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Xenobiotica
the fate of foreign compounds in biological systems
Volume 36, 2006 - Issue 6
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Research Article

Metabolism and disposition of 2,2′,4,4′,5-pentabromodiphenyl ether (BDE99) following a single or repeated administration to rats or mice

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Pages 515-534 | Received 03 Feb 2006, Accepted 04 Mar 2006, Published online: 22 Sep 2008

References

  • Birnbaum LS, Decad GM, Matthews HB. Disposition and excretion of 2,3,7,8-tetrachlorodibenzodioxin in the rat. Toxicology and Applied Pharmacology 1980; 55: 342–352
  • Birnbaum LS, Staskal DF. Brominated flame retardants: Cause for concern?. Environmental Health Perspectives 2004; 112: 9–17
  • Charbonneau M, Strasser J, Lock EA, Turner MJ, Swenberg JA. Involvement of reversible binding to α2u-globulin in 1,4-dichlorobenzene-induced nephrotoxicity. Toxicology and Applied Pharmacology 1989; 99: 122–132
  • Cope AC, Tiffany BD. Cyclic polyolefins. XVIII. Rearrangement of cyclooctatetraene oxide to 1,3,5-cyclooctatrien-7-one. Journal of the American Chemical Society 1951; 73: 4158–4161
  • Darnerud PO, Risberg S. Tissue localisation of tetra- and pentabromodiphenyl ether congeners (BDE-47, -85 and -99) in perinatal and adult C57BL mice. Chemosphere 2006; 62: 485–493
  • De Wit CA. An overview of brominated flame retardants in the environment. Chemosphere 2002; 46: 583–624
  • Eriksson P, Viberg H, Jakobsson E, Örn U, Fredriksson A. A brominated flame retardant, 2,2′,4,4′,5-pentabromodiphenyl ether: Uptake, retention, and induction of neurobehavioral alterations in mice during a critical phase of neonatal brain development. Toxicological Sciences 2002; 67: 98–103
  • Fowles JR, Fairbrother A, Baecher-Steppan L, Kerkvliet NI. Immunologic and endocrine effects of the flame retardant pentabromodiphenyl ether (DE71) in C57BL/6J mice. Toxicology 1994; 86: 49–61
  • Hakk H, Larsen G, Bergman Å, Örn U. Binding of brominated diphenyl ethers to male rat carrier proteins. Xenobiotica 2002b; 32: 1079–1091
  • Hakk H, Larsen G, Klasson-Wehler E. Tissue disposition, excretion and metabolism of 2,2′,4,4′,5-pentabromodiphenyl ether (BDE-99) in the male Sprague–Dawley rat. Xenobiotica 2002a; 32: 369–382
  • International Programme on Chemical SafetyBrominated diphenyl ethersEnvironmental Health Criteria No. 162Geneva: World Health Organization, IPCS. 1994
  • Livesey JC, Anders MW, Langvardt PW, Putzig CL, Reitz RH. Stereochemistry of the glutathione-dependent biotransformation of vicinal-dihaloalkanes to alkenes. Drug Metabolism and Disposition 1982; 10: 201–204
  • Marsh G, Bergman Å, Bladh L-G, Gillner M, Jakobsson E. Synthesis of p-hydroxybromodiphenyl ethers and binding to the thyroid receptor. Organohalogen Compounds 1998; 37: 305–308
  • Matthews HB. Excretion and elimination of toxicants and their metabolites. Introduction to biochemical toxicology, 2nd, E Hodgson, PE Levi. Appleton & Lange, East Norwalk, CT 1994; 186
  • Matthews HB, Anderson MW. The distribution and excretion of 2,4,5,2′,5′-pentachlorobiphenyl in the rat. Drug Metabolism and Disposition 1975; 3: 211–219
  • Meerts IATM, Letcher RJ, Hoving S, Marsh G, Bergman Å, Lemmen JG, Van der Burg B, Brouwer A. In vitro estrogenicity of polybrominated diphenyl ethers, hydroxylated PBDEs, and polybrominated bisphenol A compounds. Environmental Health Perspectives 2001; 109: 399–407
  • Meerts IATM, Van Zanden JJ, Luijks EAC, Van Leeuwen-Bol I, Marsh G, Jakobsson E, Bergman Å, Brouwer A. Potent competitive interactions of some brominated flame retardants and related compounds with human transthyretin in vitro. Toxicological Sciences 2000; 56: 95–104
  • Meironyté D, Norén K, Bergman Å. Analysis of polybrominated diphenyl ethers in Swedish human milk. A time-related trend study, 1972–1997. Journal of Toxicology and Environmental Health A 1999; 58: 329–341
  • National Toxicology ProgramToxicology and carcinogenesis studies of decabromodiphenyl oxide (CAS No. 1163-19-5) in F344/N rats and B6C3F1 mice (feed studies)US DHHS NTP Technical Report No. 309, NIH Publication No. 86-25651986
  • Sanders JM, Burka LT, Smith CS, Black W, James R, Cunningham ML. Differential expression of CYP1A, 2B, and 3A genes in the F344 rat following exposure to a polybrominated diphenyl ether mixture or individual components. Toxicological Sciences 2005; 88: 127–133
  • Sanders JM, Chen L-J, Lebetkin EH, Burka LT. Metabolism and disposition of 2,2′,4,4′-tetrabromodiphenyl ether following administration of single or multiple doses to rats and mice. Xenobiotica 2006; 36: 103–117
  • Schecter A, Pavuk M, Papke O, Ryan JJ, Birnbaum L, Rosen R. Polybrominated diphenyl ethers (PBDEs) in U.S. mother's milk. Environmental Health Perspectives 2003; 111: 1723–1729
  • Sjödin A, Jones RS, Focant J-F, Lapeza C, Wang RY, McGahee EE, Zhang Y, Turner WE, Slazyk B, Needham LL, Patterson DG. Retrospective time-trend study of polybrominated diphenyl ether and polybrominated and polychlorinated biphenyl levels in human serum from the United States. Environmental Health Perspectives 2004; 112: 654–658
  • Tulp M ThM, Sundström G, Martron LBJM, Hutzinger O. Metabolism of chlorodiphenyl ethers and Irgasan® DP 300. Xenobiotica 1979; 9: 65–77
  • Zhou T, Ross DG, DeVito MJ, Crofton KM. Effects of short-term in vivo exposure to polybrominated diphenyl ethers on thyroid hormones and hepatic enzyme activities in weanling rats. Toxicological Sciences 2001; 61: 76–82
  • Zhou T, Tayler MM, DeVito MJ, Crofton KM. Developmental exposure to polybrominated diphenyl ethers results in thyroid hormone disruption. Toxicological Sciences 2002; 66: 105–116

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