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Xenobiotica
the fate of foreign compounds in biological systems
Volume 36, 2006 - Issue 9
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Original

Disposition and metabolism of almotriptan in rats, dogs and monkeys

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Pages 807-823 | Received 04 Apr 2006, Accepted 13 May 2006, Published online: 11 Aug 2009

References

  • Aronson JK, Dengler HJ, Dettli L, Follath F. Standardization of symbols in clinical pharmacology. European Journal of Clinical Pharmacology 1988; 35: 1–7
  • Bou J, Domenech T, Puig J, Heredia A, Gras J, Fernandez-Forner D, Beleta J, Palacios JM. Pharmacological characterization of almotriptan: An indolic 5-HT receptor agonist for the treatment of migraine. European Journal of Pharmacology 2000; 410: 33–41
  • Bou J, Gras J, Cortijo J, Morcillo EJ, Llenas J, Palacios JM. Vascular effects of the new anti-migraine agent almotriptan on human cranial and peripheral arteries. Cephalgia 2001; 21: 804–812
  • Buchan P, Wade A, Ward C, Oliver SD, Stewart AJ, Freestone S. Frovatriptan: A review of drug–drug interactions. Headache 2002; 42(Suppl. 2)S63–S73
  • Cabarrocas X, Esbri R, Peris F, Ferrer P. Long-term efficacy and safety of oral almotriptan: Interim analysis of a 1-year open study. Headache 2001; 41: 57–62
  • Committee for Pharmacokinetic Nomenclature of the American College of Clinical Pharmacology. Manual of symbols, equations and definitions in Pharmacokinetics. Journal of Clinical Pharmacology 1982; 22: 1S–23S
  • Dixon CM, Park GR, Tarbit MH. Characterization of the enzyme responsible for the metabolism of sumatriptan in human liver. Biochemical and Pharmacology 1994; 47: 1253–1257
  • Dixon CM, Saynor DA, Andrew PD, Oxford J, Bradbeyrt A, Tarbit MH. Disposition of sumatriptan in laboratory animals and humans. Drug Metabolism and Disposition 1993; 21: 761–769
  • Dodick DW. Oral almotriptan in the treatment of migraine: Safety and tolerability. Headache 2001; 41: 449–455
  • Dodick DW, Martin V. Triptans and CNS side-effects: Pharmacokinetic and metabolic mechanisms. Cephalalgia 2004; 24: 417–424
  • Evans DC, O’Connor D, Lake BG, Evers R, Allen C, Hargreaves R. Eletriptan metabolism by human hepatic CYP450 enzymes and transport by human P-glycoprotein. Drug Metabolism and Disposition 2003; 31(7)861–869
  • Ferrari MD, Saxena PR. 5-HT1 receptors in migraine pathophysiology and treatment. European Journal of Neurology 1995; 2: 5–21
  • Gras J, Bou J, Llenas J, Fernandez AG, Palacios JM. Functional profile of almotriptan in animal models predictive of antimigraine activity. European Journal of Pharmacology 2000a; 410: 43–51
  • Gras J, Cardelus I, Llenas J, Palacios JM. Cardiovascular safety profile of almotriptan, a new indolic derivative for the treatment of migraine. European Journal of Pharmacology 2000b; 410: 53–59
  • Jansat JM, Costa J, Salva P, Fernandez FJ, Martinez-Tobed A. Absolute bioavailability, pharmacokinetics, and urinary excretion of the novel antimigraine agent almotriptan in healthy male volunteers. Journal of Clinical Pharmacology 2002; 42: 1303–1310
  • Mathew NT. Naratriptan: A review. Expert Opinions in Investigational Drugs 1999; 8: 687–695
  • Milton KA, Scott NR, Allen MJ, Abel S, Jenkins VC, James GC, Rance DJ, Eve MD. Pharmacokinetics, pharmacodynamics, and safety of the 5-HT(1B/1D) agonist eletriptan following intravenous and oral administration. Journal of Clinical Pharmacology 2002; 42(5)528–539
  • Pascual J, Falk RM, Piessens F, Prusinski A, Docekal P, Robert M, Ferrer P, Luria X, Segarra R, Zayas JM. Consistent efficacy and tolerability of almotriptan in the acute treatment of multiple migraine attacks: Results of a large, randomized, double-blind, placebo-controlled study. Cephalgia 2000; 20: 588–596
  • Perry CM, Markham A. Sumatriptan. An updated review of its use in migraine. Drugs 1998; 55: 889–922
  • Salva M, Jansat JM, Martinez-Tobed A, Palacios P. Identification of the human liver enzymes involved in the metabolism of the antimigraine agent almotriptan. Drug Metabolism and Disposition 2003; 31: 404–411
  • Seaber EJ, Peck RW, Smith DA, Allanson J, Hefting NR, Van Lier JJ, Sollie FA, Wemer J, Jonkman JH. The absolute bioavailability and effect of food on the pharmacokinetics of zolmitriptan in healthy volunteers. British Journal of Clinical Pharmacology 1998; 48: 433–439
  • Ullberg S, Larsson B. Whole-body autoradiography. Methods in Enzymology 1981; 77: 64–80
  • Vyas KP, Halpin RA, Geer LA, Ellis JD, Liu L, Cheng H, Chavez-Eng C, Matuszewski BK, Varga SL, Guiblin AR, Rogers JD. Disposition and pharmacokinetics of the antimigraine drug, rizatriptan, in humans. Drug Metabolism and Disposition 2000; 28: 89–95
  • Wild MJ, McKillop D, Butters CJ. Determination of the human cytochrome P450 isoforms involved in the metabolism of zolmitriptan. Xenobiotica 1999; 29: 847–885
  • Yates RA, Tateno M, Nairn K, Ikegami A, Dane A, Kemp J. The pharmacokinetics of the antimigraine compound zolmitriptan in Japanese and Caucasian subjects. European Journal of Clinical Pharmacology 2002; 58(4)247–252

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