Possible multiple transporters were involved in hepatobiliary excretion of antofloxacin in rats

References

• Akashi M, Tanaka A, Takikawa H. Effect of cyclosporin A on the biliary excretion of cholephilic compounds in rats. Hepatology Research 2006; 34: 193–198
   PubMedGoogle Scholar
• Bodó A, Bakos É, Szeri F, Váradi A, Sarkadi B. Differential modulation of the human liver conjugate transporters MRP2 and MRP3 by bile acids and organic anion. Journal of Biological Chemistry 2003; 278: 23529–23537
   PubMed Web of Science ®Google Scholar
• Bradford MM. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Analytical Biochemistry 1976; 72: 248–254
   PubMed Web of Science ®Google Scholar
• Chadwick RW, Copeland MF, Carlson GP, Trela BA, Most BM. Comparison of in vivo and in vitro methods for assessing the effects of carbon tetrachloride on the hepatic drug-metabolizing enzyme system. Toxicology Letters 1988; 42: 309–316
   PubMedGoogle Scholar
• Chan LM, Lowes S, Hirst BH. The ABCs of drug transport in intestine and liver: Efflux proteins limiting drug absorption and bioavailability. European Journal of Pharmaceutical Sciences 2004; 21: 25–51
   PubMed Web of Science ®Google Scholar
• Chen ZS, Kawabe T, Ono M, Aoki S, Sumizawa T, Furukawa T, Uchiumi T, Wada M, Kuwano M, Akiyama SI. Effect of multidrug resistance-reversing agents on transporting activity of human canalicular multispecific organic anion transporter. Molecular Pharmacology 1999; 56: 1219–1228
   PubMed Web of Science ®Google Scholar
• Dautrey S, Felice K, Petiet A, Lacour B, Carbon C, Farinotti R. Active intestinal elimination of ciprofloxacin in rats: Modulation by different substrates. British Journal of Pharmacology 1999; 127: 1728–1734
   PubMed Web of Science ®Google Scholar
• Dietrich CG, Geier A, Oude Elferink RPJ. ABC of oral bioavailability: Transporters as gatekeepers in the gut. Gut 2003; 52: 1788–1795
   PubMed Web of Science ®Google Scholar
• Faber KN, Muller M, Jasen PL. Drug transport proteins in the liver. Advanced Drug Delivery Reviews 2003; 55: 107–124
   PubMed Web of Science ®Google Scholar
• Hata S, Wang P, Eftychiou N, Ananthanarayanan M, Batta A, Salen G, Pang KS, Wolkoff AW. Substrate specificities of rat oatp1 and ntcp: Implications for hepatic organic anion uptake. American Journal of Physiology. Gastrointestinal and Liver Physiology 2003; 285: G829–G839
   Google Scholar
• Heilborna U, Rostb BR, Arboreliusc L, Brodina E. Arthritis-induced increase in cholecystokinin release in the rat anterior cingulate cortex is reversed by diclofenac. Brain Research 2007; 1136: 51–58
   PubMedGoogle Scholar
• Hiroyuki K, Yuichi S. Efflux transport systems for drugs at the blood–brain barrier and blood–cerebrospinal fluid barrier. Drug Discovery Today 2001; 6: 150–156
   PubMedGoogle Scholar
• Hu JH, Liu XD, Xie L. An HPLC method for the determination of antofloxacin in rat plasma and bile and its pharmacokineic study. Journal of China Pharmaceutical University 2006; 37: 153–156, (Chinese)
   Google Scholar
• Huang ZH, Murakami T, Okochi A, Yumoyo R, Nagai J, Takano M. Expression and function of P-glycoprotein in rats with carbon tetrachloride-induced acute hepatic failure. Journal of Pharmacy and Pharmacology 2001; 53: 873–881
   PubMed Web of Science ®Google Scholar
• Khamdang S, Takeda M, Noshiro R, Narikawa S, Enomoto A, Anzai N, Piyachaturawat P, Endou H. Interactions of human organic anion transporters and human organic cation transporters with nonsteroidal anti-inflammatory drugs. Journal of Pharmacology and Experimental Therapeutics 2002; 303: 534–539
   PubMed Web of Science ®Google Scholar
• Liu XD, Zhang L, Xie L. Effect of P-glycoprotein inhibitors erythromycin and cyclosporin A on brain pharmacokinetics of nimodipine in rats. European Journal of Drug Metabolism and Pharmacokinetics 2003; 28: 309–313
   PubMedGoogle Scholar
• Merino G, Alvarez AI, Pulido MM, Molina AJ, Schinkel AH, Prieto JG. Breast cancer resistance protein (bcrp/abcg2) transports fluoroquinolone antibiotics and affects their oral availability, pharmacokinetics, and milk secretion. Drug Metabolism and Disposition 2006; 34: 690–695
   PubMed Web of Science ®Google Scholar
• Mostafavi SA, Foster RT. Influence of cimetidine co-administration on the pharmacokinetics of acebutolol enantiomers and its metabolite diacetolol in a rat model: The effect of gastric pH on double-peak phenomena. International Journal of Pharmaceutics 2003; 255: 81–86
   PubMedGoogle Scholar
• Motohashi H, Uwai Y, Hiramoto K, Okuda M, Inui K. Different transport properties between famotidine and cimetidine by human renal organic ion transporters (SLC22A). European Journal of Pharmacology 2004; 503: 25–30
   PubMed Web of Science ®Google Scholar
• Murakami T, Yumoto R, Nagai J, Takano M. Factors affecting the expression and function of P-glycoprotein in rats: Drug treatments and diseased states. Pharmazie 2002; 57: 102–107
   PubMed Web of Science ®Google Scholar
• Murata M, Tamai I, Sai Y, Nagata O, Kato H, Sugiyama Y, Tsuji A. Hepatobiliary transport kinetics of HSR-903, a new quinolone antibacterial agent. Drug Metabolism and Disposition 1998; 26: 1113–1119
   PubMed Web of Science ®Google Scholar
• Nadai M, Zhao YL, Wang L, Nushio Y, Takagi K, Kitaichi K, Takagi K, Yoshizami H, Hasegawa T. Endotoxin impairs biliary transport of sparfloxacin and its glucuronide in rats. European Journal of Pharmacology 2001; 432: 99–105
   PubMedGoogle Scholar
• Naruhashi K, Tamai I, Inoue N, Muraoka H, Sai Y, Suzuki N, Tsuji A. Active intestinal secretion of new quinolone antimicrobials and the partial contribution of P-glycoprotein. Journal of Pharmacy and Pharmacology 2001; 53: 699–709
   PubMed Web of Science ®Google Scholar
• Niinuma K, Kato Y, Suzuki H, Tyson CA, Weiter V, Dabbs JE, Froehlich R, Green CE, Sugiyama Y. Primary active transport of organic anions on bile canalicular membrane in humans. American Journal of Physiology 1999; 276: 1153–1164
   PubMed Web of Science ®Google Scholar
• Oh YH, Han HK. Pharmacokinetic interaction of tetracycline with non-steroidal anti-inflammatory drugs via organic anion transporters in rats. Pharmacological Research 2006; 53: 75–79
   PubMedGoogle Scholar
• Pavek P, Merino G, Wagenaar E, Bolscher E, Novotna M, Jonker JW, Schinkel AH. Human breast cancer resistance protein: Interactions with steroid drugs, hormones, the dietary carcinogen 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine, and transport of cimetidine. Journal of Pharmacology and Experimental Therapeutics 2005; 312: 144–152
   PubMed Web of Science ®Google Scholar
• Potschka H, Baltes S, Löscher W. Inhibition of multidrug transporters by verapamil or probenecid does not alter blood–brain barrier penetration of levetiracetam in rats. Epilepsy Research 2004; 58: 85–91
   PubMed Web of Science ®Google Scholar
• Rodriguez-Ibanez M, Nalda-Molina R, Montalar-Montero M, Bermejo MV, Merino V, Garrigues TM. Transintestinal secretion of ciprofloxacin, grepafloxacin and sparfloxacin: In vitro and in situ inhibition studies. European Journal of Pharmaceutics and Biopharmaceutics 2003; 55: 241–246
   PubMed Web of Science ®Google Scholar
• Sallustio BC, Holbrook FL. In vivo perturbation of rat hepatocyte canalicular membrane function by diclofenac. Drug Metabolism and Disposition 2001; 29: 1535–1538
   PubMed Web of Science ®Google Scholar
• Sasabe H, Terasaki T, Tsuji A, Sugiyama Y. Carrier-mediated hepatic uptake of quinolone antibiotics in the rat. Journal of Pharmacology and Experimental Therapeutics 1997; 282: 162–171
   PubMed Web of Science ®Google Scholar
• Sasabe H, Kato Y, Tsuji A, Sugiyama Y. Stereoselective hepatobiliary transport of the quinolone antibiotic grepafloxacin and its glucuronide in the rat. Journal of Pharmacology and Experimental Therapeutics 1998a; 284: 661–668
   PubMedGoogle Scholar
• Sasabe H, Tsuji A, Sugiyama Y. Carrier-mediated mechanism for the biliary excretion of the quinolone antibiotic grepafloxacin and its glucuronide in rats. Journal of Pharmacology and Experimental Therapeutics 1998b; 284: 1033–1039
   PubMed Web of Science ®Google Scholar
• Shitara Y, Sato H, Sugiyama Y. Evaluation of drug–drug interaction in the hepatobiliary and renal transport of drugs. Annual Review of Pharmacology and Toxicology 2005; 45: 689–723
   PubMed Web of Science ®Google Scholar
• Song IS, Lee YM, Chung SJ, Shim CK. Multiple alterations of canalicular membrane transport activities in rats with CCl4-induced hepatic injury. Drug Metabolism and Disposition 2003; 31: 482–490
   PubMed Web of Science ®Google Scholar
• Strassburg CP, Barut A, Obermayer-Straub P, Li Q, Nguyen N, Tukey RH, Manns MP. Identification of cyclosporin A and tacrolimus glucuronidation in human liver and the gastrointestinal tract by a differentially expressed UDP-glucuronosyltransferase: UGT2B7. Journal of Hepatology 2001; 34: 865–872
   PubMed Web of Science ®Google Scholar
• Suzuki T, Zaima C, Moriki Y, Fukami T, Tomono K. P-glycoprotein mediates brain-to-blood efflux transport of buprenorphine across the blood–brain barrier. Journal of Drug Targeting 2007; 15: 67–74
   PubMed Web of Science ®Google Scholar
• Uchaipichat V, Mackenzie PI, Guo XH, Gardner-Stephen D, Galetin A, Houston JB, Miners JO. Human UDP-glucuronosyltransferases: Isoform selectivity and kinetics of 4-methylumbelliferone and 1-naphthol glucuronidation, effects of organic solvents, and inhibition by diclofenac and probenecid. Drug Metabolism and Disposition 2005; 33: 1925–1926
   Google Scholar
• van Montfoort JE, Hagenbuch B, Groothuis GM, Koepsell H, Meier PJ, Meijer DK. Drug uptake systems in liver and kidney. Current Drug Metabolism 2003; 4: 185–211
   PubMed Web of Science ®Google Scholar
• Yagi Y, Shibutani S, Hodoshima N, Ishiwata K, Okudaira N, Li Q, Sai Y, Kato Y, Tsuji A. Involvement of multiple transport systems in the disposition of an active metabolite of a prodrug-type new quinolone antibiotic, prulifloxacin. Drug Metabolism and Pharmacokinetics 2003; 18: 381–389
   PubMedGoogle Scholar
• Ye H, Wu JM, Yang YS, Chen KX, Ji RY. Antibacterial activities of the derivatives YH54 and YH57 of levofloxacin in vitro. Chinese Pharmacological Bulletin 2002; 18: 112–113
   Google Scholar
• Yumoto R, Murakami T, Nakamoto Y, Hasegawa R, Nagai J, Takano M. Transport of rhodamine 123, a P-glycoprotein substrate, across rat intestine and Caco-2 cell monolayers in the presence of cytochrome P-450 3A-related compounds. Journal of Pharmacology and Experimental Therapeutics 1999; 289: 149–155
   PubMed Web of Science ®Google Scholar
• Zhang L, Liu XD, Wang GJ, Xie L, Wang GJ. P-glycoprotein restricted transport of nimodipine across blood–brain barrier. Acta Pharmacologica Sinica 2003; 24: 903–906
   PubMed Web of Science ®Google Scholar
• Zhao YL, Cai SH, Wang L, Kitaichi K, Tatsumi Y, Nadai M, Yoshizumi H, Takagi K. Possible involvement of P-glycoprotein in the biliary excretion of grepafloxacin. Clinical and Experimental Pharmacology and Physiology 2002; 29: 167–172
   PubMed Web of Science ®Google Scholar