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Xenobiotica
the fate of foreign compounds in biological systems
Volume 35, 2005 - Issue 12
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Research Article

Styrene monomer primarily induces CYP2B1 mRNA in rat liver

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Pages 1089-1099 | Received 24 Jun 2005, Published online: 22 Sep 2008

References

  • Barker CW, Fagan JB, Pasco DS. Down-regulation of P4501A1 and P4501A mRNA expression in isolated hepatocytes by oxidative stress. Journal of Biological Chemistry 1994; 269: 3985–3990
  • Bond JA. Review of the toxicology of styrene. CRC Critical Reviews in Toxicology 1989; 19: 227–249
  • Carlson GP. Effects of inducers and inhibitors on the microsomal metabolism of styrene to styrene oxide in mice. Journal of Toxicology and Environmental Health 1997; 51: 477–488
  • Carlson GP. In vitro metabolism of styrene to styrene oxide in liver and lung of CYP2E1 knockout mice. Journal of Toxicology and Environmental Health, Part A 2003; 66: 861–869
  • Carlson GP, Hynes DE, Mantick NA. Effects of inhibitors of CYP1A and CYP2B on styrene metabolism in mouse liver and lung microsomes. Toxicology letters 1998; 98: 131–137
  • Daré E, Tofighi R, Nutt L, Vettori MV, Emgård M, Mutti A, Ceccatelli S. Styrene 7,8-oxide induces mitochondrial damage and oxidative stress in neurons. Toxicology 2004; 201: 125–132
  • Goodwin B, Moore LB, Stoltz CM, Mckee DD, Kliewer SA. Regulation of the human CYP2B6 gene by the Nuclear pregnane X receptor. Molecular Pharmacology 2001; 60: 427–431
  • Green T, Toghill A, Foster JR. The role cytochromes P-450 in styrene-induced pulmonary toxicity and carcinogenicity. Toxicology 2001; 169: 107–117
  • Hanioka N, Jinno H, Tanaka-Kagawa T, Nishimura T, Ando M. In vitro metabolism of chlorotriazines: characterization of simazine, atrazine, and propazine metabolism using liver microsomes from rats treated with various cytochrome P450 inducers. Toxicology and Applied Pharmacology 1999; 156: 195–205
  • Hynes DE, DeNicola DB, Carlson GP. Metabolism of styrene by mouse and rat isolated lung cells. Toxicological Sciences 1999; 51: 195–201
  • Imaoka S, Osada M, Minamiyama Y, Yukimura T, Toyokuni S, Takemura S, Hiroi T, Funae Y. Role of phenobarbital-inducible cytochrome P450s as a source of active oxygen species in DNA-oxidation. Cancer Letters 2004; 203: 117–125
  • International Agency for Reserch on Cancer. Styrene. IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Humans 1994a; 60: 233–320
  • International Agency for Reserch on Cancer. Styrene-7,8-oxide. IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Humans 1994b; 60: 321–346
  • Jacobs JM, Nichols CE, Andrew AS, Marek DE, Wood SG, Sinclair PR, Wrighton SA, Kostrubsky VE, Sinclair JF. Effect of arsenite on induction of CYP1A, CYP2B, and CYP3A in primary cultures of rat hepatocytes. Toxicology and Applied Pharmacology 1999; 157: 51–59
  • Jentzsch AM, Bachman H, Furst P, Biesalski HK. Improved analysis malondialdehyde in human body fluids. Free Radical Biology and Medicine 1996; 20: 251–256
  • Kinoshita A, Wanibuchi H, Imaoka S, Ogawa M, Masuda C, Morimura K, Funae Y, Fukushima S. Formation of 8-hydroxydeoxyguanosine and cell-cycle arrest in the rat liver via generation of oxidative stress by phenobarbital: association with expression profiles of p21WAF1/Cip1, cyclin D1 and Ogg1. Carcinogenesis 2002; 23: 341–349
  • Kyhse-Andersen J. Electroblotting of multiple gels: a simple apparatus without buffer tank for rapid transfer of proteins from polyacrylamide to nitrocellulose. Journal of Biochemical and Biophysical Methods 1984; 10: 203–209
  • Laemmli UK. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature (London) 1970; 227: 680–685
  • Laffon B, Pérez-Cadahía B, Pásaro E, Méndez J. Individual sensitivity to DNA damage induced by styrene in vitro: influence of cytochrome P450, epoxide hydrolase and glutathione S-transferase genotypes. Toxicology 2003; 186: 131–141
  • Lowry OH, Rosenbrough NJ, Farr AL, Randall RJ. Protein measurement with the folin phenol reagent. Journal of Biological Chemistry 1951; 193: 265–275
  • Minamiyama Y, Takemura S, Toyokuni S, Imaoka S, Funae Y, Hirohashi K, Yoshikawa T, Okada S. CYP3A induction aggravates endotoxemic liver injury via reactive oxygen species in male rats. Free Radical Biology and Medicine 2004; 37: 703–712
  • Nakajima T, Elovaara E, Gonzalez FJ, Gelboin HV, Raunio H, Pelkonen O, Vainio H, Aoyama T. Styrene metabolism by cDNA-expressed human hepatic and pulumonary cytochromes P450. Chemical Research in Toxicology 1994b; 7: 891–896
  • Nakajima T, Wang RS, Elovaara E, Gonzalez FJ, Gelboin HV, Vainio H, Aoyama T. CYP2C11 and CYP2B1 are major cytochrome P450 forms involved in styrene oxidation in liver and lung microsomes from untreated rats, respectively. Biochemical Pharmacolgy 1994a; 48: 637–642
  • Navasumrit P, Ward TH, Dodd NJF, O’Connor PJO. Ethanol-induced free radicals and hepatic DNA strand breaks are prevented in vivo by antioxidants: effects of acute and chronic ethanol exposure. Carcinogenesis 2000; 21: 93–99
  • Novak RF, Woodcroft KJ. The alcohol-inducible form of cytochrome P450 (CYP2E1): role in toxicology and regulation of expression. Archives of Pharmacal Research 2000; 23: 267–282
  • Roberts BJ, Song BJ, Soh Y, Park SS, Shoaf SE. Ethanol induces CYP2E1 by protein stabilization. Role of ubiquitin conjugation in the rapid degradation of CYP2E1. Journal of Biological Chemistry 1995; 270: 29632–29635
  • Song BJ, Veech RL, Park SS, Gelboin HV, Gonzalez FJ. Induction of rat hepatic N-nitrosodimethylamine demetythylase by acetone is due to protein stabilization. Journal of Biological Chemistry 1989; 264: 3568–3572
  • Srivastava SP, Das M, Seth PK. Enhancement of lipid peroxidation in rat iver on acute exposure to styrene and acrylamide a consequence of glutathione depletion. Chemico-Biological Interactions 1983; 45: 373–380
  • Sumner S, Ghanayem B, Asgharian B, Williams C, Chana B, Gonzalez F, Fennell T. The role of cytochrome P450 in the metabolism of (13C/14C) styrene. Toxicologist 2001; 60: 403
  • Taura K, Yamada H, Naito E, Ariyoshi N, Mori M, Oguri K. Activation of microsomal epoxide hydrolase by interaction with cytochromes P450: kinetic analysis of the association and substrate-specific activation of epoxide hydrolase function. Archives of Biochemistry and Biophysics 2002; 402: 275–280
  • Turner M, Mantick NA, Carlson GP. Comparison of the depletion of glutathione in mouse liver and lung following administration of styrene and its metabolites styrene oxide and 4-vinylphenol. Toxicology 2005; 206: 383–388
  • Vettori MV, Caglieri A, Goldoni M, Castoldi AF, Darè E, Alinovi R, Ceccatelli S, Mutti A. Analysis of oxidative stress in SK-N-MC neurons exposed to styrene-7,8-oxide. Toxicology in Vitro 2005; 19: 11–20
  • Vodicka P, Koskinen M, Vodicková L, Štetina R, Šmerák P, Bárta I, Hemminki K. DNA adducts, strand breaks and micronuclei in mice exposed to styrene by inhalation. Chemico-Biological Interactions 2001; 137: 213–227
  • Wang H, Faucette S, Sueyoshi T, Moore R, Forguson S, Negishi M, LeCluyse EL. A novel distal enhancer module regulated by pregnane X receptor/constitutive androstane receptor is essential for the maximal induction of CYP2B6 gene expression. Journal of Biological Chemistry 2003; 278: 14146–14152
  • Wei P, Zhang J, Egan-Hafley M, Liang S, Moore DD. The nuclear receptor CAR mediates specific xenobiotic induction of drug metabolism. Nature 2000; 407: 920–923
  • Whitlock Jr, JP. Induction of cytochrome P450 1A1. Annual Review of Pharmacology and Toxicology 1999; 39: 103–125
  • Yamamoto Y, Moore R, Goldsworthy TL, Negishi M, Maronpot RR. The orphan nuclear receptor constitutive active/androstane receptor is essential for liver tumor promotion by phenobarbital in mice. Cancer Research 2004; 64: 7197–7200
  • Yamazoe Y, Murayama N, Shimada M, Yamauchi K, Kato R. Cytochrome P450 in livers of diabetic rats: regulation by growth formone and insulin. Archives of Biochemistry Biophysics 1989; 268: 567–575
  • Yoshinari K, Sato T, Okino N, Sugatani J, Miwa M. Expression and induction of cytochromes P450 in rat white adipose tissue. Journal of Pharmacology and Experimental Therapeutics 2004; 311: 147–154
  • Zhang H, Leculyse E, Liu L, Hu M, Matoney L, Zhu W, Yan B. Rat pregnane X receptor: Molecular cloning, tissue distribution, and xenobiotic regulation. Archives of Biochemistry and Biophysics 1999; 368: 14–22
  • Zhang J, Huang W, Chua SS, Wei P, Moore DD. Modulation of acetaminophen-induced hepatotoxicity by the xenobiotic receptor CAR. Science 2002; 298: 422–424

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