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Xenobiotica
the fate of foreign compounds in biological systems
Volume 36, 2006 - Issue 1
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Research Article

Intestinal CYP3A4 is not involved in the enantioselective disposition of lansoprazole

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Pages 95-102 | Received 03 Aug 2005, Published online: 22 Sep 2008

References

  • Ameer B, Weintraub RA. Drug interactions with grapefruit juice. Clinical Pharmacokinetics 1997; 33: 103–121
  • Andersson T. Pharmacokinetics, metabolism and interactions of acid pump inhibitors. Focus on omeprazole, lansoprazole and pantoprazole. Clinical Pharmacokinetics 1996; 31: 9–28
  • Bailey DG, Malcolm J, Arnold O, Spence JD. Grapefruit juice–drug interactions. British Journal of Clinical Pharmacology 1998; 46: 101–110
  • De Morais SM, Wilkinson GR, Blaisdell J, Meyer UA, Nakamura K, Goldstein JA. Identification of a new genetic defect responsible for the polymorphism of (S)-mephenytoin metabolism in Japanese. Molecular Pharmacology 1994; 46: 594–598
  • Hall SD, Thummel KE, Watkins PB, Lown KS, Benet LZ, Paine MF, Mayo RR, Turgeon DK, Bailey DG, Fontana RJ, Wrighton SA. Molecular and physical mechanisms of first-pass extraction. Drug Metabolism and Disposition 1999; 27: 161–166
  • Katsuki H, Hamada A, Nakamura C, Arimori K, Nakano M. Role of CYP3A4 and CYP2C19 in the stereoselective metabolism of lansoprazole by human liver microsomes. European Journal of Clinical Pharmacology 2001; 57: 709–715
  • Katsuki H, Nakamura C, Arimori K, Fujiyama S, Nakano M. Genetic polymorphism of CYP2C19 and lansoprazole pharmacokinetics in Japanese subjects. European Journal of Clinical Pharmacology 1997; 52: 391–396
  • Kim KA, Kim MJ, Park JY, Shon JH, Yoon YR, Lee SS, Liu KH, Chun JH, Hyun MH, Shin JG. Stereoselective metabolism of lansoprazole by human liver cytochrome P450 enzymes. Drug Metabolism and Disposition 2003; 31: 1227–1234
  • Kolars JC, Lown KS, Schmiedlin-Ren P, Ghosh M, Fang C, Wrighton SA, Merion RM, Watkins PB. CYP3A gene expression in human gut epithelium. Pharmacogenetics 1994; 4: 247–259
  • Miura M, Tada H, Suzuki T. Simultaneous determination of lansoprazole enantiomers and their metabolites in plasma by liquid chromatography with solid-phase extraction. Journal of Chromatography B 2004b; 804: 389–395
  • Miura M, Tada H, Yasui-Furukori N, Uno T, Sugawara K, Tateishi T, Suzuki T. Pharmacokinetic differences between the enantiomers of lansoprazole and its metabolite, 5-hydroxylansoprazole, in relation to CYP2C19 genotypes. European Journal of Clinical Pharmacology 2004a; 60: 623–628
  • Miura M, Tada H, Yasui-Furukori N, Uno T, Sugawara K, Tateishi T, Suzuki T. The effect of clarithromycin on the enantioselective disposition of lansoprazole in relation to CYP2C19 genotypes. Chirality 2005a; 17: 338–344
  • Miura M, Tada H, Yasui-Furukori N, Uno T, Sugawara K, Tateishi T, Suzuki T. Enantioselective disposition of lansoprazole in relation to CYP2C19 genotypes in the presence of fluvoxamine. British Journal of Clinical Pharmacology 2005b; 60: 61–68
  • Nagaya H, Satoh H, Maki Y. Possible mechanism for the inhibition of acid formation by the proton pump inhibitor AG-1749 in isolated canine parietal cells. Journal of Pharmacology and Experimental Therapeutics 1990; 252: 1289–1295
  • Pearce RE, Rodrigues AD, Goldstein JA, Parkinson A. Identification of the human P450 enzymes involved in lansoprazole metabolism. Journal of Pharmacology and Experimental Therapeutics 1996; 277: 805–816
  • Pichard L, Curi-Pedrosa R, Bonfils C, Jacqz-Aigrain E, Domerque J, Joyeux H, Cosme J, Guengerich FP. Oxidative metabolism of lansoprazole by human liver cytochromes P450. Molecular Pharmacology 1995; 47: 410–418
  • Prueksaritanont T, Gorham LM, Hochman JH, Tran LO, Vyas KP. Comparative studies of drug-metabolizing enzymes in dog, monkey, and human small intestines, and in Caco-2 cells. Drug Metabolism and Disposition 1996; 24: 634–642
  • Wacher VJ, Salphati L, Benet LZ. Active secretion and enterocytic drug metabolism barriers to drug absorption. Advanced Drug Delivery Reviews 2001; 46: 89–102
  • Watkins PB. The barrier function of CYP3A4 and P-glycoprotein in the small bowel. Advanced Drug Delivery Reviews 1997; 27: 161–170
  • Zhang QY, Dunbar D, Ostrowska A, Zeisloft S, Yang J, Kaminsky LS. Characterization of human small intestinal cytochromes P-450. Drug Metabolism and Disposition 1999; 27: 804–809

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