Publication Cover
Xenobiotica
the fate of foreign compounds in biological systems
Volume 36, 2006 - Issue 7
338
Views
25
CrossRef citations to date
0
Altmetric
Research Article

Identification of phenacetin metabolites in human urine after administration of phenacetin-C2H3: Measurement of futile metabolic deacetylation via HPLC/MS-SPE-NMR and HPLC-ToF MS

, , , &
Pages 615-629 | Received 26 Jan 2006, Accepted 22 Mar 2006, Published online: 22 Sep 2008

References

  • Brodie BB, Axelrod J. The fate of acetaphenetidin (phenacetin) in man and its metabolites in biological materials. Journal of Pharmacology and Experimental Therapeutics 1949; 97: 58–67
  • Buckalew VM, Jr. Habitual use of acetaminophen as a risk factor for chronic renal failure: A comparison with phenacetin. American Journal of Kidney Diseases 1996; 28: S7–13
  • Duggin GG. Mechanisms in the development of analgesic nephropathy. Kidney International 1980; 18: 553–561
  • Duggin GG. The biochemistry and pharmacology of antipyretic-analgesics. Analgesic and NSAID-induced kidney disease, JH Stewart. Oxford Medical, Oxford 1993; 5–16
  • Gloor FJ. Historical introduction. Analgesic and NSAID-induced kidney disease, JH Stewart. Oxford Medical, Oxford 1993; 1–3
  • Goldstein RS, Schnellmann RG. Toxic responses of the kidney. Casarett and Doull's toxicology: The basic science of poisons, CD Klassen. McGraw-Hill, New York, NY 1996; 417–442
  • Green CR, Ham KN, Tange JD. Kidney lesions induced in rats by p-aminophenol. British Medical Journal 1969; 1: 162–164
  • Guengerich FP, Shimada T. Human cytochrome P450 enzymes and chemical carcinogenesis. Human drug metabolism: from molecular biology to man, EH Jeffrey. CRC Press, Boca Raton, FL 1993; 5–12
  • Hinson JA. Reactive metabolites of phenacetin and acetaminophen: A review. Environmental Health Perspectives 1983; 49: 71–79
  • McLaughlin JK, Lipworth L, Wong-Ho C, Blot WJ. Analgesic use and chronic renal failure: A critical review of the epidemiologic literature. Kidney International 1998; 54: 679–686
  • Nelson SD. Metabolic activation and drug toxicity. Journal of Medical Chemistry 1982; 25: 753–765
  • Nicholls AW, Caddick S, Wilson ID, Farrant RD, Lindon JC, Nicholson JK. High resolution NMR spectroscopic studies on the metabolism and futile deacetylation of 4-hydroxyacetanilide (paracetamol) in the rat. Biochemical Pharmacology 1995; 49: 1155–1164
  • Nicholls AW, Farrant RD, Shockcor JP, Unger SE, Wilson ID, Lindon JC, Nicholson JK. NMR and HPLC-NMR spectroscopic studies of futile deacetylation in paracetamol metabolites in rat and man. Journal of Pharmaceutical and Biomedical Analysis 1997b; 15: 901–910
  • Nicholls AW, Lindon JC, Caddick S, Farrant RD, Wilson ID, Nicholson JK. NMR spectroscopic studies on the metabolism and futile deacetylation of phenacetin in the rat. Xenobiotica 1997a; 27: 1175–1186
  • Raaflaub J, Dubach UC. On the pharmacokinetics of phenacetin in man. European Journal of Clinical Pharmacology 1975; 8: 261–265
  • Sandler DP, Smith JC, Weinberg CR, Buckalew MD Jr, Dennis VW, Blythe WB, Burgess WP. Analgesic use and chronic renal disease. New England Journal of Medicine 1989; 320: 1238–1243
  • Smith PK. Acetophenetidin: A critical bibliographic review. Interscience, New York, NY 1958
  • Spühler O, Zollinger HU. Die chronisch-interstitiellenephritis. Zeitschrift für Klinische Medizin 1953; 151: 1–50
  • Thomas SHL. Paracetamol (acetaminophen) poisoning. Pharmacology and Therapeutics 1993; 60: 91–120

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.