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Xenobiotica
the fate of foreign compounds in biological systems
Volume 36, 2006 - Issue 1
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Research Article

Metabolism of 3-chloro-4-fluoroaniline in rat using [14C]-radiolabelling, 19F-NMR spectroscopy, HPLC-MS/MS, HPLC-ICPMS and HPLC-NMR

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Pages 59-77 | Received 30 Aug 2005, Published online: 22 Sep 2008

References

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  • Scarfe GB, Clayton E, Wilson ID, Nicholson JK. Identification and quantification of metabolites of 2,3,5,6-tetrafluoro-4-trifluoromethylaniline in rat urine using 19F nuclear magnetic resonance spectroscopy, high-performance liquid chromatography-nuclear magnetic resonance spectroscopy and high-performance liquid chromatography-mass spectrometry. Journal of Chromatography B 2000; 748: 311–319
  • Scarfe GB, Lindon JC, Nicholson JK, Wright B, Clayton E, Taylor S, Wilson ID. Investigation of the quantitative metabolic fate and excretion of 3-methyl-4-trifluoromethylaniline and 3-methyl-4-trifluoromethylacetanilide in the rat. Drug Metabolism and Disposition 1999c; 27: 1171–1178
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  • Scarfe GB, Wright B, Clayton E, Taylor S, Wilson ID, Lindon JC, Nicholson JK. Quantitative studies on the urinary metabolic fate of 2-chloro-4-trifluoromethylaniline in the rat using 19F-NMR spectroscopy and directly coupled HPLC-NMR-MS. Xenobiotica 1999b; 29: 77–91
  • Tugnait M, Lenz EM, Phillips P, Hofmann M, Spraul M, Lindon JC, Nicholson JK, Wilson ID. The metabolism of 4-trifluoromethoxyaniline and [13C]-4-trifluoromethoxyaniline in the rat: detection and identification of metabolites excreted in the urine by NMR and HPLC NMR. Journal of Pharmaceutical and Biomedical Analysis 2002; 8: 875–885
  • Vervoort J, De PA, Steenbergen J, Rietjiens IMCM. Development of a 19F-NMR method for studies on the in vivo and in vitro metabolism of 2-fluoroaniline. Xenobiotica 1990; 20: 657–660
  • Williams DH, Fleming I. Spectroscopic methods in organic chemistry, 4th ed. McGraw-Hill, Maidenhead 1989

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