a; 19: 422–429
   PubMedGoogle Scholar
• Nishimura M, Naito S. Tissue-specific mRNA expression profiles of human toll-like receptors and related genes. Biological and Pharmaceutical Bulletin 2005; 28: 886–892
   PubMed Web of Science ®Google Scholar
• Nishimura M, Naito S, Yokoi T. Tissue-specific mRNA expression profiles of human nuclear receptor subfamilies. Drug Metabolism and Pharmacokinetics 2004b; 19: 135–149
   PubMedGoogle Scholar
• Nishimura M, Ueda N, Naito S. Effects of dimethyl sulfoxide on the gene induction of cytochrome P450 isoforms UGT-dependent glucuronosyltransferase isoforms, and ABCB1 in primary culture of human hepatocytes. Biological and Pharmaceutical Bulletin 2003b; 26: 1052–1056
   PubMed Web of Science ®Google Scholar
• Nishimura M, Yaguti H, Yoshitsugu H, Naito S, Satoh T. Tissue distribution of mRNA expression of human cytochrome P450 isoforms assessed by high-sensitivity real-time reverse transcription PCR. Yakugaku Zasshi 2003a; 123: 369–375
   PubMed Web of Science ®Google Scholar
• Nishimura M, Yamaguchi M, Yamauchi A, Ueda N, Naito S. Role of soybean oil fat emulsion in the prevention of hepatic xenobiotic transporter mRNA up- and down-regulation induced by overdose of fat-free total parenteral nutrition in infant rats. Drug Metabolism and Pharmacokinetics 2005a; 20: 46–54
   PubMedGoogle Scholar
• Nishimura M, Yamauchi A, Yamaguchi M, Ueda N, Naito S. Soybean oil in total parenteral nutrition maintains albumin and antioxidant enzyme mRNA levels. Biological and Pharmaceutical Bulletin 2005b; 28: 1265–1269
   PubMed Web of Science ®Google Scholar
• Nishimura M, Yokoi T, Tateno C, Kataoka M, Takahashi E, Horie T, Yoshizato K, Naito S. Induction of human CYP1A2 and CYP3A4 in primary culture of hepatocytes from chimeric mice with humanized liver. Drug Metabolism and Pharmacokinetics 2005c; 20: 121–126
   PubMedGoogle Scholar
• Nishimura M, Yoshitsugu H, Naito S, Hiraoka I. Evaluation of gene induction of drug-metabolizing enzymes and transporters in primary culture of human hepatocytes using high-sensitivity real-time reverse transcription PCR. Yakugaku Zasshi 2002; 122: 339–361
   PubMed Web of Science ®Google Scholar
• Pan J, Xiang Q, Ball S. Use of a novel real-time quantitative reverse transcription-polymerase chain reaction method to study the effects of cytokines on cytochrome P450 mRNA expression in mouse liver. Drug Metabolism and Disposition 2000; 28: 709–713
   PubMed Web of Science ®Google Scholar
• Robertson GR, Field J, Goodwin B, Bierach S, Tran M, Lehnert A, Liddle C. Transgenic mouse models of human CYP3A4 gene regulation. Molecular Pharmacology 2003; 64: 42–50
   PubMed Web of Science ®Google Scholar
• Rodrigues AD, Rushmore TH. Cytochrome P450 pharmacogenetics in drug development: In vitro studies and clinical consequences. Current Drug Metablism 2002; 3: 289–309
   PubMed Web of Science ®Google Scholar
• Roymans D, Van Looveren C, Leone A, Parker JB, McMillian M, Johnson MD, Koganti A, Gilissen R, Silber P, Mannens G, et al. Determination of cytochrome P450 1A2 and cytochrome P450 3A4 induction in cryopreserved human hepatocytes. Biochemical Pharmacology 2004; 67: 427–437
   PubMed Web of Science ®Google Scholar
• Tateno C, Yoshizane Y, Saito N, Kataoka M, Utoh R, Yamasaki C, Tachibana A, Soeno Y, Asahina K, Hino H, et al. Near-completely humanized liver in mice shows human-type metabolic responses to drugs. American Journal of Pathology 2004; 165: 901–912
   PubMed Web of Science ®Google Scholar
• Vaisman BL, Lambert G, Amar M, Joyce C, Ito T, Shamburek RD, Cain WJ, Fruchart-Najib J, Neufeld ED, Remaley AT, et al. ABCA1 overexpression leads to hyperalphalipoproteinemia and increased biliary cholesterol excretion in transgenic mice. Journal of Clinical Investigation 2001; 108: 303–309
   PubMed Web of Science ®Google Scholar
• Walle T, Otake Y, Galijatovic A, Ritter JK, Walle UK. Induction of UDP-glucuronosyltransferase UGT1A1 by the flavonoid chrysin in the human hepatoma cell line Hep G2. Drug Metabolism and Disposition 2000; 28: 1077–1082
   PubMed Web of Science ®Google Scholar
• Watanabe T, Shibata N, Westerman KA, Okitsu T, Allain JE, Sakaguchi M, Totsugawa T, Maruyama M, Matsumura T, Noguchi H, et al. Establishment of immortalized human hepatic stellate scavenger cells to develop bioartificial livers. Transplantation 2003; 75: 1873–1880
   PubMed Web of Science ®Google Scholar
• Waxman DJ. P450 gene induction by structurally diverse xenochemicals: Central role of nuclear receptors CAR, PXR, and PPAR. Archives of Biochemistry and Biophysics 1999; 369: 11–23
   PubMed Web of Science ®Google Scholar
• Wilkening S, Stahl F, Bader A. Comparison of primary human hepatocytes and hepatoma cell line Hepg2 with regard to their biotransformation properties. Drug Metabolism and Disposition 2003; 31: 1035–1042
   PubMed Web of Science ®Google Scholar
• Zhang W, Purchio AF, Chen K, Wu J, Lu L, Coffee R, Contag PR, West DB. A transgenic mouse model with a luciferase reporter for studying in vivo transcriptional regulation of the human CYP3A4 gene. Drug Metabolism and Disposition 2003; 31: 1054–1064
   PubMed Web of Science ®Google Scholar