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Xenobiotica
the fate of foreign compounds in biological systems
Volume 37, 2007 - Issue 8
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Research Article

Functional involvement of organic cation transporter1 (OCT1/Oct1) in the hepatic uptake of organic cations in humans and rats

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Pages 818-831 | Received 14 May 2007, Accepted 30 Jun 2007, Published online: 22 Sep 2008

References

  • Gorboulev V, Ulzheimer JC, Akhoundova A, Ulzheimer-Teuber I, Karbach U, Quester S, Baumann C, Lang F, Busch AE, Koepsell H. Cloning and characterization of two human polyspecific organic cation transporters. DNA and Cell Biology 1997; 16: 871–881
  • Grundemann D, Gorboulev V, Gambaryan S, Veyhl M, Koepsell H. Drug excretion mediated by a new prototype of polyspecific transporter. Nature 1994; 372: 549–552
  • Hasegawa M, Kusuhara H, Endou H, Sugiyama Y. Contribution of organic anion transporters to the renal uptake of anionic compounds and nucleoside derivatives in rat. Journal of Pharmacology and Experimental Therapeutics 2003; 305: 1087–1097
  • Kekuda R, Prasad PD, Wu X, Wang H, Fei YJ, Leibach FH, Ganapathy V. Cloning and functional characterization of a potential-sensitive, polyspecific organic cation transporter (OCT3) most abundantly expressed in placenta. Journal of Biological Chemistry 1998; 273: 15971–15979
  • Kimura N, Masuda S, Tanihara Y, Ueo H, Okuda M, Katsura T, Inui K. Metformin is a superior substrate for renal organic cation transporter OCT2 rather than hepatic OCT1. Drug Metabolism and Pharmacokinetics 2005; 20: 379–386
  • Koepsell H, Schmitt BM, Gorboulev V. Organic cation transporters. Reviews of Physiology, Biochemistry and Pharmacology 2003; 150: 36–90
  • Miyauchi S, Sugiyama Y, Sawada Y, Iga T, Hanano M. Conjugative metabolism of 4-methylumbelliferone in the rat liver: verification of the sequestration process in multiple indicator dilution experiments. Chemical and Pharmaceutical Bulletin 1987; 35: 4241–4248
  • Motohashi H, Uwai Y, Hiramoto K, Okuda M, Inui K. Different transport properties between famotidine and cimetidine by human renal organic ion transporters (SLC22A). European Journal of Pharmacology 2004; 503: 25–30
  • Muller M, Jansen PL. Molecular aspects of hepatobiliary transport. American Journal of Physiology 1997; 272: G1285–G1303
  • Okuda M, Saito H, Urakami Y, Takano M, Inui K. cDNA cloning and functional expression of a novel rat kidney organic cation transporter, OCT2. Biochemical and Biophysical Research Communications 1996; 224: 500–507
  • Shikata E, Yamamoto R, Takane H, Shigemasa C, Ikeda T, Otsubo K, Ieiri I. Human organic cation transporter (OCT1 and OCT2) gene polymorphisms and therapeutic effects of metformin. Journal of Human Genetics 17 2006, [Epub before print]
  • Shitara Y, Li AP, Kato Y, Lu C, Ito K, Itoh T, Sugiyama Y. Function of uptake transporters for taurocholate and estradiol 17β-D-glucuronide in cryopreserved human hepatocytes. Drug Metabolism and Pharmacokinetics 2003; 18: 33–41
  • Slitt AL, Cherrington NJ, Hartley DP, Leazer TM, Klaassen CD. Tissue distribution and renal developmental changes in rat organic cation transporter mRNA levels. Drug Metabolism and Pharmacokinetics 2002; 30: 212–219
  • Umehara K, Iwatsubo T, Noguchi K, Kamimura H. Comparison of kinetic characteristics of inhibitory effects by biguanides and H2-blockers on the organic cation transporters-mediated transport between human (OCT) and rat (oct): Insight into the application to the development of drug candidates. Xenobiotica 2007; 37: 618–634
  • Wang DS, Jonker JW, Kato Y, Kusuhara H, Schinkel AH, Sugiyama Y. Involvement of organic cation transporter 1 in hepatic and intestinal distribution of metformin. Journal of Pharmacology and Experimental Therapeutics 2002; 302: 510–515
  • Wang DS, Kusuhara H, Kato Y, Jonker JW, Schinkel AH, Sugiyama Y. Involvement of organic cation transporter 1 in the lactic acidosis caused by metformin. Molecular Pharmacology 2003; 63: 844–848
  • Wu X, Huang W, Ganapathy ME, Wang H, Kekuda R, Conway SJ, Leibach FH, Ganapathy V. Structure, function, and regional distribution of the organic cation transporter OCT3 in the kidney. AJP: Renal Physiology 2000; 279: F449–F458
  • Yamazaki M, Akiyama S, Nishigaki R, Sugiyama Y. Uptake is the rate-limiting step in the overall hepatic elimination of pravastatin at steady-state in rats. Pharmaceutical Research 1996a; 13: 1559–1564
  • Yamazaki M, Suzuki H, Sugiyama Y. Recent advances in carrier-mediated hepatic uptake and biliary excretion of xenobiotics. Pharmaceutical Research 1996b; 13: 497–513
  • Zhang L, Dresser MJ, Gray AT, Yost SC, Terashita S, Giacomini KM. Cloning and functional expression of a human liver organic cation transporter. Molecular Pharmacology 1997; 51: 913–921

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